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公开(公告)号：US20120264735A1
公开(公告)日：2012-10-18
申请号：US13517321
申请日：2010-12-14
申请人： Jonathan Young , Barbara Czako , Michael Altman , David Guerin , Michelle Martinez , Alexey Rivkin , Kevin Wilson , Kathryn Lipford , Catherine White , Laura Surdi , Stephanie Chichetti , Matthew H. Daniels , Sean P. Ahearn , Danielle Falcone , Ekundayo Osimboni
发明人： Jonathan Young , Barbara Czako , Michael Altman , David Guerin , Michelle Martinez , Alexey Rivkin , Kevin Wilson , Kathryn Lipford , Catherine White , Laura Surdi , Stephanie Chichetti , Matthew H. Daniels , Sean P. Ahearn , Danielle Falcone , Ekundayo Osimboni
IPC分类号： A61K31/501 , A61K31/506 , C07D413/12 , A61P35/00 , C07D413/14 , C07D417/14 , A61K31/541 , C07D403/04 , A61K31/5377
CPC分类号： C07D403/04 , C07D237/14 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04
摘要： The present invention relates to pyridazin-4(1H)-one derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及哒嗪-4（1H） - 酮衍生物，其可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病，以及用于抑制受体酪氨酸激酶MET。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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2.发明申请GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 有权作为JANUS KINASE抑制剂的GEMYALLY取代的氰基乙基吡唑啉吡啶公开(公告)号：US20160272632A1
公开(公告)日：2016-09-22
申请号：US14778046
申请日：2014-03-19
申请人： Matthew Lloyd CHILDERS , Peter FULLER , David GUERIN , Jason David KATZ , Qinglin PU , Mark E. SCOTT , Christopher E. THOMPSON , Michelle MARTINEZ , Danielle FALCONE , Luis TORRES , Yongqi DENG , Ravi KURUKULASURIYA , Hongbo ZENG , Yunfeng BAI , Norman KONG , Yumei LIU , MERCK SHARP & DOHME CORP.
发明人： Matthew Lloyd Childers , Peter Fuller , David Guerin , Jason David Katz , Qinglin Pu , Mark E. Scott , Christopher F. Thompson , Michelle Martinez , Danielle Falcone , Luis Torres , Yongqi Deng , Ravi Kurukulasuriya , Hongbo Zeng , Yunfeng Bai , Norman Kong , Yumei Liu , Zhixiang Zheng
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为JAK抑制剂的式（I）化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。
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公开(公告)号：US20160272634A1
公开(公告)日：2016-09-22
申请号：US14778055
申请日：2014-03-19
申请人： Christopher DINSMORE , Peter FULLER , David GUERIN , Jason David KATZ , Christopher F. THOMPSON , Danielle FALCONE , Wei DENG , Luis TORRES , Hongbo ZENG , Yunfeng BAI , Jianmin FU , Norman KONG , Yumei LIU , Zhixiang ZHENG , Mark E. SCOTT , MERCK SHARP & DOHME CORP.
发明人： Christopher Dinsmore , Peter Fuller , David Guerin , Jason David Katz , Christopher F. Thompson , Danielle Falcone , Wei Deng , Luis Torres , Hongbo Zeng , Yunfeng Bai , Jianmin Fu , Norman Kong , Yumei Liu , Zhixiang Zheng , Mark E. Scott
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。
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4.发明申请N-(2-CYANO HETEROCYCLYL) PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 有权N-（2-氰基杂环基）吡唑并吡喃酮作为甘薯激酶抑制剂公开(公告)号：US20160272633A1
公开(公告)日：2016-09-22
申请号：US14778052
申请日：2014-03-19
申请人： Christopher DINSMORE , Peter FULLER , David GUERIN , Christopher F. THOMPSON , Qinglin PU , Mark E. SCOTT , Jason David KATZ , Ravi KURUKLASURIYA , Joshua T. CLOSE , Danielle FALCONE , Jason BRUDAKER , Hongbo ZENG , Yunfeng BAI , Jianmin FU , Norman KONG , Yumei LIU , Zhixiang ZHENG , MERCK SHARP & DOHME CORP.
发明人： Christopher Dinsmore , Peter Fuller , David Guerin , Christopher F. Thompson , Qinglin Pu , Mark E. Scott , Jason David Katz , Ravi Kuruklasuriya , Joshua T. Close , Danielle Falcone , Jason Brubaker , Hongbo Zeng , Yunfeng Bai , Jianmin Fu , Norman Kong , Yumei Liu , Zhixiang Zheng
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.
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5.发明申请CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS 有权甘氨酸激酶抑制剂CYCLOALKYL NITRILE PYRAZOLO PYRIDONES公开(公告)号：US20160280704A1
公开(公告)日：2016-09-29
申请号：US14778019
申请日：2014-03-19
申请人： Matthew Lloyd Childers , Christopher Dinsmore , Peter Fuller , David Guerin , Jason David Katz , Qinglin Pu , Mark E. Scott , Christopher F. Thompson , Hongjun Zhang , Danielle Falcone , Luis Torres , Jason Brubaker , Hongbo Zeng , Jiaqiang Cai , Xiaoxing Du , Chonggang Wang , Yunfeng Bai , Norman Kong , Yumei Liu , Zhixiang Zheng , Merck Sharp & Dohme Corp.
