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1.发明申请公开(公告)号：US20120207778A1
公开(公告)日：2012-08-16
申请号：US13398079
申请日：2012-02-16
申请人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Hervé Tettelin
发明人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Hervé Tettelin
IPC分类号： A61K39/09 , C07K16/12 , C07K7/08 , A61K38/16 , A61P31/04 , C07K7/06 , C07K14/315 , C07H21/04
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , Y02A50/464 , Y02A50/466 , Y02A90/22 , Y02A90/26
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。
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公开(公告)号：US20060275315A1
公开(公告)日：2006-12-07
申请号：US10513024
申请日：2003-05-02
申请人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Herve Tettelin
发明人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Herve Tettelin
IPC分类号： A61K39/116 , A61K39/295 , G06F19/00 , C07H21/04 , C12P21/06 , C12N1/21 , C12N15/74 , C07K14/315
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , Y02A50/464 , Y02A50/466 , Y02A90/22 , Y02A90/26
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。
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公开(公告)号：US20100105865A1
公开(公告)日：2010-04-29
申请号：US10415182
申请日：2001-10-29
申请人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Herve Tettelin
发明人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Herve Tettelin
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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4.发明申请Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae 审中-公开革兰氏阳性菌如无乳链球菌的免疫原性组合物公开(公告)号：US20090317420A1
公开(公告)日：2009-12-24
申请号：US11658842
申请日：2005-07-29
申请人： John Telford , Guido Grandi , Peter Lauer , Marlrosa Mora , Immaculada Margarit Y Ros , Domenico Malone , Guiliano Bensi , Daniela Rinaudo , Vega Masignani , Michelle Barocchi , Rino Rappuloi
发明人： John Telford , Guido Grandi , Peter Lauer , Marlrosa Mora , Immaculada Margarit Y Ros , Domenico Malone , Guiliano Bensi , Daniela Rinaudo , Vega Masignani , Michelle Barocchi , Rino Rappuloi
IPC分类号： A61K39/085 , A61P31/04 , C12N1/20 , C12P21/02 , C07K14/315
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/095 , A61K2039/523 , C07K16/1267 , Y02A50/396
摘要： The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.
摘要翻译： 本发明涉及鉴定几组A组和B组链球菌血清型和分离株的基因组中的新粘附素岛。 粘附素岛被认为编码在细菌的毒力中重要的表面蛋白质。 因此，本发明的粘附素岛蛋白可用于免疫原性组合物，用于针对GAS或GBS感染的预防性或治疗性免疫。 例如，本发明可以包括包含一种或多种所发现的粘附素岛蛋白的免疫原性组合物。
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公开(公告)号：US20130129740A1
公开(公告)日：2013-05-23
申请号：US13598657
申请日：2012-08-30
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Hervé Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Hervé Tettelin , Claire Fraser
IPC分类号： C07K14/315
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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公开(公告)号：US20060210582A1
公开(公告)日：2006-09-21
申请号：US11434203
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
发明人： John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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公开(公告)号：US20060210581A1
公开(公告)日：2006-09-21
申请号：US11434199
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
发明人： John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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公开(公告)号：US08431139B2
公开(公告)日：2013-04-30
申请号：US11434203
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
IPC分类号： A61K39/09
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号：US20060258849A1
公开(公告)日：2006-11-16
申请号：US11434127
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
发明人： John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号：US20060210580A1
公开(公告)日：2006-09-21
申请号：US11434184
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
发明人： John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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