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    Analyte sensor method of making the same
    6.
    发明授权
    Analyte sensor method of making the same 有权
    分析物传感器的制作方法

    公开(公告)号：US07003336B2

    公开(公告)日：2006-02-21

    申请号：US09779282

    申请日：2001-02-08

    申请人： James D. Holker ,  Guillermo A. Calle ,  Kevin D. Branch ,  John J. Mastrototaro ,  William P. Van Antwerp ,  Nannette Van Antwerp

    发明人： James D. Holker ,  Guillermo A. Calle ,  Kevin D. Branch ,  John J. Mastrototaro ,  William P. Van Antwerp ,  Nannette Van Antwerp

    IPC分类号： B65D85/38 ,  A61B5/05 ,  A61B5/04

    CPC分类号： A61B5/14865 ,  A61B5/6849 ,  A61M2005/1726

    摘要： A sensor and method of making the same for implantation in a body that includes a substrate with notches cut in the substrate to form a necked down region in the substrate; and at least one sensor electrode formed from one or more conductive layers. Preferably, the thickness of the substrate ranges from approximately 25μ to 350μ, but the thickness of the substrate can range from 5μ to 750μ. The sensor may be incorporated in to a sensor assembly includes a slotted needle having a slot. The notches creating the necked down region allow the substrate to slide into the slotted needle, which that has the slot narrow enough to permit passage of the necked down region. However, a non-necked down region of the substrate is prevented from pulling out of the slotted needle through the slot. The slot of the slotted needle may also permit the necked down region of the substrate to slide down the slot.

    摘要翻译： 一种传感器及其制造方法，用于植入体内，其包括在衬底中切口切口的衬底，以在衬底中形成颈缩区域; 以及由一个或多个导电层形成的至少一个传感器电极。 优选地，基板的厚度范围为约25μm至350μm，但基板的厚度可以在5μm至750μm的范围内。 传感器可以结合到传感器组件中，包括具有槽的开槽针。 产生颈缩区域的切口允许基底滑入开槽针，其具有足够窄的狭槽以允许颈缩区域的通过。 然而，防止了衬底的非颈缩区域从槽缝拉出。 开槽针的槽还可以允许衬底的颈缩区域沿着槽滑下来。

    Transcutaneous sensor insertion set
    7.
    发明授权
    Transcutaneous sensor insertion set 失效
    经皮传感器插入组

    公开(公告)号：US5390671A

    公开(公告)日：1995-02-21

    申请号：US213101

    申请日：1994-03-15

    申请人： Peter C. Lord ,  William P. Van Antwerp ,  John J. Mastrototaro ,  Paul S. Cheney, II ,  Nannette M. Schnabel

    发明人： Peter C. Lord ,  William P. Van Antwerp ,  John J. Mastrototaro ,  Paul S. Cheney, II ,  Nannette M. Schnabel

    IPC分类号： G01N33/483 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  A61B17/34 ,  A61M25/02 ,  G01N27/28 ,  G01N33/49 ,  A61B5/05 ,  A61B5/04

    CPC分类号： A61B5/14865 ,  A61B17/3403 ,  A61B5/6849 ,  A61M25/02 ,  A61M2025/0206

    摘要： An insertion set is provided for transcutaneous placement of a sensor such as a glucose sensor at a selected site within the body of a patient. The insertion set comprises a slotted insertion needle extending through a mounting base adapted for mounting onto the patient's skin. A flexible thin film sensor includes a proximal segment carried by the mounting base and defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment protruding from the mounting base with sensor electrodes for transcutaneous placement. The proximal and distal segments of the sensor are linearly offset or misaligned, with the distal segment fitted within the insertion needle for transcutaneous sensor placement with the needle as the mounting base is pressed onto the patient's skin. The insertion needle can then be withdrawn to leave the sensor distal segment at the selected insertion position with the sensor electrodes in contact with patient blood or other extracellular fluid.

