公开(公告)号：US20110028766A1

公开(公告)日：2011-02-03

申请号：US12935719

申请日：2009-03-18

申请人： John R. Briggs ,  Bruce D. Hook ,  William J. Kruper Jr. ,  Anil Mehta ,  Robert M. Alvarado ,  Sascha Noormann ,  Perry S. Basile

发明人： John R. Briggs ,  Bruce D. Hook ,  William J. Kruper Jr. ,  Anil Mehta ,  Robert M. Alvarado ,  Sascha Noormann ,  Perry S. Basile

IPC分类号： C07C31/34 ,  B01J19/00

CPC分类号： C07C29/62 ,  C07C31/42 ,  C07C31/36

摘要： The present invention relates to a process for converting at least one multihydroxylated-aliphatic hydrocarbon and/or an ester thereof to at least one chlorohydrin and/or an ester thereof, comprising at least one reaction step in which the multihydroxylated-aliphatic hydrocarbon and/or ester thereof is contacted with hydrogen chloride under reaction conditions to produce the chlorohydrin and/or ester thereof, followed by at least one downstream processing step in which the effluents of the reaction step are processed, wherein the downstream processing step is performed in such conditions that the effluents containing the chlorohydrin and/or ester thereof are kept at a temperature of less than 120° C. The invention allows to minimize the liberation of hydrogen chloride from the products of the hydrochlorination reaction, hence reducing the corrosion of the downstream equipment and reducing the need to use costly corrosion resistant materials.

摘要翻译： 本发明涉及将至少一种多羟基化脂族烃和/或其酯转化为至少一种氯代醇和/或其酯的方法，该方法包括至少一个反应步骤，其中多羟基化脂族烃和/或 其酯在反应条件下与氯化氢接触以产生氯醇和/或其酯，随后是至少一个下游处理步骤，其中反应步骤的流出物被处理，其中下游处理步骤在以下条件下进行： 含有氯代醇和/或其酯的流出物保持在小于120℃的温度。本发明允许氯化氢从氢氯化反应的产物中释放最小化，从而减少下游设备的腐蚀并减少 需要使用昂贵的耐腐蚀材料。

公开(公告)号：US20100152499A1

公开(公告)日：2010-06-17

申请号：US12595396

申请日：2008-04-11

申请人： John R. Briggs ,  Bruce D. Hook ,  William J. Kruper, JR. ,  Anil Mehta ,  Robert M. Alvarado ,  Sascha Noormann ,  Perry S. Basile

发明人： John R. Briggs ,  Bruce D. Hook ,  William J. Kruper, JR. ,  Anil Mehta ,  Robert M. Alvarado ,  Sascha Noormann ,  Perry S. Basile

IPC分类号： C07C31/36 ,  B01J19/00

CPC分类号： C07C29/62 ,  C07C31/36 ,  C07C31/42

摘要： The present invention relates to a process for converting at least one multihydroxylated-aliphatic hydrocarbon and/or an ester thereof to at least one chlorohydrin and/or an ester thereof, comprising at least one reaction step in which the multihydroxylated-aliphatic hydrocarbon and/or ester thereof is contacted with hydrogen chloride under reaction conditions to produce the chlorohydrin and/or ester thereof, followed by at least one downstream processing step in which the effluents of the reaction step are processed, wherein the downstream processing step is performed in such conditions that the effluents containing the chlorohydrin and/or ester thereof are kept at a temperature of less than 12O° C. The invention allows to minimize the liberation of hydrogen chloride from the products of the hydrochlorination reaction, hence reducing the corrosion of the downstream equipment and reducing M the need to use costly corrosion resistant materials.

摘要翻译： 本发明涉及将至少一种多羟基化脂族烃和/或其酯转化为至少一种氯代醇和/或其酯的方法，该方法包括至少一个反应步骤，其中多羟基化脂族烃和/或 其酯在反应条件下与氯化氢接触以产生氯醇和/或其酯，随后是至少一个下游处理步骤，其中反应步骤的流出物被处理，其中下游处理步骤在以下条件下进行： 含有氯代醇和/或其酯的流出物保持在低于120℃的温度。本发明允许氯化氢从氢氯化反应的产物中释放最小化，从而减少下游设备的腐蚀并减少 M需要使用昂贵的耐腐蚀材料。

