公开(公告)号：US20070281025A1

公开(公告)日：2007-12-06

申请号：US11752460

申请日：2007-05-23

申请人： John Hughes ,  Panayiotis Constantinides ,  Jerald Darlington

发明人： John Hughes ,  Panayiotis Constantinides ,  Jerald Darlington

IPC分类号： A61K33/00 ,  A61K31/19 ,  A61K31/27 ,  A61K31/35 ,  A61K31/405 ,  A61K31/435 ,  A61K47/00 ,  A61P9/00 ,  A61K9/00 ,  A61K38/00 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/70

CPC分类号： A61K33/00 ,  A61K31/19 ,  A61K31/27 ,  A61K31/35 ,  A61K31/405 ,  A61K31/435 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/70 ,  A61K45/06 ,  A61K2300/00

摘要： Layered phyllosilicates are useful for adsorbing and/or binding to cholesterol and, thereby, reducing blood cholesterol in a patient. Accordingly, provided herein is a method of reducing hypercholesteremia in a mammal comprising administering to said mammal a layered phyllosilicate material alone and in combination with other cholesterol-reducing agents in an amount effective to reduce hypercholesteremia in said mammal.

摘要翻译： 层状页硅酸盐可用于吸附和/或结合胆固醇，从而降低患者的血液胆固醇。 因此，本文提供的是减少哺乳动物的高胆固醇血症的方法，包括向所述哺乳动物单独施用层状页硅酸盐物质，并与其它降胆固醇剂组合施用有效降低所述哺乳动物血清胆固醇血症的量。

公开(公告)号：US20070231412A1

公开(公告)日：2007-10-04

申请号：US11641639

申请日：2006-12-18

申请人： John Hughes ,  Panayiotis Constantinides ,  Jerald Darlington

发明人： John Hughes ,  Panayiotis Constantinides ,  Jerald Darlington

IPC分类号： A61K48/00 ,  A61K33/06 ,  A61K33/12 ,  A61K33/38

CPC分类号： C09C1/42 ,  A01N59/00 ,  A01N59/06 ,  C01P2004/20 ,  C01P2004/61

摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses. Accordingly, provided herein is a method of inactivating a virus in the gastrointestinal tract of a mammalian subject comprising administering to said subject a composition comprising a layered phyllosilicate material in an amount effective for virus inactivation. Also provided are methods of treating a viral infection in the gastrointestinal tract of a mammalian subject. Methods of delivering a therapeutic agent to a mammalian subject and methods of inactivating a virus in waste expelled from a mammal are also provided.

摘要翻译： 层状页硅酸盐可用于吸附和/或结合病毒，从而使病毒失活。 因此，本文提供的是灭活哺乳动物受试者的胃肠道中的病毒的方法，包括向所述受试者施用含有有效用于病毒灭活的量的层状页硅酸盐材料的组合物。 还提供了治疗哺乳动物受试者的胃肠道中的病毒感染的方法。 还提供了向哺乳动物受试者递送治疗剂的方法和从哺乳动物排出的废物中灭活病毒的方法。

公开(公告)号：US20070224293A1

公开(公告)日：2007-09-27

申请号：US11641319

申请日：2006-12-18

申请人： John Hughes ,  Jerald Darlington ,  Panayiotis Constantinides

发明人： John Hughes ,  Jerald Darlington ,  Panayiotis Constantinides

IPC分类号： A61K33/12 ,  A61K33/06

CPC分类号： C09C1/42 ,  A01N59/00 ,  A01N59/06 ,  C01P2004/20 ,  C01P2004/61

摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses. Accordingly, provided herein is a method of inhibiting transfer of a virus to a surface comprising contacting the surface with a composition comprising a layered phyllosilicate material in an amount sufficient for inhibiting the transfer of the virus thereto. Also provided are methods of inactivating a virus on a surface comprising contacting the surface with a composition comprising a layered phyllosilicate material in an amount sufficient to inactivate said virus.

