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    Cryo-medical injection device and method of use
    1.
    发明授权
    Cryo-medical injection device and method of use 有权
    冷冻医用注射装置及其使用方法

    公开(公告)号：US08409184B2

    公开(公告)日：2013-04-02

    申请号：US12607721

    申请日：2009-10-28

    申请人： John M. Baust ,  John G. Baust ,  Anthony T. Robilotto ,  Kristi K. Snyder ,  Robert G. Van Buskirk

    发明人： John M. Baust ,  John G. Baust ,  Anthony T. Robilotto ,  Kristi K. Snyder ,  Robert G. Van Buskirk

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2018/0212 ,  A61K9/0024 ,  A61K9/145 ,  A61K31/00 ,  A61K31/282 ,  A61K31/337 ,  A61K31/513 ,  A61K31/59 ,  A61K31/7048 ,  A61K45/06 ,  A61M5/44 ,  A61M37/0069 ,  A61M2205/3606

    摘要： The resorbable cryoprobe device and process is a novel approach for treating localized disease allowing for the precise combined application of freezing temperatures and cytotoxic or cryosensitizing agents within a self-contained matrix/package for optimized tissue destruction. The cryopellet is comprised of a list of components including a source of cryogen to produce the sub-zero temperatures, a porous matrix to contain the cytotoxic agent, cytotoxic agent, and a delivery packet. Data presented herein demonstrates the efficacy of this approach in destroying cancerous tissue. For example, the application of freezing temperatures to −10° C. results in approximately 15% cell death, while exposure to cytotoxic agents such as TRAIL produces minimal cell death. The utilization of the cryopellet approach results in a synergistic effect yielding complete cell death at the same temperature. The innovation behind the resorbable probe application includes the strategic combination of agents to activate intrinsic or extrinsic cell death responses (including apoptosis and necrosis), unique packaging of the cryogen and cytotoxic agent, and a unique delivery system. The resorbable cryoprobe technology will assist directly in the treatment of cancer, as well as will likely lead to broader application for disease treatment.

    摘要翻译： 可再吸收的冷冻探针装置和方法是用于治疗局部疾病的新方法，其允许在自包含的基质/包装内精确地联合应用冷冻温度和细胞毒性或冷冻敏化剂以优化组织破坏。 冷冻条由包括产生低于零温度的冷冻源的组分的列表组成，含有细胞毒剂，细胞毒性剂和递送包的多孔基质。 本文提供的数据显示了这种方法在破坏癌组织中的功效。 例如，将冻结温度施加到-10℃导致约15％的细胞死亡，而暴露于细胞毒性剂如TRAIL的细胞会导致最小的细胞死亡。 cryopellet方法的利用导致在相同温度下产生完全细胞死亡的协同效应。 可再吸收探针应用的创新包括激活内在或外在细胞死亡反应（包括细胞凋亡和坏死），冷冻剂和细胞毒性剂的独特包装以及独特的递送系统的药剂的战略组合。 可再吸收的冷冻探针技术将有助于直接治疗癌症，并可能导致更广泛的疾病治疗应用。

    Cell Culture Media Supplement and Method of Molecular Stress Control
    3.
    发明申请
    Cell Culture Media Supplement and Method of Molecular Stress Control 审中-公开
    细胞培养基补充和分子应激控制方法

    公开(公告)号：US20120028933A1

    公开(公告)日：2012-02-02

    申请号：US13192722

    申请日：2011-07-28

    申请人： John M. Baust ,  John G. Baust ,  William L. Corwin ,  Robert G. Van Buskirk

    发明人： John M. Baust ,  John G. Baust ,  William L. Corwin ,  Robert G. Van Buskirk

    IPC分类号： A61K31/593 ,  A61K31/47 ,  A61K31/05 ,  A61P39/06 ,  A61K31/34 ,  A61K31/355 ,  C09K15/00 ,  C12N5/074 ,  A61K31/07

