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    Thermal cycler for PCR
    2.
    发明授权
    Thermal cycler for PCR 有权

    公开(公告)号：US09044753B2

    公开(公告)日：2015-06-02

    申请号：US11654239

    申请日：2007-01-17

    申请人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    发明人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    IPC分类号： H01L35/28 ,  B01L7/00 ,  C12Q1/68 ,  F25B21/04 ,  G01R27/20 ,  G05D23/19 ,  H01L35/30

    CPC分类号： B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/686 ,  F25B21/04 ,  F25B2321/021 ,  G01R27/205 ,  G05D23/1919 ,  H01L35/30 ,  Y10T137/1516

    摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The sample block is of low thermal mass and is constructed of silver. The Peltier devices are designed to provide fast temperature excursions over a wide range. The heat sink has a perimeter trench to minimize edge losses and is adjacent to a continuously variable fan. A perimeter heater is used to improve the thermal uniformity across the sample block to approximately ±0.2° C. A heated platen pushes down onto the tube caps to apply a minimum acceptable force for seating the tubes into the block, ensuring good thermal contact with the block. The force is applied about the periphery of the tube caps to prevent distortion of the caps during thermal cycling. The platen is heated to provided thermal isolation from ambient conditions and to prevent evaporation from the surface of the sample into the upper portion of the sample tube. A control algorithm manipulates the current supplied to the thermoelectric coolers such that the dynamic thermal performance of the block can be controlled so that pre-defined thermal profiles for the sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument has a graphical user interface. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

    Thermal cycler for PCR
    4.
    发明授权
    Thermal cycler for PCR 有权
    热循环仪用于PCR

    公开(公告)号：US08246243B2

    公开(公告)日：2012-08-21

    申请号：US12686100

    申请日：2010-01-12

    申请人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    发明人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    IPC分类号： G01K1/00 ,  G01N25/00

    CPC分类号： B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/686 ,  F25B21/04 ,  F25B2321/021 ,  G01R27/205 ,  G05D23/1919 ,  H01L35/30 ,  Y10T137/1516

    摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics.

    摘要翻译： 提供了一种使用组件，加热盖和内部计算机执行高精度PCR的仪器。 组件由样品块，多个珀耳帖热电器件和散热器组成，夹在一起。 控制算法控制提供给热电冷却器的电流，使得可以控制块的动态热性能，从而可以执行样本温度的预定义热分布。 计算样品温度，而不是使用设计特定的模型和方程来测量。 控制软件包括校准诊断，其允许从仪器到仪器的热电冷却器的性能的变化被补偿，使得所有仪器执行相同的操作。 块/散热器组件可以改变为相同或不同设计的另一个。 该组件携带在板载存储器件中表征其自身性能所需的必要信息，允许组件在仪器之间可互换，同时保持其精密操作特性。

    Thermal cycler for PCR
    5.
    发明授权
    Thermal cycler for PCR 有权
    热循环仪用于PCR

    公开(公告)号：US07537377B2

    公开(公告)日：2009-05-26

    申请号：US11057960

    申请日：2005-02-15

    申请人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    发明人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    IPC分类号： G01K15/00 ,  G01K19/00

    CPC分类号： B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/686 ,  F25B21/04 ,  F25B2321/021 ,  G01R27/205 ,  G05D23/1919 ,  H01L35/30 ,  Y10T137/1516

    摘要： A method for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled by the computer. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics. The instrument monitors the thermoelectric devices and warns of changes in resistance that may result in failure.

    摘要翻译： 使用组件，加热盖和内部计算机执行高精度PCR的方法。 该组件由样品块，多个珀耳帖热电装置和散热器组成，夹在一起。 样品块温度由计算机控制的热电装置专门改变。 控制软件包括校准诊断，其允许从仪器到仪器的热电冷却器的性能的变化被补偿，使得所有仪器执行相同的操作。 块式散热器组件可以改变为相同或不同设计的另一种。 该组件携带在板载存储器件中表征其自身性能所需的必要信息，允许组件在仪器之间可互换，同时保持其精密操作特性。 仪器监测热电器件，并警告可能导致故障的电阻变化。

    Thermal Cycler for PCR
    7.
    发明申请
    Thermal Cycler for PCR 有权
    热循环仪用于PCR

    公开(公告)号：US20100173400A1

    公开(公告)日：2010-07-08

    申请号：US12686100

    申请日：2010-01-12

    申请人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    发明人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    IPC分类号： C12M1/00 ,  F25B21/02

    CPC分类号： B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/686 ,  F25B21/04 ,  F25B2321/021 ,  G01R27/205 ,  G05D23/1919 ,  H01L35/30 ,  Y10T137/1516

    摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics.

    摘要翻译： 提供了一种使用组件，加热盖和内部计算机执行高精度PCR的仪器。 组件由样品块，多个珀耳帖热电器件和散热器组成，夹在一起。 控制算法控制提供给热电冷却器的电流，使得可以控制块的动态热性能，从而可以执行样本温度的预定义热分布。 计算样品温度，而不是使用设计特定的模型和方程来测量。 控制软件包括校准诊断，其允许从仪器到仪器的热电冷却器的性能的变化被补偿，使得所有仪器执行相同的操作。 块/散热器组件可以改变为相同或不同设计的另一个。 该组件携带在板载存储器件中表征其自身性能所需的必要信息，允许组件在仪器之间可互换，同时保持其精密操作特性。

    Thermal cycler for PCR
    8.
    发明授权
    Thermal cycler for PCR 有权
    热循环仪用于PCR

    公开(公告)号：US07645070B2

    公开(公告)日：2010-01-12

    申请号：US11804298

    申请日：2007-05-17

    申请人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    发明人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    IPC分类号： G01K1/14 ,  G01K17/00 ,  G01K13/12 ,  G01K25/00 ,  G12M1/34

    CPC分类号： B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/686 ,  F25B21/04 ,  F25B2321/021 ,  G01R27/205 ,  G05D23/1919 ,  H01L35/30 ,  Y10T137/1516

    摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics.

