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    FLUIDICS INTERFACE SYSTEMS AND METHODS
    2.
    发明申请
    FLUIDICS INTERFACE SYSTEMS AND METHODS 有权
    流体界面系统和方法

    公开(公告)号：US20120143531A1

    公开(公告)日：2012-06-07

    申请号：US13340484

    申请日：2011-12-29

    Applicant: Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    Inventor： Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    IPC: G06F19/00 ,  G01M3/28

    CPC classification number: G01N33/48785

    Abstract: A system including a communication interface to communicatively couple to a sensor cartridge, a fluidic subsystem to exchange a reagent solution with the sensor cartridge, and a computational circuitry communicatively coupled to the communication interface and the fluidic subsystem. The computation circuitry is to monitor a sensor signal of a sensor of the sensor cartridge, detect a leak based on the sensor signal, and control fluid flow of the fluidic subsystem in response to detecting.

    Abstract translation: 一种系统，包括通信接口以通信地耦合到传感器盒，流体子系统以与所述传感器盒交换试剂溶液，以及可通信地耦合到所述通信接口和所述流体子系统的计算电路。 计算电路是监测传感器盒的传感器的传感器信号，基于传感器信号检测泄漏，并响应于检测来控制流体子系统的流体流动。

    Method and apparatus for monitoring combustion instability and other performance deviations in turbine engines and like combustion systems
    5.
    发明申请
    Method and apparatus for monitoring combustion instability and other performance deviations in turbine engines and like combustion systems 审中-公开
    用于监测涡轮发动机和类似燃烧系统中的燃烧不稳定性和其它性能偏差的方法和装置

    公开(公告)号：US20070234730A1

    公开(公告)日：2007-10-11

    申请号：US11248448

    申请日：2005-10-12

    Applicant: James Markham ,  David Marran ,  James Scire

    Inventor： James Markham ,  David Marran ,  James Scire

    IPC: G01N21/61 ,  F23N5/14

    CPC classification number: G01N21/359 ,  G01N21/3504 ,  G01N2021/3595

    Abstract: The sensor arrangement, performance-monitored machine system, and method, utilize radiance of exhaust streams to indicate performance deviation, due to combustion instability or machine malfunction, in propulsion gas turbine engines, augmentors used on such engines, stationary power generating gas turbine engines, and other air-breathing combustion-based turbine machines and systems. Sensor operation is based upon high-speed measurements of radiant emission from the hot exhaust stream, taken at a minimum rate of 2000, and preferably at a rate of at least 8000, samples per second. Select infrared wavelengths of light are used to capture temporal variations in the radiance, which are Fourier analyzed to determine the magnitude and frequency of the combustion instability. The apparatus and method enable detection of incipient combustion instability, combustion system health, power loss, stall, surge, and fuel light-off; information and feedback are available for combustion control, to provide an early warning and diagnosis of a physical and/or mechanical malfunction, and to indicate a need for condition-based maintenance.

    Abstract translation: 传感器装置，性能监视的机器系统和方法利用排气流的辐射来指示在推进燃气涡轮发动机，在这种发动机上使用的增压器，固定式发电燃气涡轮发动机，由于燃烧不稳定或机器故障引起的性能偏差， 和其他空气呼吸燃烧式涡轮机和系统。 传感器操作基于以最小速率2000进行的来自热排气流的辐射发射的高速测量，并且优选地以每秒至少8000次的速率测量。 选择红外波长的光用于捕获辐射的时间变化，这是经傅立叶分析以确定燃烧不稳定性的大小和频率。 该装置和方法能够检测初期燃烧不稳定性，燃烧系统健康，功率损耗，失速，浪涌和燃料熄灭; 信息和反馈可用于燃烧控制，以提供物理和/或机械故障的早期预警和诊断，并指示需要基于条件的维护。

    FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS
    8.
    发明申请
    FLUIDICS SYSTEM FOR SEQUENTIAL DELIVERY OF REAGENTS 有权
    用于顺序递送试剂的流体系统

    公开(公告)号：US20100300559A1

    公开(公告)日：2010-12-02

    申请号：US12785667

    申请日：2010-05-24

    Applicant: Jonathan Schultz ,  David Marran

    Inventor： Jonathan Schultz ,  David Marran

    IPC: F16L41/00

    CPC classification number: B01L3/502715 ,  B01J2219/00389 ,  B01J2219/00394 ,  B01L3/502 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502769 ,  B01L3/502776 ,  B01L3/52 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2400/0487 ,  C12Q1/6869 ,  G01N27/447 ,  G01N35/1002 ,  G01N35/1097 ,  Y10T137/0318 ,  Y10T137/0424 ,  Y10T137/85938 ,  C12Q2565/629 ,  C12Q2527/119

    Abstract: The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion. The invention is particularly advantageous in apparatus for performing sensitive multistep reactions, such as pH-based DNA sequencing reactions.

