公开(公告)号：US11589767B2

公开(公告)日：2023-02-28

申请号：US16536146

申请日：2019-08-08

申请人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

发明人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

IPC分类号： A61B5/0538 ,  A61N1/05 ,  A61N1/36 ,  A61N1/365 ,  A61N1/37 ,  A61B5/0215 ,  A61B5/029

摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

公开(公告)号：US09295404B2

公开(公告)日：2016-03-29

申请号：US13425119

申请日：2012-03-20

申请人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

发明人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

IPC分类号： A61N1/36 ,  A61B5/053 ,  A61N1/05 ,  A61N1/365 ,  A61N1/37

CPC分类号： A61B5/0538 ,  A61B5/0215 ,  A61B5/029 ,  A61N1/056 ,  A61N1/36125 ,  A61N1/36521 ,  A61N1/3706

摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

摘要翻译： 用于测量动物或人类患者中的复电导纳和/或复电阻抗的装置包括第一电极和适于设置在患者体内的至少第二电极。 该装置包括适于设置在患者体内的壳体。 壳体设置有与至少第一电极电连通的刺激器，以用电流或电压来刺激第一电极，传感器至少与第二电极电连通，以基于第二电极感测来自第二电极的响应 对第一电极的刺激以及与传感器电通信的信号处理器，以确定患者的复杂电导纳或阻抗。

公开(公告)号：US10376177B2

公开(公告)日：2019-08-13

申请号：US15044842

申请日：2016-02-16

申请人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

发明人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

IPC分类号： A61N1/36 ,  A61B5/053 ,  A61N1/05 ,  A61N1/365 ,  A61N1/37 ,  A61B5/0215 ,  A61B5/029

摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

公开(公告)号：US20160262653A1

公开(公告)日：2016-09-15

申请号：US15044842

申请日：2016-02-16

申请人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

发明人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

IPC分类号： A61B5/053 ,  A61N1/37 ,  A61B5/0215 ,  A61N1/365 ,  A61N1/05 ,  A61B5/029

CPC分类号： A61B5/0538 ,  A61B5/0215 ,  A61B5/029 ,  A61N1/056 ,  A61N1/36125 ,  A61N1/36521 ,  A61N1/3706

摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

公开(公告)号：US20130023946A1

公开(公告)日：2013-01-24

申请号：US13425119

申请日：2012-03-20

申请人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

发明人： Jonathan W. Valvano ,  Marc D. Feldman ,  John Porterfield ,  John A. Pearce ,  Erik Larson ,  Lev Shuhatovich ,  Kathryn Loeffler ,  Raffaele Cetrulo

IPC分类号： A61N1/365

CPC分类号： A61B5/0538 ,  A61B5/0215 ,  A61B5/029 ,  A61N1/056 ,  A61N1/36125 ,  A61N1/36521 ,  A61N1/3706

摘要： An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

摘要翻译： 用于测量动物或人类患者中的复电导纳和/或复电阻抗的装置包括第一电极和适于设置在患者体内的至少第二电极。 该装置包括适于设置在患者体内的壳体。 壳体设置有与至少第一电极电连通的刺激器，以用电流或电压来刺激第一电极，传感器至少与第二电极电连通，以基于第二电极感测来自第二电极的响应 对第一电极的刺激以及与传感器电通信的信号处理器，以确定患者的复杂电导纳或阻抗。

公开(公告)号：US20120150252A1

公开(公告)日：2012-06-14

申请号：US13373850

申请日：2011-12-02

申请人： Marc D. Feldman ,  John Porterfield ,  Erik Larson ,  Jonathan W. Valvano ,  John A. Pearce

发明人： Marc D. Feldman ,  John Porterfield ,  Erik Larson ,  Jonathan W. Valvano ,  John A. Pearce

IPC分类号： A61N1/365 ,  A61N1/362

CPC分类号： A61N1/36571 ,  A61B5/0538 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： An apparatus for treating a heart of a patient includes a first lead and at least a second lead for pacing the heart adapted to be in electrical communication with the heart. The apparatus includes a microcontroller in communication with the first and second leads which triggers the first lead at either different times or the same time from when the microcontroller triggers the second lead. Alternatively, the apparatus includes a microcontroller in communication with the first and second leads that determines heart volume, including stroke volume, end-systolic volume, and calculated values including ejection fraction, from admittance from signals from the first and second leads and uses the admittance as feedback to control heart volume ejected, as measured by stroke volume, calculated values such as ejection fraction, and control end-systolic volume, with respect to the first and second leads. A method for treating the heart of a patient.

