公开(公告)号：US5549601A

公开(公告)日：1996-08-27

申请号：US321398

申请日：1994-10-11

申请人： John McIntyre ,  Peter S. Brown ,  Stephen A. Morse

发明人： John McIntyre ,  Peter S. Brown ,  Stephen A. Morse

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/24 ,  A61B19/00 ,  A61B17/36

CPC分类号： A61B18/24 ,  A61B17/320758 ,  A61B2017/00274 ,  A61B2017/0084 ,  A61B2017/22072 ,  A61B2017/22077 ,  A61B2017/22078 ,  A61B2018/00547 ,  A61B90/361

摘要： A system for delivering a probe into a body part to perform a therapeutic or diagnostic procedure therein which includes an elongated probe device which is disposed within a protective sheath and which has a rotary drive unit connected to its proximal extremity to rotate the probe about its longitudinal axis, preferably at a rate above 50 rpms while applying axial pressure thereto to cause the distal end of the probe to penetrate through the patient's tissue to a desired location in the body part where the procedure is to occur. In a presently preferred embodiment, the probe is an optical fiber which is delivered into a male patient's prostate gland through the patient's prostatic urethral wall. The optical fiber is optically connected to a source for laser energy (815 nm) which is emitted from the distal end of the optical fiber to ablate prostatic tissue surrounding the distal end. A sheath is disposed about the optical fiber to support the shaft thereof and to minimize damage to the working channel of a cystoscope through which the device is usually advanced to reach the desired location within the patient's prostatic urethra.

摘要翻译： 一种用于将探针输送到身体部分以执行其中的治疗或诊断程序的系统，其包括设置在保护护套内的细长探针装置，并且具有连接到其近端的旋转驱动单元，以围绕其纵向 轴，优选地以高于50rpms的速率，同时向其施加轴向压力，以使探针的远端穿过患者组织穿过要进行手术的身体部位中的期望位置。 在目前优选的实施方案中，探针是通过患者的前列腺尿道壁输送到男性患者的前列腺中的光纤。 光纤被光学连接到从光纤的远端发射的激光能量源（815nm），以消融围绕远端的前列腺组织。 护套设置在光纤周围以支撑其轴并且最小化对膀胱镜的工作通道的损伤，通过该护套通常将器械推进到达患者前列腺尿道内的期望位置。

公开(公告)号：US5336237A

公开(公告)日：1994-08-09

申请号：US111984

申请日：1993-08-25

申请人： Albert K. Chin ,  John McIntyre ,  Stephen A. Morse

发明人： Albert K. Chin ,  John McIntyre ,  Stephen A. Morse

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B17/32

CPC分类号： A61B17/3207 ,  A61B17/00234 ,  A61B17/320016 ,  A61B2017/00287 ,  A61B2017/00685 ,  A61B2017/320775

摘要： A method and system for removing an organ or piece of tissue severed from its supporting tissue within a patient's body cavity, such as the abdominal cavity, which includes an elongated expandable tubular member with a sealed interior. In one preferred embodiment for morcellation, means are provided within the sealed interior to tear or cut off tissue fragments from the organ or tissue which are small enough to pass out of the patient's body cavity through an inner lumen of an exit trocar sheath disposed within the patient and in communication with the body cavity. The organ or piece of tissue is placed within an inner lumen defined by the sealed interior through an opening provided in a leading portion of the elongated expandable tubular member. The organ or piece of tissue is fragmented into smaller pieces which are withdrawn from the patient's body cavity by the passage of the morcellation system through the inner lumen of the exit trocar sheath. In one embodiment of the morcellation system, one or more elongated cutting strips are disposed within the inner lumen defined by the sealed interior and secured to the lining to cut or tear the tissue into small fragments. In another embodiment of the invention one or more elongated helical ribbons are provided to cut or tear the tissue into small fragments.

