公开(公告)号：US20070220147A1

公开(公告)日：2007-09-20

申请号：US11674196

申请日：2007-02-13

申请人： Joseph Armstrong ,  Shu-Ching Hsu ,  Mark Johnston ,  Rahul Kelkar ,  Judy King ,  Brian Kress ,  Radhika Pennepalli ,  Kesava Pulijala ,  Guangji Shen ,  Pushkar Singh ,  Keven Stoner ,  Rajendran Vishwanathan

发明人： Joseph Armstrong ,  Shu-Ching Hsu ,  Mark Johnston ,  Rahul Kelkar ,  Judy King ,  Brian Kress ,  Radhika Pennepalli ,  Kesava Pulijala ,  Guangji Shen ,  Pushkar Singh ,  Keven Stoner ,  Rajendran Vishwanathan

IPC分类号： G06F15/173

CPC分类号： G06F9/5027 ,  G06F9/52 ,  G06F2209/5014 ,  H04L67/1002 ,  H04L67/1023

摘要： A method for provisioning servers in a computer arrangement allows more than one administrator to utilize the servers and prevents the servers from being influenced by more than one administrator at the same time. The computer arrangement includes at least one server, at least one administrator operable to control the usage of the servers by making provisioning decisions, and a deployment server operable to provision the servers according to the provisioning decisions of the administrators. An administrator is required to exclusively reserve the server before the administration unit can use the server. This prevents the server from being used by two or more interfering administrators, meanwhile allowing a flexible assignment between servers and administrators.

摘要翻译： 用于在计算机装置中配置服务器的方法允许多个管理员利用服务器并且防止服务器同时受到多个管理员的影响。 计算机装置包括至少一个服务器，至少一个管理员，可操作以通过做出供应决定来控制服务器的使用;以及部署服务器，其可操作以根据管理员的供应决定来配置服务器。 在管理单位可以使用服务器之前，需要管理员专门保留服务器。 这样可以防止服务器被两个或更多的干扰管理员使用，同时允许服务器和管理员之间的灵活分配。

公开(公告)号：US20070208844A1

公开(公告)日：2007-09-06

申请号：US11685485

申请日：2007-03-13

申请人： Joseph Armstrong ,  Shu-Ching Hsu ,  Mark Johnston ,  Rahul Kelkar ,  Judy King ,  Brian Kress ,  Radhika Pennepalli ,  Kesava Pulijala ,  Guangji Shen ,  Pushkar Singh ,  Kevin Stoner ,  Rajendran Vishwanathan

发明人： Joseph Armstrong ,  Shu-Ching Hsu ,  Mark Johnston ,  Rahul Kelkar ,  Judy King ,  Brian Kress ,  Radhika Pennepalli ,  Kesava Pulijala ,  Guangji Shen ,  Pushkar Singh ,  Kevin Stoner ,  Rajendran Vishwanathan

IPC分类号： G06F15/173

CPC分类号： G06F9/505 ,  G06F9/4843 ,  G06F9/50 ,  G06F2209/508 ,  H04L41/0896 ,  H04L67/1002 ,  H04L67/1008 ,  H04L67/16 ,  H04L67/42

摘要： A computer arrangement for providing services to clients over a network includes: at least two servers, each server hosting at least one application, an automated administrator configured to automatically provision the servers to provide the services, and at least one network load balancer connected to the clients and the servers. The network load balancer is responsible for at least one of the services and is configured to gather state information on the state of the servers and/or the applications hosted on the servers and is operable to route incoming requests of clients to at least one of the servers. The network load balancer provides the automated administrator with the state information. The automated administrator provides the network load balancer with provisioning information regarding which servers are provisioned to provide the at least one service for which the network load balancer is responsible.

摘要翻译： 用于通过网络向客户端提供服务的计算机装置包括：至少两个服务器，托管至少一个应用的每个服务器，被配置为自动配置服务器以提供服务的自动管理器，以及至少一个网络负载平衡器 客户端和服务器。 所述网络负载平衡器负责所述服务中的至少一个，并且被配置为收集关于所述服务器和/或所述服务器上托管的应用的状态的状态信息，并且可操作地将客户端的传入请求路由到所述服务器中的至少一个 服务器 网络负载平衡器为自动管理员提供状态信息。 自动管理员为网络负载平衡器提供关于哪些服务器被配置以提供网络负载均衡器负责的至少一个服务的供应信息。

公开(公告)号：US20050268153A1

公开(公告)日：2005-12-01

申请号：US11101720

申请日：2005-04-07

申请人： Joseph Armstrong ,  Shu-Ching Hsu ,  Miriyala Sreekanth

发明人： Joseph Armstrong ,  Shu-Ching Hsu ,  Miriyala Sreekanth

IPC分类号： G06F11/00 ,  G06F11/07 ,  G06F15/177

CPC分类号： G06F11/0709 ,  G06F11/0793 ,  G06F11/1425 ,  G06F11/1482 ,  H04L43/0811 ,  H04L43/10

摘要： In a cluster system comprising at least two nodes connected via a communication network and having a name and a host weight assigned to it, a method is implemented comprising the steps of inspecting the communication link, determining which node has to be shut down after a failure, creating an advertisement report for the node to be shut down, sending the advertisement report to at least one node of the cluster system, calculating a delay time depending on the weight of the first node and sending the shut down command to the node for which a failure report was received. In one embodiment of the invention the advertisement reports include a master node, which allows identifying and specifying the surviving subcluster. The method will send shut down signals to those nodes of a subcluster with lower weight than the surviving subcluster. A failsafe mechanism is implemented.

