-
公开(公告)号：US07300770B2
公开(公告)日：2007-11-27
申请号：US11117635
申请日：2005-04-28
申请人： Stephanie M. Martin , John Gavin MacDonald , Allison Salyer Bagwell , Jason Lye , Robert B. Johnson
发明人： Stephanie M. Martin , John Gavin MacDonald , Allison Salyer Bagwell , Jason Lye , Robert B. Johnson
IPC分类号： C12Q1/22
CPC分类号： C12Q1/04 , G01N33/528
摘要： An elastomeric article that contains a chromogen that undergoes a detectable change in color in the presence of one or more microbes is provided. For example, in one embodiment, the chromogen is a solvatochromic dye (e.g., Reichardt's dye) that undergoes a color change in the presence of bacteria or other microbes. More specifically, such dyes may respond to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth.
摘要翻译： 提供了包含在一种或多种微生物存在下经历可检测的颜色变化的色原体的弹性制品。 例如，在一个实施方案中，色原是在细菌或其它微生物存在下经历颜色变化的溶剂化色素染料（例如，Reichardt's染料）。 更具体地，这样的染料可以响应微生物组分（例如细胞膜，细胞质等）与细胞外的环境之间的极性差异。 或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。
-
公开(公告)号：US07619008B2
公开(公告)日：2009-11-17
申请号：US11194039
申请日：2005-07-29
申请人： Shu-Ping Yang , Lei Huang , Stephanie M. Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
发明人： Shu-Ping Yang , Lei Huang , Stephanie M. Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
IPC分类号： A61K31/045
CPC分类号： A61K31/7004 , A61K9/0034 , A61K31/047
摘要： A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.
摘要翻译： 提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。 治疗剂能够抑制和/或杀死加德纳（Gardnerella vaginalis），念珠菌（例如白色念珠菌）和/或滴虫（例如阴道毛滴虫）病原体。 理想地，实现了这样的抗微生物效能，而基本上不抑制嗜酸乳杆菌的生长。 例如，本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。 在一个具体实施方案中，D-木糖醇用作治疗剂。
-
公开(公告)号：US07786176B2
公开(公告)日：2010-08-31
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
发明人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
IPC分类号： A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译： 提供了一种当与阴离子粘膜天然存在的单价或多价阳离子（例如钠（Na +）和钙（Ca 2+））阳离子接触时，迅速形成凝胶的阴道治疗组合物。 凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。 除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。 另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。 以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。 例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。
-
公开(公告)号：US08703179B2
公开(公告)日：2014-04-22
申请号：US11302992
申请日：2006-05-11
申请人： RameshBabu Boga , Robert B. Johnson
发明人： RameshBabu Boga , Robert B. Johnson
IPC分类号： A61K9/127 , A01N57/26 , A61K31/685 , A61K31/565
CPC分类号： A61K9/127 , A61K31/565 , A61K31/685 , A61K2300/00
摘要： A mucosal formulation for administration to mucosal membranes, such as in the mouth, nasal passage, stomach, vagina, etc., is disclosed. The mucosal formulation contains a lipid-pharmaceutical agent complex formed from phospholipids possessing a hydrophobic moiety that orients into a hydrophobic phase and a polar head moiety that orients towards the aqueous phase (i.e., “amphipathic” lipids). When placed in an aqueous medium (e.g., vaginal fluid), the phospholipids form liposomes or other small lipid vesicles (e.g., micelles) that may then be used to deliver pharmaceutical agents into a living organism.
摘要翻译： 公开了用于施用于粘膜的粘膜制剂，例如在口腔，鼻腔，胃，阴道等中。 粘膜制剂包含由具有疏水部分的磷脂形成的脂质 - 药剂复合物，所述疏水部分定位于疏水相和朝向水相定向的极性头部分（即“两亲性”脂质）。 当放置在水性介质（例如阴道液）中时，磷脂形成脂质体或其它小脂质囊泡（例如胶束），然后可以将其用于将药剂递送到生物体内。
-
公开(公告)号：US07258878B2
公开(公告)日：2007-08-21
申请号：US11017226
申请日：2004-12-20
申请人： Sharon Linda Greene , Yanbin Huang , Lei Huang , Ilona F. Weart , Shu-Ping Yang , Sohail Malik , Robert B. Johnson
发明人： Sharon Linda Greene , Yanbin Huang , Lei Huang , Ilona F. Weart , Shu-Ping Yang , Sohail Malik , Robert B. Johnson
IPC分类号： A61K36/752
CPC分类号： A61K45/06 , A61K31/19 , A61K31/215 , A61K31/7048 , A61K36/61 , A61K2300/00
摘要： The present invention is directed to anti-microbial compositions and methods for treating fungal and yeast infections.
摘要翻译： 本发明涉及用于治疗真菌和酵母菌感染的抗微生物组合物和方法。
-
公开(公告)号：US5146297A
公开(公告)日：1992-09-08
申请号：US783432
申请日：1991-10-25
IPC分类号： H01L27/08 , H01L29/06 , H01L29/861
CPC分类号： H01L27/0814 , H01L29/0692 , H01L29/861
摘要： A precision voltage reference device having a forward biased and reverse biased silicon junctions arranged as a concentric circular annular monolithic structure is described. Selective hardening of the forward biased junction is provided to adjust carrier lifetime in said junction thereby providing a radiation hardened device. The selective hardening is provided by implanting non-dopant species to induce a predetermined amount of lattice damage at the forward biased junction. This arrangement permits both the forward biased junction and the reverse biased junction to be fabricated on a common substrate.
