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公开(公告)号：US20130129740A1
公开(公告)日：2013-05-23
申请号：US13598657
申请日：2012-08-30
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Hervé Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Hervé Tettelin , Claire Fraser
IPC分类号： C07K14/315
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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2.发明申请公开(公告)号：US20120207778A1
公开(公告)日：2012-08-16
申请号：US13398079
申请日：2012-02-16
申请人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Hervé Tettelin
发明人： John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Hervé Tettelin
IPC分类号： A61K39/09 , C07K16/12 , C07K7/08 , A61K38/16 , A61P31/04 , C07K7/06 , C07K14/315 , C07H21/04
CPC分类号： C07K14/315 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , Y02A50/464 , Y02A50/466 , Y02A90/22 , Y02A90/26
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。
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公开(公告)号：US08431139B2
公开(公告)日：2013-04-30
申请号：US11434203
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
IPC分类号： A61K39/09
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号：US08137673B2
公开(公告)日：2012-03-20
申请号：US11434199
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号：US07939087B2
公开(公告)日：2011-05-10
申请号：US10415182
申请日：2001-10-29
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号：US08025890B2
公开(公告)日：2011-09-27
申请号：US11434184
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供了来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号：US07955604B2
公开(公告)日：2011-06-07
申请号：US11434127
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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公开(公告)号：US09139621B2
公开(公告)日：2015-09-22
申请号：US13070448
申请日：2011-03-23
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： C07K14/22 , A61K39/095 , A61K39/00 , A61K38/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US08524251B2
公开(公告)日：2013-09-03
申请号：US13359471
申请日：2012-01-26
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/095 , A61K39/02 , A61K38/00 , C07K1/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US20070219347A1
公开(公告)日：2007-09-20
申请号：US11711740
申请日：2007-02-26
申请人： Claire Fraser , Erin Hickey , Jeremy Peterson , Herve Tettelin , J. Venter , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
发明人： Claire Fraser , Erin Hickey , Jeremy Peterson , Herve Tettelin , J. Venter , Vega Masignani , Cesira Galeotti , Marirosa Mora , Giulio Ratti , Maria Scarselli , Vincenzo Scarlato , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
CPC分类号： C07K14/22 , A61K38/00 , A61K2039/53 , C12Q1/6886 , C12Q1/689
摘要： The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics
摘要翻译： 本发明提供了从包括奈瑟氏球菌在内的基因组序列获得免疫原性蛋白质的方法，包括氨基酸序列和相应的核苷酸序列，以及脑膜炎奈瑟氏球菌B的基因组序列。如此获得的蛋白质是疫苗，免疫原性组合物和 /或诊断
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