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公开(公告)号：US09017944B2
公开(公告)日：2015-04-28
申请号：US10582705
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth Lukas , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth Lukas , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与细胞的无病存活和/或应答的方法 乳腺组织增生性疾病，进行内分泌治疗。
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2.发明申请公开(公告)号：US20080254447A1
公开(公告)日：2008-10-16
申请号：US10582705
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan , Almuth Marx , Heinz Hoefler
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与细胞的无病存活和/或应答的方法 乳腺组织增生性疾病，进行内分泌治疗。
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3.发明申请公开(公告)号：US20060024684A1
公开(公告)日：2006-02-02
申请号：US11011332
申请日：2004-12-13
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Manfred Schmitt , Ralf Lesche , Dimo Dietrich , Volkmar Mueller , Antje Kluth , Ina Schwope , Oliver Hartmann , Peter Adorjan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.
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4.发明授权Method for determining risk of relapse of breast cancer following tamoxifen adjuvant therapy 有权替莫昔芬辅助治疗后确定乳腺癌复发风险的方法公开(公告)号：US08101359B2
公开(公告)日：2012-01-24
申请号：US10517741
申请日：2003-10-01
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime P. Look , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John W. Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime P. Look , Almuth Marx , Heinz Hoefler
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与乳腺组织的细胞增殖性病症的反应的方法 ，进行内分泌治疗。
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5.发明申请Method and Nucleic Acids for the Improved Treatment of Breast Cell Proliferative Disorders 审中-公开改善乳腺增生性疾病治疗的方法和核酸公开(公告)号：US20120184455A1
公开(公告)日：2012-07-19
申请号：US13352238
申请日：2012-01-17
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime P. Look , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime P. Look , Almuth Marx , Heinz Hoefler
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与乳腺组织的细胞增殖性病症的反应的方法 ，进行内分泌治疗。
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6.发明申请Method and nucleic acids for the improved treatment of breast cell proliferative disorders 有权用于改善乳腺增生性疾病治疗的方法和核酸公开(公告)号：US20060121467A1
公开(公告)日：2006-06-08
申请号：US10517741
申请日：2003-10-01
申请人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime Look , Almuth Marx , Heinz Hoefler
发明人： John Foekens , Nadia Harbeck , Thomas Koenig , Sabine Maier , John Martens , Fabian Model , Inko Nimmrich , Tamas Rujan , Armin Schmitt , Manfred Schmitt , Maxime Look , Almuth Marx , Heinz Hoefler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于预测受试者与乳腺组织的细胞增殖性病症的反应的方法 ，进行内分泌治疗。
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7.发明申请Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients 审中-公开用于预测乳腺增生性疾病患者的治疗反应和/或存活的预后标志物公开(公告)号：US20090269736A1
公开(公告)日：2009-10-29
申请号：US11628703
申请日：2005-06-06
申请人： Inko Nimmrich , Ralf Lesche , Ina Schwope , Sabine Maier , Antje Kluth Lukas , Oliver Hartmann , Almuth Marx
发明人： Inko Nimmrich , Ralf Lesche , Ina Schwope , Sabine Maier , Antje Kluth Lukas , Oliver Hartmann , Almuth Marx
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.
摘要翻译： 本发明的方面提供了用于预测和/或预测乳腺增生性疾病患者，特别是乳腺癌患者的雌激素治疗结果的组合物和方法。 在优选的实施方案中，这通过确定PITX2的表达水平和/或与基因PITX2相关的基因组DNA的遗传或表观遗传修饰至少部分地实现。 本发明的另外的方面提供新的序列，低聚物（例如，寡核苷酸或肽核酸（PNA）寡聚体））和抗体，其在所述的发明方法和组合物中具有实用性。
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8.发明申请Method and nucleic acids for the analysis of a colon cell proliferative disorder 审中-公开用于分析结肠细胞增殖性疾病的方法和核酸公开(公告)号：US20060246433A1
公开(公告)日：2006-11-02
申请号：US10506111
申请日：2003-02-27
申请人： Peter Adorjan , Matthias Burger , Sabine Maier , Inko Nimmrich , Evelyne Becker , Ralf Lesche , Tamas Rujan , Armin Schmitt
发明人： Peter Adorjan , Matthias Burger , Sabine Maier , Inko Nimmrich , Evelyne Becker , Ralf Lesche , Tamas Rujan , Armin Schmitt
CPC分类号： C12Q1/6886 , C12Q2600/154 , Y10T436/143333
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of colon cell proliferative disorders, or the predisposition to colon cell proliferative disorders.
摘要翻译： 本发明涉及修饰和基因组序列，寡核苷酸和/或PNA寡聚物，用于检测基因组DNA的胞嘧啶甲基化状态，以及一种用于在分化确定基因的遗传和/或后生参数以供使用， 诊断，治疗和/或结肠细胞增殖性疾病的监测，或易患结肠癌细胞增殖性疾病。
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9.发明申请Method and nucleic acids for the analysis of a lung cell proliferative disorder 审中-公开用于分析肺细胞增殖性疾病的方法和核酸公开(公告)号：US20070128592A1
公开(公告)日：2007-06-07
申请号：US10498430
申请日：2002-12-10
申请人： Matthias Burger , John Field , Bulent Genc , Triantafillos Liloglou , Evelyne Lipscher , Sabine Maier , Inko Nimmrich
发明人： Matthias Burger , John Field , Bulent Genc , Triantafillos Liloglou , Evelyne Lipscher , Sabine Maier , Inko Nimmrich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/112 , C12Q2600/154 , C12Q2600/16 , C12Q2531/113 , C12Q2523/125 , C12Q2521/331 , C12Q2565/627
摘要： The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of lung cell proliferative disorders, or the predisposition to lung cell proliferative disorders.
摘要翻译： 本发明涉及修饰和基因组序列，用于检测基因组DNA的胞嘧啶甲基化状态的寡核苷酸和/或PNA寡聚体，以及用于确定用于分化的基因的遗传和/或表观遗传学参数的方法， 诊断，治疗和/或监测肺细胞增殖性疾病，或对肺细胞增殖性疾病的倾向。
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