公开(公告)号：US20090156917A1

公开(公告)日：2009-06-18

申请号：US11957610

申请日：2007-12-17

申请人： Jorg Martini ,  Jeffrey Roe ,  Peter Kiesel ,  Michael Bassler ,  Alan Bell ,  Richard H. Bruce ,  Noble M. Johnson

发明人： Jorg Martini ,  Jeffrey Roe ,  Peter Kiesel ,  Michael Bassler ,  Alan Bell ,  Richard H. Bruce ,  Noble M. Johnson

IPC分类号： A61B5/00

CPC分类号： A61B5/1459 ,  A61B5/14532 ,  G01N21/03 ,  G01N21/39 ,  G01N21/8507

摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.

摘要翻译： 诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。 该产品还可以包括流体组件，例如过滤器组件，其控制影响或移动光谱特征或特性的物体的转移，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中等强度宽度， 作为全宽半最大值（FWHM）。 分析物，例如 葡萄糖分子可以主要包括在一组物体中，其比其它物体更快地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。 因此，来自容器的输出光包括关于分析物的信息。

公开(公告)号：US08320983B2

公开(公告)日：2012-11-27

申请号：US11957610

申请日：2007-12-17

申请人： Joerg Martini ,  Jeffrey Roe ,  Peter Kiesel ,  Michael Bassler ,  Alan Bell ,  Richard H. Bruce ,  Noble M. Johnson

发明人： Joerg Martini ,  Jeffrey Roe ,  Peter Kiesel ,  Michael Bassler ,  Alan Bell ,  Richard H. Bruce ,  Noble M. Johnson

IPC分类号： A61B5/1455

CPC分类号： A61B5/1459 ,  A61B5/14532 ,  G01N21/03 ,  G01N21/39 ,  G01N21/8507

摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.

摘要翻译： 诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。 该产品还可以包括流体组件，例如过滤器组件，其控制影响或移动光谱特征或特性的物体的转移，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中等强度宽度， 作为全宽半最大值（FWHM）。 分析物，例如 葡萄糖分子可以主要包括在一组物体中，其比其它物体更快地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。 因此，来自容器的输出光包括关于分析物的信息。

公开(公告)号：US20110082353A1

公开(公告)日：2011-04-07

申请号：US12968115

申请日：2010-12-14

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

IPC分类号： A61B5/00

CPC分类号： G01N21/03 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/31

摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.

摘要翻译： 可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。 第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。 第二部分包括封闭的容器并且包含参考流体。 可植入产品还可以包括光源组件和感光组件中的一个或两个。 可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。 两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

公开(公告)号：US08040526B2

公开(公告)日：2011-10-18

申请号：US12968115

申请日：2010-12-14

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

IPC分类号： G01B9/02

CPC分类号： G01N21/03 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/31

摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.

摘要翻译： 可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。 第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。 第二部分包括封闭的容器并且包含参考流体。 可植入产品还可以包括光源组件和感光组件中的一个或两个。 可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。 两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

公开(公告)号：US07852490B2

公开(公告)日：2010-12-14

申请号：US11702329

申请日：2007-02-05

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

IPC分类号： G01B9/02

CPC分类号： G01N21/03 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/31

摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.

摘要翻译： 可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。 第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。 第二部分包括封闭的容器并且包含参考流体。 可植入产品还可以包括光源组件和感光组件中的一个或两个。 可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。 两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

公开(公告)号：US20080186483A1

公开(公告)日：2008-08-07

申请号：US11702329

申请日：2007-02-05

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

IPC分类号： G01N1/10

CPC分类号： G01N21/03 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/31

摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.

