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公开(公告)号：US07399608B2
公开(公告)日：2008-07-15
申请号：US11117651
申请日：2005-04-28
IPC分类号： C12Q1/02
CPC分类号： C12Q1/06 , C12Q1/04 , Y10T442/2566
摘要： A method for semi-quantitatively or quantitatively detecting the presence of a microbe in a sample is provided. The method utilizes a test dye that undergoes a detectable color change in the presence of one or more microbes. For example, in one embodiment, the test dye is a solvatochromic dye (e.g., Reichardt's dye) that responds to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth. Regardless, the color of the test dye may be compared to the color of a control dye, wherein the color of the control dye corresponds to a known microbe concentration.
摘要翻译： 提供了一种半定量或定量检测样品中微生物存在的方法。 该方法利用在一种或多种微生物存在下经历可检测的颜色变化的测试染料。 例如，在一个实施方案中，测试染料是响应于微生物组分（例如细胞膜，细胞质等）与细胞外的环境的极性差异的溶剂化色素染料（例如，Reichardt's染料）。 或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。 无论如何，可以将测试染料的颜色与对照染料的颜色进行比较，其中对照染料的颜色对应于已知的微生物浓度。
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公开(公告)号：US07300770B2
公开(公告)日：2007-11-27
申请号：US11117635
申请日：2005-04-28
申请人： Stephanie M. Martin , John Gavin MacDonald , Allison Salyer Bagwell , Jason Lye , Robert B. Johnson
发明人： Stephanie M. Martin , John Gavin MacDonald , Allison Salyer Bagwell , Jason Lye , Robert B. Johnson
IPC分类号： C12Q1/22
CPC分类号： C12Q1/04 , G01N33/528
摘要： An elastomeric article that contains a chromogen that undergoes a detectable change in color in the presence of one or more microbes is provided. For example, in one embodiment, the chromogen is a solvatochromic dye (e.g., Reichardt's dye) that undergoes a color change in the presence of bacteria or other microbes. More specifically, such dyes may respond to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth.
摘要翻译： 提供了包含在一种或多种微生物存在下经历可检测的颜色变化的色原体的弹性制品。 例如，在一个实施方案中，色原是在细菌或其它微生物存在下经历颜色变化的溶剂化色素染料（例如，Reichardt's染料）。 更具体地，这样的染料可以响应微生物组分（例如细胞膜，细胞质等）与细胞外的环境之间的极性差异。 或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。
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公开(公告)号：US07727513B2
公开(公告)日：2010-06-01
申请号：US11303001
申请日：2005-12-15
摘要： A method for rapidly detecting infectious conjunctivitis in a host is provided. The method includes contacting an ocular test sample with a chromogen (e.g., Reichardt's dye) that exhibits a color change in the presence of a microbe. The present inventors have discovered that the extent of the color change may vary depending on whether the microbe is a bacteria or virus. Without intending to be limited by theory, the present inventors believe that the chromogen interacts with the peptidoglycan-based cell wall structure of bacteria to induce a color change that is even more apparent at infectious levels. It is believed that this interaction occurs to a much greater extent in bacteria than in viruses. Accordingly, although the chromogen may still undergo a color change in the presence of the viruses, it is typically to a much lesser extent. In this manner, the degree of color change of the chromogen may be used in the present invention as a mechanism for differentiating between viral and bacterial conjunctivitis.
摘要翻译： 提供了一种快速检测宿主感染性结膜炎的方法。 该方法包括使眼睛测试样品与在微生物存在下显示颜色变化的色原体（例如，Reichardt's染料）接触。 本发明人已经发现，颜色变化的程度可以根据微生物是细菌还是病毒而变化。 不期望受理论的限制，本发明人相信色原体与细菌的基于聚肽聚糖的细胞壁结构相互作用以诱导在感染水平上更加明显的颜色变化。 相信这种相互作用在细菌中比在病毒中更大程度地发生。 因此，虽然染色体在病毒存在的情况下仍可能发生颜色变化，但通常其程度要小得多。 以这种方式，在本发明中可以使用色原体的颜色变化程度作为区分病毒和细菌性结膜炎的机制。
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公开(公告)号：US08361742B2
公开(公告)日：2013-01-29
申请号：US12843922
申请日：2010-07-27
CPC分类号： A61L15/56 , G01N2333/245 , G01N2333/31 , G01N2333/40
摘要： A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida. For example, the colorant may change from a first color to a second color, from colorless to a color, or from a color to colorless. The colorant is typically capable of differentiating between Candida (e.g., Candida albicans) and other microorganisms commonly associated with diaper rash, such as S. aureus and E. coli. Thus, when a dermal sample is placed into contact with the colorant, the color change may simply be observed to determine whether the infection is caused by Candida. If the color change occurs to a certain extent (e.g., from yellow to bright red), it may be determined that the test sample contains Candida. Likewise, if a color change occurs to a lesser extent (e.g., from yellow to faint orange) or not at all, it may be determined that the dermal sample contains other microorganisms (e.g., S. aureus or E. coli), no infection is present, or that the infection is simply due to other causes. Regardless, it will become readily apparent whether or not treatment for Candida is needed.