公开(公告)号：US08088957B2

公开(公告)日：2012-01-03

申请号：US11628269

申请日：2005-07-18

申请人： William J. Kruper, Jr. ,  David J. Schreck ,  Kenneth L. Kearns ,  Richard D. Varjian ,  Mark E. Jones ,  Robert M. Campbell ,  Bruce D. Hook ,  John R. Briggs ,  Jeffrey G. Hippler

发明人： William J. Kruper, Jr. ,  David J. Schreck ,  Kenneth L. Kearns ,  Richard D. Varjian ,  Mark E. Jones ,  Robert M. Campbell ,  Bruce D. Hook ,  John R. Briggs ,  Jeffrey G. Hippler

IPC分类号： C07C31/34

CPC分类号： C07D301/24 ,  C07C29/62 ,  C07C29/82 ,  C07C31/36 ,  C07C31/42

摘要： The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

摘要翻译： 本发明涉及将多羟基化脂肪族烃或其酯转化为氯代醇的方法，该方法是将多羟基化脂族烃或其起始原料与氯化氢的超大气压分压源接触足够的时间和 足够的温度，并且其中这种收缩步骤在不显着除去水的情况下进行，以产生所需的氯代醇产物; 其中所需的产物或产物可以高产率制备而不显着形成不需要的过氯化副产物。 此外，本发明的某些催化剂可以在超大气压，大气压和低于大气压的条件下用于本方法，并具有改进的结果。

公开(公告)号：US07910781B2

公开(公告)日：2011-03-22

申请号：US11710010

申请日：2007-02-22

申请人： Bruce D. Hook ,  John Briggs ,  Robert M. Campbell ,  William J. Kruper, Jr. ,  David J. Schreck ,  Richard D. Varjian ,  Jeffrey G. Hippler

发明人： Bruce D. Hook ,  John Briggs ,  Robert M. Campbell ,  William J. Kruper, Jr. ,  David J. Schreck ,  Richard D. Varjian ,  Jeffrey G. Hippler

IPC分类号： C07C31/34

CPC分类号： C07D301/27 ,  C07C29/62 ,  C07C67/287 ,  C07C69/003 ,  C07C69/63 ,  C07C31/36 ,  C07C31/42

摘要： A process for converting a crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof to a chlorohydrin, by contacting the crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; wherein said crude glycerol, said ester of crude glycerol, or mixture thereof is derived from a renewable raw material. Chlorohydrins made by the process of the present invention are useful in preparing epoxides such as epichlorohydrins.

摘要翻译： 通过将粗甘油，天然衍生的多羟基化脂肪族烃或其酯的起始原料的粗混合物与超大气压源的原料甘油，天然衍生的多羟基化脂肪族烃或其酯的粗混合物与氯代醇反应， 氯化氢的分压足够的时间和足够的温度，并且其中这种收缩步骤在不基本除去水的情况下进行，以产生所需的氯代醇产物; 其中所需产物或产物可以以高产率制备而不显着形成不需要的过氯化副产物; 其中所述粗甘油，所述粗甘油酯或其混合物衍生自可再生原料。 通过本发明方法制备的氯代醇可用于制备环氧化物如表氯醇。

公开(公告)号：US20110178315A1

公开(公告)日：2011-07-21

申请号：US13023783

申请日：2011-02-09

申请人： Bruce D. Hook ,  John Briggs ,  Robert M. Campbell ,  William J. Kruper, JR. ,  David J. Schreck ,  Richard D. Varjian ,  Jeffrey G. Hippler

发明人： Bruce D. Hook ,  John Briggs ,  Robert M. Campbell ,  William J. Kruper, JR. ,  David J. Schreck ,  Richard D. Varjian ,  Jeffrey G. Hippler

IPC分类号： C07D301/02 ,  C07C31/36

CPC分类号： C07D301/27 ,  C07C29/62 ,  C07C67/287 ,  C07C69/003 ,  C07C69/63 ,  C07C31/36 ,  C07C31/42

摘要： A process for converting a crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof to a chlorohydrin, by contacting the crude glycerol, crude mixtures of naturally derived multihydroxylated-aliphatic hydrocarbons or esters thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; wherein said crude glycerol, said ester of crude glycerol, or mixture thereof is derived from a renewable raw material. Chlorohydrins made by the process of the present invention are useful in preparing epoxides such as epichlorohydrins.

