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    Processes for the preparation of D-chiro-inositol
    2.
    发明授权
    Processes for the preparation of D-chiro-inositol 失效
    D-手性肌醇的制备方法

    公开(公告)号：US5932774A

    公开(公告)日：1999-08-03

    申请号：US539424

    申请日：1995-11-06

    申请人： David A. Riley ,  Ashok V. Bhatia ,  Steven A. Chamberlin ,  Gregg E. Robinson

    发明人： David A. Riley ,  Ashok V. Bhatia ,  Steven A. Chamberlin ,  Gregg E. Robinson

    IPC分类号： C07C29/09 ,  C07C35/16 ,  C07C69/013

    CPC分类号： C07C69/013 ,  C07C29/095 ,  C07C35/16 ,  C07C2101/14

    摘要： A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.

    摘要翻译： 一种从春雷霉素制备D-手性肌醇的方法，包括以下步骤：（a）使春日霉素与乙酰化试剂反应形成六醋酸中间体中间体; （b）纯化粗中间体以形成纯化的六醋酸酯中间体; （c）将纯化的中间体脱乙酰以形成D-手性肌醇; 和（d）分离D-手性肌醇。 该方法可有效，大规模地制备D-手性肌醇，而不需要对最终D-手性肌醇产品进行广泛的色谱纯化。

    Method for the preparation of D-chiro-inositol
    3.
    发明授权
    Method for the preparation of D-chiro-inositol 失效
    D-手性肌醇的制备方法

    公开(公告)号：US5463142A

    公开(公告)日：1995-10-31

    申请号：US337656

    申请日：1994-11-10

    申请人： David A. Riley ,  Steven A. Chamberlin ,  Ashok V. Bhatia

    发明人： David A. Riley ,  Steven A. Chamberlin ,  Ashok V. Bhatia

    IPC分类号： C07C29/09 ,  C07C35/16 ,  C07C69/013

    CPC分类号： C07C29/09 ,  C07C35/16 ,  C07C69/013 ,  C07B2200/07 ,  C07C2101/14

    摘要： A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of:(a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate;(b) purifying the crude intermediate to form purified hexa-acetate intermediate;(c) deacetylating the purified intermediate to form D-chiro-inositol; and(d) isolating the D-chiro-inositol.The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.

    摘要翻译： 一种从春雷霉素制备D-手性肌醇的方法，包括以下步骤：（a）使春日霉素与乙酰化试剂反应形成六醋酸中间体中间体; （b）纯化粗中间体以形成纯化的六醋酸酯中间体; （c）将纯化的中间体脱乙酰以形成D-手性肌醇; 和（d）分离D-手性肌醇。 该方法可有效，大规模地制备D-手性肌醇，而不需要对最终D-手性肌醇产品进行广泛的色谱纯化。

    Process for clarifying alkoxylated alcohols
    4.
    发明授权
    Process for clarifying alkoxylated alcohols 失效
    澄清烷氧基化醇的方法

    公开(公告)号：US5352842A

    公开(公告)日：1994-10-04

    申请号：US39635

    申请日：1993-03-30

    申请人： Upali Weerasooriya ,  Steve V. Orsak ,  Clint Osborne ,  John Lin ,  Mark W. Hellums ,  Linton LeCompte ,  David A. Riley

    发明人： Upali Weerasooriya ,  Steve V. Orsak ,  Clint Osborne ,  John Lin ,  Mark W. Hellums ,  Linton LeCompte ,  David A. Riley

    IPC分类号： C07C41/36 ,  C08G65/30 ,  C07C41/34

    CPC分类号： C08G65/30 ,  C07C41/36

    摘要： A process for clarifying an alkoxylated product mixture produced using a calcium-based catalyst wherein the product mixture is heated to a temperature of from about 80.degree. C. to about 175.degree. C. to produce a filtration feed, the filtration feed being passed through a filter medium comprising material possessing polar groups to produce a clarified filtrate, the filtration feed being passed through the filter medium within about 5 days of being prepared, the filtration feed being passed through the filter medium until the desired degree of clarification is obtained, the temperature of the clarified filtrate being less than about 30.degree. C. but above the pour point of the clarified filtrate.

    摘要翻译： 一种用于澄清使用钙基催化剂制备的烷氧基化产物混合物的方法，其中将产物混合物加热至约80℃至约175℃的温度以产生过滤进料，该过滤进料通过 过滤介质包含具有极性基团的材料以产生澄清的滤液，过滤进料在制备的约5天内通过过滤介质，过滤进料通过过滤介质直至获得所需的澄清度，温度 的澄清滤液小于约30℃，但高于澄清滤液的倾点。

    Preparation of crystal form II of clarithromycin
    6.
    发明授权
    Preparation of crystal form II of clarithromycin 失效
    克拉霉素晶型II的制备

    公开(公告)号：US5844105A

    公开(公告)日：1998-12-01

    申请号：US681695

    申请日：1996-07-29

    申请人： Jih-Hua Liu ,  David A. Riley

    发明人： Jih-Hua Liu ,  David A. Riley

    IPC分类号： C07H17/08 ,  C07G3/00 ,  C07H1/00 ,  C07H15/00

    CPC分类号： C07H17/08

    摘要： The present invention provides a process for the preparation of 6-O-methylerythromycin A Form II comprising converting erythromycin A to 6-O-methylerythromycin A and treating the 6-O-methylerythromycin A with a number of common organic solvents or mixtures of common organic solvents.

    摘要翻译： 本发明提供了制备6-O-甲基红霉素A形式II的方法，包括将红霉素A转化为6-O-甲基红霉素A，并用许多常见的有机溶剂或常见有机溶剂的混合物处理6-O-甲基红霉素A 溶剂。

    Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
    7.
    发明授权
    Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives 失效
    使用9-羟基红霉素衍生物制备6-O-甲基红霉素a的方法

    公开(公告)号：US5892008A

    公开(公告)日：1999-04-06

    申请号：US991648

    申请日：1997-12-16

    申请人： Yi-Yin Ku ,  David A. Riley ,  Elaine C. Lee ,  Jien-Heh Tien

    发明人： Yi-Yin Ku ,  David A. Riley ,  Elaine C. Lee ,  Jien-Heh Tien

    IPC分类号： C07H17/08 ,  C07H1/00

    CPC分类号： C07H17/08

    摘要： The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4"-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.

    摘要翻译： 所要求保护的发明提供了制备6-O-甲基红霉素A的新方法。该方法包括将红霉素A的9-酮基还原形成9-羟基红霉素A的步骤，保护9-，2'- 和/或4“ - 羟基，选择甲基化9-羟基红霉素A衍生物的6位，使羟基脱保护并氧化9-羟基，得到6-O-甲基红霉素A.