摘要翻译： 层状页硅酸盐可用于吸附和/或结合病毒，从而灭活病毒。 因此，本文提供了一种抑制病毒转移到表面的方法，包括使表面与包含层状页硅酸盐材料的组合物接触，所述组合物的量足以抑制病毒转移到其上。 还提供了使表面灭活病毒的方法，包括使表面与含有足以灭活所述病毒的量的层状页硅酸盐材料的组合物接触。

公开(公告)号：US20170101854A1

公开(公告)日：2017-04-13

申请号：US15384715

申请日：2016-12-20

申请人： John Hughes ,  James Wilburn Schmidt ,  Shane D'Arcy

发明人： John Hughes ,  James Wilburn Schmidt ,  Shane D'Arcy

IPC分类号： E21B43/10 ,  E21B33/14

CPC分类号： E21B43/10 ,  E21B21/00 ,  E21B23/01 ,  E21B33/129 ,  E21B33/14

摘要： A liner hanger assembly to run-in a liner on a liner hanger, cement the liner in place and set the liner hanger in one trip. Then, a wellbore treatment process can proceed while the running string remains downhole or via a second trip. The liner hanger assembly includes a liner hanger running tool and a liner hanger.

公开(公告)号：US08672036B2

公开(公告)日：2014-03-18

申请号：US13180354

申请日：2011-07-11

申请人： John Hughes ,  Ryan Dwaine Rasmussen ,  Delton Andrew Campbell

发明人： John Hughes ,  Ryan Dwaine Rasmussen ,  Delton Andrew Campbell

IPC分类号： E21B34/06 ,  E21B34/12

CPC分类号： E21B23/006 ,  E21B34/12 ,  E21B34/14 ,  E21B43/26

摘要： A circulation valve includes: an outer tubular sleeve telescopically mounted at its end over a tubular mandrel; a fluid passage between sleeve and the mandrel, the fluid passage providing fluid communication between the inner bore of the valve and its outer surface; a dual knife seal assembly to control flow out of the fluid flow path through the fluid passage, the dual knife seal assembly including a first annular knife seal edge and land that seal up when the sleeve and mandrel are in a fully axially compressed position and a second annular knife seal edge and land that seal up when the sleeve and mandrel are pulled into a fully in tension position; and, a J-slot position indexing mechanism including a slot and a key to guide movement of the sleeve and the mandrel between the fully in tension position and the fully compressed position. The circulation valve is employed in a wellbore treatment assembly and methods.

摘要翻译： 循环阀包括：外管状套筒，其端部可伸缩地安装在管状心轴上; 在套筒和心轴之间的流体通道，流体通道提供阀的内孔与其外表面之间的流体连通; 双刀密封组件，用于控制流过流体通道的流体流动路径，双刀密封组件包括第一环形刀片密封边缘和当套筒和心轴处于完全轴向压缩位置时密封的平台， 第二环形刀密封边缘和当套筒和心轴被拉入完全张紧位置时密封的平台; 以及J槽位置分度机构，其包括槽和键，以引导套筒和心轴在完全张紧位置和完全压缩位置之间的运动。 循环阀用于井筒处理组件和方法。

公开(公告)号：US08567501B2

公开(公告)日：2013-10-29

申请号：US12887860

申请日：2010-09-22

申请人： Mark Zimmerman ,  Blake Cox ,  John Hughes

发明人： Mark Zimmerman ,  Blake Cox ,  John Hughes

IPC分类号： E21B43/16

CPC分类号： E21B34/14 ,  E21B43/14 ,  E21B43/26

摘要： A system and method for selectively stimulating a plurality of producing zones in a wellbore in oil and gas wells. The system includes a plurality of modules connected in a string that may be selectively actuated to stimulate a producing zone. Each module may be adapted to engage a tubing run ball seat. After installation of the string within the wellbore, a ball seat may be run into the well and positioned to selectively engage a desired module. The ball seat may be used to open a sleeve of the module permitting the stimulation of the producing zone. After stimulation of the producing zone, the ball seat may be removed from the wellbore rather than needing to drill out the ball seat. The sleeve may include a profile adapted to engage a shifting tool permitting the selective closure of the sleeve after stimulation of the producing zone.

