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    Cellular Biomarker Antioxidant Assay and Uses Thereof
    1.
    发明申请
    Cellular Biomarker Antioxidant Assay and Uses Thereof 审中-公开
    细胞生物标志物抗氧化测定及其用途

    公开(公告)号：US20080312128A1

    公开(公告)日：2008-12-18

    申请号：US11912446

    申请日：2006-04-28

    Applicant: Edward Chaum ,  John Lang

    Inventor： Edward Chaum ,  John Lang

    IPC: A61K38/02 ,  C12Q1/02 ,  C12Q1/26 ,  C12Q1/68 ,  A61K31/375

    CPC classification number: G01N33/5044 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5091 ,  G01N2800/16

    Abstract: The invention encompasses cell-based systems comprising biomarkers that respond to oxidative stress (OS) in a quantitative manner, and methods of use thereof. The systems are useful for screening, identifying and testing antioxidant agents, combinations, and formulations thereof for preventing, treating, or reducing symptoms of conditions associated with oxidative damage to cells. The cell-based systems are useful for identifying effective new antioxidant agents and for optimizing antioxidant formulations for targeted therapeutic applications. One cell-based system utilizes RPE cells of the eye for identifying and optimizing antioxidant compositions effective for treatment of age-related conditions such as macular degeneration. The cell-based systems provide a convenient, inexpensive and physiologically relevant in vitro alternative to human population-based methods for testing efficacy of nutritional and pharmaceutical compositions comprising antioxidants. The invention further encompasses nutritional or pharmaceutical compositions targeting particular diseases such as AMD, formulated using methods as disclosed herein.

    Abstract translation: 本发明包括基于细胞的系统，其包括以定量方式响应于氧化应激（OS）的生物标志物及其使用方法。 该系统可用于筛选，鉴定和测试用于预防，治疗或减少与细胞氧化损伤相关的病症症状的抗氧化剂，组合和制剂。 基于细胞的系统可用于鉴定有效的新抗氧化剂并优化用于靶向治疗应用的抗氧化剂制剂。 一个基于细胞的系统利用眼睛的RPE细胞来鉴定和优化有效治疗年龄相关病症如黄斑变性的抗氧化剂组合物。 基于细胞的系统提供方便，便宜和生理上相关的体外替代人群基于方法，用于测试包含抗氧化剂的营养和药物组合物的功效。 本发明还包括使用本文公开的方法配制的靶向特定疾病例如AMD的营养或药物组合物。

    Self-priming adapter apparatus and method
    3.
    发明申请
    Self-priming adapter apparatus and method 审中-公开
    自吸适配器装置和方法

    公开(公告)号：US20080089777A1

    公开(公告)日：2008-04-17

    申请号：US11897523

    申请日：2007-08-30

    Applicant: John Lang

    Inventor： John Lang

    IPC: F04D9/02

    CPC classification number: F04D9/006

    Abstract: Some embodiments of the invention provide a self-priming adapter system including a pump inlet receiving liquid mixed with air, a pump coupled to the pump inlet, and a self-priming adapter coupled to the pump. The self-priming adapter includes a separation chamber. The separation chamber includes one or more baffles to substantially separate the air from the liquid. The self-priming adapter system also includes a recirculation line coupled to the self-priming adapter to return the liquid to the pump inlet. Some embodiments of the invention provide a self-priming adapter for use with existing pumps of any type. Some embodiments of the invention provide a method of self-priming a pump using a self-priming adapter.

