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1.发明授权Yeast expressing cellulases for simultaneous saccharification and fermentation using cellulose 有权酵母表达纤维素酶用于同时糖化和发酵使用纤维素公开(公告)号：US09102955B2
公开(公告)日：2015-08-11
申请号：US13130549
申请日：2009-11-23
申请人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willes , John Bardsley , Anu Koivula , Sanni Voutilainen
发明人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willes , John Bardsley , Anu Koivula , Sanni Voutilainen
CPC分类号： C12P7/10 , C12N9/2437 , C12N9/2445 , C12N15/80 , C12P7/14 , C12P39/00 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： Host cells, comprising Kluveryomyces expressing heterologous cellulases produce ethanol from cellulose In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose The recombinant yeast strains and co-cultures of the yeast strains can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of sacchanfication and fermentation processes.
摘要翻译： 包含表达异源纤维素酶的克氏杆菌的宿主细胞从纤维素产生乙醇此外，可以将表达不同杂种纤维素酶的多个宿主细胞共同共培养并用于从纤维素产生乙醇可以使用酵母菌株的重组酵母菌株和共培养物 自己生产乙醇，也可以与外加纤维素酶组合使用，以提高发酵和发酵过程的效率。
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2.发明申请Yeast Expressing Cellulases for Simultaneous Saccharification and Fermentation Using Cellulose 有权酵母表达纤维素酶用于同时糖化和发酵使用纤维素公开(公告)号：US20120129229A1
公开(公告)日：2012-05-24
申请号：US13130549
申请日：2009-11-23
申请人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willes , John Bardsley , Anu Koivula , Sanni Voutilainen
发明人： John McBride , Elena Brevnova , Mark Mellon , Allan Froehlich , Kristen Deleault , Vineet Rajgarhia , Riaan Den Haan , Merja Penttila , Marja Ilmen , Matti Siika-Aho , Jaana Uusitalo , Emily A. Stonehouse , Alan Gilbert , Haowen Xu , Deidre Willes , John Bardsley , Anu Koivula , Sanni Voutilainen
CPC分类号： C12P7/10 , C12N9/2437 , C12N9/2445 , C12N15/80 , C12P7/14 , C12P39/00 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16 , Y02E50/17
摘要： Host cells, comprising Kluveryomyces expressing heterologous cellulases produce ethanol from cellulose In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose The recombinant yeast strains and co-cultures of the yeast strains can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of sacchanfication and fermentation processes
摘要翻译： 包含表达异源纤维素酶的克氏杆菌的宿主细胞从纤维素产生乙醇此外，可以将表达不同杂种纤维素酶的多个宿主细胞共同共培养并用于从纤维素产生乙醇可以使用酵母菌株的重组酵母菌株和共培养物 自己生产乙醇，也可以与外加的纤维素酶组合使用，以提高发酵和发酵过程的效率
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3.发明申请Methods and materials for the production of organic products in cells of Candida species 审中-公开在假丝酵母菌种细胞中生产有机产物的方法和材料公开(公告)号：US20070092956A1
公开(公告)日：2007-04-26
申请号：US11507289
申请日：2006-08-21
申请人： Vineet Rajgarhia , Merja Penttila , Laura Ruohonen , Marja Ilmen , Kari Koivuranta , Pirkko Suominen
发明人： Vineet Rajgarhia , Merja Penttila , Laura Ruohonen , Marja Ilmen , Kari Koivuranta , Pirkko Suominen
CPC分类号： C12N15/81 , C12N9/0006 , C12N15/815 , C12P7/56
摘要： The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More specifically, the invention relates to genetically modified Candida cells, methods for making the Candida cells, and their use in production of organic products, particularly lactic acid.
摘要翻译： 本发明涉及作为Crabtree阴性表型的细胞的生物催化剂，其包含编码与细胞异源的基因的表达载体，其能够增加有机产物的产生。 更具体地，本发明涉及遗传修饰的念珠菌细胞，制备念珠菌细胞的方法，以及它们在生产有机产物，特别是乳酸中的用途。
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公开(公告)号：US20060110810A1
公开(公告)日：2006-05-25
申请号：US11263496
申请日：2005-10-31
CPC分类号： C12N9/0006 , C12N15/81 , C12P7/56
摘要： This invention provides biocatalysts that are recombinant yeast cells comprising recombinant expression vectors encoding heterologous lactate dehydrogenase genes for producing lactate.