摘要翻译： 一种用于治疗患者心脏的装置包括第一引线和至少第二引线，用于起搏适于与心脏电连通的心脏。 该装置包括与第一和第二引线通信的微控制器，其在微控制器触发第二引线的不同时间或同时触发第一引线。 或者，该装置包括与第一和第二引线通信的微控制器，其从来自第一和第二引线的信号的导纳确定心脏体积，包括笔画体积，收缩末期容积以及包括射血分数的计算值，并使用导纳 作为反馈以控制排出的心脏体积，如通过卒中体积测量的计算值，例如相对于第一和第二引线的射血分数和控制收缩末容积。 一种治疗患者心脏的方法。

公开(公告)号：US10076669B2

公开(公告)日：2018-09-18

申请号：US13373850

申请日：2011-12-02

申请人： Marc D. Feldman ,  John Porterfield ,  Erik Larson ,  Jonathan W. Valvano ,  John A. Pearce

发明人： Marc D. Feldman ,  John Porterfield ,  Erik Larson ,  Jonathan W. Valvano ,  John A. Pearce

IPC分类号： A61N1/365 ,  A61B5/053 ,  A61N1/368

CPC分类号： A61N1/36571 ,  A61B5/0538 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： An apparatus for treating a heart of a patient includes a first lead and at least a second lead for pacing the heart adapted to be in electrical communication with the heart. The apparatus includes a microcontroller in communication with the first and second leads which triggers the first lead at either different times or the same time from when the microcontroller triggers the second lead. Alternatively, the apparatus includes a microcontroller in communication with the first and second leads that determines heart volume, including stroke volume, end-systolic volume, and calculated values including ejection fraction, from admittance from signals from the first and second leads and uses the admittance as feedback to control heart volume ejected, as measured by stroke volume, calculated values such as ejection fraction, and control end-systolic volume, with respect to the first and second leads. A method for treating the heart of a patient.

公开(公告)号：US20230038471A1

公开(公告)日：2023-02-09

申请号：US17962451

申请日：2022-10-07

申请人： Jonathan W. Valvano ,  John A. Pearce ,  Marc D. Feldman ,  Kaarthik Rajendran ,  John Porterfield ,  Anil Kottam ,  Wes Johnson

发明人： Jonathan W. Valvano ,  John A. Pearce ,  Marc D. Feldman ,  Kaarthik Rajendran ,  John Porterfield ,  Anil Kottam ,  Wes Johnson

IPC分类号： A61N1/365 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/00 ,  A61N1/362 ,  G16H40/63 ,  A61N1/05

摘要： An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.

公开(公告)号：US20190298997A1

公开(公告)日：2019-10-03

申请号：US16316548

申请日：2017-07-12

申请人： Jonathan W. Valvano ,  John A. Pearce ,  Marc D. Feldman ,  Kaarthik Rajendran ,  John Porterfield ,  Anil Kottam ,  Wes Johnson

发明人： Jonathan W. Valvano ,  John A. Pearce ,  Marc D. Feldman ,  Kaarthik Rajendran ,  John Porterfield ,  Anil Kottam ,  Wes Johnson

IPC分类号： A61N1/365 ,  A61B5/0205 ,  A61B5/053 ,  A61B5/00 ,  A61N1/05 ,  A61N1/362 ,  G16H40/63

摘要： An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.

公开(公告)号：US11478646B2

公开(公告)日：2022-10-25

申请号：US16316548

申请日：2017-07-12

申请人： Jonathan W. Valvano ,  John A. Pearce ,  Marc D. Feldman ,  Kaarthik Rajendran ,  John Porterfield ,  Anil Kottam ,  Wes Johnson

发明人： Jonathan W. Valvano ,  John A. Pearce ,  Marc D. Feldman ,  Kaarthik Rajendran ,  John Porterfield ,  Anil Kottam ,  Wes Johnson

IPC分类号： A61N1/36 ,  A61N1/365 ,  G16H40/63 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/00 ,  A61N1/05 ,  A61N1/362 ,  A61B5/029 ,  A61B5/08

摘要： An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.