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    Rhodococcus erythropolis strain
    4.
    发明授权
    Rhodococcus erythropolis strain 有权
    红球菌红细菌菌株

    公开(公告)号：US08119389B2

    公开(公告)日：2012-02-21

    申请号：US12506596

    申请日：2009-07-21

    申请人： Nigel Ian Bowers ,  Paul M. Skonezny ,  Gregory L. Stein ,  Thomas Franceschini ,  Shu-Jen Chiang ,  Wendy L. Anderson ,  Li You ,  Zizhuo Xing

    发明人： Nigel Ian Bowers ,  Paul M. Skonezny ,  Gregory L. Stein ,  Thomas Franceschini ,  Shu-Jen Chiang ,  Wendy L. Anderson ,  Li You ,  Zizhuo Xing

    IPC分类号： C12N1/20

    CPC分类号： C12R1/01 ,  C12P13/001

    摘要： The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.

    摘要翻译： 本发明涉及制备（2R，3S）-1-卤代-2-羟基-3-（被保护的）氨基-4-取代的丁烷的方法，包括将具有ATCC保藏号的诱变的红球菌红景天 （3S）-1-卤代-2-氧代-3-（保护的）氨基-4-取代的丁烷底物的PTA-6648。 本发明还涉及一种方法，其包括在至少一种溶剂的存在下将（2R，3S）-1-卤代-2-羟基-3-（保护的）氨基-4-取代的丁烷与至少一个碱混合以产生 含有（2R，3S）-1,2-环氧-3-（保护）氨基-4-取代丁烷的反应混合物。 本发明还涉及通过将水和反应混合物同时加入，使（2R，3S）-1,2-环氧-3-（被保护的）氨基-4-取代丁烷从反应混合物中结晶出来的方法。 本发明还涉及具有ATCC保藏号的诱变的红球菌红球菌。 PTA-6648。

    Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
    5.
    发明授权
    Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof 有权
    制备（2R，3S）-1,2-环氧-3-（保护）氨基-4-取代丁烷的方法及其中间体

    公开(公告)号：US07582468B2

    公开(公告)日：2009-09-01

    申请号：US11365275

    申请日：2006-03-01

    申请人： Nigel Ian Bowers ,  Paul M. Skonezny ,  Gregory L. Stein ,  Thomas Franceschini ,  Shu-Jen Chiang ,  Wendy L. Anderson ,  Li You ,  Zizhuo Xing

    发明人： Nigel Ian Bowers ,  Paul M. Skonezny ,  Gregory L. Stein ,  Thomas Franceschini ,  Shu-Jen Chiang ,  Wendy L. Anderson ,  Li You ,  Zizhuo Xing

    IPC分类号： C12P41/00

    CPC分类号： C12R1/01 ,  C12P13/001

    摘要： The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.

    摘要翻译： 本发明涉及制备（2R，3S）-1-卤代-2-羟基-3-（被保护的）氨基-4-取代的丁烷的方法，包括将具有ATCC保藏号的诱变的红球菌红景天 （3S）-1-卤代-2-氧代-3-（保护的）氨基-4-取代的丁烷底物的PTA-6648。 本发明还涉及一种方法，其包括在至少一种溶剂的存在下将（2R，3S）-1-卤代-2-羟基-3-（保护的）氨基-4-取代的丁烷与至少一个碱混合以产生 含有（2R，3S）-1,2-环氧-3-（保护）氨基-4-取代丁烷的反应混合物。 本发明还涉及通过将水和反应混合物同时加入，使（2R，3S）-1,2-环氧-3-（被保护的）氨基-4-取代丁烷从反应混合物中结晶出来的方法。 本发明还涉及具有ATCC保藏号的诱变的红球菌红球菌。 PTA-6648。

    PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED) AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF
    6.
    发明申请
    PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED) AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF 有权
    制备（2R，3S）-1,2-环氧-3-（保护的）氨基-4-取代的丁烷的方法及其中间体

    公开(公告)号：US20090286303A1

    公开(公告)日：2009-11-19

    申请号：US12506596

    申请日：2009-07-21

    申请人： Nigel Ian Bowers ,  Paul M. Skonezny ,  Gregory L. Stein ,  Thomas Franceschini ,  Shu-Jen Chiang ,  Wendy L. Anderson ,  Li You ,  Zizhuo Xing

    发明人： Nigel Ian Bowers ,  Paul M. Skonezny ,  Gregory L. Stein ,  Thomas Franceschini ,  Shu-Jen Chiang ,  Wendy L. Anderson ,  Li You ,  Zizhuo Xing

    IPC分类号： C12N1/21

    CPC分类号： C12R1/01 ,  C12P13/001

    摘要： The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.

    摘要翻译： 本发明涉及制备（2R，3S）-1-卤代-2-羟基-3-（被保护的）氨基-4-取代的丁烷的方法，其包括将具有ATCC保藏号的诱变的红球菌红景天 （3S）-1-卤代-2-氧代-3-（保护的）氨基-4-取代的丁烷底物的PTA-6648。 本发明还涉及一种方法，其包括在至少一种溶剂的存在下将（2R，3S）-1-卤代-2-羟基-3-（保护的）氨基-4-取代的丁烷与至少一个碱混合以产生 含有（2R，3S）-1,2-环氧-3-（保护）氨基-4-取代丁烷的反应混合物。 本发明还涉及通过将水和反应混合物同时加入，使（2R，3S）-1,2-环氧-3-（被保护的）氨基-4-取代丁烷从反应混合物中结晶出来的方法。 本发明还涉及具有ATCC保藏号的诱变的红球菌红球菌。 PTA-6648。