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1.发明授权公开(公告)号：US07927284B2
公开(公告)日：2011-04-19
申请号：US11431806
申请日：2006-05-10
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/02028 , A61B5/0215 , A61B5/0402 , A61B5/053 , A61B5/113 , A61B5/145 , A61B5/14532 , A61B5/4839 , A61N1/3627
摘要： Systems and methods provide for assessing a patient's hemodynamic response to a drug therapy. A patient's hemodynamic response to a drug therapy is monitored using sensor data acquired using one or more sensors. The patient's hemodynamic response to the drug therapy is quantified, such as by quantifying a patient's sensitivity or refractoriness to the drug therapy. The quantified data may be used to optimize a patient's drug therapy, among other uses.
摘要翻译： 系统和方法用于评估患者对药物治疗的血液动力学反应。 使用使用一个或多个传感器获取的传感器数据监测患者对药物治疗的血液动力学响应。 患者对药物治疗的血液动力学反应是量化的，例如通过量化患者对药物治疗的敏感性或不耐受性。 量化的数据可以用于优化患者的药物治疗以及其他用途。
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2.发明授权Rapid shallow breathing detection for use in congestive heart failure status determination 有权快速浅呼吸检测用于充血性心力衰竭状态测定公开(公告)号：US07775983B2
公开(公告)日：2010-08-17
申请号：US11229316
申请日：2005-09-16
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译： 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。
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3.发明授权Decongestive therapy titration for heart failure patients using implantable sensor 有权使用植入式传感器进行心衰患者的消化疗法滴定公开(公告)号：US08271080B2
公开(公告)日：2012-09-18
申请号：US11805311
申请日：2007-05-23
IPC分类号： A61N1/00
CPC分类号： A61B5/4839 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/0402 , A61B5/0537 , A61B5/145 , A61B5/14539 , A61B5/14546 , A61B5/4261 , A61B5/4833 , A61B7/04 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/125 , A61N1/36114 , A61N1/36135 , A61N1/3627 , A61N1/365 , A61N1/37258 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： Assessing decongestive therapy delivered to a heart failure patient involves use of an implantable sensor configured to sense a physiologic parameter indicative of the patient's diuresis status and a processor coupled to the implantable sensor. The sensor may comprise a thoracic fluid sensor, a heart sounds sensor, a cardiac chamber or arterial pressure sensor, a respiration sensor, or a blood chemistry sensor, for example. The processor is configured to determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient, and to produce an output in response to determining that the target level of patient diuresis has been achieved. The processor may be disposed in an implantable housing, in a patient-external housing, or in a network server system.
摘要翻译： 评估递送给心力衰竭患者的减肥疗法涉及使用被配置为感测指示患者利尿状态的生理参数的植入式传感器和与可植入传感器耦合的处理器。 传感器可以包括例如胸部流体传感器，心脏声音传感器，心室或动脉压力传感器，呼吸传感器或血液化学传感器。 处理器被配置为基于所感测的生理参数和为患者开发的阈值之间的关系来确定患者利尿的目标水平是否已经实现，并且响应于确定患者利尿的目标水平具有 已经实现。 处理器可以被布置在可植入的壳体中，在患者外部壳体中，或者在网络服务器系统中。
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公开(公告)号：US07731658B2
公开(公告)日：2010-06-08
申请号：US11839638
申请日：2007-08-16
CPC分类号： A61B5/14503 , A61B5/0452 , A61B5/14532 , A61B7/04 , A61B2562/0219 , A61M5/14276 , A61M5/1723 , A61M2210/125 , A61M2230/201
摘要： An apparatus for monitoring a patient's blood glucose level. The apparatus includes an implantable medical device having a controller and an implantable heart sounds sensor configured to transmit signals to the controller of the implantable medical device. The controller is configured to determine if a patient is hypoglycemic or hyperglycemic based on the signals from the heart sounds sensor. A method is also disclosed that includes sensing the patient's heart sounds, determining the amplitude of the S2 heart sound, determining the length of the interval from the S1 heart sound to the S2max heart sound, determining the length of the interval from the S1 heart sound to the S2end heart sound, and determining the patient's blood glucose status based on the patient's heart sounds.
摘要翻译： 一种用于监测患者血糖水平的装置。 该装置包括具有控制器和可植入心音传感器的可植入医疗装置，其被配置为向可植入医疗装置的控制器发送信号。 控制器被配置为基于来自心脏声音传感器的信号来确定患者是否是低血糖或高血糖。 还公开了一种方法，其包括感测患者的心脏声音，确定S2心音的幅度，确定从S1心音到S2max心音的间隔的长度，确定从S1心音发出的间隔的长度 到S2end心音，并且基于患者的心脏声音来确定患者的血糖状态。
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公开(公告)号：US20090048503A1
公开(公告)日：2009-02-19
申请号：US11839638
申请日：2007-08-16
CPC分类号： A61B5/14503 , A61B5/0452 , A61B5/14532 , A61B7/04 , A61B2562/0219 , A61M5/14276 , A61M5/1723 , A61M2210/125 , A61M2230/201
摘要： An apparatus for monitoring a patient's blood glucose level. The apparatus includes an implantable medical device having a controller and an implantable heart sounds sensor configured to transmit signals to the controller of the implantable medical device. The controller is configured to determine if a patient is hypoglycemic or hyperglycemic based on the signals from the heart sounds sensor. A method is also disclosed that includes sensing the patient's heart sounds, determining the amplitude of the S2 heart sound, determining the length of the interval from the S1 heart sound to the S2max heart sound, determining the length of the interval from the S1 heart sound to the S2end heart sound, and determining the patient's blood glucose status based on the patient's heart sounds.