摘要翻译： 可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。 第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。 第二部分包括封闭的容器并且包含参考流体。 可植入产品还可以包括光源组件和感光组件中的一个或两个。 可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。 两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

公开(公告)号：US20100157291A1

公开(公告)日：2010-06-24

申请号：US12337796

申请日：2008-12-18

申请人： Peter Kiesel ,  Markus Beck ,  Michael Bassler ,  Noble M. Johnson

发明人： Peter Kiesel ,  Markus Beck ,  Michael Bassler ,  Noble M. Johnson

IPC分类号： G01N21/01

CPC分类号： G01N15/1429 ,  G01N15/1459 ,  G01N21/532 ,  G01N21/645 ,  G01N21/65 ,  G01N2015/1075

摘要： Sensors can be used to obtain encoded sensing results from objects that have nonuniform relative motion. A photosensor or impedance-based sensor, for example, can obtain sensing results from objects that have relative motion within a sensing region relative to the sensor, with the relative motion being, for example, periodically varying, randomly varying, chirp-varying, or modulated relative motion that completes at least one modulation cycle within the sensing region. Relative motion can be caused by varying objects' speed and/or direction or by controlling flow of fluid carrying objects, movement of a channel, movement of a support structure, movement of a sensor, and/or pattern movement. A fluidic implementation can include shaped channel wall parts and/or a displacement component causing time-varying lateral displacement. A support structure implementation can include a scanner device and a rotary device that respectively control scanning and rotating movement of a movable support structure or of a sensor.

摘要翻译： 传感器可用于从具有不均匀相对运动的物体获得编码的感测结果。 例如，光传感器或基于阻抗的传感器可以从相对于传感器的感测区域内具有相对运动的物体获得感测结果，相对运动例如是周期性变化的，随机变化的线性调频脉冲变化或 调制的相对运动，其在感测区域内完成至少一个调制周期。 可以通过改变物体的速度和/或方向或通过控制流体携带物体的流动，通道的移动，支撑结构的运动，传感器的运动和/或图案运动来引起相对运动。 流体实现可以包括形成通道壁部分和/或引起时变横向位移的位移部件。 支撑结构实现可以包括分别控制可移动支撑结构或传感器的扫描和旋转运动的扫描器装置和旋转装置。

公开(公告)号：US20090195852A1

公开(公告)日：2009-08-06

申请号：US12025394

申请日：2008-02-04

申请人： Michael Bassler ,  Peter Kiesel ,  Markus Beck ,  Alex Hegyi ,  Tobias Buergel ,  Noble M. Johnson

发明人： Michael Bassler ,  Peter Kiesel ,  Markus Beck ,  Alex Hegyi ,  Tobias Buergel ,  Noble M. Johnson

IPC分类号： G02F1/01

CPC分类号： G01N21/645 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/53 ,  G01N21/6486 ,  G01N2021/0346 ,  G01N2021/6421 ,  G01N2021/6471

摘要： A transmissive and/or reflective optical filter can receive input light, which can emanate from objects traveling along paths past the filter, e.g. from biological cells, viruses, colored spots or other markings on documents, and so forth. In response, the filter can provide output light in accordance with a combined transmission function that is approximately equal to a superposition or scaled superposition of a set of simpler transmission functions. The set can include two or more non-uniform transmission functions, a subset of which can be different from each other and positioned relative to each other so that the output light has time variation in accordance with each of the functions in the subset. The subset could include, for example, a random function and a periodic function, a chirp function and a periodic function, or any other suitable combination of two or more simpler functions.

摘要翻译： 透射和/或反射光学滤光器可以接收输入光，其可以从沿着过滤器的路径行进的物体发射，例如， 来自生物细胞，病毒，彩色斑点或文件上的其他标记等等。 作为响应，滤波器可以根据组合传输函数提供输出光，其大致等于一组更简单的传输函数的叠加或缩放叠加。 该集合可以包括两个或多个非均匀传输函数，其子集可以彼此不同并且相对于彼此定位，使得输出光具有根据子集中的每个功能的时间变化。 子集可以包括例如随机函数和周期函数，啁啾函数和周期函数，或两个或更多个更简单函数的任何其它合适的组合。