摘要翻译： 在包括通过通信网络连接并具有分配给它的名称和主机权重的至少两个节点的集群系统中，实现一种方法，包括检查通信链路的步骤，确定哪个节点必须在故障之后被关闭 创建关闭节点的广告报告，将广告报告发送给集群系统的至少一个节点，根据第一个节点的权重计算延迟时间，并向其节点发送关闭命令， 收到失败报告。 在本发明的一个实施例中，广告报告包括主节点，其允许识别和指定幸存子集群。 该方法将发送关闭信号到具有比剩余子集群更低的权重的子集群的那些节点。 实施故障安全机制。

公开(公告)号：US20120009207A1

公开(公告)日：2012-01-12

申请号：US13107504

申请日：2011-05-13

申请人： Li-Te CHIN ,  Shu-Ching Hsu

发明人： Li-Te CHIN ,  Shu-Ching Hsu

IPC分类号： A61K35/14 ,  A61P37/06

CPC分类号： A61K35/26 ,  A61K38/17 ,  C07K16/2818 ,  C07K2317/34 ,  C07K2317/92 ,  G01N33/505

摘要： The present invention provides a CTLA-4 non-blocking agent of a complete human antibody nature, thus is non-immunogenic in a human. The immunoassay method using such a non-blocking agent measures the CTLA-4 content in a sample of a human subject. The present invention further provides a novel method for isolating human regulatory T cells. The resultant enriched and depleted cellular populations are useful in treating or ameliorating of human diseases.

摘要翻译： 本发明提供了完全人抗体性质的CTLA-4非阻断剂，因此在人体中是非免疫原性的。 使用这种非阻断剂的免疫测定方法测量人受试者样品中的CTLA-4含量。 本发明还提供了一种分离人类调节性T细胞的新方法。 所产生的富含和消耗的细胞群可用于治疗或改善人类疾病。

公开(公告)号：US07892709B2

公开(公告)日：2011-02-22

申请号：US11610510

申请日：2006-12-14

申请人： Chi-Kuang Lai ,  Ju-Yu Lee ,  An-Hsu Lu ,  Shu-Ching Hsu ,  Lu-Kuen Chang

发明人： Chi-Kuang Lai ,  Ju-Yu Lee ,  An-Hsu Lu ,  Shu-Ching Hsu ,  Lu-Kuen Chang

IPC分类号： G02B5/20

CPC分类号： G02B5/201 ,  G02F1/133512 ,  G02F1/133516 ,  G02F2001/133388

摘要： A method of fabricating a color filter substrate is provided. First, a transparent substrate having a display region, a peripheral region and a buffer region is provided. Next, a shielding pattern layer is formed in the peripheral region of the transparent substrate, and a color filter layer is formed in the display region of the transparent substrate. Further, at least one buffer pattern is formed in the buffer region.

摘要翻译： 提供了制造滤色器基板的方法。 首先，提供具有显示区域，周边区域和缓冲区域的透明基板。 接下来，在透明基板的周边区域中形成屏蔽图案层，并且在透明基板的显示区域中形成滤色器层。 此外，在缓冲区域中形成至少一个缓冲图案。

公开(公告)号：US07843811B2

公开(公告)日：2010-11-30

申请号：US11101720

申请日：2005-04-07

申请人： Joseph W. Armstrong ,  Shu-Ching Hsu ,  Sreekanth Miriyala

发明人： Joseph W. Armstrong ,  Shu-Ching Hsu ,  Sreekanth Miriyala

IPC分类号： G01R31/08 ,  G06F11/00

CPC分类号： G06F11/0709 ,  G06F11/0793 ,  G06F11/1425 ,  G06F11/1482 ,  H04L43/0811 ,  H04L43/10

摘要： In a cluster system comprising at least two nodes connected via a communication network and having a name and a host weight assigned to it, a method is implemented comprising the steps of inspecting the communication link, determining which node has to be shut down after a failure, creating an advertisement report for the node to be shut down, sending the advertisement report to at least one node of the cluster system, calculating a delay time depending on the weight of the first node and sending the shut down command to the node for which a failure report was received. In one embodiment of the invention the advertisement reports include a master node, which allows identifying and specifying the surviving subcluster. The method will send shut down signals to those nodes of a subcluster with lower weight than the surviving subcluster. A failsafe mechanism is implemented.