    CPC分类号： C12N5/0081 ,  A61K31/05 ,  A61K31/07 ,  A61K31/34 ,  A61K31/355 ,  A61K31/47 ,  A61K31/593 ,  C12N5/00 ,  C12N5/0606 ,  C12N5/0696 ,  C12N2500/02 ,  C12N2500/60 ,  C12N2502/02 ,  C12N2502/45 ,  C12N2523/00 ,  G01N33/5008

    摘要： A novel class of agents has been identified to serve as cell-guard agents and/or target-specific supplements to increase cell quality and yield, as well as select for target cell populations. Laboratory experiments have demonstrated the use of cell-guard agents and/or target-specific supplements in the bioprocessing of cells as well as in selecting out a desired cell population. Several potential additive agents (both natural and synthetic) have been identified during these studies, including Vitamin D3, NAC, resveratrol, salubrinal, AKT, and tunicamycin (among others) that hold promise for application in cell models. In one embodiment, hypothermic stress regimes are utilized. In another embodiment, normothermic conditions are utilized while other stressors are tested in the processing. The methods of maintaining mass cell cultures and/or selecting out particular cell populations for further research and clinical use represents an important step in therapeutic discovery. The cell-guard agents are process-matched and cell-matched to protect and/or select particular cells during laboratory and clinical manipulation. The components modulate cell stress and survival pathways.

    摘要翻译： 已经鉴定出新的一类试剂用作细胞保护剂和/或靶标特异性补充物以增加细胞质量和产量，以及选择靶细胞群体。 实验室实验已经证明了在细胞的生物处理中以及选择所需的细胞群体中使用细胞保护剂和/或靶标特异性补充物。 在这些研究中已经鉴定了几种潜在的添加剂（天然和合成），包括在细胞模型中有希望应用的维生素D3，NAC，白藜芦醇，salubrinal，AKT和衣霉素（等）。 在一个实施方案中，利用低温胁迫方案。 在另一个实施方案中，在加工过程中测试其它应激物时，使用常温条件。 保持大量细胞培养和/或选择特定细胞群以进行进一步研究和临床应用的方法代表治疗发现中的重要步骤。 细胞保护剂在过程匹配和细胞匹配以在实验室和临床操作期间保护和/或选择特定的细胞。 组分调节细胞应激和存活途径。

    Flexible Cryogenic Probe Tip
    4.
    发明申请
    Flexible Cryogenic Probe Tip 审中-公开
    柔性低温探针尖

    公开(公告)号：US20110184402A1

    公开(公告)日：2011-07-28

    申请号：US13077399

    申请日：2011-03-31

    申请人： John M. Baust ,  John G. Baust ,  Roy Cheeks ,  Anthony T. Robilotto ,  Claudia Lueckge

    发明人： John M. Baust ,  John G. Baust ,  Roy Cheeks ,  Anthony T. Robilotto ,  Claudia Lueckge

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2017/00084 ,  A61B2017/003 ,  A61B2018/00202 ,  A61B2018/00208 ,  A61B2018/00577 ,  A61B2018/00797 ,  A61B2018/0212

    摘要： One embodiment of the invention is a flexible cryogenic probe tip. The flexible probe tip has a linear freeze zone at a distal end of the probe that allows for its placement and precisely controlled movements. The flexible cryogenic probe tip precisely conforms to the target tissue surface to create a linear lesion. In addition, the probe tip is steerable to facilitate proper placement with minimal access points into a patient's body. Various configurations of the flexible probe tip allow it to conform and ablate tissue of many sizes, shapes, and/or dimensions. Methods of utilizing the cryogenic probe tip include steps of positioning the distal end at a tissue site for at least one ablative procedure, maneuvering the distal end to the tissue site, directing a cryogen from the supply source to the distal end, controlling a flow of cryogen from the supply source to the distal end and back to the supply source, and segmenting control of the distal end mechanically or through the step of controlling the flow of cryogen.

