Methods for treating or preventing alzheimer's disease using substituted 1-aryl-3-piperazin-1′-yl propanones
    4.
    发明授权
    Methods for treating or preventing alzheimer's disease using substituted 1-aryl-3-piperazin-1′-yl propanones 失效
    使用取代的1-芳基-3-哌嗪-1-基丙酮治疗或预防阿尔茨海默病的方法

    公开(公告)号:US06306857B1

    公开(公告)日:2001-10-23

    申请号:US09371667

    申请日:1999-08-10

    IPC分类号: A61K3150

    摘要: Disclosed are compounds of formula I: or the pharmaceutically acceptable salts thereof wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independently represent aryl groups; and Y is hydrogen; or Y and R1 or R2 together represent CH2; CH2CH2; CH20; CH2S forming a five or six membered ring and such ring may be optionally substituted with loweralkyl or phenyl; or pharmaceutically acceptable salts thereof, useful in the treatment of neoplastic diseases, and bacterial or fungal infections, and for preventing or decreaseing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with Alzheimer's Disease and, therefore for treating Alzheimer's Disease.

    摘要翻译: 公开了式I化合物或其药学上可接受的盐,其中X是被任选取代的苯基取代的羰基,磺酰基,亚甲基或亚甲基; Z是氮或CH; Ar1​​和Ar2独立地表示芳基; 和Y是氢; 或Y和R 1或R 2一起表示CH 2; CH2CH2; CH20; 形成五或六元环的CH 2 S,并且这种环可以任选被低级烷基或苯基取代; 或其药学上可接受的盐,其可用于治疗肿瘤性疾病和细菌或真菌感染,以及用于预防或减少与阿尔茨海默病相关的异常磷酸化的成对螺旋丝(PHF)表位的产生,因此用于治疗阿尔茨海默氏病。