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公开(公告)号：US08389597B2
公开(公告)日：2013-03-05
申请号：US13370364
申请日：2012-02-10
IPC分类号： G02B1/04
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译： 公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。 还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。
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公开(公告)号：US20120141408A1
公开(公告)日：2012-06-07
申请号：US13370364
申请日：2012-02-10
IPC分类号： A61K31/785 , C08F226/10 , A61P27/02 , B05D5/00 , A61K31/79 , C08F220/56 , C08F230/08
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译： 公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。 还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。
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公开(公告)号：US20090142292A1
公开(公告)日：2009-06-04
申请号：US12266646
申请日：2008-11-07
IPC分类号： A61K31/74 , A61K31/715 , A61P27/02 , A61K31/79 , A61K31/785 , A61K31/765
CPC分类号： G02B1/043 , A61K9/0051
摘要： A method for the mitigation of symptoms of dry eye is disclosed. The method involves at least (a) incorporating one or more non-functionalized polymers having one or more hydrophilic moieties into an ophthalmic device that is a polymerization product of a comonomer mixture comprising: (i) a major amount of a non-silicone-containing hydrophilic monomer; and (ii) an end terminal functionalized surfactant; and (b) inserting the ophthalmic device in the eye of a patient.
摘要翻译： 公开了一种减轻干眼症状的方法。 该方法至少包括（a）将一种或多种具有一个或多个亲水部分的非官能化聚合物掺入到作为共聚单体混合物的聚合产物的眼科装置中，所述共聚单体混合物包含：（i）主要量的非含硅氧烷 亲水单体; 和（ii）末端官能化表面活性剂; 和（b）将眼科装置插入患者的眼睛。
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公开(公告)号：US20090191256A1
公开(公告)日：2009-07-30
申请号：US12350262
申请日：2009-01-08
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译： 公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。 还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。
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公开(公告)号：US08138290B2
公开(公告)日：2012-03-20
申请号：US12350262
申请日：2009-01-08
IPC分类号： C08F20/00
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译： 公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。 还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。
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6.发明申请Trimethylsilyl-Capped Polysiloxane Macromonomers Containing Polar Fluorinated Side-Chains 审中-公开含有极性氟化侧链的三甲基甲硅烷基封端的聚硅氧烷大分子单体公开(公告)号：US20090168013A1
公开(公告)日：2009-07-02
申请号：US12269442
申请日：2008-11-12
IPC分类号： G02C7/04 , C07F7/02 , C08F290/06
CPC分类号： C08F290/068 , C08G77/20 , C08G77/385 , G02B1/043 , C08L51/085
摘要： A method for reducing the modulus of polymer siloxane hydrogel compositions by employing monomeric polysiloxanes endcapped with trimethylsilyl to reduce the crosslinking density of the hydrogel. The synthesis consists of a single vessel acid catalyzed ring opening polymerization and may be employed to produce copolymers useful as hydrogel contact lens materials.
摘要翻译： 通过使用用三甲基甲硅烷基封端的单体聚硅氧烷降低聚合物硅氧烷水凝胶组合物的模量以降低水凝胶的交联密度的方法。 该合成由单容器酸催化的开环聚合组成，可用于产生可用作水凝胶隐形眼镜材料的共聚物。
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公开(公告)号：US06908978B2
公开(公告)日：2005-06-21
申请号：US10000136
申请日：2001-11-02
CPC分类号： C08G77/045 , A61L27/16 , C07F7/0838 , G02B1/043 , C08L51/085 , C08L51/08
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more siloxysilane monomers or the copolymerization of one or more siloxysilane monomers with one or more aromatic or non-aromatic non-siloxy monomers, hydrophobic monomers or hydrophilic monomers.
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公开(公告)号：US06881809B2
公开(公告)日：2005-04-19
申请号：US10848308
申请日：2004-05-18
CPC分类号： C07F7/081 , Y10S623/905 , Y10S623/907
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based silyl monomers or the copolymerization of one or more aromatic-based silyl monomers with one or more aromatic or non-aromatic non-siloxy-based monomers, hydrophobic monomers or hydrophilic monomers.
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公开(公告)号：US06762271B2
公开(公告)日：2004-07-13
申请号：US10003616
申请日：2001-11-02
IPC分类号： C08G7700
CPC分类号： C07F7/081 , Y10S623/905 , Y10S623/907
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based silyl monomers or the copolymerization of one or more aromatic-based silyl monomers with one or more aromatic or non-aromatic non-siloxy-based monomers, hydrophobic monomers or hydrophilic monomers.
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10.发明授权公开(公告)号：US08828420B2
公开(公告)日：2014-09-09
申请号：US11611508
申请日：2006-12-15
IPC分类号： A61K9/00 , G02B1/04 , C08G77/388
CPC分类号： C08G77/388 , G02B1/043
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic random copolymers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized siloxane prepolymer containing pendant cationic and polymerizable groups.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地，本发明涉及能聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些阳离子无规共聚物。 这些性质包括用水提取聚合的医疗装置的能力。 这避免了使用本领域典型的有机溶剂。 聚合物组合物包含聚合的含有阳离子和可聚合基团的聚硅氧烷预聚物。
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