公开(公告)号：US08263955B2

公开(公告)日：2012-09-11

申请号：US12337796

申请日：2008-12-18

申请人： Peter Kiesel ,  Markus Beck ,  Michael Bassler ,  Noble M. Johnson

发明人： Peter Kiesel ,  Markus Beck ,  Michael Bassler ,  Noble M. Johnson

IPC分类号： G01N21/55 ,  G01N21/25 ,  G01N21/00

CPC分类号： G01N15/1429 ,  G01N15/1459 ,  G01N21/532 ,  G01N21/645 ,  G01N21/65 ,  G01N2015/1075

摘要： Sensors can be used to obtain encoded sensing results from objects that have nonuniform relative motion. A photosensor or impedance-based sensor, for example, can obtain sensing results from objects that have relative motion within a sensing region relative to the sensor, with the relative motion being, for example, periodically varying, randomly varying, chirp-varying, or modulated relative motion that completes at least one modulation cycle within the sensing region. Relative motion can be caused by varying objects' speed and/or direction or by controlling flow of fluid carrying objects, movement of a channel, movement of a support structure, movement of a sensor, and/or pattern movement. A fluidic implementation can include shaped channel wall parts and/or a displacement component causing time-varying lateral displacement. A support structure implementation can include a scanner device and a rotary device that respectively control scanning and rotating movement of a movable support structure or of a sensor.

摘要翻译： 传感器可用于从具有不均匀相对运动的物体获得编码的感测结果。 例如，光传感器或基于阻抗的传感器可以从相对于传感器的感测区域内具有相对运动的物体获得感测结果，相对运动例如是周期性变化的，随机变化的线性调频脉冲变化或 调制的相对运动，其在感测区域内完成至少一个调制周期。 可以通过改变物体的速度和/或方向或通过控制流体携带物体的流动，通道的移动，支撑结构的运动，传感器的运动和/或图案运动来引起相对运动。 流体实现可以包括形成通道壁部分和/或引起时变横向位移的位移部件。 支撑结构实现可以包括分别控制可移动支撑结构或传感器的扫描和旋转运动的扫描器装置和旋转装置。

公开(公告)号：US08153950B2

公开(公告)日：2012-04-10

申请号：US12337771

申请日：2008-12-18

申请人： Peter Kiesel ,  Markus Beck ,  Joerg Martini ,  Michael Bassler ,  Noble M. Johnson

发明人： Peter Kiesel ,  Markus Beck ,  Joerg Martini ,  Michael Bassler ,  Noble M. Johnson

IPC分类号： G01J1/42 ,  F21V9/16 ,  G01N21/25

CPC分类号： G01J3/2803 ,  G01J3/02 ,  G01J3/027 ,  G01N15/12 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1075 ,  G01N2021/1734

摘要： An encoder/sensor can obtain sensing results from objects in an encoding/sensing region; a trigger detector can respond to objects in a trigger detection region, providing respective trigger signals; and a relative motion component can cause relative motion of objects into the trigger detection region, from it into the encoding/sensing region, and within the encoding/sensing region. In response to an object's trigger signal, control circuitry can cause the encoder/sensor and/or the relative motion component to operate so that the encoder/sensor obtains sensing results indicating a time-varying waveform and processing circuitry can obtain data from the sensing results indicating a time-varying waveform. The time-varying waveform can include information resulting from the relative motion within the encoding/sensing region. The encoder/sensor and trigger detector can be implemented, for example, with discrete components or as sets of cells in a photosensing array on an integrated circuit.

摘要翻译： 编码器/传感器可以从编码/感测区域中的对象获得感测结果; 触发检测器可以响应触发检测区域中的对象，提供相应的触发信号; 并且相对运动分量可以引起物体进入触发检测区域的相对运动，从而进入编码/感测区域，并且在编码/感测区域内。 响应于物体的触发信号，控制电路可以使编码器/传感器和/或相对运动分量运行，使得编码器/传感器获得指示时变波形的感测结果，并且处理电路可以从感测结果获得数据 表示时变波形。 时变波形可以包括由编码/感测区域内的相对运动产生的信息。 编码器/传感器和触发检测器可以例如利用集成电路中的光敏阵列中的分立组件或单元组来实现。