公开(公告)号：US20120264735A1

公开(公告)日：2012-10-18

申请号：US13517321

申请日：2010-12-14

申请人： Jonathan Young ,  Barbara Czako ,  Michael Altman ,  David Guerin ,  Michelle Martinez ,  Alexey Rivkin ,  Kevin Wilson ,  Kathryn Lipford ,  Catherine White ,  Laura Surdi ,  Stephanie Chichetti ,  Matthew H. Daniels ,  Sean P. Ahearn ,  Danielle Falcone ,  Ekundayo Osimboni

发明人： Jonathan Young ,  Barbara Czako ,  Michael Altman ,  David Guerin ,  Michelle Martinez ,  Alexey Rivkin ,  Kevin Wilson ,  Kathryn Lipford ,  Catherine White ,  Laura Surdi ,  Stephanie Chichetti ,  Matthew H. Daniels ,  Sean P. Ahearn ,  Danielle Falcone ,  Ekundayo Osimboni

IPC分类号： A61K31/501 ,  A61K31/506 ,  C07D413/12 ,  A61P35/00 ,  C07D413/14 ,  C07D417/14 ,  A61K31/541 ,  C07D403/04 ,  A61K31/5377

CPC分类号： C07D403/04 ,  C07D237/14 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04

摘要： The present invention relates to pyridazin-4(1H)-one derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

摘要翻译： 本发明涉及哒嗪-4（1H） - 酮衍生物，其可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病，以及用于抑制受体酪氨酸激酶MET。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

公开(公告)号：US08367706B2

公开(公告)日：2013-02-05

申请号：US12665045

申请日：2008-06-16

申请人： Michael Altman ,  Matthew Christopher ,  Jonathan B. Grimm ,  Andrew Haidle ,  Kaleen Konrad ,  Jongwon Lim ,  Rachel N. MacCoss ,  Michelle Machacek ,  Ekundayo Osimboni ,  Ryan D. Otte ,  Tony Siu ,  Kerrie Spencer ,  Brandon Taoka ,  Paul Tempest ,  Kevin Wilson ,  Hyun Chong Woo ,  Jonathan Young ,  Anna Zabierek

发明人： Michael Altman ,  Matthew Christopher ,  Jonathan B. Grimm ,  Andrew Haidle ,  Kaleen Konrad ,  Jongwon Lim ,  Rachel N. MacCoss ,  Michelle Machacek ,  Ekundayo Osimboni ,  Ryan D. Otte ,  Tony Siu ,  Kerrie Spencer ,  Brandon Taoka ,  Paul Tempest ,  Kevin Wilson ,  Hyun Chong Woo ,  Jonathan Young ,  Anna Zabierek

IPC分类号： A61K31/4436 ,  C07D409/12

CPC分类号： C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/10 ,  C07F9/65586 ,  C07F9/65685

摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

公开(公告)号：US20100256097A1

公开(公告)日：2010-10-07

申请号：US12665045

申请日：2008-06-16

申请人： Michael Altman ,  Matthew Christopher ,  Jonathan B. Grimm ,  Andrew Haidle ,  Kaleen Konrad ,  Jongwon Lim ,  Rachel N. MacCoss ,  Michelle Machacek ,  Ekundayo Osimboni ,  Ryan D. Otte ,  Tony Siu ,  Kerrie Spencer ,  Brandon Taoka ,  Paul Tempest ,  Kevin Wilson ,  Hyan Chong Woo ,  Jonathan Young ,  Anna Zabierek

发明人： Michael Altman ,  Matthew Christopher ,  Jonathan B. Grimm ,  Andrew Haidle ,  Kaleen Konrad ,  Jongwon Lim ,  Rachel N. MacCoss ,  Michelle Machacek ,  Ekundayo Osimboni ,  Ryan D. Otte ,  Tony Siu ,  Kerrie Spencer ,  Brandon Taoka ,  Paul Tempest ,  Kevin Wilson ,  Hyan Chong Woo ,  Jonathan Young ,  Anna Zabierek

IPC分类号： A61K31/675 ,  C07D409/14 ,  A61K31/4439 ,  A61K31/4436 ,  C07D413/14 ,  A61K31/5377 ,  C07D409/12 ,  A61K31/501 ,  C07F9/28 ,  C07D417/14 ,  A61K31/541

CPC分类号： C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/10 ,  C07F9/65586 ,  C07F9/65685

摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.