摘要翻译： 用于选择性地刺激油气井井眼中的多个生产区的系统和方法。 该系统包括连接在串中的多个模块，其可选择性地被致动以刺激生产区。 每个模块可以适于接合管道球座。 在将井筒安装在井筒内之后，球座可能会进入井眼并且定位成选择性地接合所需的模块。 球座可用于打开模块的套筒，允许刺激生产区。 刺激生产区后，球座可以从井筒中取出，而不需要钻出球座。 套筒可以包括适于接合移动工具的轮廓，允许在刺激产生区域之后选择性地关闭套筒。

公开(公告)号：US20120067583A1

公开(公告)日：2012-03-22

申请号：US12887860

申请日：2010-09-22

申请人： Mark Zimmerman ,  Blake Cox ,  John Hughes

发明人： Mark Zimmerman ,  Blake Cox ,  John Hughes

IPC分类号： E21B43/26 ,  E21B34/06

CPC分类号： E21B34/14 ,  E21B43/14 ,  E21B43/26

摘要： A system and method for selectively stimulating a plurality of producing zones in a wellbore in oil and gas wells. The system includes a plurality of modules connected in a string that may be selectively actuated to stimulate a producing zone. Each module may be adapted to engage a tubing run ball seat. After installation of the string within the wellbore, a ball seat may be run into the well and positioned to selectively engage a desired module. The ball seat may be used to open a sleeve of the module permitting the stimulation of the producing zone. After stimulation of the producing zone, the ball seat may be removed from the wellbore rather than needing to drill out the ball seat. The sleeve may include a profile adapted to engage a shifting tool permitting the selective closure of the sleeve after stimulation of the producing zone.

摘要翻译： 用于选择性地刺激油气井井眼中的多个生产区的系统和方法。 该系统包括连接在串中的多个模块，其可选择性地被致动以刺激生产区。 每个模块可以适于接合管道球座。 在将井筒安装在井筒内之后，球座可能会进入井眼并且定位成选择性地接合所需的模块。 球座可用于打开模块的套筒，允许刺激生产区。 刺激生产区之后，可以将球座从井筒中取出，而不需要钻出球座。 套筒可以包括适于接合移动工具的轮廓，允许在刺激产生区域之后选择性地关闭套筒。

公开(公告)号：US20100286612A1

公开(公告)日：2010-11-11

申请号：US12724411

申请日：2010-03-15

申请人： WILLIAM CIRILLO ,  John Hughes

发明人： WILLIAM CIRILLO ,  John Hughes

IPC分类号： A61M5/31 ,  A61M5/50 ,  G06F1/32 ,  G05D7/06 ,  G08B17/00 ,  H04N7/18

CPC分类号： A61M5/31525 ,  A61M2005/3125 ,  A61M2005/3126 ,  A61M2205/52 ,  A61M2205/58 ,  G06F19/3418 ,  G06F19/3468 ,  G09F9/00

摘要： A medication injection supervisor device, in one example embodiment, comprises a particular sleeve, the particular sleeve being designed to lock onto to a prefabricated injection pen of a particular design, a universal header designed slide onto the particular sleeve irrespective of the particular model of the prefabricated injection pen, an electronics assembly housed by the universal header, a sensor to detect an injection automatically, the sensor being communicatively coupled to the electronics assembly, a display to display injection data, and a button to allow manipulation and display of the injection data, including resetting of the time. The medication injection supervisor device can infer the completion of the injection from a plunger of the injection pen being depressed. The medication injection supervisor device can further include a dosage reading system to read a dosage of medication delivered by the prefabrication injection pen, the dosage reading system including a clip specific to the prefabricated injection pen coupled to a plunger of the prefabricated injection pen, the dosage being determined by a position of the clip. The medication injection supervisor device can further include a micro optics subsystem communicatively coupled to the electronics assembly and having a dial reader to take one or more images of a dosage dial of the prefabricated injection pen, and an imaging subsystem communicatively coupled to the electronics assembly to recognize characters in the images taken by the dial reader.

