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公开(公告)号：US10053735B2
公开(公告)日：2018-08-21
申请号：US12067633
申请日：2006-09-21
申请人： John Foekens , John W. Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
发明人： John Foekens , John W. Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
IPC分类号： C07H21/04 , C12Q1/68 , C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.
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公开(公告)号：US20090111707A1
公开(公告)日：2009-04-30
申请号：US12067633
申请日：2006-09-21
申请人： John Foekens , John Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
发明人： John Foekens , John Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.
摘要翻译： 本发明涉及预测细胞增殖性疾病患者蒽环类治疗结果的方法。 这通过确定选自PITX2的至少一种基因的表达水平来实现; TFF1和PLAU。 本发明还涉及可以在所述方法中使用的序列，寡核苷酸和抗体。
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公开(公告)号：US09017944B2
公开(公告)日：2015-04-28
申请号：US10582705
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth Lukas , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth Lukas , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与细胞的无病存活和/或应答的方法 乳腺组织增生性疾病，进行内分泌治疗。
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4.发明申请公开(公告)号：US20080254447A1
公开(公告)日：2008-10-16
申请号：US10582705
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与细胞的无病存活和/或应答的方法 乳腺组织增生性疾病，进行内分泌治疗。
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5.发明申请公开(公告)号：US20060024684A1
公开(公告)日：2006-02-02
申请号：US11011332
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.
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6.发明申请Epigenetic Methods and Nucleic Acids for the Detection of Lung Cell Proliferative Disorders 审中-公开表观遗传学方法和核酸检测肺细胞增殖性疾病公开(公告)号：US20080171318A1
公开(公告)日：2008-07-17
申请号：US11664374
申请日：2005-09-30
申请人： Achim Plum , Tamas Rujan , Sabine Maier , Ralf Lesche , Alexander Graham , Marie South , Iacona Bailey
发明人： Achim Plum , Tamas Rujan , Sabine Maier , Ralf Lesche , Alexander Graham , Marie South , Iacona Bailey
CPC分类号： C12Q1/6827 , C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/16 , C12Q2531/113 , C12Q2523/125
摘要： The invention provides methods, nucleic acids and kits for detecting, classifying and/or distinguishing between or among lung cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测，分类和/或区分肺细胞增殖性疾病之间或之中的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。
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7.发明申请EPIGENETIC METHODS AND NUCLEIC ACIDS FOR THE DETECTION OF BREAST CELL PROLIFERATIVE DISORDERS 审中-公开用于检测乳腺细胞增殖性疾病的方法和核酸公开(公告)号：US20110269126A1
公开(公告)日：2011-11-03
申请号：US13025099
申请日：2011-02-10
申请人： Ralf Lesche , Anne Fassbender , Klaus Juenemann , John Foekens , John W. Martens
发明人： Ralf Lesche , Anne Fassbender , Klaus Juenemann , John Foekens , John W. Martens
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present application provides methods and nucleic acids for the detection and differentiation of breast cell proliferative disorders. This is achieved by the analysis of the methylation of a panel of genes, or subsets thereof. The invention may be used for the detection and/or differentiation of a variety of tissue types including breast cancer and benign breast disorders as well as other cancers and tissue types.
摘要翻译： 本申请提供了用于乳腺增生性疾病的检测和分化的方法和核酸。 这通过分析一组基因或其亚组的甲基化来实现。 本发明可用于检测和/或分化各种组织类型，包括乳腺癌和良性乳房疾病以及其它癌症和组织类型。
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8.发明申请Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders 审中-公开用于检测乳腺增生性疾病的表观遗传学方法和核酸公开(公告)号：US20090298054A1
公开(公告)日：2009-12-03
申请号：US11632824
申请日：2005-07-18
申请人： Ralf Lesche , Anne Fassbender , Klaus Juenemann , John Foekens , John W. Martens
发明人： Ralf Lesche , Anne Fassbender , Klaus Juenemann , John Foekens , John W. Martens
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present application provides methods and nucleic acids for the detection and differentiation of breast cell proliferative disorders. This is achieved by the analysis of the methylation of a panel of genes, or subsets thereof. The invention may be used for the detection and/or differentiation of a variety of tissue types including breast cancer and benign breast disorders as well as other cancers and tissue types.
摘要翻译： 本申请提供了用于乳腺增生性疾病的检测和分化的方法和核酸。 这通过分析一组基因或其亚组的甲基化来实现。 本发明可用于检测和/或分化各种组织类型，包括乳腺癌和良性乳房疾病以及其它癌症和组织类型。
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公开(公告)号：US09695478B2
公开(公告)日：2017-07-04
申请号：US12779856
申请日：2010-05-13
申请人： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
发明人： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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10.发明申请公开(公告)号：US20060286576A1
公开(公告)日：2006-12-21
申请号：US11405322
申请日：2006-04-17
申请人： Cathy Lofton-Day , Andrew Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
发明人： Cathy Lofton-Day , Andrew Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测或检测和鉴别肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之间的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。
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