    Abstract translation: 本发明的一些实施例提供了一种自吸适配器系统，其包括泵入口接收与空气混合的液体，耦合到泵入口的泵以及耦合到泵的自吸适配器。 自吸适配器包括分离室。 分离室包括一个或多个挡板，以使空气基本上与液体分离。 自吸适配器系统还包括耦合到自吸适配器以将液体返回到泵入口的再循环管线。 本发明的一些实施例提供了一种用于任何类型的现有泵的自吸适配器。 本发明的一些实施例提供了一种使用自吸适配器自吸泵的方法。

    Useful pharmaceutical salts of 7-[(3R, 4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3, 5-dihydro-pyrrolo [3, 2-D] pyrimidin-4-one
    5.
    发明授权
    Useful pharmaceutical salts of 7-[(3R, 4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3, 5-dihydro-pyrrolo [3, 2-D] pyrimidin-4-one 有权
    7 - [（3R，4R）-3-羟基-4-羟甲基 - 吡咯烷-1-基甲基] -3,5-二氢 - 吡咯并[3,2-D]嘧啶-4-酮的有用药用盐

    公开(公告)号：US08501753B2

    公开(公告)日：2013-08-06

    申请号：US13258497

    申请日：2010-03-24

    Applicant: Gary Bartley ,  Thomas Cleary ,  John Lang

    Inventor： Gary Bartley ,  Thomas Cleary ,  John Lang

    IPC: C07D487/04 ,  A61K31/513

    CPC classification number: C07D487/04

    Abstract: The present disclosure provides novel hemi- and mono-salts of 7-[(3R,4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one (Compound 1) with various organic and inorganic acids. In one embodiment, the organic acid is a C4 organic diacids. The present disclosure further provides novel methods for preparing these salts. The novel monohydrates hemisalts of the C4 organic diacids are isostructural and can be prepared with different properties. Multiple acids can be used simultaneously and the proportion of acids can be varied offering the opportunity to select hemi-salts of compound 1 with desired properties.

    Abstract translation: 本公开提供了7 - [（3R，4R）-3-羟基-4-羟甲基 - 吡咯烷-1-基甲基] -3,5-二氢 - 吡咯并[3,2-d]的新型半 - 和单 - 盐， 嘧啶-4-酮（化合物1）与各种有机和无机酸反应。 在一个实施方案中，有机酸是C4有机二酸。 本公开进一步提供了制备这些盐的新方法。 C4有机二酸的新型一水合物半盐是同构的，可以用不同的性质制备。 可以同时使用多种酸，并且可以改变酸的比例，这提供了选择具有所需性质的化合物1的半盐的机会。

    Golf range game
    7.
    发明授权
    Golf range game 失效
    高尔夫球场游戏

    公开(公告)号：US5588652A

    公开(公告)日：1996-12-31

    申请号：US529770

    申请日：1995-09-18

    Applicant: John Lang

    Inventor： John Lang

    IPC: A63B69/36 ,  A63B71/06 ,  A63B67/02

    CPC classification number: A63B69/3691 ,  A63B71/0672 ,  A63B2071/0691 ,  A63B2102/32 ,  A63B2220/13 ,  A63B69/3697

    Abstract: A method and a facility for playing a game with a golf club and golf balls, the facility comprising:a site having a range area visibly divided into a plurality of contiguous target regions, each said target region being associated with a target identifier, and a tee area having a plurality of contiguous tees from which golf balls may be hit toward said range area;scoring means located at said site for scoring a game, said scoring means setting out a sequence of said target identifiers so as to establish a corresponding sequence of designated target regions to which golf balls are to be hit from the tee with a golf club in order, and said scoring means providing means for recording a point score for each time a player hits a golf ball; anda scoring system associated with said scoring means for awarding a point score according to the observed resting position of the golf ball relative to the designated target region.

    Abstract translation: 一种用于与高尔夫球杆和高尔夫球玩游戏的方法和设施，所述设施包括：具有可视地划分为多个连续目标区域的范围区域的站点，每个所述目标区域与目标识别符相关联，并且 具有多个邻接的三通的三通区域，高尔夫球可以从该区域撞击所述范围区域; 评分装置位于所述场地，用于对游戏进行评分，所述评分表示设置所述目标标识符的序列，以便依次按照高尔夫球杆的顺序建立高尔夫球从具有高尔夫球杆的命中所指定的目标区域的相应序列 并且所述评分装置提供用于每次玩家击中高尔夫球时记录积分的装置; 以及与所述评分装置相关联的评分系统，用于根据所述高尔夫球相对于所指定的目标区域的观察到的静止位置来奖励点分数。