摘要翻译： 通过将粗甘油，天然衍生的多羟基化脂肪族烃或其酯的起始原料的粗混合物与超大气压源的原料甘油，天然衍生的多羟基化脂肪族烃或其酯的粗混合物与氯代醇反应， 氯化氢的分压足够的时间和足够的温度，并且其中这种收缩步骤在不基本除去水的情况下进行，以产生所需的氯代醇产物; 其中所需产物或产物可以以高产率制备而不显着形成不需要的过氯化副产物; 其中所述粗甘油，所述粗甘油酯或其混合物衍生自可再生原料。 通过本发明方法制备的氯代醇可用于制备环氧化物如表氯醇。

公开(公告)号：US20110124892A1

公开(公告)日：2011-05-26

申请号：US13017681

申请日：2011-01-31

申请人： William J. Kruper, JR. ,  Tina Arrowood ,  Bruce Michael Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

发明人： William J. Kruper, JR. ,  Tina Arrowood ,  Bruce Michael Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

IPC分类号： C07D301/26 ,  C07C29/60 ,  C07C67/00

CPC分类号： C07D301/27 ,  C07C29/62 ,  C07C67/08 ,  C07C67/287 ,  C07C69/003 ,  C07C69/63 ,  C07C31/36 ,  C07C31/42

摘要： The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of hydrogen chloride at superatmospheric, atmospheric and subatmospheric pressure conditions for a sufficient time and at a sufficient temperature, preferably wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; said process carried out without a step undertaken to specifically remove volatile chlorinated hydrocarbon by-products or chloroacetone, wherein the combined concentration of volatile chlorinated hydrocarbon by-products and chloroacetone is less than 2000 ppm throughout any stage of the said process.

公开(公告)号：US07906690B2

公开(公告)日：2011-03-15

申请号：US11710002

申请日：2007-02-22

申请人： William J. Kruper, Jr. ,  Tina Arrowood ,  Bruce Michael Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

发明人： William J. Kruper, Jr. ,  Tina Arrowood ,  Bruce Michael Bell ,  John Briggs ,  Robert M. Campbell ,  Bruce D. Hook ,  Anh Nguyen ,  Curt Theriault ,  Ralf Fitschen

IPC分类号： C07C31/34

CPC分类号： C07D301/27 ,  C07C29/62 ,  C07C67/08 ,  C07C67/287 ,  C07C69/003 ,  C07C69/63 ,  C07C31/36 ,  C07C31/42

摘要： The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of hydrogen chloride at superatmospheric, atmospheric and subatmospheric pressure conditions for a sufficient time and at a sufficient temperature, preferably wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; said process carried out without a step undertaken to specifically remove volatile chlorinated hydrocarbon by-products or chloroacetone, wherein the combined concentration of volatile chlorinated hydrocarbon by-products and chloroacetone is less than 2000 ppm throughout any stage of the said process.

摘要翻译： 本发明涉及一种将多羟基化脂肪族烃或其酯转化为氯代醇的方法，其通过使多羟基化的脂族烃或其起始原料与超大气压，大气压和低于大气压的条件下的氯化氢源接触足够的 时间和足够的温度，优选地其中这种收缩步骤在不基本除去水的情况下进行，以产生所需的氯代醇产物; 其中所需产物或产物可以以高产率制备而不显着形成不需要的过氯化副产物; 所述方法没有进行特别去除挥发性氯化烃副产物或氯丙酮的步骤，其中在所述方法的任何阶段，挥发性氯化烃副产物和氯丙酮的组合浓度小于2000ppm。

公开(公告)号：US08338627B2

公开(公告)日：2012-12-25

申请号：US12512227

申请日：2009-07-30

申请人： William W. Fan ,  Christian D. Kneupper ,  Sascha Noormann ,  Ranate Patrascu ,  Bruce D. Hook ,  Charles W. Lipp ,  Michael D. Cloeter ,  Heinz Groenewald

发明人： William W. Fan ,  Christian D. Kneupper ,  Sascha Noormann ,  Ranate Patrascu ,  Bruce D. Hook ,  Charles W. Lipp ,  Michael D. Cloeter ,  Heinz Groenewald

IPC分类号： C07D301/24

CPC分类号： C07D301/26 ,  C07D303/04 ,  C07D303/08 ,  Y02P20/127

摘要： A process for producing epoxide, the process including contacting an organic phase including at least one halohydrin(s) with at least one aqueous phase including a base in a plug-flow mixer/reactor system to disperse the organic phase in the aqueous phase via a mixing device imparting a power-to-mass ratio of at least 0.2 W/kg to convert at least a portion of the at least one halohydrin to an epoxide.