    摘要翻译： 本发明的一个实施例是柔性低温探针尖端。 柔性探针尖端在探头的远端具有允许其放置和精确控制运动的线性冻结区。 柔性低温探针尖端精确地符合目标组织表面以产生线性损伤。 此外，探针尖是可操纵的，以便于以最小的接入点进入患者身体的正确放置。 柔性探针尖端的各种构造允许其适应并消融许多尺寸，形状和/或尺寸的组织。 使用低温探​​针尖端的方法包括以下步骤：将远端定位在组织部位处至少一个烧蚀程序，将远端操纵到组织部位，将冷冻剂从供应源引导到远端，控制流动 冷冻剂从供应源到远端并返回到供应源，并且机械地或通过控制冷冻剂流动的步骤来分段远端的控制。

    Resorbable Probe Including a Device and Method for Minimally Invasive Tissue Sensitization and Treatment
    5.
    发明申请
    Resorbable Probe Including a Device and Method for Minimally Invasive Tissue Sensitization and Treatment 有权
    包括微创组织敏化和治疗的装置和方法的可再生探针

    公开(公告)号：US20110060323A1

    公开(公告)日：2011-03-10

    申请号：US12607721

    申请日：2009-10-28

    申请人： John M. Baust ,  John G. Baust ,  Robert G. Van Buskirk ,  Anthony Robilotto ,  Kristi Snyder

    发明人： John M. Baust ,  John G. Baust ,  Robert G. Van Buskirk ,  Anthony Robilotto ,  Kristi Snyder

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2018/0212 ,  A61K9/0024 ,  A61K9/145 ,  A61K31/00 ,  A61K31/282 ,  A61K31/337 ,  A61K31/513 ,  A61K31/59 ,  A61K31/7048 ,  A61K45/06 ,  A61M5/44 ,  A61M37/0069 ,  A61M2205/3606

    摘要： The resorbable cryoprobe device and process is a novel approach for treating localized disease allowing for the precise combined application of freezing temperatures and cytotoxic or cryosensitizing agents within a self-contained matrix/package for optimized tissue destruction. The cryopellet is comprised of a list of components including a source of cryogen to produce the sub-zero temperatures, a porous matrix to contain the cytotoxic agent, cytotoxic agent, and a delivery packet. Data presented herein demonstrates the efficacy of this approach in destroying cancerous tissue. For example, the application of freezing temperatures to −10° C. results in approximately 15% cell death, while exposure to cytotoxic agents such as TRAIL produces minimal cell death. The utilization of the cryopellet approach results in a synergistic effect yielding complete cell death at the same temperature. The innovation behind the resorbable probe application includes the strategic combination of agents to activate intrinsic or extrinsic cell death responses (including apoptosis and necrosis), unique packaging of the cryogen and cytotoxic agent, and a unique delivery system. The resorbable cryoprobe technology will assist directly in the treatment of cancer, as well as will likely lead to broader application for disease treatment.

    摘要翻译： 可再吸收的冷冻探针装置和方法是用于治疗局部疾病的新方法，其允许在自包含的基质/包装内精确地联合应用冷冻温度和细胞毒性或冷冻敏化剂以优化组织破坏。 冷冻条由包括产生低于零温度的冷冻源的组分的列表组成，含有细胞毒剂，细胞毒性剂和递送包的多孔基质。 本文提供的数据显示了这种方法在破坏癌组织中的功效。 例如，将冻结温度施加到-10℃导致约15％的细胞死亡，而暴露于细胞毒性剂如TRAIL的细胞会导致最小的细胞死亡。 cryopellet方法的利用导致在相同温度下产生完全细胞死亡的协同效应。 可再吸收探针应用的创新包括激活内在或外在细胞死亡反应（包括细胞凋亡和坏死），冷冻剂和细胞毒性剂的独特包装以及独特的递送系统的药剂的战略组合。 可再吸收的冷冻探针技术将有助于直接治疗癌症，并可能导致更广泛的疾病治疗应用。

    Multi-Lumen Axial Cryogenic Connector
    7.
    发明申请
    Multi-Lumen Axial Cryogenic Connector 审中-公开
    多流明轴向低温连接器