摘要翻译： 描述了具有布置为同心圆形环形整体结构的正向偏置和反向偏置硅结的精密电压参考装置。 提供正向偏置结的选择性硬化以调节所述结中的载流子寿命，从而提供辐射硬化装置。 选择性硬化是通过注入非掺杂剂物质以在正向偏置结处引起预定量的晶格损伤来提供的。 这种布置允许正向偏置结和反向偏置结两者制造在公共衬底上。
-
公开(公告)号：US4795413A
公开(公告)日：1989-01-03
申请号：US44005
申请日：1987-04-29
申请人： Robert B. Johnson , Robert P. Smith
发明人： Robert B. Johnson , Robert P. Smith
CPC分类号： B65B43/30 , B31B2217/0053 , Y10T156/1906 , Y10T29/53683
摘要： The invention provides an apparatus and method for automatically opening a plastic bag-type liner as part of a container lining process. The apparatus comprises at least one movable jaw assembly disposed on each side of the liner to be opened and a tongue on the other side of the liner opposing each jaw assembly. To open the bag, the jaws are opened and the jaw assemblies are moved toward and contact the liner and the opposing tongue pushes the liner between the gripping surfaces of the jaws of the opposing jaw assembly; as the jaw assemblies begin to move apart, the jaws close, gripping and retaining the layer of liner in direct contact with the gripping surfaces of each jaw, the tongues slide out from between the layers of the liner, separating the sides of the unsealed end of the liner. A stream of air may then be directed into the open end of the bag for completely blowing the bag open prior to placing the bag over the open end of the container to be lined and forcing the liner into the container.
摘要翻译： 本发明提供一种自动打开塑料袋式衬套作为容器衬里工艺的一部分的装置和方法。 该装置包括设置在待打开的衬垫的每一侧上的至少一个活动夹爪组件和位于衬套的另一侧上的与每个夹爪组件相对的舌头。 为了打开袋子，夹爪被打开并且钳口组件移动并接触衬套，并且相对的舌片将衬垫推到相对的钳口组件的钳口的夹持表面之间; 当钳口组件开始分离时，钳口关闭，夹持并保持衬垫层与每个钳口的抓握表面直接接触，舌片从衬垫层之间滑出，分离未密封端的侧面 的班轮。 然后可以将空气流引导到袋的开口端中，以在将袋放置在待衬里的容器的开口端上并迫使衬垫进入容器之前完全吹动袋打开。
-
公开(公告)号：US4451880A
公开(公告)日：1984-05-29
申请号：US202821
申请日：1980-10-31
CPC分类号： G06F13/1642 , G06F13/28
摘要： A memory controller controls the operation of a number of memory module units and includes a number of queues which couple to the module units. Each queue includes an address queue register, a control queue register and a data queue register. Each address queue register has tristate control for independent operation. Control circuits which couple to the queue address, control and data registers assign memory cycles between queues on an alternate basis when the queue control registers store requests which are being processed. This enables the interleaving of memory requests which eliminates processing delays particularly in cases where such requests involve multiword transfers over successive memory cycles of operation.
摘要翻译： 存储器控制器控制多个存储器模块单元的操作，并且包括耦合到模块单元的多个队列。 每个队列包括地址队列寄存器，控制队列寄存器和数据队列寄存器。 每个地址队列寄存器都有三态控制，用于独立操作。 当队列控制寄存器存储正在处理的请求时，耦合到队列地址，控制和数据寄存器的控制电路在备用的队列之间分配存储器周期。 这使得能够消除处理延迟的存储器请求的交织，特别是在这种请求涉及在连续存储器操作周期中的多字传输的情况下。
-
公开(公告)号：US4376972A
公开(公告)日：1983-03-15
申请号：US110521
申请日：1980-01-08
摘要： A memory subsystem which couples to a multiword bus for processing memory requests received therefrom includes at least a pair of independently addressable dynamic memory module units. Each memory unit includes a number of rows of random access memory (RAM) chips. The subsystem further includes an adder circuit, a pair of tri-state operated address register circuits and timing circuits. The address circuits include a pair of tri-state operated address registers which couple to the bus and to the set of address lines to each memory unit. In response to a memory request, the registers store row and column address portions of a chip address of the memory request. A multibit adder circuit is connected to increment by one the low order row address when the least significant address bits of the memory request indicate a subboundary address condition thereby enabling access to a pair of sequential word locations. Whenever a memory request specifies an address which cannot access a double word, boundary circuits upon detecting the condition cause the timing circuits to generate only timing signals necessary for accessing the first word location.
摘要翻译： 耦合到多字总线以用于处理从其接收的存储器请求的存储器子系统包括至少一对独立可寻址的动态存储器模块单元。 每个存储器单元包括多行随机存取存储器（RAM）芯片。 子系统还包括加法器电路，一对三态操作地址寄存器电路和定时电路。 地址电路包括一对三态操作地址寄存器，其耦合到总线和到每个存储器单元的地址线集合。 响应于存储器请求，寄存器存储存储器请求的芯片地址的行和列地址部分。 当存储器请求的最低有效地址位指示子边界地址条件从而使得能够访问一对顺序字位置时，多位加法器电路被连接以递增一个低位行地址。 每当存储器请求指定不能访问双字的地址时，边界电路在检测到条件时，使定时电路仅产生访问第一字位置所必需的定时信号。
-
公开(公告)号：USD830488S1
公开(公告)日：2018-10-09
申请号：US29574578
申请日：2016-08-17
-
-
-
-
-
-
-
-
-
搜索结果
42 条记录 (耗时 0.032 秒)
