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7 条记录 (耗时 0.022 秒)

    Biocompatible poly-beta-1-4-N-acetylglucosamine
    1.
    发明申请
    Biocompatible poly-beta-1-4-N-acetylglucosamine 审中-公开
    生物相容性聚-β-1-4-N-乙酰氨基葡萄糖

    公开(公告)号：US20070105815A1

    公开(公告)日：2007-05-10

    申请号：US11642773

    申请日：2006-12-19

    申请人： John Vournakis ,  Sergio Finkielsztein ,  Ernest Pariser ,  Mike Helton

    发明人： John Vournakis ,  Sergio Finkielsztein ,  Ernest Pariser ,  Mike Helton

    IPC分类号： A61K31/715 ,  A01N43/04

    CPC分类号： C12N5/0068 ,  A61K9/205 ,  A61K31/715 ,  A61K47/61 ,  A61K47/69 ,  A61L15/28 ,  A61L31/042 ,  C06D5/00 ,  C08B37/003 ,  C12N2533/70 ,  C12P19/26 ,  C12R1/89 ,  C08L5/08

    摘要： The present invention relates to a purified, easily produced poly-β-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a β-1→4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.

    摘要翻译： 本发明涉及纯化的，容易制备的多聚-β-1→4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖种类。 本发明的p-GlcNAc是高分子量的聚合物，其构成单糖以β-1→4构象连接，并且不含蛋白质，基本上不含单一氨基酸，以及其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。

    Methods and apparatus for a manual vascular compression device
    3.
    发明申请
    Methods and apparatus for a manual vascular compression device 有权

    公开(公告)号：US20060229664A1

    公开(公告)日：2006-10-12

    申请号：US11392200

    申请日：2006-03-29

    申请人： Sergio Finkielsztein ,  Marco Finkielsztein ,  John Vournakis

    发明人： Sergio Finkielsztein ,  Marco Finkielsztein ,  John Vournakis

    IPC分类号： A61B17/00

    CPC分类号： A61B17/12 ,  A61B2017/12004

    摘要： A vascular compression apparatus and method for applying pressure onto an area of a patient generally including a blood vessel and a wound site, such as a blood vessel puncture, after a cannulated procedure for the purpose of controlling bleeding and achieving hemostasis. The vascular compression apparatus includes a handle, a shaft and a pad. The shaft extends generally downward from the center of the bottom side of the handle. The pad is connected generally off-center of its top side to the bottom end of the shaft. The bottom side of the pad is convex to allow the vascular compression device to be rocked back and forth. In use, the pad is generally placed proximal to the catheter insertion site and over the blood vessel containing the catheter. The device is rocked proximally to control blood flow while removing the catheter. After the catheter is removed from the puncture site, the device is rocked distally to the puncture site, where pressure is applied until hemostasis is achieved.

    Methods and apparatus for a manual vascular compression device
    4.
    发明申请
    Methods and apparatus for a manual vascular compression device 审中-公开
    手动血管压缩装置的方法和装置

    公开(公告)号：US20060229662A1

    公开(公告)日：2006-10-12

    申请号：US11092369

    申请日：2005-03-29

    申请人： Sergio Finkielsztein ,  Marco Finkielsztein ,  John Vournakis

    发明人： Sergio Finkielsztein ,  Marco Finkielsztein ,  John Vournakis

    IPC分类号： A61B17/00

    CPC分类号： A61B17/12 ,  A61B2017/12004

    摘要： A vascular compression apparatus and method for applying pressure onto an area of a patient generally including a blood vessel and a wound site, such as a blood vessel puncture, after a cannulated procedure for the purpose of controlling bleeding and achieving hemostasis. The vascular compression apparatus includes a handle, a shaft and a pad. The shaft extends generally downward from the center of the bottom side of the handle. The pad is connected generally off-center of its top side to the bottom end of the shaft. The bottom side of the pad is convex to allow the vascular compression device to be rocked back and forth. In use, the pad is generally placed proximal to the catheter insertion site and over the blood vessel containing the catheter. The device is rocked proximally to control blood flow while removing the catheter. After the catheter is removed from the puncture site, the device is rocked distally to the puncture site, where pressure is applied until hemostasis is achieved.

    摘要翻译： 一种血管压缩装置和方法，用于在用于控制出血和实现止血的插管程序之后，将压力通常包括血管和伤口部位（例如血管穿刺）施加到患者的区域上。 血管压缩装置包括手柄，轴和垫。 轴从手柄底部的中心大致向下延伸。 垫的上侧通常偏离轴的底端。 垫的底部是凸的以允许血管压缩装置来回摇摆。 在使用中，垫通常放置在导管插入部位的近侧并且在包含导管的血管上方。 该装置向近侧摇摆以控制血液流动同时移除导管。 导管从穿刺部位取出后，将装置向远端向穿刺部位进行摇摆，在该部位施加压力，直到达到止血。

    Cell-polymer fiber compositions and uses thereof
    6.
    发明申请
    Cell-polymer fiber compositions and uses thereof 审中-公开
    细胞 - 聚合物纤维组合物及其用途

    公开(公告)号：US20080026064A1

    公开(公告)日：2008-01-31

    申请号：US11903935

    申请日：2007-09-24

    申请人： John Vournakis ,  Sergio Finkielsztein

    发明人： John Vournakis ,  Sergio Finkielsztein

    IPC分类号： A61K35/16 ,  A61K9/14 ,  A61P17/02

    CPC分类号： A61L26/0057 ,  A01N1/02 ,  A01N1/0205 ,  A01N1/0231 ,  A61K35/16 ,  A61L26/0023 ,  A61K2300/00 ,  C08L5/08

    摘要： The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The present invention encompasses compositions comprising poly-β-1→4-N-acetylglucosamine polymers and stored platelets and their use for promoting wound healing and achieving hemostasis.

    摘要翻译： 本发明涉及包含人细胞和聚合物纤维的复合物的组合物及其用于治疗目的的方法。 还提供了制备这种组合物的方法。 本发明包括包含聚-β-1→4-N-乙酰氨基葡萄糖聚合物和储存的血小板的组合物及其用于促进伤口愈合和实现止血的用途。