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公开(公告)号：US08658398B2
公开(公告)日：2014-02-25
申请号：US13003200
申请日：2009-07-07
申请人： Elena E. Brevnova , Vineet Rajgarhia , Mark Mellon , Anne Warner , John McBride , Chhayal Gandhi , Erin Wiswall
发明人： Elena E. Brevnova , Vineet Rajgarhia , Mark Mellon , Anne Warner , John McBride , Chhayal Gandhi , Erin Wiswall
IPC分类号： C12P19/14
CPC分类号： C12N9/2437 , C12N15/81 , C12N15/815 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16
摘要： The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast Saccharomyces cerevisiae. The cellulases can also be co-expressed in host cells with other cellulases. The expression in such host cells of the termite and termite-associated symbiont cellulases, and variants and combinations thereof, result in yeast with improved cellulosic activity. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
摘要翻译： 本发明提供白蚁和白蚁相关共生体纤维素酶的异源表达。 纤维素酶可以例如密码子优化并在酵母宿主细胞中表达，例如酵母酿酒酵母（Saccharomyces cerevisiae）。 纤维素酶也可以与其他纤维素酶在宿主细胞中共表达。 在白蚁和白蚁相关共生体纤维素酶的这种宿主细胞中的表达及其变体和组合导致具有改善的纤维素活性的酵母。 因此，这些基因和表达系统对于有效和成本有效的整合生物处理系统是有用的。
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公开(公告)号：US20120003701A1
公开(公告)日：2012-01-05
申请号：US13003200
申请日：2009-07-07
申请人： Elena E. Brevnova , Vineet Rajgarhia , Mark Mellon , Anne Warner , John Mcbride , Chhayal Gandhi , Erin Wiswall
发明人： Elena E. Brevnova , Vineet Rajgarhia , Mark Mellon , Anne Warner , John Mcbride , Chhayal Gandhi , Erin Wiswall
CPC分类号： C12N9/2437 , C12N15/81 , C12N15/815 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , Y02E50/16
摘要： The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast Saccharomyces cerevisiae. The cellulases can also be co-expressed in host cells with other cellulases. The expression in such host cells of the termite and termite-associated symbiont cellulases, and variants and combinations thereof, result in yeast with improved cellulosic activity. Thus, such genes and expression systems are useful for efficient and cost-effective consolidated bioprocessing systems.
摘要翻译： 本发明提供白蚁和白蚁相关共生体纤维素酶的异源表达。 纤维素酶可以例如密码子优化并在酵母宿主细胞中表达，例如酵母酿酒酵母（Saccharomyces cerevisiae）。 纤维素酶也可以与其他纤维素酶在宿主细胞中共表达。 在白蚁和白蚁相关共生体纤维素酶的这种宿主细胞中的表达及其变体和组合导致具有改善的纤维素活性的酵母。 因此，这些基因和表达系统对于有效和成本有效的整合生物处理系统是有用的。
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7.发明授权Yeast cells expressing an exogenous cellulosome and methods of using the same 有权表达外源性纤维素酶的酵母细胞及其使用方法公开(公告)号：US09315833B2
公开(公告)日：2016-04-19
申请号：US13201257
申请日：2010-02-18
申请人： John McBride , Mark Mellon , Vineet Rajgarhia , Elena E. Brevnova , Erin Wiswall , David A. Hogsett , Danie LaGrange , Shaunita Rose , Emile Van Zyl
发明人： John McBride , Mark Mellon , Vineet Rajgarhia , Elena E. Brevnova , Erin Wiswall , David A. Hogsett , Danie LaGrange , Shaunita Rose , Emile Van Zyl
CPC分类号： C12P7/10 , C07K14/33 , C07K2319/035 , C07K2319/70 , C12N9/2402 , C12N9/2437 , C12N9/2445 , C12N9/248 , C12N15/81 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01037 , C12Y302/01091 , Y02E50/16 , Y02P20/52
摘要： The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction.
摘要翻译： 本发明涉及在微生物中异源纤维素酶体的工程和表达，以促进生物质转化为有用的产物。 在一些实施方案中，本发明涉及形成纤维素酶的核的骨架蛋白的表达。 纤维素酶或其他生物降解酶可以通过泊松特蛋白结构域 - 凝聚素结构域相互作用而非共价连接至支架蛋白。
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8.发明申请Yeast Cells Expressing An Exogenous Cellulosome And Methods of Using The Same 有权表达外源性纤维素酶的酵母细胞及其使用方法公开(公告)号：US20120142046A1
公开(公告)日：2012-06-07
申请号：US13201257
申请日：2010-02-18
申请人： John McBride , Mark Mellon , Vineet Rajgarhia , Elena E. Brevnova , Erin Wiswall , David A. Hogsett , Danie LaGrange , Shaunita Rose , Emile Van Zyl
发明人： John McBride , Mark Mellon , Vineet Rajgarhia , Elena E. Brevnova , Erin Wiswall , David A. Hogsett , Danie LaGrange , Shaunita Rose , Emile Van Zyl
CPC分类号： C12P7/10 , C07K14/33 , C07K2319/035 , C07K2319/70 , C12N9/2402 , C12N9/2437 , C12N9/2445 , C12N9/248 , C12N15/81 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01037 , C12Y302/01091 , Y02E50/16 , Y02P20/52
摘要： The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction.
摘要翻译： 本发明涉及在微生物中异源纤维素酶体的工程和表达，以促进生物质转化为有用的产物。 在一些实施方案中，本发明涉及形成纤维素酶的核的骨架蛋白的表达。 纤维素酶或其他生物降解酶可以通过泊松特蛋白结构域 - 凝聚素结构域相互作用而非共价连接至支架蛋白。
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9.发明申请GENETICALLY MODIFIED YEAST SPECIES, AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权遗传修饰的YEAST物种和使用基因改造的YEAST的发酵过程公开(公告)号：US20110287506A1
公开(公告)日：2011-11-24
申请号：US13107882
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeastcells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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10.发明申请GENETICALLY MODIFIED YEAST SPECIES, AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权遗传修饰的YEAST物种和使用基因改造的YEAST的发酵过程公开(公告)号：US20110287505A1
公开(公告)日：2011-11-24
申请号：US13107881
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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