摘要翻译： 提供了用于快速检测宿主皮肤上的假丝酵母的方法和系统，例如具有尿布疹的婴儿。 该方法包括使真皮样品与在假丝酵母存在下显示特定光谱响应（例如颜色变化）的着色剂接触。 例如，着色剂可以从第一颜色变为第二颜色，从无色到颜色，或从颜色变为无色。 着色剂通常能够区分假丝酵母（例如白色念珠菌）和通常与尿布疹相关的其它微生物，例如金黄色葡萄球菌和大肠杆菌。 因此，当真皮样品与着色剂接触时，可以简单地观察颜色变化以确定感染是否由念珠菌引起。 如果颜色变化发生一定程度（例如，从黄色到鲜红色），则可以确定测试样品含有念珠菌。 同样地，如果在较小程度上发生颜色变化（例如，从黄色到微弱橙色），或根本不发生变色，则可以确定真皮样品含有其他微生物（例如金黄色葡萄球菌或大肠杆菌），无感染 存在，或感染仅仅是由于其他原因。 无论是否需要对念珠菌的治疗，将变得显而易见。
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公开(公告)号：US08338128B2
公开(公告)日：2012-12-25
申请号：US12749814
申请日：2010-03-30
申请人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie M. Martin
发明人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie M. Martin
CPC分类号： C12Q1/04
摘要： Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye.
摘要翻译： 合适的染料在本文中用于通过以水溶液的形式将它们喷雾到表面上来表示存在微生物污染。 染料溶液也可以干燥，从而产生水溶液的干燥残余物。 据信这些染料响应于环境极性的变化而改变颜色。 由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。
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公开(公告)号：US20110158917A1
公开(公告)日：2011-06-30
申请号：US12826017
申请日：2010-06-29
IPC分类号： A61K31/194 , A61K9/70 , A61P31/12
CPC分类号： A61K31/194 , A61K31/00
摘要： Anti-viral tissues are provided with a pH indicator which can communicate to a tissue user by means of visual indicia, via color changes, that the tissue has active ingredients. Furthermore, the pH indicators can be used to illustrate neutralization of the pH of infected nasal discharge, which has a higher pH than healthy nasal discharge, giving the user a reason to believe that the product is working to deactivate virus.
摘要翻译： 抗病毒组织设置有pH指示剂，其可以通过视觉标记通过颜色变化与组织使用者通信组织具有活性成分。 此外，pH指示剂可用于说明中和感染的鼻腔排泄物的pH，其具有比健康的鼻腔排出物更高的pH值，给予用户认为该产品正在致力于使病毒失活的理由。
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公开(公告)号：US20090143516A1
公开(公告)日：2009-06-04
申请号：US11998685
申请日：2007-11-30
IPC分类号： C08K5/17
CPC分类号： A61M25/1027 , A41D13/11 , A41D19/0027 , A41D19/0055 , A61B5/015 , A61F6/04 , C08K5/0041 , G01K11/12 , G01K2207/00 , C08L21/00 , C08L13/02
摘要： A material composition including a flexible, polymeric matrix and a reverse-thermochromic colorant is described. When subjected to a heat source, the polymeric material can change color from a pale or neutral color to a darker or more vibrant color of a Delta E (ΔE) change of >3. The reverse-thermochromic colorant exhibits a color change when exposed to a heat source within a period of about 30 seconds, and is observable by an unaided human eye under either natural daylight or ambient artificial normal lighting conditions. One or more different reverse-thermochromic colorants in combination may be incorporated. The polymeric matrix surrounds or encapsulates a solvatochromic dye molecule with a phenolate betaine structure. The polymeric matrix includes a dipole orientating agent that induces said solvatochromic dye to express locally when subjected to a temperature change. Various uses for the composition and articles that incorporate the composition are also described, in addition to a method of indicating the temperature of an object or environmental condition.