    Air aspiration device
    9.
    发明授权
    Air aspiration device 有权
    空气抽吸装置

    公开(公告)号：US09140398B2

    公开(公告)日：2015-09-22

    申请号：US13079755

    申请日：2011-04-04

    Applicant: John Lang ,  Mark Mohr ,  Colin Jaedike

    Inventor： John Lang ,  Mark Mohr ,  Colin Jaedike

    IPC: B05B1/20 ,  F16L55/11 ,  B01F5/04 ,  B05B1/16 ,  B05B15/06

    CPC classification number: F16L21/065 ,  B05B1/1645 ,  B05B1/20 ,  B05B15/658 ,  F16L21/03 ,  F16L55/1108 ,  Y10T137/6851 ,  Y10T137/85938

    Abstract: Embodiments of the invention provide an air aspiration device to release trapped air in a pipe containing a solution that is to be delivered to a nozzle body. The air aspiration device can include an air port in fluid communication with the air and the solution, an exit port, and a passageway in fluid communication with the air port and the exit port. The air aspiration device can also include a main body and a female pipe fitting forming an end cap for one end of the pipe.

    Abstract translation: 本发明的实施例提供了一种空气抽吸装置，用于将含有待输送到喷嘴体的溶液的管中的被截留空气释放。 空气抽吸装置可以包括与空气和溶液流体连通的空气口，出口和与空气口和出口流体连通的通道。 空气抽吸装置还可以包括形成用于管的一端的端盖的主体和阴管配件。

    Useful Pharmaceutical Salts of 7- [(3R, 4R) - 3 - Hydroxy -4 - Hydroxymethyl - Pyrrolidin -1- Ylmethyl] -3, 5-Dihydro-Pyrrolo [3, 2-D] Pyrimidin -4-One
    10.
    发明申请
    Useful Pharmaceutical Salts of 7- [(3R, 4R) - 3 - Hydroxy -4 - Hydroxymethyl - Pyrrolidin -1- Ylmethyl] -3, 5-Dihydro-Pyrrolo [3, 2-D] Pyrimidin -4-One 有权
    7 - [（3R，4R）-3-羟基-4-羟甲基 - 吡咯烷-1-基甲基] -3,5-二氢 - 吡咯并[3,2-D]嘧啶-4-酮的有用药物盐

    公开(公告)号：US20120165526A1

    公开(公告)日：2012-06-28

    申请号：US13258497

    申请日：2010-03-24

    Applicant: Gary Bartley ,  Thomas Cleary ,  John Lang

    Inventor： Gary Bartley ,  Thomas Cleary ,  John Lang

    IPC: C07D487/04

    CPC classification number: C07D487/04

    Abstract: The present disclosure provides novel hemi- and mono-salts of 7-[(3R,4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one (Compound 1) with various organic and inorganic acids. In one embodiment, the organic acid is a C4 organic diacids. The present disclosure further provides novel methods for preparing these salts. The novel monohydrates hemisalts of the C4 organic diacids are isostructural and can be prepared with different properties. Multiple acids can be used simultaneously and the proportion of acids can be varied offering the opportunity to select hemi-salts of compound 1 with desired properties.

    Abstract translation: 本公开提供了7 - [（3R，4R）-3-羟基-4-羟甲基 - 吡咯烷-1-基甲基] -3,5-二氢 - 吡咯并[3,2-d]的新型半 - 和单 - 盐， 嘧啶-4-酮（化合物1）与各种有机和无机酸反应。 在一个实施方案中，有机酸是C4有机二酸。 本公开进一步提供了制备这些盐的新方法。 C4有机二酸的新型一水合物半盐是同构的，可以用不同的性质制备。 可以同时使用多种酸，并且可以改变酸的比例，这提供了选择具有所需性质的化合物1的半盐的机会。

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