摘要翻译： 一种用于去除患者体腔（例如腹腔）内的其支撑组织切除的器官或系统的方法和系统，其包括具有密封内部的细长可扩张管状构件。 在一个优选的实施方式中，在密封的内部设置有用于撕开或切断器官或组织的组织碎片的装置，该器官或组织足够小以通过设置在内部的出口套管针护套的内腔 患者和身体的沟通。 器官或组织被放置在由密封内部限定的内腔内，通过设置在细长可扩张管状构件的引导部分中的开口。 器官或组织碎片被分割成较小的片，其通过穿过出口套管针鞘的内腔而从患者体腔抽出。 在切割系统的一个实施例中，一个或多个细长切割条设置在由内部限定的内腔内并固定到衬里上以将组织切割或撕裂成小碎片。 在本发明的另一个实施例中，提供一个或多个细长螺旋带以将组织切割或撕裂成小碎片。

公开(公告)号：US5833707A

公开(公告)日：1998-11-10

申请号：US498506

申请日：1995-07-05

申请人： John McIntyre ,  Geoffrey A. Orth ,  Peter S. Brown

发明人： John McIntyre ,  Geoffrey A. Orth ,  Peter S. Brown

IPC分类号： A61F2/00 ,  A61F2/92 ,  A61M29/00

CPC分类号： A61F2/962 ,  A61F2/92 ,  A61F2002/9511 ,  A61F2210/0019 ,  A61F2220/0075

摘要： An apparatus and method for temporarily implanting an intraluminal stent in a body lumen and its subsequent removal. A stent is formed from a thin sheet that has been wound around itself into a generally cylindrical roll. The stent has a deployed configuration with a deployed diameter generally the size of the lumen diameter. The stent has a delivery configuration, formed by winding the stent more tightly than the deployed configuration, with the delivery diameter smaller than the deployed diameter in order to allow low profile delivery into the body lumen. The stent will transform from the delivery configuration to the deployed configuration when exposed to body heat. The stent can be deployed by an intraluminal delivery catheter that secures the stent in its delivery configuration during intraluminal delivery of the stent. The stent can be removed from the body lumen via a removal catheter that coils the stent into a sheath at the end of the removal catheter.

摘要翻译： 一种用于临时植入管腔内支架在体腔中并随后移除的装置和方法。 支架由已经自身缠绕成大致圆柱形的卷的薄片形成。 支架具有展开的直径通常为管腔直径的尺寸的展开构造。 支架具有通过比展开构造更紧密地缠绕支架而形成的输送构造，其中输送直径小于展开直径，以便允许低调输送到体腔。 当暴露于体热时，支架将从输送配置转变为展开配置。 支架可以通过管腔内输送导管部署，其在支架的腔内递送期间将支架固定在其输送构造中。 支架可以通过去除导管从体腔去除，该导管将支架线圈在移除导管末端的护套中。

公开(公告)号：US10151309B2

公开(公告)日：2018-12-11

申请号：US15160093

申请日：2016-05-20

申请人： John McIntyre

发明人： John McIntyre

IPC分类号： F04B43/12 ,  F04B45/08

摘要： A peristaltic pump device includes a resilient tube secured in a pump housing with a rotor having rollers squeezing against the resilient tube facilitating the pumping of a liquid or gas. A cylindrical rotor rotates in a bore provided in the pump housing. The rotor has steps in which rollers freely slide and rotate. As the rotor rotates, the rollers also rotate and are slidingly held in the rotor step thereby frictional contact with the compressing resilient tube and consequently the liquid or gas within goes out of the resilient tube. The pump is inexpensive to build, reliable, and by design promotes the long life of the resilient tube as compared to existing roller type peristaltic pumps.

公开(公告)号：US09248549B2

公开(公告)日：2016-02-02

申请号：US14051520

申请日：2013-10-11

申请人： John McIntyre

发明人： John McIntyre

IPC分类号： B24C7/00 ,  B24C5/04 ,  B24C5/02

CPC分类号： B24C7/0084 ,  B24C5/02 ,  B24C5/04 ,  B24C7/0092

摘要： The present concept a wet abrasive blasting system includes a splitter manifold receiving compressed air from a source of compressed air. The splitter manifold includes at least two passageways and also a manifold pre-nozzle associated with each passageway respectively. The splitter manifold communicates air through the passageways to corresponding air conduits which feed compressed air to at least two wet blasters respectively wherein the blasters each include an exit nozzle which are substantially the same or smaller in size than the pre-nozzles.

