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公开(公告)号:US20110104820A1
公开(公告)日:2011-05-05
申请号:US12902261
申请日:2010-10-12
IPC分类号: G01N33/566 , C07K16/00
CPC分类号: C07K16/44 , C07K2317/34 , G01N33/574 , G01N33/6842
摘要: The invention discloses 94 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies that specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译: 本发明公开了在癌和白血病中鉴定的94个新的磷酸化位点,包含本发明的磷酸化位点的肽(包括AQUA肽),特异性结合本发明的新的磷酸化位点的抗体以及上述的诊断和治疗用途。
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公开(公告)号:US20110045603A1
公开(公告)日:2011-02-24
申请号:US12763886
申请日:2010-04-20
申请人: Ailan Guo , Albrecht Moritz , Anthony Possemato , Ting-Lei Gu , Jian Yu , Charles Lawrence Farnsworth , Corinne Michaud , Hong Ren , Jessica Ann Cherry , Jing Zhou , Valerie Lee Goss , Erik Spek , Yu Li , Meghan Ann Tucker , John Edward Rush, II , Matthew Stokes , Klarisa Rikova
发明人: Ailan Guo , Albrecht Moritz , Anthony Possemato , Ting-Lei Gu , Jian Yu , Charles Lawrence Farnsworth , Corinne Michaud , Hong Ren , Jessica Ann Cherry , Jing Zhou , Valerie Lee Goss , Erik Spek , Yu Li , Meghan Ann Tucker , John Edward Rush, II , Matthew Stokes , Klarisa Rikova
CPC分类号: C07K16/18 , C07K14/47 , C07K16/44 , G01N33/6842
摘要: The invention discloses 990 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译: 本发明公开了在癌和白血病中鉴定的990个新的磷酸化位点,包含本发明的磷酸化位点的肽(包括AQUA肽),特异性结合本发明的新的磷酸化位点的抗体,以及上述的诊断和治疗用途。
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公开(公告)号:US20100120055A1
公开(公告)日:2010-05-13
申请号:US12311464
申请日:2007-09-28
申请人: Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
发明人: Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
CPC分类号: C12Q1/485 , A61K38/00 , A61K39/0011 , C07K14/4748 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K16/44 , C07K2317/34 , C12Q1/42 , G01N33/574 , G01N33/6812 , G01N33/6842
摘要: The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译: 本发明公开了在癌中鉴定的318个新的磷酸化位点,包含本发明的磷酸化位点的肽(包括AQUA肽),特异性结合本发明的新的磷酸化位点的抗体,以及上述的诊断和治疗用途。
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公开(公告)号:US20090098581A1
公开(公告)日:2009-04-16
申请号:US12148547
申请日:2008-04-18
申请人: Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人: Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
IPC分类号: G01N33/574 , C07K16/30 , G01N33/566
CPC分类号: G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要: The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译: 本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点,包含本发明的磷酸化位点的肽(包括AQUA肽),特异性结合本发明的新的磷酸化位点的抗体,以及上述的诊断和治疗用途。
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公开(公告)号:US07977462B2
公开(公告)日:2011-07-12
申请号:US12148547
申请日:2008-04-18
申请人: Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人: Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
CPC分类号: G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要: The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译: 本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点,包含本发明的磷酸化位点的肽(包括AQUA肽),特异性结合本发明的新的磷酸化位点的抗体,以及上述的诊断和治疗用途。
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公开(公告)号:US20110143368A1
公开(公告)日:2011-06-16
申请号:US12806766
申请日:2010-08-20
申请人: Ting-Lei Gu , Anthony Possemato , Klarisa Rikova , Jian Yu , Valerie Goss , Corinne Michaud , Charles Farnsworth , Ailan Guo , Albrecht Moritz , Yu Li
发明人: Ting-Lei Gu , Anthony Possemato , Klarisa Rikova , Jian Yu , Valerie Goss , Corinne Michaud , Charles Farnsworth , Ailan Guo , Albrecht Moritz , Yu Li
CPC分类号: C07K16/44 , C07K16/30 , C07K2317/34 , G01N33/6842
摘要: The invention discloses 142 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译: 本发明公开了142个在癌中鉴定的新的磷酸化位点,包含本发明的磷酸化位点的肽(包括AQUA肽),特异性结合本发明的新的磷酸化位点的抗体,以及上述的诊断和治疗用途。
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7.