摘要翻译： 描述了包括柔性聚合物基质和反向热变色着色剂的材料组合物。 当经受热源时，聚合物材料可以将颜色从浅色或中性色变为Delta E（DeltaE）变化> 3的较暗或更鲜艳的颜色。 反向热变色着色剂在约30秒的时间内暴露于热源时显示颜色变化，并且在自然日光或环境人造正常照明条件下由肉眼观察到。 可并入一种或多种不同的反相热色素着色剂。 聚合物基质围绕或封装具有酚盐甜菜碱结构的溶剂化色素染料分子。 聚合物基质包括偶极取向剂，其在经受温度变化时诱导所述溶剂化色素染料局部表达。 除了指示物体的温度或环境条件的方法之外，还描述了包含组合物的组合物和制品的各种用途。
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公开(公告)号：US08029190B2
公开(公告)日：2011-10-04
申请号：US11801637
申请日：2007-05-10
IPC分类号： G01K11/00
CPC分类号： G01K3/08 , A41D13/002 , A41D13/1281 , A61B5/01 , A61B5/6804 , G01K11/12 , G01K13/002 , G01K2207/00
摘要： A method for determining the relative body temperature of a warm-bodied animal is described. The method, in part, involves an article of manufacture that provides a manifestation, or visually observable indication on an exterior surface, of a relative state of the warm-bodied animal's body temperature, either being too cold or too hot, as a measure against relative levels of hypothermia or hyperthermia, or poor circulation.
摘要翻译： 描述了用于确定温暖动物的相对体温的方法。 该方法的一部分涉及一种制品，其提供在外表面上的表现或视觉上可观察的指示，即温热的动物体温相对状态太冷或太热，作为对抗 低温或高热相对水平或循环不良。
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公开(公告)号：US20090155327A1
公开(公告)日：2009-06-18
申请号：US11955696
申请日：2007-12-13
摘要： A wipe that includes a bacteriostatic agent that contains cations having an affinity for the negatively charged cell walls of bacteria is provided. The affinity of the bacteriostatic agent for the bacteria allows the wipe to capture bacteria, thereby removing them from a surface and also inhibiting their spread to other surfaces that may contact the wipe. Of particular advantage, the bacteriostatic agent may help protect against the spread or infection of pathogens without the use of chemicals, such as antiseptics or antibiotics. Still further, the wipe of the present invention also contains a solvatochromatic indicator that undergoes a color change in the presence of a broad spectrum of bacteria. Thus, when the wipe captures bacteria, the indicator undergoes a color change that signals to the user that the wipe is functioning properly. The lack of a color change may likewise provide the user with the assurance that the area is generally free of bacteria and clean.
摘要翻译： 提供了包含具有对细菌带负电荷的细胞壁具有亲和性的阳离子的抑菌剂的擦拭物。 抑菌剂对细菌的亲和力允许擦拭物捕获细菌，从而从表面除去它们，并且还抑制它们扩散到可能接触擦拭物的其它表面。 特别有利的是，抑菌剂可以帮助防止病原体的扩散或感染而不使用诸如防腐剂或抗生素的化学物质。 此外，本发明的擦拭物还含有在广谱细菌存在下经历颜色变化的溶剂色素指示剂。 因此，当擦拭物捕获细菌时，指示器经历颜色变化，向用户发出指示擦拭物正常工作的颜色变化。 缺少颜色变化也可以为用户提供该区域通常没有细菌和清洁的保证。
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公开(公告)号：US08518375B2
公开(公告)日：2013-08-27
申请号：US12826017
申请日：2010-06-29
IPC分类号： A61K31/194 , A61K9/70 , A61P31/12
CPC分类号： A61K31/194 , A61K31/00
摘要： Anti-viral tissues are provided with a pH indicator which can communicate to a tissue user by means of visual indicia, via color changes, that the tissue has active ingredients. Furthermore, the pH indicators can be used to illustrate neutralization of the pH of infected nasal discharge, which has a higher pH than healthy nasal discharge, giving the user a reason to believe that the product is working to deactivate virus.
摘要翻译： 抗病毒组织设置有pH指示剂，其可以通过视觉标记通过颜色变化与组织使用者通信组织具有活性成分。 此外，pH指示剂可用于说明中和感染的鼻腔排泄物的pH，其具有比健康的鼻腔排出物更高的pH值，给予用户认为该产品正在致力于使病毒失活的理由。
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