摘要翻译： 现在的概念是湿式喷砂系统包括从压缩空气源接收压缩空气的分流歧管。 分流歧管包括至少两个通道以及分别与每个通道相关联的歧管预喷嘴。 分流器歧管将空气通过通道连通到相应的空气管道，空气管道将压缩空气分别送至至少两个湿式喷砂机，其中，喷射器各自包括与预喷嘴基本上相同或更小尺寸的出口喷嘴。

公开(公告)号：US08217003B2

公开(公告)日：2012-07-10

申请号：US12568400

申请日：2009-09-28

申请人： William Tedford ,  John McIntyre ,  Daniel Hopkins Russell ,  Peter Carlson

发明人： William Tedford ,  John McIntyre ,  Daniel Hopkins Russell ,  Peter Carlson

IPC分类号： A01N37/18 ,  A01P7/04

CPC分类号： A01N25/02 ,  A01N37/18 ,  A01N37/46 ,  A01N63/02 ,  A61K38/1767 ,  C07K14/43518 ,  C07K14/43522 ,  A01N2300/00

摘要： Procedures are described which use solvents to increase the topical insecticidal activity of toxic insect peptides. These procedures comprise drying the peptides, if needed, followed by the addition of either: 1) a polar organic solvent, with or without water, to a dried peptide, or 2) the addition of polar aprotic solvent or other adjuvant to the dried peptide, followed by the addition of either: 1) a polar organic solvent, with or without water, (where a polar aprotic solvent is added first) or 2) a polar aprotic solvent or other adjuvant to the peptide polar organic solvent (where the polar organic solvent is added first), to the peptide formulation.

摘要翻译： 描述了使用溶剂来增加毒性昆虫肽的局部杀虫活性的方法。 这些方法包括如果需要，干燥肽，然后加入以下物质之一：1）有或者没有水的极性有机溶剂加入到干燥的肽中，或者2）向干燥的肽中加入极性非质子溶剂或其它佐剂 ，然后加入：1）有或无水的极性有机溶剂（其中首先加入极性非质子溶剂）或2）极性非质子溶剂或其它助剂加入到肽极性有机溶剂（其中极性有机溶剂 有机溶剂首先加入），制成肽。

公开(公告)号：US08118578B2

公开(公告)日：2012-02-21

申请号：US12334054

申请日：2008-12-12

申请人： John McIntyre

发明人： John McIntyre

IPC分类号： F01C19/00 ,  F04C2/00

CPC分类号： F04C2/3442 ,  F01C21/0845 ,  F01C21/0881 ,  F04C2240/20

摘要： A rotary pump device includes a stator chamber with a cylindrical inner wall having intake and exhaust ports therein, and a two-part, expanding rotor eccentrically mounted for rotation within the chamber. The rotor comprises two crescentoid bodies with end surfaces in sliding, mating contact. A spring rod is placed between the inner rotor body surfaces to maintain rotor contact points in continuous wiping contact with the chamber wall. A full intake/exhaust cycle occurs every 180° of rotor travel.

摘要翻译： 旋转泵装置包括具有圆柱形内壁的定子室，其中具有进气和排气口，以及偏心地安装用于在室内旋转的两部分膨胀转子。 转子包括两个新月形体，其端面呈滑动，配合接触。 弹簧杆放置在内转子体表面之间，以保持转子接触点与腔壁连续擦拭接触。 转子行程每180°进行一次完全的进气/排气循环。

公开(公告)号：US20060141541A1

公开(公告)日：2006-06-29

申请号：US11359489

申请日：2006-02-23

申请人： John McIntyre

发明人： John McIntyre

IPC分类号： G01N33/567 ,  G01N33/53

CPC分类号： G01N33/92 ,  G01N33/564 ,  G01N33/6854 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/285

摘要： A neurodegenerative disease or condition is diagnosed in a subject by obtaining a sample of cerebral spinal fluid from the subject and assaying the sample by an assay method that detects the presence of at least one antiphospholipid autoantibody in the sample, wherein an elevated level of at least one antiphospholipid autoantibody in the sample of cerebral spinal fluid correlates with a neurodegenerative disease or condition in the subject. The neurodegenerative disease or condition may also be diagnosed by assaying a sample of cerebral spinal fluid to detect nitrosylated antibodies, wherein an elevated level of nitrosylated antibodies correlates with a neurodegenerative disease or condition in said subject. A neurodegenerative disease or condition is also detected or diagnosed by assaying a first sample of cerebral spinal fluid from the subject to determine a level of at least one autoantibody having a selected specificity, treating a second sample of cerebral spinal fluid with an oxidizing agent and assaying the oxidized second sample to determine a level the at least autoantibody having the selected specificity, and comparing the level of the at least one autoantibody in the first sample with the level of the at least one autoantibody in the oxidized second sample, wherein a lack of increase in the level of the at least one autoantibody in the oxidized second sample as compared to the level of the at least one autoantibody in the first sample correlates with a neurodegenerative disease or condition in said subject.

