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    Methods of Preventing and Removing Trisulfide Bonds
    2.
    发明申请
    Methods of Preventing and Removing Trisulfide Bonds 有权
    防止和清除三硫键的方法

    公开(公告)号：US20140295495A1

    公开(公告)日：2014-10-02

    申请号：US14117554

    申请日：2012-05-11

    Applicant: Rashmi Rohit Kshirasagar ,  Alan Gilbert

    Inventor： Rashmi Rohit Kshirasagar ,  Alan Gilbert

    IPC: C07K16/00 ,  C12P21/00

    CPC classification number: C12P21/00 ,  A61K39/39591 ,  A61K2039/505 ,  C07K1/1133 ,  C07K16/00 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/94 ,  C12N5/0018 ,  C12N2500/34

    Abstract: The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.

    Abstract translation: 本发明涉及在蛋白质如抗体中预防和消除三硫键的方法。 在一个实施方案中，作为色谱纯化方法的一部分，将蛋白质中的三硫键转化为二硫键。 在另一个实施方案中，通过在这些蛋白质的细胞培养生产期间实施本文所述的方法来抑制蛋白质中三硫键的形成。 在另一个实施方案中，通过本文所述的方法产生单克隆抗体。

    FIRST TIME CONFIRMATION OF DATABASE ENTRY
    3.
    发明申请
    FIRST TIME CONFIRMATION OF DATABASE ENTRY 有权
    第一次确认数据库进入

    公开(公告)号：US20130186950A1

    公开(公告)日：2013-07-25

    申请号：US13357669

    申请日：2012-01-25

    Applicant: Gary Keefe ,  Alan Gilbert

    Inventor： Gary Keefe ,  Alan Gilbert

    IPC: G06F17/40

    CPC classification number: G06F19/326 ,  G06F19/00 ,  G06F19/36 ,  G06K7/1413 ,  G06Q50/22

    Abstract: Provided is an apparatus that stores a formulary. The apparatus includes a memory device that stores the formulary, the formulary comprising a plurality of drug entries. A user input device allows a user to verify a drug of the plurality of drug entries of the formulary. A code reader interprets computer-readable codes. After a computer-readable code that is associated with the drug is read by the code reader, the drug is verified using the user input device.

    Abstract translation: 提供存储处方集的装置。 所述装置包括存储所述处方集的存储装置，所述处方集包括多个药物入口。 用户输入设备允许用户验证处方集中的多个药物条目的药物。 代码阅读器解释计算机可读代码。 在通过代码读取器读取与药物相关联的计算机可读代码之后，使用用户输入设备验证药物。

    Road spike device
    4.
    发明授权
    Road spike device 失效
    道路装置

    公开(公告)号：US6048128A

    公开(公告)日：2000-04-11

    申请号：US256890

    申请日：1999-02-24

    Applicant: Charles M. Jones, III ,  J. Alan Gilbert ,  Peter Furthner

    Inventor： Charles M. Jones, III ,  J. Alan Gilbert ,  Peter Furthner

    IPC: E01F13/12 ,  E01F13/00

    CPC classification number: E01F13/12

    Abstract: A road spike device useful for deflating the tires of a fleeing or trespassing vehicle for the purpose of halting the vehicle. The road spike device preferably comprises a plurality of support arms and connected base members that are pivotally and replaceably secured to one another in a lazy tong configuration. A plurality of frangible cups are carried in spaced relation on the support arms. A hard rigid spike, adapted to allow air to flow through the spike, is carried by each of the frangible cups in a tight frictional fit such that spike is not readily removeable from frangible cup. As a vehicle tire (not shown) rolls onto the spike, the tire is impaled by the spike. As the tire progresses over the support arm with the spike embedded in the tire, the spike begins to rotate, relative to the axis of the frangible cup, creating a force moment against the outer lip of the frangible cup. This force moment causes the frangible cup to crumble, thus freeing the spike which remains embedded in the vehicle tire and deflates the vehicle tire. The spike of the preferred embodiment has a solid tapered tip and includes an elongated body, a shank, and a shoulder. The shank of the spike is provided with a concentric axial bore. An axial groove is provided in the elongated body of the spike and is in fluid communication with the axial bore of the shank. The preferred spike is provided with a plurality of circumferential bevels proximate the tip to act as barbs.

