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    FLUIDICS INTERFACE SYSTEMS AND METHODS
    1.
    发明申请
    FLUIDICS INTERFACE SYSTEMS AND METHODS 有权
    流体界面系统和方法

    公开(公告)号：US20120143531A1

    公开(公告)日：2012-06-07

    申请号：US13340484

    申请日：2011-12-29

    申请人： Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    发明人： Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    IPC分类号： G06F19/00 ,  G01M3/28

    CPC分类号： G01N33/48785

    摘要： A system including a communication interface to communicatively couple to a sensor cartridge, a fluidic subsystem to exchange a reagent solution with the sensor cartridge, and a computational circuitry communicatively coupled to the communication interface and the fluidic subsystem. The computation circuitry is to monitor a sensor signal of a sensor of the sensor cartridge, detect a leak based on the sensor signal, and control fluid flow of the fluidic subsystem in response to detecting.

    摘要翻译： 一种系统，包括通信接口以通信地耦合到传感器盒，流体子系统以与所述传感器盒交换试剂溶液，以及可通信地耦合到所述通信接口和所述流体子系统的计算电路。 计算电路是监测传感器盒的传感器的传感器信号，基于传感器信号检测泄漏，并响应于检测来控制流体子系统的流体流动。

    System to control fluid flow based on a leak detected by a sensor
    2.
    发明授权
    System to control fluid flow based on a leak detected by a sensor 有权
    基于由传感器检测到的泄漏来控制流体流动的系统

    公开(公告)号：US08545248B2

    公开(公告)日：2013-10-01

    申请号：US13340484

    申请日：2011-12-29

    申请人： Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    发明人： Melville Davey ,  George Roth ,  David Marran ,  William Mileski ,  John Nobile

    IPC分类号： H01R13/52

    CPC分类号： G01N33/48785

    摘要： A system including a communication interface to communicatively couple to a sensor cartridge, a fluidic subsystem to exchange a reagent solution with the sensor cartridge, and a computational circuitry communicatively coupled to the communication interface and the fluidic subsystem. The computation circuitry is to monitor a sensor signal of a sensor of the sensor cartridge, detect a leak based on the sensor signal, and control fluid flow of the fluidic subsystem in response to detecting.

    摘要翻译： 一种系统，包括通信接口以通信地耦合到传感器盒，流体子系统以与所述传感器盒交换试剂溶液，以及可通信地耦合到所述通信接口和所述流体子系统的计算电路。 计算电路是监测传感器盒的传感器的传感器信号，基于传感器信号检测泄漏，并响应于检测来控制流体子系统的流体流动。

    Fluidics Interface System
    3.
    发明申请
    Fluidics Interface System 有权
    流体接口系统

    公开(公告)号：US20110217860A1

    公开(公告)日：2011-09-08

    申请号：US12986963

    申请日：2011-01-07

    申请人： John Nobile ,  George Roth ,  David Marran ,  William Mileski

    发明人： John Nobile ,  George Roth ,  David Marran ,  William Mileski

    IPC分类号： H01R13/52 ,  H01R9/00

    CPC分类号： G01N27/4148 ,  Y10T29/49147

    摘要： A leak resistant electrical connector configured as a fluidic barrier between a fluidics device, which may comprise a chemFET sensor, and other electrical circuitry wherein the fluidics device further comprises one or more electrical contacts conductively coupled to one or more electrical contacts associated with the electrical circuitry through the connector.

    摘要翻译： 一种防漏电连接器，其构造为流体装置之间的流体阻挡层，流体装置可包括chemFET传感器，以及其它电路，其中流体装置还包括一个或多个导电耦合到与电路相关联的一个或多个电触点的电触头 通过连接器。

    Apparatus and methods for performing electrochemical reactions
    5.
    发明授权
    Apparatus and methods for performing electrochemical reactions 有权
    用于进行电化学反应的装置和方法

    公开(公告)号：US08673627B2

    公开(公告)日：2014-03-18

    申请号：US12785716

    申请日：2010-05-24

    申请人： John Nobile ,  Thomas Roth ,  Todd Rearick ,  Jonathan Schultz ,  Jonathan Rothberg ,  David Marran

    发明人： John Nobile ,  Thomas Roth ,  Todd Rearick ,  Jonathan Schultz ,  Jonathan Rothberg ,  David Marran

    IPC分类号： C12M1/34 ,  C12M3/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N27/403

    CPC分类号： G01N27/301 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00653 ,  B01J2219/00722 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0877 ,  G01N27/4145

    摘要： The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors underminimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles. Such detection of analyte- or particle-containing microwells may be used as a step in additional noise reduction methods.

