摘要:
The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要:
The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要:
The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
摘要:
Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.
摘要:
The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.
摘要:
A method of providing predicting relapse of breast cancer in bone is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them.
摘要:
A method for implementing anti-static steering for vehicle steering systems includes receiving a desired rear wheel angle input and receiving a vehicle speed input. An approved rear wheel angle output is generated using the desired rear wheel angle input and the vehicle speed input, wherein the approved rear wheel angle is based upon one of a plurality of defined operating states, the plurality of operating states including operation at a speed in a first range, operation at a speed in a second range, and transitions therebetween.
摘要:
A control system for a steering system in a vehicle comprising: a reference model responsive to an operator input that computes desired states of the vehicle; a feedforward controller in operable communication with the reference model. The feedforward controller computes a first control value based on input from said reference model and based on at least one of: a lateral velocity, a rate of lateral velocity, a lateral acceleration, and a combination, wherein the combination includes a yaw rate with at least one of a lateral velocity, a rate of lateral velocity, and a lateral acceleration of the motor vehicle. The system also includes an actuator for affecting the steering system based on the first control value, the actuator in operable communication with the feedforward controller.
摘要:
A method for automatically adjusting a vehicle stability enhancement (VSE) system is disclosed. The VSE system is used in conjunction with a steering system having a plurality of driver-selectable steering modes associated therewith. In an exemplary embodiment, the method includes configuring a reference model within the VSE system to generate desired vehicle handling aspects, the desired vehicle handling aspects being a function of one or more driver inputs to the steering system. Then, a determination is made as to which of the plurality of driver-selectable steering modes is activated, wherein each of the desired vehicle handling aspects generated is made further dependent upon a specific steering mode selected.