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    Visual indicator chronograph and the use of the same
    2.
    发明申请
    Visual indicator chronograph and the use of the same 有权
    视觉指标计时器和使用相同

    公开(公告)号：US20060114754A1

    公开(公告)日：2006-06-01

    申请号：US11000234

    申请日：2004-11-30

    申请人： John MacDonald ,  Kelly Arehart

    发明人： John MacDonald ,  Kelly Arehart

    IPC分类号： G04F1/00

    CPC分类号： G04F1/06 ,  A61F13/42 ,  G04F1/00 ,  G04F13/04 ,  G04F13/06

    摘要： A timer indicator or chronograph is described. The chronograph functions according to chromatographic principles to develop a perceptible visual image or pattern on an indicator panel or display area, which serves as a means to monitor the relative amount of time that elapses. The chronograph includes a self-contained reservoir for an activating agent, which once activated creates a mobile front that traverses the indicator panel substrate from the reservoir to a distal end at a predetermined rate. The chronograph may be used as a stand-alone device or may be incorporated as part of various articles or products, for instance, as either a training aid or as a dryness indicator. Methods for using and making the chronograph are also described.

    摘要翻译： 描述了定时器指示器或计时码表。 计时码表根据色谱原理起作用，以在显示面板或显示区域上形成一个可察觉的视觉图像或图案，这是监测经过的相对时间量的一种手段。 计时码表包括用于激活剂的独立储存器，其一旦被激活就产生以预定速率从储存器穿过指示器面板基底到远端的移动前部。 计时码表可以用作独立设备，也可以作为各种物品或产品的一部分来使用，例如作为训练助剂或干燥指示剂。 还描述了使用和制造计时码表的方法。

    Visual indicator chronograph and the use of the same
    3.
    发明申请
    Visual indicator chronograph and the use of the same 审中-公开
    视觉指标计时器和使用相同

    公开(公告)号：US20080025154A1

    公开(公告)日：2008-01-31

    申请号：US11890683

    申请日：2007-08-07

    申请人： John MacDonald ,  Kelly Arehart

    发明人： John MacDonald ,  Kelly Arehart

    IPC分类号： G04F1/00 ,  G01D21/00

    CPC分类号： G04F1/06 ,  A61F13/42 ,  G04F1/00 ,  G04F13/04 ,  G04F13/06

    摘要： A timer indicator or chronograph is described. The chronograph functions according to chromatographic principles to develop a perceptible visual image or pattern on an indicator panel or display area, which serves as a means to monitor the relative amount of time that elapses. The chronograph includes a self-contained reservoir for an activating agent, which once activated creates a mobile front that traverses the indicator panel substrate from the reservoir to a distal end at a predetermined rate. The chronograph may be used as a stand-alone device or may be incorporated as part of various articles or products, for instance, as either a training aid or as a dryness indicator. Methods for using and making the chronograph are also described.

    摘要翻译： 描述了定时器指示器或计时码表。 计时码表根据色谱原理起作用，以在显示面板或显示区域上形成一个可察觉的视觉图像或图案，这是监测经过的相对时间量的一种手段。 计时码表包括用于激活剂的独立储存器，其一旦被激活就产生以预定速率从储存器穿过指示器面板基底到远端的移动前部。 计时码表可以用作独立设备，也可以作为各种物品或产品的一部分来使用，例如作为训练助剂或干燥指示剂。 还描述了使用和制造计时码表的方法。

    THERMOCHROMIC ELASTIC ARTICLES
    4.
    发明申请
    THERMOCHROMIC ELASTIC ARTICLES 审中-公开
    热敏弹性文章

    公开(公告)号：US20070252115A1

    公开(公告)日：2007-11-01

    申请号：US11380682

    申请日：2006-04-28

    申请人： Kelly Arehart ,  Scott Englebert ,  John MacDonald

    发明人： Kelly Arehart ,  Scott Englebert ,  John MacDonald

    IPC分类号： C09K9/00

    CPC分类号： A41D19/0082 ,  A61B42/00 ,  A61B42/30 ,  C09K9/00

    摘要： Disclosed herein are thermochromic elastic articles suitable for a variety of uses. The thermochromic elastic articles include at least one elastic polymeric composition having at least one thermochromic pigment substantially uniformly dispersed therein, and the elastomeric polymers include such as elastomeric emulsion-based polymers and elastomeric solution-based polymers. Such thermochromic elastic articles are highly useful for use in protective wear products, health care and medical care products, bandages and the like, and are capable of signaling environmental temperature change or temperature change in a wearer or user via a change in color. Additionally provided are articles of manufacture including the thermochromic elastic articles, such as articles including without limitation gloves, medical wraps, garments, and stress indicating articles.