    Abstract translation: 本发明提供了一种用于将不同流体引导到公共体积（例如反应室或流动池）的无源流体回路，而不会混合或交叉污染。 通过流体回路的连接点，节点和通道的流动方向和流速由上游阀（例如打开或关闭）的状态，电路入口或上游储存器处的差分流体压力，流动阻力等来控制。 通过所选择的入口流体的流动防止流体从未选择的入口到共同的出口或其他入口处的自由扩散或泄漏，其一部分由未选择的流体的入口扫过并且通过废物端口离开流体回路 ，从而产生阻止与出口流通过泄漏或扩散的不期望的混合的屏障。 本发明在用于进行灵敏多步反应（例如基于pH的DNA测序反应）的装置中特别有利。

    Fourier transform infrared spectrometer
    9.
    发明申请
    Fourier transform infrared spectrometer 审中-公开
    傅里叶变换红外光谱仪

    公开(公告)号：US20060238768A1

    公开(公告)日：2006-10-26

    申请号：US11115039

    申请日：2005-04-26

    Applicant: Stuart Brorson ,  Carl Brouillette ,  Robert Carangelo ,  David Marran

    Inventor： Stuart Brorson ,  Carl Brouillette ,  Robert Carangelo ,  David Marran

    IPC: G01B9/02 ,  G01J3/45

    CPC classification number: G01J3/4535

    Abstract: A method and apparatus for measuring radiometric signals. An infrared energy signal is directed through a sample and combined with a selected signal to reduce the effect of analog-to-digital converter nonlinearity. The combined signal is processed to, for example, accurately and repeatably identify the types of and concentration of molecules within the sample.

    Abstract translation: 一种用于测量辐射信号的方法和装置。 红外能量信号被引导通过样本并与所选择的信号组合以减少模数转换器非线性的影响。 处理组合信号以例如准确地且可重复地识别样品内分子的类型和浓度。

    Integrated sensor arrays for biological and chemical analysis
    10.
    发明授权
    Integrated sensor arrays for biological and chemical analysis 有权
    用于生物和化学分析的集成传感器阵列

    公开(公告)号：US08936763B2

    公开(公告)日：2015-01-20

    申请号：US13125133

    申请日：2009-10-22

    Applicant: Jonathan Rothberg ,  James Bustillo ,  Mark Milgrew ,  Jonathan Schultz ,  David Marran ,  Todd Rearick ,  Kim Johnson

    Inventor： Jonathan Rothberg ,  James Bustillo ,  Mark Milgrew ,  Jonathan Schultz ,  David Marran ,  Todd Rearick ,  Kim Johnson

    IPC: G01N27/403 ,  G01N27/414 ,  C12Q1/68 ,  H01L21/82

    CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

    Abstract: The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.

    Abstract translation: 本发明涉及包括大规模化学场效应晶体管阵列的装置和芯片，其包括能够保留来自样品流体的化学或生物样品用于分析的样品保持区阵列。 在一个方面，这种晶体管阵列具有10μm或更小的间距，并且每个采样保持区域位于至少一个化学场效应晶体管上，该晶体管被配置为产生与化学或生物样品的特性相关的至少一个输出信号 在这样的样品保留区域中。 在一个实施方案中，所述化学或生物样品的特征是带电物质的浓度，并且其中每个所述化学场效应晶体管是离子敏感场效应晶体管，其具有在其表面上具有介电层的浮置栅极， 电介质层与所述样品流体接触并且能够与所述样品流体中的带电物质的浓度成比例地积累电荷。 在一个实施方案中，这种带电物质是氢离子，使得传感器测量样品流体在其样品保持区域中或其附近的pH值的变化。 本发明的装置和芯片可适用于大规模的基于pH的DNA测序和其他生物科学和生物医学应用。

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