发明人： Matthew Lloyd Childers , Christopher Dinsmore , Peter Fuller , David Guerin , Jason David Katz , Qinglin Pu , Mark E. Scott , Christopher F. Thompson , Hongjun Zhang , Danielle Falcone , Luis Torres , Jason Brubaker , Hongbo Zeng , Jiaqiang Cai , Xiaoxing Du , Chonggang Wang , Yunfeng Bai , Norman Kong , Yumei Liu , Zhixiang Zheng
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
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公开(公告)号：US20060293358A1
公开(公告)日：2006-12-28
申请号：US11473273
申请日：2006-06-22
申请人： Christopher Dinsmore , Ana Gabarda Ortega , David Guerin , James Jewell , Jason Katz , Jongwon Lim , Michelle Machacek , Ryan Otte , Jonathan Young
发明人： Christopher Dinsmore , Ana Gabarda Ortega , David Guerin , James Jewell , Jason Katz , Jongwon Lim , Michelle Machacek , Ryan Otte , Jonathan Young
IPC分类号： A61K31/473 , C07D221/02
CPC分类号： C07D471/04 , C07D221/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/10 , C07D491/113 , C07F7/1804
摘要： The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US08637119B2
公开(公告)日：2014-01-28
申请号：US12810718
申请日：2008-12-22
IPC分类号： B05D3/02
CPC分类号： C08J7/14 , B05D7/52 , C08J5/18 , C08J2329/04 , D21H19/20 , D21H19/32 , Y10T428/265 , Y10T428/31855 , Y10T428/3188
摘要： Film having liquid-water, grease, gas and water-vapor barrier properties, comprising a PVA film grafted on the surface with a fatty acid.
摘要翻译： 具有液态水，油脂，气体和水蒸气阻隔性的膜，其包含在表面上与脂肪酸接枝的PVA膜。
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公开(公告)号：US10207287B2
公开(公告)日：2019-02-19
申请号：US13885262
申请日：2011-11-16
IPC分类号： B05D3/00 , B05C9/12 , C08J7/14 , D21H17/06 , D21H17/11 , D21H17/14 , D21H21/16 , D21H25/02 , D21H25/04
摘要： The invention relates to a machine for chromatogenous grafting treatment of a scrolling substrate (S) having a hydroxylated face (Fh), comprising: an application device (3) of a grafting reagent on the hydroxylated face (Fh) of the substrate, a heating roller (4) for the development of the grafting reaction on the hydroxylated face (Fh) of the substrate, said roller (4) being provided with a bar-end system (5a, 5b) for applying a face of the substrate (S) against said heating roller (4), an extraction device (6) of the hydrochloric acid produced during the grafting reaction, an application device (7) of an air knife on the treated face of the substrate for eliminating the residual grafting reagent. The invention also relates to a chromatogenous grafting process used in said machine.
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9.发明申请MACHINE AND TREATMENT PROCESS VIA CHROMATOGENOUS GRAFTING OF A HYDROXYLATED SUBSTRATE 审中-公开机械和处理方法通过羟基化的底物的色谱法公开(公告)号：US20130236647A1
公开(公告)日：2013-09-12
申请号：US13885262
申请日：2011-11-16
CPC分类号： B05C9/12 , B05D3/007 , C08J7/14 , C08J2301/02 , D21H17/06 , D21H17/11 , D21H17/14 , D21H21/16 , D21H25/02 , D21H25/04
摘要： The invention relates to a machine for chromatogenous grafting treatment of a scrolling substrate (S) having a hydroxylated face (Fh), comprising: an application device (3) of a grafting reagent on the hydroxylated face (Fh) of the substrate, a heating roller (4) for the development of the grafting reaction on the hydroxylated face (Fh) of the substrate, said roller (4) being provided with a bar-end system (5a, 5b) for applying a face of the substrate (S) against said heating roller (4), an extraction device (6) of the hydrochloric acid produced during the grafting reaction, an application device (7) of an air knife on the treated face of the substrate for eliminating the residual grafting reagent. The invention also relates to a chromatogenous grafting process used in said machine.
摘要翻译： 本发明涉及一种用于对具有羟基化面（Fh）的滚动衬底（S）进行染色体接枝处理的机器，包括：在所述衬底的羟基化面（Fh）上的接枝剂的施加装置（3），加热 用于在基材的羟基化面（Fh）上开发接枝反应的辊（4），所述辊（4）设置有用于施加基材（S）的表面的棒端系统（5a，5b） 在接枝反应过程中产生的盐酸的提取装置（6），用于消除残余接枝试剂的基板处理面上的气刀施加装置（7）的加热辊（4）。 本发明还涉及用于所述机器中的染色体接枝方法。
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公开(公告)号：US20060020016A1
公开(公告)日：2006-01-26
申请号：US11078147
申请日：2005-03-11
申请人： Gerald Tanoury , Minzhang Chen , Andrew Jones , Philip Nyce , Martin Trudeau , David Guerin , John Snoonian
发明人： Gerald Tanoury , Minzhang Chen , Andrew Jones , Philip Nyce , Martin Trudeau , David Guerin , John Snoonian
IPC分类号： A61K31/4025 , C07D405/02
CPC分类号： C07D207/16 , C07D209/52 , C07D211/60 , C07D405/12 , C07D417/06 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
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