摘要翻译： 一种用于监测患者血糖水平的装置。 该装置包括具有控制器和可植入心音传感器的可植入医疗装置，其被配置为向可植入医疗装置的控制器发送信号。 控制器被配置为基于来自心脏声音传感器的信号来确定患者是否是低血糖或高血糖。 还公开了一种方法，其包括感测患者的心脏声音，确定S2心音的幅度，确定从S1心音到S2max心音的间隔的长度，确定从S1心音发出的间隔的长度 到S2end心音，并且基于患者的心脏声音来确定患者的血糖状态。
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公开(公告)号：US09655520B2
公开(公告)日：2017-05-23
申请号：US13620462
申请日：2012-09-14
IPC分类号： A61N1/00 , A61B5/0205 , A61B5/00 , A61B5/053 , A61M5/142 , A61M5/172 , A61N1/36 , A61N1/362 , A61N1/372 , A61B5/021 , A61B5/0402 , A61B5/145 , A61B7/04 , G06F19/00
CPC分类号： A61B5/4839 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/0402 , A61B5/0537 , A61B5/145 , A61B5/14539 , A61B5/14546 , A61B5/4261 , A61B5/4833 , A61B7/04 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/125 , A61N1/36114 , A61N1/36135 , A61N1/3627 , A61N1/365 , A61N1/37258 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： Assessing decongestive therapy delivered to a heart failure patient involves use of an implantable sensor configured to sense a physiologic parameter indicative of the patient's diuresis status and a processor coupled to the implantable sensor. The sensor may comprise a thoracic fluid sensor, a heart sounds sensor, a cardiac chamber or arterial pressure sensor, a respiration sensor, or a blood chemistry sensor, for example. The processor is configured to determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient, and to produce an output in response to determining that the target level of patient diuresis has been achieved. The processor may be disposed in an implantable housing, in a patient-external housing, or in a network server system.
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7.发明申请Rapid Shallow Breathing Detection for use in Congestive Heart Failure Status Determination 有权快速浅呼吸检测用于充血性心力衰竭状态测定公开(公告)号：US20100298732A1
公开(公告)日：2010-11-25
申请号：US12847645
申请日：2010-07-30
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译： 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。
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8.发明申请Decongestive Therapy Titration for Heart Failure Patients using Implantable Sensor 审中-公开使用植入式传感器的心力衰竭患者的减肥治疗滴定公开(公告)号：US20130018234A1
公开(公告)日：2013-01-17
申请号：US13620462
申请日：2012-09-14
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/053 , A61B7/00 , A61B5/01 , A61B5/08 , A61B5/024 , A61B5/0402 , A61B5/145 , A61N1/36 , A61B5/021
CPC分类号： A61B5/4839 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/0402 , A61B5/0537 , A61B5/145 , A61B5/14539 , A61B5/14546 , A61B5/4261 , A61B5/4833 , A61B7/04 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/125 , A61N1/36114 , A61N1/36135 , A61N1/3627 , A61N1/365 , A61N1/37258 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： Assessing decongestive therapy delivered to a heart failure patient involves use of an implantable sensor configured to sense a physiologic parameter indicative of the patient's diuresis status and a processor coupled to the implantable sensor. The sensor may comprise a thoracic fluid sensor, a heart sounds sensor, a cardiac chamber or arterial pressure sensor, a respiration sensor, or a blood chemistry sensor, for example. The processor is configured to determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient, and to produce an output in response to determining that the target level of patient diuresis has been achieved. The processor may be disposed in an implantable housing, in a patient-external housing, or in a network server system.
摘要翻译： 评估递送给心力衰竭患者的减肥疗法涉及使用被配置为感测指示患者利尿状态的生理参数的植入式传感器以及耦合到可植入传感器的处理器。 传感器可以包括例如胸部流体传感器，心脏声音传感器，心室或动脉压力传感器，呼吸传感器或血液化学传感器。 处理器被配置为基于所感测的生理参数和为患者开发的阈值之间的关系来确定患者利尿的目标水平是否已经实现，并且响应于确定患者利尿的目标水平具有 已经实现。 处理器可以被布置在可植入的壳体中，在患者外部壳体中，或者在网络服务器系统中。
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9.发明授权System and method for generating a trend parameter based on respiration rate distribution 有权基于呼吸速率分布生成趋势参数的系统和方法公开(公告)号：US07731663B2
公开(公告)日：2010-06-08
申请号：US11438977
申请日：2006-05-23
IPC分类号： A61B5/0205
CPC分类号： A61B5/0816 , A61B5/053 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods provide for assessing the heart failure status of a patient and, more particularly, to generating a trend parameter based on a distribution of the patient's respiration rate. Systems and methods provide for detecting, using an implantable device or a patient-external device, patient respiration and computing a respiration rate based on the detected patient respiration. A distribution of the respiration rate is calculated, and a trend parameter based on the respiration rate distribution is generated. The trend parameter is indicative of a patient's heart failure status. An output signal indicative of the patient's heart failure status may be generated based on the trend parameter.
摘要翻译： 系统和方法提供用于评估患者的心力衰竭状态，更具体地，用于基于患者的呼吸速率的分布来生成趋势参数。 系统和方法提供用于基于检测到的患者呼吸来检测，使用可植入装置或患者外部装置进行患者呼吸并计算呼吸速率。 计算呼吸率的分布，并生成基于呼吸率分布的趋势参数。 趋势参数表示患者的心力衰竭状态。 可以基于趋势参数生成表示患者心力衰竭状态的输出信号。
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10.发明授权Rapid shallow breathing detection for use in congestive heart failure status determination 有权快速浅呼吸检测用于充血性心力衰竭状态测定公开(公告)号：US07993280B2
公开(公告)日：2011-08-09
申请号：US12847645
申请日：2010-07-30
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译： 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。
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