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公开(公告)号：US07083646B2
公开(公告)日：2006-08-01
申请号：US10187056
申请日：2002-06-28
申请人： Paul L. Valint, Jr. , Joseph A. McGee , Wenyan Yan , Joseph C. Salamone , Daniel M. Ammon, Jr. , Jay F. Kunzler
发明人： Paul L. Valint, Jr. , Joseph A. McGee , Wenyan Yan , Joseph C. Salamone , Daniel M. Ammon, Jr. , Jay F. Kunzler
IPC分类号： A61F2/16
CPC分类号： C08J7/12 , A61F2/14 , A61F2/16 , A61L27/34 , A61L2400/18 , A61L2430/16
摘要： Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.
摘要翻译： 表面改性的医疗装置，例如由一种或多种含官能团的材料形成的眼内透镜植入物，其使用反应性亲水性聚合物，用于减少或消除其上的晶状体上皮细胞生长，减少或消除随后手术暴露时的硅油吸收和/或 本文提供减少或消除植入插入物摩擦。 另外，提供了制造和使用表面改性的眼内透镜植入物的方法。
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2.发明授权Surface treatment for silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating 失效硅氧烷水凝胶隐形眼镜的表面处理包括连接到中间碳涂层的亲水性聚合物链公开(公告)号：US06902812B2
公开(公告)日：2005-06-07
申请号：US10430826
申请日：2003-05-06
申请人： Paul L. Valint, Jr. , Daniel M. Ammon, Jr. , Joseph A. McGee , George L. Grobe, III , Richard M. Ozark
发明人： Paul L. Valint, Jr. , Daniel M. Ammon, Jr. , Joseph A. McGee , George L. Grobe, III , Richard M. Ozark
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , C08J7/00 , C08J7/04 , C08L43/04 , G02B1/04 , G02B1/10 , B32B7/04
CPC分类号： C08J7/045 , B29D11/00192 , C08J2383/04 , G02B1/043 , Y10T428/249921 , Y10T428/31504 , Y10T428/31536 , Y10T428/3154 , Y10T428/31663 , C08L83/10
摘要： The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.
摘要翻译： 本发明通过依次使透镜表面在含烃气氛中进行等离子体聚合，然后将预先形成的亲水性聚合物共价连接到碳涂层的表面上，在硅树脂医疗装置的表面上提供光学透明的亲水涂层 。 本发明特别适用于在硅酮隐形眼镜上形成生物相容性涂层。
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3.发明授权Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating 失效硅氧烷水凝胶隐形眼镜的表面处理包括附着在中间碳涂层上的亲水聚合物链公开(公告)号：US06630243B2
公开(公告)日：2003-10-07
申请号：US09315306
申请日：1999-05-20
申请人： Paul L. Valint, Jr. , Daniel M. Ammon, Jr. , Joseph A. McGee , George L. Grobe, III , Richard M. Ozark
发明人： Paul L. Valint, Jr. , Daniel M. Ammon, Jr. , Joseph A. McGee , George L. Grobe, III , Richard M. Ozark
IPC分类号： B32B704
CPC分类号： C08J7/045 , B29D11/00192 , C08J2383/04 , G02B1/043 , Y10T428/249921 , Y10T428/31504 , Y10T428/31536 , Y10T428/3154 , Y10T428/31663 , C08L83/10
摘要： The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.
摘要翻译： 本发明通过依次使透镜表面在含烃气氛中进行等离子体聚合，然后将预先形成的亲水性聚合物共价连接到碳涂层的表面，从而在硅树脂医疗装置的表面上提供光学透明的亲水涂层 。 本发明特别适用于在硅酮隐形眼镜上形成生物相容性涂层。
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4.发明授权Plasma surface treatment of silicone hydrogel contact lenses with a flexible carbon coating 失效具有柔性碳涂层的硅酮水凝胶隐形眼镜的等离子体表面处理公开(公告)号：US06213604B1
公开(公告)日：2001-04-10
申请号：US09315558
申请日：1999-05-20
IPC分类号： G02C704
CPC分类号： C08J7/06 , C08J7/123 , C08J2383/04 , G02B1/043
摘要： The present invention is directed to the surface treatment of silicone hydrogel contact lenses. In particular, the present invention is directed to a method of modifying the surface of a contact lens to increase its hydrophilicity by coating the lens with a carbon-containing layer made from a diolefinic compound having 4 to 8 carbon atoms. In one embodiment, an optically clear, hydrophilic coating is provided upon the surface of a silicone hydrogel lens by sequentially subjecting the surface of the lens to: a plasma oxidation reaction, followed by a plasma polymerization reaction in a the presence of a diolefin in the absence of air. Finally, the resulting carbon layer is rendered hydrophilic by a further plasma oxidation reaction or by the attachment of a hydrophilic polymer chains.
