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43 条记录 (耗时 0.022 秒)

    Derivatives of 4- or 5-aminosalicylic acid
    5.
    发明申请
    Derivatives of 4- or 5-aminosalicylic acid 有权
    4-或5-氨基水杨酸的衍生物

    公开(公告)号：US20070197479A1

    公开(公告)日：2007-08-23

    申请号：US11278395

    申请日：2006-03-31

    申请人： John Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vincenzo Santagada ,  Stefano Fiorucci

    发明人： John Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vincenzo Santagada ,  Stefano Fiorucci

    IPC分类号： A61K31/66 ,  C07F9/02

    CPC分类号： C07C323/59 ,  C07C323/60 ,  C07C327/42 ,  C07C327/48 ,  C07D339/04 ,  C07F9/3895 ,  C07F9/65785

    摘要： The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

    摘要翻译： 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物，其可用于治疗肠疾病如炎性肠病（IBD）和 肠易激综合征（IBS）和预防/治疗结肠癌。 更具体地说，这些衍生物包含通过偶氮，酯，酸酐，硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外，本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。

    Multi-function mounting/latch component for electrical connectors
    8.
    发明授权
    Multi-function mounting/latch component for electrical connectors 失效
    用于电气连接器的多功能安装/闩锁部件

    公开(公告)号：US06659796B1

    公开(公告)日：2003-12-09

    申请号：US10177511

    申请日：2002-06-21

    申请人： Kent D. Waddell ,  Denise Brennan ,  Eugene Folan ,  John M. Horgan ,  Enda Kelly ,  Joseph McCarthy ,  Brian Murphy ,  John Wallace ,  Jay H. Neer ,  John Meaney

    发明人： Kent D. Waddell ,  Denise Brennan ,  Eugene Folan ,  John M. Horgan ,  Enda Kelly ,  Joseph McCarthy ,  Brian Murphy ,  John Wallace ,  Jay H. Neer ,  John Meaney

    IPC分类号： H01R1373

    CPC分类号： H01R13/745 ,  H01R12/7047

    摘要： An electrical connector assembly is provided for mounting to a first side of a panel and through an opening in the panel. A connector housing is adapted for mounting through the opening in the panel and carries a plurality of terminals. A multi-function mounting/latch component includes at least one mounting boss for mounting the connector housing on a circuit board. The multi-function component includes at least one mounting aperture for receiving a mounting post of the connector housing for mounting the connector housing at the first side of the panel and through the opening in the panel. The multi-function component includes at least one latch arm projecting through the opening to a second side of the panel. A locking plate is engageable with the latch arm at the second side of the panel to hold the connector in assembly through the panel. The latch arm includes a latching aperture to facilitate latching the connector assembly to a complementary mating connector at the second side of the panel.

    摘要翻译： 电连接器组件被提供用于安装到面板的第一侧并穿过面板中的开口。 连接器壳体适于通过面板中的开口安装并且承载多个端子。 多功能安装/闩锁部件包括至少一个用于将连接器壳体安装在电路板上的安装凸台。 多功能部件包括至少一个用于接收连接器壳体的安装柱的安装孔，用于将连接器壳体安装在面板的第一侧并穿过面板中的开口。 多功能部件包括至少一个通过该开口突出到该面板第二侧的闩锁臂。 锁定板可在面板的第二侧处与闩锁臂接合，以将连接器固定通过面板组装。 闩锁臂包括闩锁孔，以有助于将连接器组件锁定在面板的第二侧处的互补配合连接器。

    Apparatus for presenting blind rivets
    9.
    发明授权
    Apparatus for presenting blind rivets 失效
    用于提供黑眼圈的装置

    公开(公告)号：US5156314A

    公开(公告)日：1992-10-20

    申请号：US701029

    申请日：1991-05-16

    申请人： John Wallace

    发明人： John Wallace

    IPC分类号： B21J15/32 ,  B21J15/00 ,  B21J15/28 ,  B21J15/34 ,  B21J15/36

    CPC分类号： B21J15/32 ,  B21J15/28

    摘要： Apparatus for presenting blind rivets (11) of the type comprising a shell (12) and a projecting stem (13), one at a time for pick-up by the nosepiece (28) of a rivet setting tool, includes gate means comprising a pair of guide members (24) for receiving a rivet (11) blown by air along a hose (39). The guide membes are urged by a spring (25) into their closed position, in which they arrest each rivet and position it in uniform orientation with its stem (13) projecting. Locating means (30) receives the nose piece (28) and guides it into the correct position and orientation for picking up the rivet by its projecting stem. A proximity detector (37) detects when the tool nose tip is correctly located, and actuates a pneumatically driven plunger (18) which pushes the guide members (24) apart to release the rivet into the tool nosepiece (28).

    Selective stereospecific biologically active beta-lactams
    10.
    发明授权
    Selective stereospecific biologically active beta-lactams 失效
    选择性立体定向生物活性β-内酰胺

    公开(公告)号：US5006661A

    公开(公告)日：1991-04-09

    申请号：US382531

    申请日：1989-07-19

    申请人： Richard A. Day ,  John Wallace

    发明人： Richard A. Day ,  John Wallace

    IPC分类号： C07D263/44 ,  C07D499/00

    CPC分类号： C07D263/44 ,  C07D499/00

    摘要： The present invention relates to a method for producing novel 4-[1-oxoalkyl]-2,5-oxazolidinediones, (4-1 OOD), and their use in a stereoselective method of producing beta-lactam-containing compounds which include several biologically active compounds such as the well-known families of pencillin and cephalosporin antibiotics. The method of the present invention involves generally the reaction of the above-described 4-[1-oxoalkyl]-2,5-oxazolidinediones so produced with a thiol amine having a geometry amenable to forming the precursor of the desired beta-lactam-containing compound or, in one scheme, forming the beta-lactam-containing compound itelf directly. This is done either by direct reaction of the 4-1 ODD with a thiol amine (which by one pathway proceeds directly to the beta-lactam-containing compound) or by first converting the 4-1 OOD to its 2-[1-oxoalkyl]-2-amino acid form before its reaction with the thiol amine; and then forming the beta lactam by action of cyanogen). The beta-lactam-containing compounds can be further modified according to methods known in the art to produce specific derivatives as desired.

    摘要翻译： 本发明涉及一种生产新型4- [1-氧代烷基] -2,5-恶唑烷二酮（4-1OOD）的方法及其在立体选择性方法中用于制备含有β-内酰胺的化合物的方法，其包括几种生物学 活性化合物如着名的青霉素和头孢菌素类抗生素家族。 本发明的方法通常涉及如此制备的上述4- [1-氧代烷基] -2,5-恶唑烷二酮与具有适于形成所需含β-内酰胺的前体的几何形状的硫醇胺的反应 或者在一个方案中，直接形成含有β-内酰胺的化合物。 这可以通过4-1ODD与硫醇胺的直接反应（其通过一条途径直接进入含有β-内酰胺的化合物）或通过首先将4-1OOD转化为其2- [1-氧代烷基 ] -2-氨基酸形式，然后与硫醇胺反应; 然后通过氰的作用形成β-内酰胺）。 可以根据本领域已知的方法进一步修饰含有β-内酰胺的化合物以根据需要产生特定的衍生物。