    Abstract translation: 用于为了停止车辆而使逃离或侵入车辆的轮胎放气的道路钉装置。 道路钉装置优选地包括多个支撑臂和连接的基部构件，所述基座构件以懒惰钳构造可枢转地和可替换地彼此固定。 多个易碎杯在支撑臂上以间隔的关系承载。 适合于允许空气流过穗状物的硬刚性尖钉由紧密摩擦配合的每个易碎杯承载，使得尖峰不易于从易碎杯中移除。 当车辆轮胎（未示出）滚动到钉子上时，轮胎被尖钉刺穿。 当轮胎在支撑臂上行进时，穗状物嵌入在轮胎中，尖峰相对于易碎杯的轴线开始旋转，从而产生抵抗易碎杯的外唇的力矩。 这种力矩使脆弱的杯子破碎，从而释放保持在车辆轮胎中的尖峰，并使车辆的轮胎缩短。 优选实施例的尖头具有实心锥形尖端，并且包括细长主体，柄和肩部。 尖钉的柄设置有同心轴向孔。 轴向凹槽设置在尖钉的细长主体中并且与柄的轴向孔流体连通。 优选的尖钉设置有靠近尖端的多个圆周斜面以用作倒钩。

    Systems and methods for securing internet access on restricted mobile platforms
    5.
    发明授权
    Systems and methods for securing internet access on restricted mobile platforms 有权
    在受限制的移动平台上保护互联网访问的系统和方法

    公开(公告)号：US09021578B1

    公开(公告)日：2015-04-28

    申请号：US13231919

    申请日：2011-09-13

    Applicant: Jim Casaburi ,  Alan Gilbert ,  Ryan McGann

    Inventor： Jim Casaburi ,  Alan Gilbert ,  Ryan McGann

    IPC: G06F9/00 ,  H04L29/06

    CPC classification number: H04L63/14 ,  H04L63/0227 ,  H04L63/0272 ,  H04L63/1416

    Abstract: A computer-implemented method for securing Internet access on restricted mobile platforms may include identifying an attempt by a mobile computing system to establish a virtual private network connection with a security server and, in response to identifying the attempt, (1) assigning an Internet Protocol address to the mobile computing system and (2) identifying a security filter customized to filter communications for an account associated with the mobile computing system. The method may also include (1) receiving, via the virtual private network connection, a request for an Internet resource and (2) providing, via the virtual private network connection, a response to the request to the mobile computing system based at least in part on the security filter. Various other methods, systems, and computer-readable media are also disclosed.

    Abstract translation: 用于在受限的移动平台上保护因特网接入的计算机实现的方法可以包括识别移动计算系统尝试建立与安全服务器的虚拟专用网络连接，并且响应于识别该尝试，（1）分配因特网协议 地址到移动计算系统，以及（2）识别用于过滤与移动计算系统相关联的帐户的通信的定制的安全过滤器。 该方法还可以包括（1）经由虚拟专用网络连接接收对因特网资源的请求，以及（2）至少在以下方面中，经由虚拟专用网络连接向移动计算系统提供对该请求的响应 部分安全过滤器。 还公开了各种其它方法，系统和计算机可读介质。

    Systems and methods for mitigating mobile device loss
    6.
    发明授权
    Systems and methods for mitigating mobile device loss 有权
    减轻移动设备丢失的系统和方法

    公开(公告)号：US08911507B1

    公开(公告)日：2014-12-16

    申请号：US13302871

    申请日：2011-11-22

    Applicant: Alan Gilbert ,  Jim Casaburi

    Inventor： Alan Gilbert ,  Jim Casaburi

    IPC: G06F7/04 ,  G06F12/14 ,  H04W4/02 ,  H04L29/06 ,  G06F17/30

    CPC classification number: H04W4/028 ,  H04L63/107 ,  H04W4/029 ,  H04W12/08

    Abstract: A computer-implemented method for mitigating mobile device loss may include (1) identifying historical data specifying a plurality of past locations of a mobile computing device, (2) identifying a current location of the mobile computing device, (3) determining that the current location deviates from an expected location based on the historical data, and (4) performing a security measure on the mobile computing device in response to determining that the current location deviates from the expected location. Various other methods, systems, and computer-readable media are also disclosed.