摘要翻译： 通过从受试者获得脑脊液的样品并通过检测样品中至少一种抗磷脂自身抗体的存在的测定方法来测定样品，在受试者中诊断神经变性疾病或病症，其中升高的水平至少 脑脊髓液样品中的一种抗磷脂自身抗体与受试者的神经变性疾病或病症相关。 神经变性疾病或病症也可以通过测定脑脊髓液样品来检测亚硝酰化抗体来诊断，其中升高水平的亚硝基化抗体与所述受试者的神经变性疾病或病症相关。 还通过测定来自受试者的第一脑脊液样品来确定至少一种具有选定特异性的自身抗体的水平，用氧化剂处理脑脊髓液的第二样品和测定法来检测或诊断神经变性疾病或病症 氧化的第二样品以确定具有所选特异性的至少自身抗体的水平，并将第一样品中的至少一种自身抗体的水平与氧化的第二样品中的至少一种自身抗体的水平进行比较，其中缺乏 与第一样品中的至少一种自身抗体的水平相比，氧化的第二样品中的至少一种自身抗体的水平的增加与所述受试者的神经变性疾病或病症相关。

公开(公告)号：US06791318B2

公开(公告)日：2004-09-14

申请号：US10221998

申请日：2003-01-07

申请人： Peter O. Paulson ,  John McIntyre ,  Kevin Mitchell

发明人： Peter O. Paulson ,  John McIntyre ,  Kevin Mitchell

IPC分类号： G01N2782

CPC分类号： G01N27/82 ,  G01N27/902 ,  G01N33/383

摘要： Discloses methods to perform magnetic testing of tensioning elements in a pre-stressed concrete cylinder, such as a pipe or water reservoir and testing apparatus. The apparatus includes magnetic flux production means and detector means disposed proximal to a surface of the cylinder in a plane in common with the magnetic flux production means that is orthogonal to an axis of the cylinder. The apparatus operates over a range of low frequency signals, for example, between 20 and 300 hertz or a pulse. Output of the inspection apparatus includes a signal and distance plot showing the results of testing a cylinder at one or more frequencies. In accordance with another method of analysis, a characteristic of the phase of the output over distance is plotted, including the phase or representations of the in-phase or quadrature components of the received signal in relation to the driving signal.

摘要翻译： 公开了对预应力混凝土圆柱体（例如管道或储水器和测试装置）中的张紧元件进行磁性测试的方法。 该装置包括磁通量产生装置和检测装置，该装置在与与气缸的轴线正交的磁通量产生装置共同的平面内设置在气缸表面附近。 该装置在一些范围的低频信号上工作，例如在20和300赫兹或脉冲之间。 检查装置的输出包括示出以一个或多个频率测试圆筒的结果的信号和距离图。 根据另一种分析方法，绘制出距离输出相位的特征，包括相对于驱动信号的接收信号的同相或正交分量的相位或表示。

公开(公告)号：US5062929A

公开(公告)日：1991-11-05

申请号：US393966

申请日：1989-08-11

申请人： Tom J. Hudson ,  John McIntyre ,  Pierre Tremblay ,  Claude Allaire ,  Bohdan Gnyra

发明人： Tom J. Hudson ,  John McIntyre ,  Pierre Tremblay ,  Claude Allaire ,  Bohdan Gnyra

IPC分类号： C25C3/08

CPC分类号： C25C3/085 ,  Y02P10/138

摘要： The amount of electrically conductive material in the bottom floor lining of a conventional aluminum reduction cell is reduced by using a non-conductive lining material in its place. The non-conductive material separates the remaining electrically conductive regions from the sidewall linings of the cell and preferably confines the electrically conductive material to the "anode shadow" region of the cell floor. The non-conductive material preferably comprises a particulate alumina mixture made up of large shapes which firmly compact together and smaller particles which fill the remaining voids. Optionally, the mixture may be bonded together with amorphous alumina, in which case the mixture can also be used for cell wall linings. The linings can be used in reduction cells of conventional design and reduces undesirable magnetohydrodynamic effects as well as pollution hazards caused by conventional carbonaceous cell linings.