公开(公告)号：US20120258965A1

公开(公告)日：2012-10-11

申请号：US13531364

申请日：2012-06-22

申请人： John P. TOSCANO ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

发明人： John P. TOSCANO ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

IPC分类号： A61K31/381 ,  C07D333/38 ,  C07D409/06 ,  C07D409/04 ,  A61P9/10 ,  A61K31/4535 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  C07D409/12 ,  A61K31/5377

CPC分类号： C07C317/48 ,  C07C311/48 ,  C07D295/155 ,  C07D295/16 ,  C07D295/192 ,  C07D295/26 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38

摘要： The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：US20110306614A1

公开(公告)日：2011-12-15

申请号：US13213480

申请日：2011-08-19

申请人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

发明人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

IPC分类号： A61K31/5377 ,  C07D295/135 ,  A61K31/185 ,  A61K31/5375 ,  A61K31/495 ,  A61K31/4453 ,  C07D307/82 ,  C07D333/62 ,  C07D215/36 ,  C07D235/28 ,  C07D277/80 ,  C07D263/58 ,  A61K31/343 ,  A61K31/381 ,  A61K31/47 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/423 ,  C07D333/34 ,  C07D413/04 ,  C07D241/14 ,  A61K31/4965 ,  A61P9/00 ,  A61P9/04 ,  C07C311/48

CPC分类号： C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D213/74 ,  C07D231/18 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D295/096 ,  C07D307/82 ,  C07D309/12 ,  C07D317/14 ,  C07D333/34 ,  C07D333/62

摘要： The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下给予硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新的N-羟基磺酰胺衍生物在生理条件下以受控的速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：US20090163487A1

公开(公告)日：2009-06-25

申请号：US12239705

申请日：2008-09-26

申请人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

发明人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

IPC分类号： A61K31/5377 ,  C07C311/16 ,  A61K31/24 ,  A61K31/195 ,  A61K31/18 ,  C07D265/30 ,  A61K31/5375 ,  C07D413/12 ,  A61P9/04

CPC分类号： C07C317/48 ,  C07C311/48 ,  C07D295/155 ,  C07D295/16 ,  C07D295/192 ,  C07D295/26 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38

摘要： The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：US08227639B2

公开(公告)日：2012-07-24

申请号：US12239705

申请日：2008-09-26

申请人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

发明人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

IPC分类号： C07C303/00

CPC分类号： C07C317/48 ,  C07C311/48 ,  C07D295/155 ,  C07D295/16 ,  C07D295/192 ,  C07D295/26 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38

摘要： The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：US08674132B2

公开(公告)日：2014-03-18

申请号：US13531364

申请日：2012-06-22

申请人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

发明人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

IPC分类号： C07C303/00

CPC分类号： C07C317/48 ,  C07C311/48 ,  C07D295/155 ,  C07D295/16 ,  C07D295/192 ,  C07D295/26 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38

摘要： The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下提供硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新型N-羟基磺酰胺衍生物在生理条件下以控制速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。

公开(公告)号：US08030356B2

公开(公告)日：2011-10-04

申请号：US11724792

申请日：2007-03-16

申请人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

发明人： John P. Toscano ,  Frederick Arthur Brookfield ,  Andrew D. Cohen ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  Vincent Jacob Kalish

IPC分类号： A61K31/18 ,  C07C311/48

CPC分类号： C07C311/48 ,  C07C317/14 ,  C07C323/67 ,  C07D213/74 ,  C07D231/18 ,  C07D261/10 ,  C07D263/58 ,  C07D285/125 ,  C07D295/096 ,  C07D307/82 ,  C07D309/12 ,  C07D317/14 ,  C07D333/34 ,  C07D333/62

摘要： The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

摘要翻译： 本发明涉及在生理条件下给予硝酰基（HNO）的N-羟基磺酰胺衍生物，并且可用于治疗和/或预防对硝酰病治疗有反应的疾病或病症的发作和/或发展，包括心力衰竭和缺血/再灌注 伤害。 新的N-羟基磺酰胺衍生物在生理条件下以受控的速率释放NHO，并且通过改变N-羟基磺酰胺衍生物上官能团的性质和位置来调节HNO释放速率。