    摘要翻译： 本文公开了适用于各种用途的热变色弹性制品。 热变色弹性制品包括至少一种具有至少一种基本上均匀分散在其中的热致变色颜料的弹性聚合物组合物，弹性体聚合物包括例如基于弹性乳液的聚合物和弹性体溶液基聚合物。 这种热变色弹性制品对于用于保护性磨损产品，保健和医疗保健产品，绷带等是非常有用的，并且能够通过颜色变化来指示穿着者或使用者的环境温度变化或温度变化。 另外提供的制品包括热变色弹性制品，例如包括但不限于手套，医用包装，衣服和应力指示制品的制品。

    Microbial Detection and Quantification
    6.
    发明申请
    Microbial Detection and Quantification 有权
    微生物检测和定量

    公开(公告)号：US20070249012A1

    公开(公告)日：2007-10-25

    申请号：US10581404

    申请日：2004-12-16

    申请人： Jason Lye ,  John MacDonald ,  Ning Wei ,  Stephanie Martin

    发明人： Jason Lye ,  John MacDonald ,  Ning Wei ,  Stephanie Martin

    IPC分类号： C12Q1/04

    CPC分类号： C12Q1/04

    摘要： Solvatochromic dyes are used herein to indicate the presence of bacteria by incorporating them into various substrates such as films, woven and nonwoven fabrics, paper towels, coform and airlaid materials and bonded carded webs. These dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye. A lateral flow device incorporating solvatochromic dyes and a method of detecting bacteria are also included.

    摘要翻译： 溶剂化色素染料在本文中用于通过将它们并入各种底物如薄膜，机织和非织造织物，纸巾，共成型和气流成网材料和粘合梳理纤维网中来表示细菌的存在。 这些染料响应于环境极性的变化而改变颜色。 由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。 还包括含有溶剂化色素染料的侧流装置和检测细菌的方法。

    Method for screening for bacterial conjunctivitis
    7.
    发明申请
    Method for screening for bacterial conjunctivitis 有权
    筛选细菌性结膜炎的方法

    公开(公告)号：US20070140971A1

    公开(公告)日：2007-06-21

    申请号：US11303001

    申请日：2005-12-15

    申请人： John MacDonald ,  Stephanie Martin ,  Jason Lye

    发明人： John MacDonald ,  Stephanie Martin ,  Jason Lye

    IPC分类号： A61K49/00 ,  C12Q1/04

    CPC分类号： C12Q1/04 ,  C12Q1/14

    摘要： A method for rapidly detecting infectious conjunctivitis in a host is provided. The method includes contacting an ocular test sample with a chromogen (e.g., Reichardt's dye) that exhibits a color change in the presence of a microbe. The present inventors have discovered that the extent of the color change may vary depending on whether the microbe is a bacteria or virus. Without intending to be limited by theory, the present inventors believe that the chromogen interacts with the peptidoglycan-based cell wall structure of bacteria to induce a color change that is even more apparent at infectious levels. It is believed that this interaction occurs to a much greater extent in bacteria than in viruses. Accordingly, although the chromogen may still undergo a color change in the presence of the viruses, it is typically to a much lesser extent. In this manner, the degree of color change of the chromogen may be used in the present invention as a mechanism for differentiating between viral and bacterial conjunctivitis.

    摘要翻译： 提供了一种快速检测宿主感染性结膜炎的方法。 该方法包括使眼睛测试样品与在微生物存在下显示颜色变化的色原体（例如，Reichardt's染料）接触。 本发明人已经发现，颜色变化的程度可以根据微生物是细菌还是病毒而变化。 不期望受理论的限制，本发明人相信色原体与细菌的基于聚肽聚糖的细胞壁结构相互作用以诱导在感染水平上更加明显的颜色变化。 相信这种相互作用在细菌中比在病毒中更大程度地发生。 因此，虽然染色体在病毒存在的情况下仍可能发生颜色变化，但通常其程度要小得多。 以这种方式，在本发明中可以使用色原体的颜色变化程度作为区分病毒和细菌性结膜炎的机制。

    Absorbent pad with activated carbon ink for odor control
    8.
    发明申请
    Absorbent pad with activated carbon ink for odor control 有权
    具有活性炭墨水的吸收垫用于气味控制

