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    Low temperature pressure stabilization of implant component
    1.
    发明授权
    Low temperature pressure stabilization of implant component 有权
    植入物组件的低温压力稳定

    公开(公告)号：US06184265B2

    公开(公告)日：2001-02-06

    申请号：US09362965

    申请日：1999-07-29

    申请人： John V. Hamilton ,  Mary Beth Schmidt ,  Keith Greer

    发明人： John V. Hamilton ,  Mary Beth Schmidt ,  Keith Greer

    IPC分类号： C08F246

    CPC分类号： A61L2/081 ,  A61L2/082 ,  A61L2/087 ,  A61L27/16 ,  C08L23/06 ,  C08L2207/068 ,  C08L2312/06 ,  Y10S422/903 ,  Y10S522/911 ,  Y10S522/912

    摘要： Wear resistance and oxidation resistance of polymer material or a polymer component for bioimplantation are improved by packaging a polymer object in a sealed gas impermeable package substantially free of oxygen, irradiating the package with penetrating radiation to an extent sufficient to effect a desired substantial level of cross-linking within the polymer, and warming the packaged object while maintaining an elevated hydrostatic pressure to cause gases released during irradiation to recombine, stabilizing the material against subsequent oxidative change. The pressure stabilization terminates active sites, substantially eliminating free radicals. When applied to finished parts, the process simultaneously hardens and sterilizes the parts without degrading mechanical properties or dimensions. When applied to bulk material or unfinished parts, the part may be subsequent machined or otherwise finished, and sterilized by any conventional means. The procedure achieves high levels of cross linking without increasing susceptibility to aging or chemical degradation.

    摘要翻译： 聚合物材料或用于生物植入的聚合物组分的耐磨性和抗氧化性通过将聚合物物体包装在基本上不含氧的密封气体不可渗透的包装中，通过将穿透辐射照射到足以实现期望的相当程度的交叉 在聚合物内连接并加热包装物体，同时保持升高的静水压力以引起在照射期间释放的气体重组，使材料稳定化以防止随后的氧化变化。 压力稳定终止活性位点，基本上消除自由基。 当应用于成品时，该工艺同时硬化和消毒零件，而不会降低机械性能或尺寸。 当应用于散装材料或未完成的部件时，可以随后机械加工或以其他方式完成该部件，并且通过任何常规方法进行灭菌。 该程序实现高水平的交联，而不增加对老化或化学降解的易感性。

    Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
    4.
    发明授权
    Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof 有权
    用于治疗关节软骨，骨或软骨缺损和损伤的无细胞基质植入物及其使用方法

    公开(公告)号：US07217294B2

    公开(公告)日：2007-05-15

    申请号：US10882581

    申请日：2004-06-30

    申请人： Akihiko Kusanagi ,  Laurence J. B. Tarrant ,  Mary Beth Schmidt

    发明人： Akihiko Kusanagi ,  Laurence J. B. Tarrant ,  Mary Beth Schmidt

    IPC分类号： A61F2/30

    CPC分类号： A61F2/30756 ,  A61F2002/30535 ,  A61F2250/0058 ,  A61L27/24 ,  A61L27/34 ,  A61L27/3633 ,  A61L27/3654 ,  A61L27/52 ,  A61L27/58 ,  A61L2430/06

    摘要： An acellular matrix implant for treatment of defects and injuries of articular cartilage, bone or osteochondral bone and a method for treatment of injured, damaged, diseased or aged articular cartilage or bone, using the acellular matrix implant implanted into a joint cartilage lesion in situ and a bone-inducing composition implanted into an osteochondral or bone defect. A method for repair and restoration of the injured, damaged, diseased or aged cartilage or bone into its full functionality by implanting the acellular matrix implant between two layers of biologically acceptable sealants and/or the bone-inducing composition into the osteochondral bone or skeletal bone defect. A method for fabrication of the acellular matrix implant of the invention. A method for preparation of bone-inducing composition.

    摘要翻译： 一种用于治疗关节软骨，骨或软骨软骨缺损和损伤的无细胞基质植入物，以及使用植入关节软骨病变中的无细胞基质植入物治疗损伤的，损伤的，患病的或老化的关节软骨或骨的方法，以及 植入骨软骨或骨缺损的骨诱导组合物。 通过将无细胞基质植入物植入两层生物学上可接受的密封剂和/或骨诱导组合物进入骨软骨骨或骨骼骨中来修复和恢复损伤的，损伤的，患病的或老化的软骨或骨骼成为其全部功能的方法 缺陷。 本发明的无细胞基质植入物的制造方法。 骨诱导组合物的制备方法。