公开(公告)号:US20100173428A1
公开(公告)日:2010-07-08
申请号:US12683835
申请日:2010-01-07
申请人: Ailan Guo , Albrecht Moritz , Anthony Possemato , Charles Farnsworth , Hong Ren , Klarisa Rikova , John Edward Rush, II , Matthew Stokes , Meghan Tucker , Yu Li
发明人: Ailan Guo , Albrecht Moritz , Anthony Possemato , Charles Farnsworth , Hong Ren , Klarisa Rikova , John Edward Rush, II , Matthew Stokes , Meghan Tucker , Yu Li
CPC分类号: C07K16/18 , C07K16/40 , C12Q1/485 , G01N33/6872
摘要: The invention discloses 461 novel phosphorylation sites identified in basophilic Ser/Thr kinase signaling pathways, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译: 本发明公开了在嗜碱性Ser / Thr激酶信号通路中鉴定的461个新的磷酸化位点,包含本发明的磷酸化位点的肽(包括AQUA肽),特异性结合本发明的新的磷酸化位点的抗体,以及 以上。
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公开(公告)号:US20130209452A1
公开(公告)日:2013-08-15
申请号:US13618400
申请日:2012-09-14
申请人: Klarisa Rikova , Herbert Haack , Laura Sullivan , Ailan Guo , Anthony Possemato , Joan MacNeill , Ting-Lei Gu , Jian Yu
发明人: Klarisa Rikova , Herbert Haack , Laura Sullivan , Ailan Guo , Anthony Possemato , Joan MacNeill , Ting-Lei Gu , Jian Yu
IPC分类号: C12Q1/68 , A61K31/713 , G01N33/68
CPC分类号: C12Q1/6886 , A61K31/713 , A61K38/00 , C07K14/47 , C07K2319/00 , C12N9/12 , C12N9/1205 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Y207/10001 , G01N33/57423 , G01N33/57484 , G01N33/6893 , G01N2333/912 , G01N2333/9121
摘要: Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides.
摘要翻译: 涉及染色体2的新型基因缺失和易位导致融合蛋白结合部分间变型淋巴瘤激酶(ALK)激酶与部分二级蛋白,已经在人体实体肿瘤中被鉴定,例如, 非小细胞肺癌(NSCLC)。 次级蛋白包括棘皮动物微管相关蛋白样4(EML-4)和TRK-融合基因(TFG)。 确认了保留ALK酪氨酸激酶活性的EML4-ALK融合蛋白,以驱动以这种突变为特征的NSCLC的增殖和存活。 因此,本发明部分地提供分离的多核苷酸和编码所公开的突变ALK激酶多肽的载体,用于检测其的探针,分离的突变多肽,重组多肽和用于检测融合和截短的多肽的试剂。 所公开的这种新的融合蛋白的鉴定使得能够筛选抑制蛋白质的化合物的方法,以及抑制以突变多核苷酸或多肽为特征的癌症进展的方法。
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公开(公告)号:US20100093000A1
公开(公告)日:2010-04-15
申请号:US12148550
申请日:2008-04-18
申请人: Jessica Cherry , Charles Farnsworth , Valerie L. Goss , Ting-Lei Gu , Ailan Guo , Peter Hornbeck , Yu Li , Albrecht Moritz , Anthony Possemato , Klarisa Rikova , Matthew Stokes , Jian Yu , Erik Spek , Corinne Michaud
发明人: Jessica Cherry , Charles Farnsworth , Valerie L. Goss , Ting-Lei Gu , Ailan Guo , Peter Hornbeck , Yu Li , Albrecht Moritz , Anthony Possemato , Klarisa Rikova , Matthew Stokes , Jian Yu , Erik Spek , Corinne Michaud
CPC分类号: C07K16/44 , G01N33/574 , G01N33/57426 , G01N2333/4725 , G01N2333/98
摘要: The invention discloses novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译: 本发明公开了在癌和/或白血病中鉴定的新的磷酸化位点,包含本发明的磷酸化位点的肽(包括AQUA肽),特异性结合本发明的新的磷酸化位点的抗体,以及上述的诊断和治疗用途。
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公开(公告)号:US20110021546A1
公开(公告)日:2011-01-27
申请号:US12891987
申请日:2010-09-28
申请人: Klarisa Rikova , Herbert Haack , Laura Sullivan , Ailan Guo , Anthony Possemato , Joan MacNeill , Ting-Lei Gu , Jian Yu
发明人: Klarisa Rikova , Herbert Haack , Laura Sullivan , Ailan Guo , Anthony Possemato , Joan MacNeill , Ting-Lei Gu , Jian Yu
IPC分类号: A61K31/517 , C12N9/12 , C07K16/40 , C07K2/00 , C07H21/00 , G01N33/573 , C12Q1/68 , G01N33/566 , A61P35/00
CPC分类号: C12Q1/6886 , A61K31/713 , A61K38/00 , C07K14/47 , C07K2319/00 , C12N9/12 , C12N9/1205 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Y207/10001 , G01N33/57423 , G01N33/57484 , G01N33/6893 , G01N2333/912 , G01N2333/9121
摘要: In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.
摘要翻译: 根据本发明,现在已经在人类实体肿瘤中鉴定了涉及染色体2的新基因缺失和易位,导致将部分间变性淋巴瘤激酶(ALK)激酶与部分二级蛋白结合的融合蛋白。 非小细胞肺癌(NSCLC)。 次级蛋白包括棘皮动物微管相关蛋白样4(EML-4)和TRK-融合基因(TFG)。 确认了保留ALK酪氨酸激酶活性的EML4-ALK融合蛋白,以驱动以这种突变为特征的NSCLC的增殖和存活。 因此,本发明部分地提供分离的多核苷酸和编码所公开的突变ALK激酶多肽的载体,用于检测其的探针,分离的突变多肽,重组多肽和用于检测融合和截短的多肽的试剂。 所公开的这种新的融合蛋白的鉴定使得能够确定生物样品中这些突变型ALK激酶多肽的存在的新方法,用于筛选抑制蛋白质的化合物的方法,以及用于突变突变型多核苷酸特征的癌症进展抑制方法 或多肽,其也由本发明提供。
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