    摘要翻译： 提供了一种使用组件，加热盖和内部计算机执行高精度PCR的仪器。 组件由样品块，多个珀耳帖热电器件和散热器组成，夹在一起。 控制算法控制提供给热电冷却器的电流，使得可以控制块的动态热性能，从而可以执行样本温度的预定义热分布。 计算样品温度，而不是使用设计特定的模型和方程来测量。 控制软件包括校准诊断，其允许从仪器到仪器的热电冷却器的性能的变化被补偿，使得所有仪器执行相同的操作。 块/散热器组件可以改变为相同或不同设计的另一个。 该组件携带在板载存储器件中表征其自身性能所需的必要信息，允许组件在仪器之间可互换，同时保持其精密操作特性。

    Thermal cycler for PCR
    9.
    发明申请
    Thermal cycler for PCR 有权
    热循环仪用于PCR

    公开(公告)号：US20080314431A1

    公开(公告)日：2008-12-25

    申请号：US12229404

    申请日：2008-08-22

    申请人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    发明人： John G. Atwood ,  Adrian Fawcett ,  Keith S. Ferrara ,  Paul M. Hetherington ,  Richard W. Noreiks ,  Douglas E. Olsen ,  John R. Widomski ,  Charles M. Wittmer

    IPC分类号： H01L35/28

    CPC分类号： B01L7/52 ,  B01L3/50853 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  C12Q1/686 ,  F25B21/04 ,  F25B2321/021 ,  G01R27/205 ,  G05D23/1919 ,  H01L35/30 ,  Y10T137/1516

    摘要： An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics.

    摘要翻译： 提供了一种使用组件，加热盖和内部计算机执行高精度PCR的仪器。 组件由样品块，多个珀耳帖热电器件和散热器组成，夹在一起。 控制算法控制提供给热电冷却器的电流，使得可以控制块的动态热性能，从而可以执行样本温度的预定义热分布。 计算样品温度，而不是使用设计特定的模型和方程来测量。 控制软件包括校准诊断，其允许从仪器到仪器的热电冷却器的性能的变化被补偿，使得所有仪器执行相同的操作。 块/散热器组件可以改变为相同或不同设计的另一个。 该组件携带必要的信息，以在车载存储设备中表征自己的性能，允许组件在仪器之间可互换，同时保持其精确的操作特性。

    OPTICAL RESONANCE ANALYSIS UNIT
    10.
    发明申请
    OPTICAL RESONANCE ANALYSIS UNIT 审中-公开
    光学谐振分析单元

    公开(公告)号：US20090213382A1

    公开(公告)日：2009-08-27

    申请号：US12330930

    申请日：2008-12-09

    申请人： David H. Tracy ,  Jennifer M. Brockman ,  Keith S. Ferrara ,  Martin Shenker ,  Robert Kersten ,  Steven E. Cohen ,  Gary Bodley ,  Patrick Tuxbury ,  Paul Hetherington ,  Enrico Picozza

    发明人： David H. Tracy ,  Jennifer M. Brockman ,  Keith S. Ferrara ,  Martin Shenker ,  Robert Kersten ,  Steven E. Cohen ,  Gary Bodley ,  Patrick Tuxbury ,  Paul Hetherington ,  Enrico Picozza

    IPC分类号： G01N21/55

    CPC分类号： G01N21/553 ,  G01N21/253 ,  G01N21/7743 ,  Y10T137/86035

    摘要： An array surface plasmon resonance (SPR) analysis instrument comprising a reflective SPR sensor array, a light source assembly arranged to project a collimated beam of light onto the reflective SPR sensor array to provide a reflected array image of the sensor array, and to scan the incident angle of the collimated beam of light over an angular range, and a detector assembly oriented to receive the reflected array image of the sensor array over the angular range, the detector assembly comprises a two-dimensional detector sensing element that is tilted with respect to the optical axis of the lens assembly in accordance with the Scheimpflug condition, and a lens assembly for focusing the reflected array image of said SPR sensor array onto said tilted detector sensing element. The lens assembly comprises an objective section which is arranged to produce a virtual image of the tilted reflected array at infinity, followed by an imaging section arranged to transform the virtual image of the tilted reflected array into a real tilted image on the tilted detector sensing element.

    摘要翻译： 阵列表面等离子体共振（SPR）分析仪器，其包括反射SPR传感器阵列，光源组件，被布置成将准直光束投射到反射SPR传感器阵列上，以提供传感器阵列的反射阵列图像，并扫描 在角度范围内的准直光束的入射角以及定向成在角度范围内接收传感器阵列的反射阵列图像的检测器组件，检测器组件包括二维检测器感测元件，其相对于 根据Scheimpflug条件的透镜组件的光轴，以及用于将所述SPR传感器阵列的反射阵列图像聚焦到所述倾斜检测器感测元件上的透镜组件。 透镜组件包括物镜部分，该物镜部分布置成产生无限远的倾斜反射阵列的虚像，随后是成像部分，被配置为将倾斜的反射阵列的虚像转换成倾斜检测器感测元件上的实际倾斜图像 。