    摘要翻译： 提供插入组用于在病人体内的选定部位经皮放置诸如葡萄糖传感器之类的传感器。 插入组包括延伸穿过适于安装到患者皮肤上的安装基座的开槽插入针。 柔性薄膜传感器包括由安装基座承载的近端段，并且限定适于与合适的监视器电连接的导电触头，以及从安装基座突出的用于经皮放置的传感器电极的远端段。 传感器的近端段和远端段线性偏移或不对准，远端段装配在插入针内，用于经皮传感器放置，随着安装基座被压在病人的皮肤上。 然后可以将插入针抽出以将传感器远端段离开所选择的插入位置，同时传感器电极与患者血液或其它细胞外液接触。

    Analyte sensor and method of making the same
    8.
    发明授权
    Analyte sensor and method of making the same 有权
    分析物传感器及其制作方法

    公开(公告)号：US06484045B1

    公开(公告)日：2002-11-19

    申请号：US09502204

    申请日：2000-02-10

    申请人： James D. Holker ,  Guillermo A. Calle ,  Kevin D. Branch ,  John J. Mastrototaro ,  William P. Van Antwerp

    发明人： James D. Holker ,  Guillermo A. Calle ,  Kevin D. Branch ,  John J. Mastrototaro ,  William P. Van Antwerp

    IPC分类号： A61B505

    CPC分类号： A61B5/14865

    摘要： A method of making a sensor includes the steps of providing a preformed self-supporting flexible substrate; sputter-depositing a metal layer on the substrate; etching the sputter-deposited metal layers to form a sensor electrode having a proximal segment and a distal segment; plating a metal layer on the sensor electrode; and separating the sensor electrode and at least a portion of the substrate underlying the sensor electrode from the remainder of the substrate. Sensors prepared according to the inventive methods, and sensor sets including the sensors, are also provided.

    摘要翻译： 制造传感器的方法包括以下步骤：提供预制的自支撑柔性基板; 在衬底上溅射沉积金属层; 蚀刻溅射沉积的金属层以形成具有近端段和远端段的传感器电极; 在传感器电极上镀金属层; 以及将所述传感器电极和所述传感器电极下方的所述衬底的至少一部分与所述衬底的其余部分分开。 还提供了根据本发明方法制备的传感器，以及包括传感器的传感器组。

    Closed loop system for controlling insulin infusion
    10.
    发明授权
    Closed loop system for controlling insulin infusion 有权
    用于控制胰岛素输注的闭环系​​统

    公开(公告)号：US06558351B1

    公开(公告)日：2003-05-06

    申请号：US09586175

    申请日：2000-06-01

    申请人： Garry M. Steil ,  Kerstin Rebrin ,  Paul V. Goode, Jr. ,  John J. Mastrototaro ,  Richard E. Purvis ,  William P. Van Antwerp ,  John J. Shin ,  Cary D. Talbot

    发明人： Garry M. Steil ,  Kerstin Rebrin ,  Paul V. Goode, Jr. ,  John J. Mastrototaro ,  Richard E. Purvis ,  William P. Van Antwerp ,  John J. Shin ,  Cary D. Talbot

    IPC分类号： A61M3700

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/7242 ,  A61M5/14244 ,  A61M5/158 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1581 ,  A61M2005/1726 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

    摘要： A closed loop infusion system controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The sensor signal is used to generate a controller input. The controller uses the controller input to generate commands to operate the delivery system. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. Preferably, the sensor system monitors the glucose concentration in the body of the user, and the liquid infused by the delivery system into the body of the user includes insulin. The sensor system uses the sensor signal to generate a message that is sent to the delivery system. The message includes the information used to generate the controller input. The sensor may be a subcutaneous sensor in contact with interstitial fluid. Also, two or more sensors may be used by the sensor system.

    摘要翻译： 闭环输注系统控制流体注入使用者身体的速度。 闭环输注系统包括传感器系统，控制器和输送系统。 传感器系统包括用于监测用户状况的传感器。 传感器产生一个传感器信号，代表用户的状态。 传感器信号用于生成控制器输入。 控制器使用控制器输入来生成操作传送系统的命令。 输送系统以由控制器的命令指示的速率将液体注入用户。 优选地，传感器系统监测用户体内的葡萄糖浓度，并且由输送系统输入到使用者体内的液体包括胰岛素。 传感器系统使用传感器信号来产生发送到传送系统的消息。 该消息包括用于生成控制器输入的信息。 传感器可以是与间质液接触的皮下传感器。 此外，传感器系统可以使用两个或更多个传感器。