    公开(公告)号：US20110225988A1

    公开(公告)日：2011-09-22

    申请号：US13050055

    申请日：2011-03-17

    申请人： John M. Baust ,  Claudia Lueckge ,  Roy Cheeks ,  Melissa K. Dobson ,  Anthony T. Robilotto

    发明人： John M. Baust ,  Claudia Lueckge ,  Roy Cheeks ,  Melissa K. Dobson ,  Anthony T. Robilotto

    IPC分类号： F17C13/00 ,  F16L39/00

    CPC分类号： F16L39/00 ,  A61B18/02 ,  A61B2018/00172 ,  F16L13/103 ,  F16L15/00 ,  F16L25/01 ,  F16L37/00 ,  F16L2201/44 ,  F17C7/02

    摘要： An embodiment of the invention is a cryo-connector, a connector that allows for the delivery and return of a cryogen in an axial configuration. In one embodiment, the connector is a tri-axial configuration allowing for the delivery and return of pressurized cryogen as well as the application of an independent vacuum in the third lumen. Various configurations, however, may accommodate any number of luminary spaces such that cryogen (or other fluids) and/or vacuum spaces may be created in a fashion complementary to the components that the connector will affix to and interconnect with. The connectors can be utilized with any low temperature, cryogenic device and at varying pressures.

    摘要翻译： 本发明的一个实施例是一种冷冻连接器，一种允许在轴向配置中输送和返回冷冻剂的连接器。 在一个实施例中，连接器是允许加压制冷剂的输送和返回以及在第三管腔中施加独立真空的三轴构造。 然而，各种配置可以容纳任何数量的发光空间，使得制冷剂（或其它流体）和/或真空空间可以以与连接器将固定到其上并与之相互连接的部件互补的方式产生。 连接器可以与任何低温，低温装置和变化的压力一起使用。

    Cryogenic System and Method of Use
    8.
    发明申请
    Cryogenic System and Method of Use 有权
    低温系统和使用方法

    公开(公告)号：US20110152849A1

    公开(公告)日：2011-06-23

    申请号：US13061171

    申请日：2009-11-02

    申请人： John M. Baust ,  John G. Haust ,  Roy Cheaks ,  Anthony T. Robilotto ,  Kristi Snyder

    发明人： John M. Baust ,  John G. Haust ,  Roy Cheaks ,  Anthony T. Robilotto ,  Kristi Snyder

    IPC分类号： A61B18/02

    CPC分类号： A61B18/0218 ,  A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0268 ,  F17C9/00

    摘要： A cryogenic medical device for delivery of subcooled liquid cryogen to various configurations of cryoprobes is designed for the treatment of damaged, diseased, cancerous or other unwanted tissues. The device is a closed or semi-closed system in which the liquid cryogen is contained in both the supply and return stages. The device is capable of generating cryogen to a supercritical state and may be utilized in any rapid cooling systems. As designed, the device comprises a number of parts including a vacuum insulated outer dewar, submersible cryogen pump, baffled linear heat exchanger, multiple pressurization cartridges, a return chamber, and a series of valves to control the flow of the liquid cryogen interconnected with cryotreatment devices including cryoprobes and catheters. The cryogenic medical device promotes subcooling to the tips of various external cryogenic instrument configurations.

    摘要翻译： 用于将过冷液体冷冻剂递送到各种构造的低温球的低温医疗装置被设计用于治疗受损害的，患病的，癌性的或其它不想要的组织。 该装置是封闭或半封闭的系统，其中液体冷冻剂包含在供应和返回阶段。 该装置能够将冷冻剂生成超临界状态，并可用于任何快速冷却系统。 根据设计，该装置包括多个部件，包括真空绝缘的外部杜瓦瓶，潜水式低温泵，挡板式线性热交换器，多个加压筒，回流室和一系列阀门，以控制与冷冻处理相互连接的液体冷冻剂的流动 装置包括冷冻探针和导管。 低温医疗装置促进对各种外部低温仪器配置的尖端的过冷。