摘要翻译： 在包括通过通信网络连接并具有分配给它的名称和主机权重的至少两个节点的集群系统中，实现一种方法，包括检查通信链路的步骤，确定哪个节点必须在故障之后被关闭 创建关闭节点的广告报告，将广告报告发送给集群系统的至少一个节点，根据第一个节点的权重计算延迟时间，并向其节点发送关闭命令， 收到失败报告。 在本发明的一个实施例中，广告报告包括主节点，其允许识别和指定幸存子集群。 该方法将发送关闭信号到具有比剩余子集群更低的权重的子集群的那些节点。 实施故障安全机制。

公开(公告)号：US20060240006A1

公开(公告)日：2006-10-26

申请号：US11111098

申请日：2005-04-20

申请人： Chishih Chu ,  Li-Te Chin ,  Shu-Ching Hsu

发明人： Chishih Chu ,  Li-Te Chin ,  Shu-Ching Hsu

IPC分类号： G01N33/567 ,  A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2818 ,  C07K2317/21

摘要： In order to provide necessary information for the production of complete human monoclonal antibodies capable of human CD152 (CTLA-4) binding, the primary structures of heavy and light chains have been elucidated. The novel amino acid sequence of identified heavy and light chains are derived from VH3 and Vλ germline genes, respectively. Antibodies comprising such novel structures cause specific binding to soluble recombinant human CD152 as well as to activated human peripheral T cells, where the expression of CD152 has been elevated.

公开(公告)号：US08021860B2

公开(公告)日：2011-09-20

申请号：US12318679

申请日：2009-01-06

申请人： Li-Te Chin ,  Shu-Ching Hsu

发明人： Li-Te Chin ,  Shu-Ching Hsu

IPC分类号： C12P21/04

CPC分类号： G01N33/5052 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2818 ,  C07K2317/73 ,  C07K2317/74 ,  G01N33/505 ,  G01N33/6854 ,  G01N2333/70521

摘要： A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of CDR1, CDR2 and CDR3 that elicit antibodies serving as antagonist, inverse agonist and agonist, respectively. Also provided is a method in the treatment of human peripheral lymphocytes for use in the screening of CD152 ligands that yield pharmacological effects.

摘要翻译： 公开了一种获得给定生理受体的激动剂，拮抗剂和反向激动剂的方法。 对于该方法，使用计算机设计合成免疫原，其在体外对人类含淋巴细胞的细胞群体起作用。 优选的受体是人CD152，特别是分别引发作为拮抗剂，反向激动剂和激动剂的抗体的CDR1，CDR2和CDR3的区域。 还提供了治疗人外周淋巴细胞用于筛选产生药理作用的CD152配体的方法。

公开(公告)号：US20110033895A1

公开(公告)日：2011-02-10

申请号：US12888713

申请日：2010-09-23

申请人： Li-Te CHIN ,  Shu-Ching Hsu

发明人： Li-Te CHIN ,  Shu-Ching Hsu

IPC分类号： C12P21/08

CPC分类号： G01N33/5052 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2818 ,  C07K2317/73 ,  C07K2317/74 ,  G01N33/505 ,  G01N33/6854 ,  G01N2333/70521

摘要： A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of CDR1, CDR2 and CDR3 that elicit antibodies serving as antagonist, inverse agonist and agonist, respectively. Also provided is a method in the treatment of human peripheral lymphocytes for use in the screening of CD152 ligands that yield pharmacological effects.

摘要翻译： 公开了一种获得给定生理受体的激动剂，拮抗剂和反向激动剂的方法。 对于该方法，使用计算机设计合成免疫原，其在体外对人类含淋巴细胞的细胞群体起作用。 优选的受体是人CD152，特别是分别引发作为拮抗剂，反向激动剂和激动剂的抗体的CDR1，CDR2和CDR3的区域。 还提供了治疗人外周淋巴细胞用于筛选产生药理作用的CD152配体的方法。

公开(公告)号：US20090286224A1

公开(公告)日：2009-11-19

申请号：US12318679

申请日：2009-01-06

申请人： Li-Te Chin ,  Shu-Ching Hsu

发明人： Li-Te Chin ,  Shu-Ching Hsu

IPC分类号： C12Q1/70 ,  G01N33/53 ,  C07K7/00 ,  C07K16/28

CPC分类号： G01N33/5052 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/2818 ,  C07K2317/73 ,  C07K2317/74 ,  G01N33/505 ,  G01N33/6854 ,  G01N2333/70521

摘要： A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of CDR1, CDR2 and CDR3 that elicit antibodies serving as antagonist, inverse agonist and agonist, respectively. Also provided is a method in the treatment of human peripheral lymphocytes for use in the screening of CD152 ligands that yield pharmacological effects.

摘要翻译： 公开了一种获得给定生理受体的激动剂，拮抗剂和反向激动剂的方法。 对于该方法，使用计算机设计合成免疫原，其在体外对人类含淋巴细胞的细胞群体起作用。 优选的受体是人CD152，特别是分别引发作为拮抗剂，反向激动剂和激动剂的抗体的CDR1，CDR2和CDR3的区域。 还提供了治疗人外周淋巴细胞用于筛选产生药理作用的CD152配体的方法。