摘要:
Tertiary alcohols containing the structural features illustrated in 3 or 4 below (Scheme I) are prepared by reacting at least one diazo carbonyl compound, e.g., 1 in Scheme I) and at least one allylic alcohol (e.g., 2 in Scheme I) in a coupling reaction run under conditions that produce carbene or carbenoid intemediates from the diazo containing substrate such as transition metal catalysis or either thermal or photochemical decomposition. In some preferred embodiments, Rh.sub.2 (OAc).sub.4 is employed to catalyze the coupling reaction. ##STR1## Indolocarbazoles (e.g., 7 below) are prepared by coupling of diazo carbonyl compounds (e.g., 5) and biindoles (e.g., 6). Indolocarbazoles are furanosylated (e.g., 7) with acetals (e.g., 8) or their open chain congeners (e.g., 9) under conditions known to promote acetal exchange or formation, such as protic or Lewis acids. Furanosylated indolocarbazoles (e.g., 10) are also prepared via ring contraction of pyranosylated indolocarbazoles (e.g., 11) under conditions know to effect oxidation and benzylic acid type rearrangements, and pyranosylated indolocarbazoles (e.g., 11) are prepared via ring expansion of the furanosylated congeners (e.g., 10). ##STR2##
摘要:
Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.
摘要:
A shared bus system having a bus and a set of client modules coupled to the bus. Each client module is capable of sending transactions on the bus to other client modules and receiving transactions on the bus from other client modules for processing. Each module has a queue for storing transactions received by the module for processing. A bus controller limits the types of transactions that can be sent on the bus to prevent any module's queue from overflowing.
摘要:
A portable wheel assembly for use with bicycles and other wheeled vehicles. The wheel assembly comprises a centrally positioned hub which is adapted for rotatable movement about an axis. A plurality of pie shaped disk segments are coupled together along their radial side edges to form a circular support disk with a central opening. Each disk segment is adapted to removably couple with the hub at its innermost radial edge and extends radially outwardly to form a portion of a circular rim at its outermost radial edge. The rim is adapted for supporting a tire. The tire comprises a non-pneumatic tire with an annular ridge which is adapted to couple with the circular rim formed by the disk. During assembly, each of the pie shaped disk segments is coupled together and then coupled to the hub assembly at the inside radial edge or central opening. As the disk segments are coupled to the hub, the tire is assembled onto the outer radial edge or rim. Securing the supporting disk structure to the hub also secures the tire to the rim.
摘要:
Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide.
摘要:
Improvements to a skateboard comprise a board having a complete string of LED's embedded in a groove around the periphery of the skateboard in the first embodiment, powered by a microcontroller and a battery mounted to the underside of the board. In the second embodiment, along the same lines, a kit is provided wherein skid bars have the LED's mounted in them, connected by wiring leading to the microcontroller and battery. The kit can be sold for after-market use, and may consist of just the two side boards, or the rear skid board as well, often called the kick board.
摘要:
Indolocarbazoles are furanosylated (e.g., 7) with acetals (e.g., 8) or their open chain congeners (e.g., 9) under conditions known to promote acetal exchange or formation, such as protic or Lewis acids. Furanosylated indolocarbazoles (e.g., 10) are also prepared via ring contraction of pyranosylated indolocarbazoles (e.g., 11) under conditions know to effect oxidation and benzylic acid type rearrangements, and pyranosylated indolocarbazoles (e.g., 11) are prepared via ring expansion of the furanosylated congeners (e.g., 10)
摘要:
A shared bus system having a bus and a set of client modules coupled to the bus. Each client module is capable of sending transactions on the bus to other client modules and receiving transactions on the bus from other client modules for processing. Each module has a queue for storing transactions received by the module for processing. A bus controller limits the types of transactions that can be sent on the bus to prevent any module's queue from overflowing.
摘要:
A bus system having a bus arbitration scheme. The bus system includes a bus and a plurality of client modules coupled to the bus. Each of the client modules is capable of transmitting information on the bus to another of client module, and only one client module is entitled to transmit information on the bus at any time. A module entitled to transmit information on the bus has control of the bus for a minimum period of time defining a cycle. To determine which module is entitled to use the bus, each client module generates an arbitration signal when it seeks to transmit information on the bus. Each client module has an arbitration signal processor responsive to the arbitration signals for determining whether the module is entitled to transmit information on said bus. The system preferably also contains a host module that informs the client modules what types of transactions allowed on the bus in a given cycle. Each arbitration signal processor preferably is also responsive to the client option signals sent by the host module during an earlier cycle.