摘要翻译： 本发明涉及硅酮水凝胶隐形眼镜的表面处理。 特别地，本发明涉及通过用由具有4-8个碳原子的二烯化合物制成的含碳层涂覆透镜来改变隐形眼镜表面以增加其亲水性的方法。 在一个实施方案中，通过将透镜表面依次经受等离子体氧化反应，然后在二烯烃存在下进行等离子体聚合反应，在硅酮水凝胶透镜的表面上提供光学透明的亲水涂层 没有空气 最后，通过进一步的等离子体氧化反应或通过附着亲水性聚合物链，使得到的碳层变得亲水。
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5.发明授权Surface-treatment of silicone medical devices comprising an intermediate carbon coating and graft polymerization 有权表面处理含有中间碳涂层和接枝聚合的有机硅医疗器械公开(公告)号：US06200626B1
公开(公告)日：2001-03-13
申请号：US09315912
申请日：1999-05-20
IPC分类号： A61L2700
CPC分类号： G02B1/043 , A61L27/34 , C08J7/045 , C08J7/16 , C08J2383/04 , A61L27/52 , A61L27/18 , C08L83/04 , C08L39/06 , C08L33/26 , C08L33/14 , C08L33/02 , C08L83/10
摘要： The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization reaction in a hydrocarbon atmosphere to form a carbon layer, and then graft polymerizinga mixture of monomers comprising hydrophilic monomers onto the carbon layer. The invention is especially useful for forming a biocompatible coating on silicone hydrogel contact lenses.
摘要翻译： 本发明通过在碳氢化合物气氛中依次使透镜表面进行等离子体聚合反应形成碳层，然后将包含亲水单体的单体混合物接枝聚合，从而提供了硅树脂医疗装置表面上的光学透明亲水涂层 到碳层上。 本发明特别适用于在硅酮水凝胶隐形眼镜上形成生物相容性涂层。
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公开(公告)号：US06193369B1
公开(公告)日：2001-02-27
申请号：US09295675
申请日：1999-04-21
IPC分类号： G02C704
CPC分类号： C08J7/123 , B29D11/00192 , B82Y15/00 , C08J2343/04 , C08J2383/04 , G02B1/043
摘要： The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone hydrogel lens by subjecting the surface of the lens to a process comprising plasma treatment, hydration, and heat sterilization that is controlled to result in a silicate-containing film having a mosaic pattern of projecting plates surrounded by fissures when viewing a 50×50 micron square AFM image, wherein the peak-to-valley distances of the fissures are on average between about 100 and 500 angströms and the plate coverage is on average between about 40% to 99%.
摘要翻译： 本发明通过对透镜的表面进行包括等离子体处理，水合和加热灭菌的方法来提供硅树脂水凝胶透镜的表面上的光学透明的亲水涂层，该方法被控制以产生含硅酸盐的膜，其具有 当观察50×50微米平方AFM图像时，由裂缝包围的突出板的马赛克图案，其中裂缝的峰谷距离平均在约100和500埃之间，平板覆盖平均在约40％至99之间 ％。
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公开(公告)号：US5981669A
公开(公告)日：1999-11-09
申请号：US69785
申请日：1998-04-29
IPC分类号： G02C7/04 , C08F283/12 , C08G18/61 , C08G18/62 , C08G18/64 , C08G77/442 , G02B1/04
CPC分类号： G02B1/043 , C08F283/12 , C08G18/61 , C08G18/6469 , C08G77/442
摘要： Low water silicone-containing elastomers are based on a hydroxy- or amino-terminated prepolymer derived from an ethylenically unsaturated silicon-containing monomer, and at least one monomer reactive with hydroxyl- or amino-functional radicals of the prepolymer. The elastomers are especially useful as contact lens materials.
摘要翻译： 低水含硅氧烷弹性体基于衍生自烯属不饱和含硅单体的羟基或氨基封端的预聚物，以及至少一种与预聚物的羟基或氨基官能团反应的单体。 弹性体特别用作隐形眼镜材料。
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公开(公告)号：US08133512B2
公开(公告)日：2012-03-13
申请号：US12459779
申请日：2009-07-08
CPC分类号： A61K9/0051 , A61K47/34
摘要： Matrix controlled diffusion drug delivery systems based on one or more silicon-containing monomers of the general formula: wherein L, X−, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.
摘要翻译： 基于一种或多种以下通式的含硅单体的基质控制扩散药物递送系统：其中L，X-，n，R 1，R 2，R 3，R 4，R 5，R 6，R 7和V如本文所述。
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9.发明授权Drug delivery systems based on degradable cationic siloxanyl macromonomers 失效基于可降解阳离子硅氧烷基大分子单体的药物输送系统公开(公告)号：US07579021B2
公开(公告)日：2009-08-25
申请号：US11527913
申请日：2006-09-27
CPC分类号： A61K9/0051 , A61K47/34
摘要： Matrix controlled diffusion drug delivery systems based on one or more silicon-containing monomers of the general formula: wherein L, X−, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.
摘要翻译： 基于一种或多种以下通式的含硅单体的基质控制扩散药物递送系统：其中L，X-，n，R 1，R 2，R 3，R 4，R 5，R 6，R 7和V如本文所述。
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公开(公告)号：US08133511B2
公开(公告)日：2012-03-13
申请号：US12459778
申请日：2009-07-08
CPC分类号： A61K9/0051 , A61K47/34
摘要： Matrix controlled diffusion drug delivery systems are described herein which are based on one or more silicon-containing monomers of the general formula: wherein L, X−, n, R1, R2, R3, R4, R5, R6, R7 and V are as set forth herein.
摘要翻译： 本文描述了基于一种或多种以下通式的含硅单体的基质控制扩散药物递送系统：其中L，X-，n，R1，R2，R3，R4，R5，R6，R7和V如 在此阐述。
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