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1.发明申请公开(公告)号：US20080003259A1
公开(公告)日：2008-01-03
申请号：US11480243
申请日：2006-06-30
申请人： Joseph C. Salamone , Yu-Chin Lai , Weihong Lang , Wenyan Yan
发明人： Joseph C. Salamone , Yu-Chin Lai , Weihong Lang , Wenyan Yan
IPC分类号： A61F2/02
摘要： A medical device having an increased surface hydrophilicity comprises a coating polymer comprising units of a polymerizable hydrophilic compound that is attached to the surface of the medical device via the Michael addition reaction. The coating polymer can be applied to a medical device comprising a hydrogel material. The attachment of the coating polymer may be enhanced by increasing the population of the medical-device surface functional groups before contacting the medical device with the coating polymer.
摘要翻译： 具有增加的表面亲水性的医疗装置包括涂覆聚合物，其包含通过迈克尔加成反应附着到医疗装置的表面上的可聚合亲水性化合物的单元。 涂层聚合物可以应用于包含水凝胶材料的医疗装置。 涂层聚合物的附着可以通过在接触医疗器械与涂层聚合物之前增加医疗器械表面官能团的数量来增强。
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公开(公告)号：US07083646B2
公开(公告)日：2006-08-01
申请号：US10187056
申请日：2002-06-28
申请人： Paul L. Valint, Jr. , Joseph A. McGee , Wenyan Yan , Joseph C. Salamone , Daniel M. Ammon, Jr. , Jay F. Kunzler
发明人： Paul L. Valint, Jr. , Joseph A. McGee , Wenyan Yan , Joseph C. Salamone , Daniel M. Ammon, Jr. , Jay F. Kunzler
IPC分类号： A61F2/16
CPC分类号： C08J7/12 , A61F2/14 , A61F2/16 , A61L27/34 , A61L2400/18 , A61L2430/16
摘要： Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.
摘要翻译： 表面改性的医疗装置，例如由一种或多种含官能团的材料形成的眼内透镜植入物，其使用反应性亲水性聚合物，用于减少或消除其上的晶状体上皮细胞生长，减少或消除随后手术暴露时的硅油吸收和/或 本文提供减少或消除植入插入物摩擦。 另外，提供了制造和使用表面改性的眼内透镜植入物的方法。
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3.发明授权公开(公告)号：US08828420B2
公开(公告)日：2014-09-09
申请号：US11611508
申请日：2006-12-15
IPC分类号： A61K9/00 , G02B1/04 , C08G77/388
CPC分类号： C08G77/388 , G02B1/043
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic random copolymers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized siloxane prepolymer containing pendant cationic and polymerizable groups.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地，本发明涉及能聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些阳离子无规共聚物。 这些性质包括用水提取聚合的医疗装置的能力。 这避免了使用本领域典型的有机溶剂。 聚合物组合物包含聚合的含有阳离子和可聚合基团的聚硅氧烷预聚物。
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公开(公告)号：US08491881B2
公开(公告)日：2013-07-23
申请号：US13460553
申请日：2012-04-30
IPC分类号： A61K31/74
CPC分类号： A61L26/0019 , A61K31/785 , A61L24/0021 , A61L24/043 , A61L24/06 , C08L35/04
摘要： A biological coating material that includes a polymerizable polyacrylate monomer; a volatile liquid; a polymer selected from a synthetic rubber, a natural rubber, and a thermoplastic elastomer. The biological liquid coating material forms a coating or bandage in the form of a film that when applied and adhered to a surface or to the skin of a user inhibits the application surface from adhering to another surface.
摘要翻译： 一种生物涂料，包括可聚合的丙烯酸酯单体; 挥发性液体; 选自合成橡胶，天然橡胶和热塑性弹性体的聚合物。 生物液体涂覆材料形成薄膜形式的涂层或绷带，当施加并粘附到使用者的表面或皮肤时，该涂层或绷带可以阻止施用表面粘附到另一个表面。
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公开(公告)号：US08389597B2
公开(公告)日：2013-03-05
申请号：US13370364
申请日：2012-02-10
IPC分类号： G02B1/04
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译： 公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。 还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。
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6.发明授权公开(公告)号：US08377464B2
公开(公告)日：2013-02-19
申请号：US13405604
申请日：2012-02-27
IPC分类号： A61F2/00
CPC分类号： G02B1/043
摘要： This invention describes the use of polymerizable surfactants as comonomers in forming ophthalmic devices such as contact lenses, intraocular lenses, corneal implants, etc.
摘要翻译： 本发明描述了可聚合表面活性剂作为共聚单体在形成眼科装置如隐形眼镜，人工晶状体，角膜植入物等中的用途。
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7.发明授权公开(公告)号：US08197803B2
公开(公告)日：2012-06-12
申请号：US12414708
申请日：2009-03-31
IPC分类号： A61K31/74
CPC分类号： A61L26/0019 , A61K31/785 , A61L24/0021 , A61L24/043 , A61L24/06 , C08L35/04
摘要： Liquid hemostatic coating materials comprise a cyanoacrylate monomer and a solvent system comprising a volatile, non-reactive liquid that is non-stinging and non-irritating to a user. The material forms a coating or bandage in the form of a film that when applied and adhered to a surface or to the skin of a user inhibits the application surface from adhering to another surface.
摘要翻译： 液体止血涂层材料包括氰基丙烯酸酯单体和包含挥发性非反应性液体的溶剂系统，其对使用者是非刺激性且不刺激性的。 该材料形成薄膜形式的涂层或绷带，当涂覆和粘附到使用者的表面或皮肤时，该涂层或绷带可以阻止涂敷表面粘附到另一表面。
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公开(公告)号：US20120141408A1
公开(公告)日：2012-06-07
申请号：US13370364
申请日：2012-02-10
IPC分类号： A61K31/785 , C08F226/10 , A61P27/02 , B05D5/00 , A61K31/79 , C08F220/56 , C08F230/08
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译： 公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。 还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。
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公开(公告)号：US08183325B2
公开(公告)日：2012-05-22
申请号：US12131434
申请日：2008-06-02
IPC分类号： C08F114/18
CPC分类号： C08G65/337 , C08G61/12 , G02B1/043
摘要： The present invention provides copolymer having repeating units based on polyoxyalkylene radicals, polysiloxane radicals and perfluorocyclobutane radicals. The copolymers are useful as biomedical devices such as contact lenses or intraocular lenses.
摘要翻译： 本发明提供了基于聚氧化烯基，聚硅氧烷基和全氟环丁烷基的重复单元的共聚物。 该共聚物可用作生物医学装置如隐形眼镜或人工晶状体。
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公开(公告)号：US20120109036A1
公开(公告)日：2012-05-03
申请号：US13382227
申请日：2010-07-07
IPC分类号： A61L24/02 , A61M5/00 , A61M25/02 , C08F230/08 , A61F13/02
CPC分类号： C08F230/08 , A61F2013/00702 , A61L24/046 , C08L83/04 , C08L33/14
摘要： A silicone pressure sensitive adhesive with amphiphilic copolymers for maintaining adhesion in a moist environment. The amphiphilic copolymers for silicone adhesives include at least one silicone moiety and at least one hydrophilic segment. Such adhesives are applicable to securing medical devices to human skin.
摘要翻译： 具有两亲性共聚物的硅氧烷压敏粘合剂，用于在潮湿环境中保持粘合。 用于硅氧烷粘合剂的两亲性共聚物包括至少一个硅氧烷部分和至少一个亲水链段。 这种粘合剂适用于将医疗装置固定在人的皮肤上。
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