    摘要翻译： 本发明涉及用于在最小噪声条件下向多个电子传感器阵列上进行的多个分析反应的多个试剂的输送和监测的装置和方法。 一方面，本发明提供了通过减去从相邻传感器测得的输出信号的平均值来提高来自电子传感器感测分析物或反应副产物的输出信号的信噪比的方法，其中分析物或反应副产物不存在。 在其它方面，本发明提供了与微孔阵列集成的电子传感器阵列，用于限制用于分析反应的分析物和/或颗粒，以及通过使传感器活性试剂通过阵列而识别含有分析物和/或颗粒的微孔的方法，以及 将传感器响应时间与分析物或颗粒的存在或不存在相关联。 含有分析物或含微粒微孔的这种检测可以用作额外的降噪方法中的步骤。

    APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS
    6.
    发明申请
    APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS 有权
    用于执行电化学反应的装置和方法

    公开(公告)号：US20100300895A1

    公开(公告)日：2010-12-02

    申请号：US12785716

    申请日：2010-05-24

    申请人： John Nobile ,  Thomas Roth ,  Todd Rearick ,  Jonathan Schultz ,  Jonathan Rothberg ,  David Marran

    发明人： John Nobile ,  Thomas Roth ,  Todd Rearick ,  Jonathan Schultz ,  Jonathan Rothberg ,  David Marran

    IPC分类号： G01N27/26

    CPC分类号： G01N27/301 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00653 ,  B01J2219/00722 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0877 ,  G01N27/4145

    摘要： The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors underminimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles. Such detection of analyte- or particle-containing microwells may be used as a step in additional noise reduction methods.

    摘要翻译： 本发明涉及用于在最小噪声条件下向多个电子传感器阵列上进行的多个分析反应的多个试剂的输送和监测的装置和方法。 一方面，本发明提供了通过减去从相邻传感器测得的输出信号的平均值来提高来自电子传感器感测分析物或反应副产物的输出信号的信噪比的方法，其中分析物或反应副产物不存在。 在其它方面，本发明提供了与微孔阵列集成的电子传感器阵列，用于限制用于分析反应的分析物和/或颗粒，以及通过使传感器活性试剂通过阵列而识别含有分析物和/或颗粒的微孔的方法，以及 将传感器响应时间与分析物或颗粒的存在或不存在相关联。 含有分析物或含微粒微孔的这种检测可以用作额外的降噪方法中的步骤。

    Integrated sensor arrays for biological and chemical analysis
    7.
    发明授权
    Integrated sensor arrays for biological and chemical analysis 有权
    用于生物和化学分析的集成传感器阵列

    公开(公告)号：US08936763B2

    公开(公告)日：2015-01-20

    申请号：US13125133

    申请日：2009-10-22

    申请人： Jonathan Rothberg ,  James Bustillo ,  Mark Milgrew ,  Jonathan Schultz ,  David Marran ,  Todd Rearick ,  Kim Johnson

    发明人： Jonathan Rothberg ,  James Bustillo ,  Mark Milgrew ,  Jonathan Schultz ,  David Marran ,  Todd Rearick ,  Kim Johnson

    IPC分类号： G01N27/403 ,  G01N27/414 ,  C12Q1/68 ,  H01L21/82

    CPC分类号： G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

    摘要： The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.

    摘要翻译： 本发明涉及包括大规模化学场效应晶体管阵列的装置和芯片，其包括能够保留来自样品流体的化学或生物样品用于分析的样品保持区阵列。 在一个方面，这种晶体管阵列具有10μm或更小的间距，并且每个采样保持区域位于至少一个化学场效应晶体管上，该晶体管被配置为产生与化学或生物样品的特性相关的至少一个输出信号 在这样的样品保留区域中。 在一个实施方案中，所述化学或生物样品的特征是带电物质的浓度，并且其中每个所述化学场效应晶体管是离子敏感场效应晶体管，其具有在其表面上具有介电层的浮置栅极， 电介质层与所述样品流体接触并且能够与所述样品流体中的带电物质的浓度成比例地积累电荷。 在一个实施方案中，这种带电物质是氢离子，使得传感器测量样品流体在其样品保持区域中或其附近的pH值的变化。 本发明的装置和芯片可适用于大规模的基于pH的DNA测序和其他生物科学和生物医学应用。