摘要翻译： 一种生产环氧化物的方法，该方法包括使包含至少一种卤代醇的有机相与至少一种包含碱的水相在活塞流混合器/反应器系统中接触，以通过经由 混合装置赋予至少0.2W / kg的功率质量比以将至少一部分卤代醇转化为环氧化物。

公开(公告)号：US08541632B2

公开(公告)日：2013-09-24

申请号：US12595430

申请日：2008-04-11

申请人： Anil J. Mehta ,  Danil Tirtowidjojo ,  Bruce D. Hook ,  John R. Briggs ,  Jeffrey G. Hippler

发明人： Anil J. Mehta ,  Danil Tirtowidjojo ,  Bruce D. Hook ,  John R. Briggs ,  Jeffrey G. Hippler

IPC分类号： C07C311/36

CPC分类号： C07C29/62 ,  C07C31/42 ,  C07C31/36

摘要： A process and apparatus for producing chlorohydrin comprising reacting a multihydroxylated-aliphatic hydrocarbon-containing stream with a stream of a first effluent exiting from a hydrochlorination reactor in at least one vessel wherein the vessel exhibits a plug flow residence time characteristic, under conditions such that at least a portion of any unreacted HCl component present in the first effluent is reacted with the multihydroxylated-aliphatic hydrocarbon present in the multihydroxylated aliphatic hydrogen-containing stream to from an amount of monochlorohydrin in a stream of a second effluent exiting from the plug flow vessel; recovering said second effluent; and then optionally using the second effluent from the plug flow reactor in a subsequent processing operation.

摘要翻译： 一种用于生产氯代醇的方法和装置，包括使多羟基化 - 脂族含烃流与在至少一个容器中从氢氯化反应器排出的第一流出物流反应，其中容器呈现塞流动停留时间特性， 存在于第一流出物中的任何未反应的HCl组分的至少一部分与存在于多羟基化脂族含氢物流中的多羟基化脂族烃与从活塞流容器排出的第二流出物流中的一氯代醇反应; 回收所述第二流出物; 然后在随后的处理操作中任选地使用来自活塞流反应器的第二流出物。

公开(公告)号：US20110004027A1

公开(公告)日：2011-01-06

申请号：US12595430

申请日：2008-04-11

申请人： Anil J. Mehta ,  Danil Tirtowidjojo ,  Bruce D. Hook ,  John R. Briggs ,  Jeffrey G. Hippler

发明人： Anil J. Mehta ,  Danil Tirtowidjojo ,  Bruce D. Hook ,  John R. Briggs ,  Jeffrey G. Hippler

IPC分类号： C07C31/36 ,  B01J19/00

CPC分类号： C07C29/62 ,  C07C31/42 ,  C07C31/36

摘要： A process and apparatus for producing chlorohydrin comprising reacting a multihydroxylated-aliphatic hydrocarbon-containing stream with a stream of a first effluent exiting from a hydrochlorination reactor in at least one vessel wherein the vessel exhibits a plug flow residence time characteristic, under conditions such that at least a portion of any unreacted HCl component present in the first effluent is reacted with the multihydroxylated-aliphatic hydrocarbon present in the multihydroxylated aliphatic hydrogen-containing stream to from an amount of monochlorohydrin in a stream of a second effluent exiting from the plug flow vessel; recovering said second effluent; and then optionally using the second effluent from the plug flow reactor in a subsequent processing operation.

摘要翻译： 一种用于生产氯代醇的方法和装置，包括使多羟基化 - 脂族含烃流与在至少一个容器中从氢氯化反应器排出的第一流出物流反应，其中容器呈现塞流动停留时间特性， 存在于第一流出物中的任何未反应的HCl组分的至少一部分与存在于多羟基化脂族含氢物流中的多羟基化脂族烃与从活塞流容器排出的第二流出物流中的一氯代醇反应; 回收所述第二流出物; 然后在随后的处理操作中任选地使用来自活塞流反应器的第二流出物。