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1.发明授权Methods and apparatus for detecting the effect of cell affecting agents on living cells 失效用于检测细胞影响剂对活细胞的影响的方法和装置
公开(公告)号：US5496697A
公开(公告)日：1996-03-05
申请号：US118094
申请日：1993-09-08
申请人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
发明人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
CPC分类号： G01N33/5008 , C12M23/12 , C12M35/08 , Y10S435/817
摘要： Methods and apparatus are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions or suspensions in intimate contact with the cells. The solutions or suspensions, which contain a cell affecting agent, are then flowed in intimate contact with the cells and the pit is measured.
摘要翻译： 公开了用于检测细胞影响剂对活细胞的影响的方法和装置。 方法步骤包括提供保留在微流动室中的活细胞。 微流动室适于与细胞紧密接触的连续或间歇流动的溶液或悬浮液。 然后将含有细胞影响剂的溶液或悬浮液与细胞紧密接触流动并测量凹坑。
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2.发明授权
公开(公告)号：US5278048A
公开(公告)日：1994-01-11
申请号：US708121
申请日：1991-05-29
申请人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
发明人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
CPC分类号： C12M35/08 , G01N33/5008 , Y10S435/817 , Y10S436/806
摘要： Methods are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions or suspensions in intimate contact with the cells. The solutions or suspensions, which contain a cell affecting agent, are then flowed in intimate contact with the cells and at least one effect of the cell affecting agent on the cells is measured by an appropriate detecting means, which is operatively associated with the micro flow chamber.
摘要翻译： 公开了用于检测细胞影响剂对活细胞的作用的方法。 方法步骤包括提供保留在微流动室中的活细胞。 微流动室适于与细胞紧密接触的连续或间歇流动的溶液或悬浮液。 然后将含有细胞影响剂的溶液或悬浮液与细胞紧密接触流动，并通过合适的检测手段测量细胞影响剂对细胞的至少一种作用，该检测手段与微量流可操作地相关联 房间。
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公开(公告)号：US4849330A
公开(公告)日：1989-07-18
申请号：US730231
申请日：1985-05-03
IPC分类号： C12Q1/00 , G01N27/30 , G01N33/543
CPC分类号： C12Q1/004 , G01N27/305 , G01N33/5438 , Y10S435/966 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/827 , Y10S436/904
摘要： Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independently detectable signals.
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公开(公告)号：US4883579A
公开(公告)日：1989-11-28
申请号：US34036
申请日：1987-04-01
IPC分类号： C12Q1/00 , G01N27/30 , G01N33/543
CPC分类号： C12Q1/004 , G01N27/305 , G01N33/5438 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/827 , Y10S436/904
摘要： Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independently detectable signals.
摘要翻译： 提供了用于通过使用光响应元件多次确定液体系统的局部（位点特异性）氧化还原状态的装置和方法，所述光响应元件可以在不同位置独立地照射以提供独立可检测的信号。
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公开(公告)号：US4704353A
公开(公告)日：1987-11-03
申请号：US604800
申请日：1984-04-27
IPC分类号： G01N21/00 , C12Q1/00 , G01N27/00 , G01N27/30 , G01N33/543 , G01N33/50 , G01N27/52 , G01N33/53
CPC分类号： G01N33/5438 , C12Q1/004 , G01N27/305 , Y10S435/966 , Y10S435/973 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/827 , Y10S436/904
摘要： Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independently detectable signals.
摘要翻译： 提供了用于通过使用光响应元件多次确定液体系统的局部（位点特异性）氧化还原状态的装置和方法，所述光响应元件可以在不同位置独立地照射以提供独立可检测的信号。
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公开(公告)号：US4741619A
公开(公告)日：1988-05-03
申请号：US47037
申请日：1987-05-05
CPC分类号： B01L3/5085 , B29C59/14 , G01N21/03 , G01N2201/0446
摘要： A microtiter plate prepared from a hydrophobic plastic is rendered more hydrophilic by treatment of the surfaces of the wells of the microplate prior to use. The resulting plates are particularly useful in vertical beam photometry.
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公开(公告)号：US5487872A
公开(公告)日：1996-01-30
申请号：US228415
申请日：1994-04-15
CPC分类号： B01L3/5085
摘要： An ultraviolet radiation transparent multi-assay plate for ultraviolet absorption spectroscopy of ultraviolet absorbing liquids comprising a plurality of cylinders fixed in a frame each covered at the bottom with a portion of an ultraviolet transparent sheet material sealed to the bottom wall of the cylinder to form a non-leaking multi-assay plate well.
摘要翻译： 一种用于紫外线吸收液的紫外线吸收光谱的紫外线透射多测定板，包括固定在框架中的多个圆筒，每个圆筒都被覆盖在底部，一部分紫外线透明片材密封在圆筒的底壁上，形成 不渗漏多分析板。
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公开(公告)号：US5104804A
公开(公告)日：1992-04-14
申请号：US532571
申请日：1990-06-04
CPC分类号： C12M25/04 , Y10S435/817
摘要： This invention encompasses porous microchambers which contain cells and permit liquid to flow in and out of the chamber while retaining cells within the chamber. These porous microchambers serve as disposable devices for placing cells in a microflowchamber so that properties of the cells within the porous microchamber can be measured.
摘要翻译： 本发明包括含有细胞并允许液体进入和流出室的多孔微室，同时保持室内的孔。 这些多孔微孔板用作将细胞置于微流室中的一次性装置，以便可以测量多孔微室内的细胞的性质。
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公开(公告)号：US5536662A
公开(公告)日：1996-07-16
申请号：US161198
申请日：1993-12-02
CPC分类号： C12M25/04 , Y10S435/817
摘要： This invention encompasses porous microchambers which contain cells and permit liquid to flow in and out of the chamber while retaining cells within the chamber. These porous microchambers serve as disposable devices for placing cells in a microflowchamber so that properties of the cells within the porous microchamber can be measured.
摘要翻译： 本发明包括含有细胞并允许液体进入和流出室的多孔微室，同时保持室内的孔。 这些多孔微孔板用作将细胞置于微流室中的一次性装置，以便可以测量多孔微室内的细胞的性质。
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