公开(公告)号：US20110190847A1

公开(公告)日：2011-08-04

申请号：US13069143

申请日：2011-03-22

申请人： John D.H. King ,  James R. Thacker

发明人： John D.H. King ,  James R. Thacker

IPC分类号： A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

摘要： A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

摘要翻译： 神经刺激系统自动校正或调整刺激量（刺激能量），以保持舒适有效的刺激疗法。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

公开(公告)号：US20110060387A1

公开(公告)日：2011-03-10

申请号：US12946574

申请日：2010-11-15

申请人： John D.H. King ,  James R. Thacker

发明人： John D.H. King ,  James R. Thacker

IPC分类号： A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

摘要： A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

公开(公告)号：US20100262209A1

公开(公告)日：2010-10-14

申请号：US12783187

申请日：2010-05-19

申请人： John D.H. King ,  James R. Thacker

发明人： John D.H. King ,  James R. Thacker

IPC分类号： A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

摘要： A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

摘要翻译： 神经刺激系统自动校正或调整刺激量（刺激能量），以保持舒适有效的刺激疗法。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

公开(公告)号：US20090281599A1

公开(公告)日：2009-11-12

申请号：US12506827

申请日：2009-07-21

申请人： James R. Thacker ,  John D.H. King ,  Kerry Bradley

发明人： James R. Thacker ,  John D.H. King ,  Kerry Bradley

IPC分类号： A61N1/08

CPC分类号： A61N1/36071 ,  A61N1/0551

摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.

摘要翻译： 用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。 切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。 估计的感知水平是基于以前的刺激结果。 然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

公开(公告)号：US07571001B2

公开(公告)日：2009-08-04

申请号：US11829742

申请日：2007-07-27

申请人： James R. Thacker ,  John D.H. King ,  Kerry Bradley

发明人： James R. Thacker ,  John D.H. King ,  Kerry Bradley

IPC分类号： A61N1/18

CPC分类号： A61N1/36071 ,  A61N1/0551

摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.

摘要翻译： 用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。 切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。 估计的感知水平是基于以前的刺激结果。 然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

公开(公告)号：US09592388B2

公开(公告)日：2017-03-14

申请号：US12765810

申请日：2010-04-22

申请人： Jon Parker ,  James R. Thacker

发明人： Jon Parker ,  James R. Thacker

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  A61N1/06 ,  A61N1/378

CPC分类号： A61N1/36071 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/06 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36157 ,  A61N1/36164 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36182 ,  A61N1/37235 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/3787

摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications. In particular embodiments, aspects of the foregoing modulation therapies may be implemented by systems and devices that have simplified functionalities.

摘要翻译： 公开了选择性高频脊髓调制，用于抑制疼痛，减少副作用和相关系统和方法。 在特定实施例中，可以将大约1.5KHz至大约50KHz范围内的高频调制施加到患者的脊弦区域以解决腰背痛而不产生不想要的感觉和/或运动副作用。 在其他实施例中，根据类似参数的调制可以应用于其他脊柱或周边位置以解决其他指示。 在具体实施例中，前述调制疗法的方面可以由具有简化功能的系统和设备来实现。

公开(公告)号：US09352161B2

公开(公告)日：2016-05-31

申请号：US11553447

申请日：2006-10-26

申请人： James R. Thacker ,  Harold Haut ,  Robert Nathan ,  David K. L. Peterson ,  Kerry Bradley

发明人： James R. Thacker ,  Harold Haut ,  Robert Nathan ,  David K. L. Peterson ,  Kerry Bradley

IPC分类号： A61N1/372 ,  A61N1/36

CPC分类号： A61N1/37247 ,  A61N1/36071 ,  A61N1/36146 ,  A61N1/36171 ,  A61N1/36175

摘要： Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses.

摘要翻译： 组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，用于传递由脉冲发生装置产生的电刺激脉冲的至少一个注入电极以及能够与脉冲发生装置通信的编程器。 刺激脉冲可以由几个参数定义，例如脉冲宽度和幅度。 在用刺激系统刺激组织的方法中，用户可以调整诸如脉冲宽度的参数之一。 编程器可以响应于脉冲宽度的变化自动调节脉冲幅度，以便保持刺激脉冲的基本恒定的效果。

公开(公告)号：US08626312B2

公开(公告)日：2014-01-07

申请号：US13069143

申请日：2011-03-22

申请人： John D. H. King ,  James R. Thacker

发明人： John D. H. King ,  James R. Thacker

IPC分类号： A61N1/37

CPC分类号： A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

摘要： A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

摘要翻译： 神经刺激系统自动校正或调整刺激量值（刺激能量），以保持舒适有效的刺激治疗。 由于与电极 - 组织界面相关的阻抗变化可以指示电流和位置引线位移的阻塞，所以引线阻抗可以指示应该传送到目标神经组织的电刺激能量的量以提供校正调整。 因此，可以在反馈回路中使用阻抗曲线的阻抗或形态的变化，以指示需要调整刺激能量，并且系统能够有效地自动校正刺激能量的大小以维持所需的治疗效果。

公开(公告)号：US08554342B2

公开(公告)日：2013-10-08

申请号：US13620138

申请日：2012-09-14

申请人： James R. Thacker ,  Michael S. Colvin ,  David K. L. Peterson ,  James P. McGivern

发明人： James R. Thacker ,  Michael S. Colvin ,  David K. L. Peterson ,  James P. McGivern

IPC分类号： A61N1/05

CPC分类号： A61N1/0558 ,  A61M25/1002 ,  A61M25/1011

摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.

摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

公开(公告)号：US20130172955A1

公开(公告)日：2013-07-04

申请号：US13620235

申请日：2012-09-14

申请人： Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

发明人： Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

IPC分类号： A61N1/36

CPC分类号： A61N1/36071 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/06 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36157 ,  A61N1/36164 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36182 ,  A61N1/37235 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/3787

摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.