    Abstract translation: 用于减轻移动设备丢失的计算机实现的方法可以包括（1）识别指定移动计算设备的多个过去位置的历史数据，（2）识别移动计算设备的当前位置，（3）确定当前 基于历史数据，位置偏离预期位置，以及（4）响应于确定当前位置偏离预期位置，在移动计算设备上执行安全措施。 还公开了各种其它方法，系统和计算机可读介质。

    Determining Properties of Fingers via Keystroke Dynamics
    8.
    发明申请
    Determining Properties of Fingers via Keystroke Dynamics 审中-公开
    通过击键动力学确定手指的属性

    公开(公告)号：US20110227831A1

    公开(公告)日：2011-09-22

    申请号：US13052106

    申请日：2011-03-20

    Applicant: Andrew Jesse Mills ,  Alan Gilbert

    Inventor： Andrew Jesse Mills ,  Alan Gilbert

    IPC: G06F3/02

    CPC classification number: G06F3/0488 ,  G06F3/02

    Abstract: Keystroke dynamics has been widely studied to authenticate and verify computer users, but never has keystroke dynamics been used to directly determine properties of the fingers of the typist. This is a significant limitation because, for example, some of the personal traits correlated with finger ratios—for example, the second to fourth digit ratio predicts success among high frequency traders—cannot be obtained easily from internet users any other way. Users either may not wish to provide this information; the accuracy of the information obtained by asking them directly would be dubious; and/or it might not appear proper for the entity seeking the information to ask for it. The present invention overcomes this by using the timing information of keystroke dynamics to directly determine properties of fingers.

    Abstract translation: 敲击动力学已被广泛研究以验证和验证计算机用户，但从来没有使用击键动力学来直接确定打字员手指的属性。 这是一个重大的限制，因为例如，与手指比率相关的一些个人特征（例如，第二到第四位数比率预测高频交易者之间的成功）不能以任何其他方式从互联网用户容易地获得。 用户可能不希望提供此信息; 通过直接询问获得的信息的准确性将是可疑的; 和/或寻求信息的实体可能不适合要求它。 本发明通过使用击键动力学的定时信息来直接确定手指的属性来克服这一点。

    Using Multi Media Players to Insert Data Items into a Media Stream of a Streaming Media
    9.
    发明申请
    Using Multi Media Players to Insert Data Items into a Media Stream of a Streaming Media 有权
    使用多媒体播放器将数据项插入到流媒体的媒体流中

    公开(公告)号：US20100275221A1

    公开(公告)日：2010-10-28

    申请号：US12772317

    申请日：2010-05-03

    Applicant: Mark DuVall ,  Alan Gilbert

    Inventor： Mark DuVall ,  Alan Gilbert

    IPC: G06F15/16 ,  G06F9/46

    CPC classification number: G06Q30/0263 ,  G06Q30/0277 ,  H04L29/06027 ,  H04L65/4084 ,  H04L65/60 ,  H04L65/605 ,  H04L67/02 ,  H04L67/2842

    Abstract: Playback of a tagged audio stream at a user's computer can be controlled using a first media player. When the first media player detects a tag in the tagged audio stream, it mutes the volume of the first media player, and transfers playback control to a second media player operating at the same computer. The second media player controls playback of untagged media content, and in response to detecting completion of the untagged media content, returns playback control to the first media player. In this way, multiple media players in a client device can control the playback of audio content and the insertion of spots into that content.

    Abstract translation: 可以使用第一媒体播放器来控制用户计算机上的标记音频流的回放。 当第一媒体播放器检测到标记音频流中的标签时，它使第一媒体播放器的音量静音，并将播放控制传送到在同一计算机上操作的第二媒体播放器。 第二媒体播放器控制未标记的媒体内容的回放，并且响应于检测到未标记的媒体内容的完成，向第一媒体播放器返回播放控制。 以这种方式，客户端设备中的多个媒体播放器可以控制音频内容的回放以及将点插入到该内容中。

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