摘要翻译： 在一个示例性实施例中，药物注射监督装置包括特定的套筒，该特定套筒被设计成锁定到特定设计的预制注射笔上，通用头部被设计成滑动到特定套筒上，而不考虑特定的模型 预制注射笔，由通用集管容纳的电子组件，用于自动检测注射的传感器，传感器通信地耦合到电子组件，显示器以显示注射数据，以及用于允许操纵和显示注射数据的按钮 ，包括重置时间。 药物注射监督装置可以推断从被压下的注射笔的柱塞完成注射。 药物注射管理装置还可以包括用于读取由预制注射笔输送的药物剂量的剂量读取系统，所述剂量读取系统包括与预制注射笔的柱塞耦合的预制注射笔特有的夹子，剂量 由夹子的位置决定。 药物注射管理装置还可以包括通信地连接到电子组件的微型光学子系统，并且具有拨号读取器以取得预制注射笔的剂量刻度盘的一个或多个图像，以及通信地耦合到电子组件的成像子系统 识别由拨号阅读器拍摄的图像中的字符。

公开(公告)号：US20090311932A1

公开(公告)日：2009-12-17

申请号：US12545813

申请日：2009-08-22

申请人： John Hughes

发明人： John Hughes

IPC分类号： B32B3/26 ,  B32B5/26 ,  B29C45/14

CPC分类号： E04C2/296 ,  B32B1/00 ,  B32B5/024 ,  B32B5/18 ,  B32B5/20 ,  B32B5/245 ,  B32B7/12 ,  B32B17/04 ,  B32B19/04 ,  B32B27/065 ,  B32B27/12 ,  B32B27/38 ,  B32B27/40 ,  B32B2250/40 ,  B32B2262/10 ,  B32B2262/108 ,  B32B2266/0278 ,  B32B2305/022 ,  B32B2307/304 ,  B32B2307/3065 ,  B32B2307/558 ,  B32B2307/72 ,  B32B2307/7265 ,  B32B2419/00 ,  B32B2419/06 ,  B32B2607/00 ,  E02D27/01 ,  E02D27/34 ,  E02D27/50 ,  E04B1/14 ,  E04B1/6145 ,  Y10T428/249953 ,  Y10T442/335

摘要： A structural insulated laminated construction panel for building structures is described. The panel comprises a rigid core material layer of expanded polymeric material having opposed flat parallel surfaces. The expanded polymeric material is injected between spaced outer and inner skins. An outer skin is secured to one of the flat surfaces and an inner skin is secured to the other of the flat surfaces. The core material is preferably an expanded polyurethane foam material. A building structure is constructed from such panels used as exterior and interior wall panels, floor panels and roof panels.

摘要翻译： 描述了一种用于建筑结构的结构绝缘层压结构面板。 面板包括具有相对平坦平行表面的膨胀聚合物材料的刚性芯材料层。 将扩展的聚合物材料注入间隔的外层和内层之间。 外皮被固定到一个平坦表面上，并且内表皮固定到另一个平坦表面。 芯材料优选为发泡聚氨酯泡沫材料。 建筑结构由用于外墙和内墙板，地板和屋顶板的面板构成。

公开(公告)号：US20090030834A1

公开(公告)日：2009-01-29

申请号：US12181780

申请日：2008-07-29

申请人： Daniel F. Moore ,  Yek Eng ,  Mark DeNat ,  Michael Galus ,  Richard Justice ,  Bruce E. Friedman ,  John Hughes ,  Peter Martyn ,  Timothy Vincent

发明人： Daniel F. Moore ,  Yek Eng ,  Mark DeNat ,  Michael Galus ,  Richard Justice ,  Bruce E. Friedman ,  John Hughes ,  Peter Martyn ,  Timothy Vincent

IPC分类号： G06Q40/00

CPC分类号： G06Q40/04 ,  G06Q20/401 ,  G06Q40/00 ,  G06Q40/06

摘要： A system for determining an opening price for products traded over a distributed, networked computer system, includes a plurality of workstations for entering orders for financial products into the distributed, networked computer system and a server computer coupled to the workstations for receiving the orders. The server computer executes a server process that determines an opening price for the product. The server process identifies the oldest of interest at the most aggressive price on each side of the market and selects the older interest of the identified interest to designate as initial interest. The server process matches initial interest against all contra side interest.

摘要翻译： 用于确定通过分布式联网计算机系统交易的产品的开价的系统包括用于将金融产品的订单输入到分布式联网计算机系统的多个工作站以及耦合到工作站的用于接收订单的服务器计算机。 服务器计算机执行确定产品的开价的服务器进程。 服务器进程以市场每一方最具侵略性的价格确定最年长的利益，并选择所识别的利益的较早利益来指定为最初利益。 服务器进程与初始兴趣匹配所有对方利益。