    公开(公告)号：US20070026209A1

    公开(公告)日：2007-02-01

    申请号：US11194102

    申请日：2005-07-29

    申请人： John MacDonald ,  Jeffrey Fish ,  Sharon Greene ,  Jaeho Kim

    发明人： John MacDonald ,  Jeffrey Fish ,  Sharon Greene ,  Jaeho Kim

    IPC分类号： A61F13/15 ,  B32B3/00

    CPC分类号： A61L15/18 ,  A61L15/42 ,  Y10T428/24802 ,  Y10T428/24901

    摘要： An absorbent pad configured for placement under a patient to absorb bodily fluids includes a liquid permeable cover layer, a liquid impermeable back sheet, and an absorbent structure disposed between the cover layer and the back sheet. At least one of the cover layer, back sheet, or absorbent structure incorporates a dried application of a liquid activated carbon ink having activated carbon, a binder, and a solvent, with the dried application of ink having a solids add-on level of at least about 2%. The activated carbon ink is applied in a pattern over between about 25% to about 95% of a total upper surface area of the pad and presents a visually contrasting color against a background color of the pad or a contrasting ink.

    摘要翻译： 构造成放置在患者身下以吸收体液的吸收垫包括透液性覆盖层，不透液性底片和设置在覆盖层和背面片之间的吸收结构。 覆盖层，底片或吸收结构中的至少一个结合了具有活性炭，粘合剂和溶剂的液体活性炭油墨的干燥应用，其中干燥施加具有固体添加量的油墨 至少约2％。 活性炭油墨的图案涂覆在垫的总上表面积的约25％至约95％之间，并且与衬垫或对比油墨的背景颜色呈现出视觉上对比的颜色。

    Technique for detecting microorganisms
    9.
    发明申请
    Technique for detecting microorganisms 审中-公开
    微生物检测技术

    公开(公告)号：US20060223052A1

    公开(公告)日：2006-10-05

    申请号：US11094807

    申请日：2005-03-30

    申请人： John MacDonald ,  Richard Borders

    发明人： John MacDonald ,  Richard Borders

    IPC分类号： C12Q1/70 ,  C12Q1/04

    CPC分类号： C12Q1/04 ,  G01N33/523

    摘要： A technique for detecting the presence of microorganisms in a simple, rapid, and efficient manner is provided. More specifically, the technique involves identifying one or more volatile compounds associated with a particular microorganism of interest. The volatile compounds may be identified, for instance, using solid phase microextraction in conjunction with gas chromatography/mass spectroscopy (“GC/MS”) analysis methods. Once identified, an indicator may then be selected that is configured to undergo a detectable color change in the presence of the identified volatile compound(s). If desired, the indicator may be provided on a substrate to form an indicator strip for use in a wide variety of applications. In this manner, the presence of the microorganism may be rapidly detected by simply observing a color change of the indicator strip.

    摘要翻译： 提供了以简单，快速和有效的方式检测微生物的存在的技术。 更具体地，该技术涉及鉴定与感兴趣的特定微生物相关联的一种或多种挥发性化合物。 可以鉴定挥发性化合物，例如使用固相微萃取与气相色谱/质谱联用（“GC / MS”）分析方法。 一旦鉴定，可以选择配置为在所鉴定的挥发性化合物存在下进行可检测的颜色变化的指示剂。 如果需要，指示器可以设置在基板上以形成用于各种应用中的指示条。 以这种方式，可以通过简单地观察指示条的颜色变化来快速检测微生物的存在。

    Detection of microbe contamination on elastomeric articles
    10.
    发明申请
    Detection of microbe contamination on elastomeric articles 有权
    检测弹性制品上的微生物污染

    公开(公告)号：US20060134613A1

    公开(公告)日：2006-06-22

    申请号：US11117635

    申请日：2005-04-28

    申请人： Stephanie Martin ,  John MacDonald ,  Allison Bagwell ,  Jason Lye ,  Robert Johnson

    发明人： Stephanie Martin ,  John MacDonald ,  Allison Bagwell ,  Jason Lye ,  Robert Johnson

    IPC分类号： C12Q1/70 ,  C12Q1/04 ,  C12M1/34

    CPC分类号： C12Q1/04 ,  G01N33/528

    摘要： An elastomeric article that contains a chromogen that undergoes a detectable change in color in the presence of one or more microbes is provided. For example, in one embodiment, the chromogen is a solvatochromic dye (e.g., Reichardt's dye) that undergoes a color change in the presence of bacteria or other microbes. More specifically, such dyes may respond to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth.

    摘要翻译： 提供了包含在一种或多种微生物存在下经历可检测的颜色变化的色原体的弹性制品。 例如，在一个实施方案中，色原是在细菌或其它微生物存在下经历颜色变化的溶剂化色素染料（例如，Reichardt's染料）。 更具体地，这样的染料可以响应微生物组分（例如细胞膜，细胞质等）与细胞外的环境之间的极性差异。 或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。