公开(公告)号：US5776784A

公开(公告)日：1998-07-07

申请号：US585333

申请日：1996-01-11

申请人： Joseph Edward Kegelman ,  Diane Kathleen Stille ,  Robert Kyle Wiedenmann ,  Paul John Zuk

发明人： Joseph Edward Kegelman ,  Diane Kathleen Stille ,  Robert Kyle Wiedenmann ,  Paul John Zuk

IPC分类号： G01N33/543 ,  B03C1/28 ,  G01N1/10 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC分类号： B03C1/288 ,  G01N2001/1006 ,  G01N2035/0436 ,  G01N2035/1088 ,  G01N35/0098 ,  Y10S436/815

摘要： Assays for separating magnetic particles include separating magnetically responsive particles from a liquid dispersion disposed in a plurality of reaction vessels, and transporting the reaction vessels in sequence past at least one processing position. A robotics reagent arm and probe dispense reagents into the reaction vessels and a reaction monitoring device is capable of relative movement with respect to the transporting device. Incomplete separation is effected by positioning a magnetic field in contact with the reaction vessel for a first shortened time interval during which the particles partially aggregate and afterwards are removed from the reaction vessel. The magnet is repositioned in contact with the reaction vessel for a third time interval to achieve full separation of particles from the liquid.

摘要翻译： 用于分离磁性颗粒的测定包括从设置在多个反应容器中的液体分散体分离磁性响应性颗粒，并且将反应容器顺序地输送至至少一个处理位置。 机器人试剂臂和探针将试剂分配到反应容器中，反应监测装置能够相对于输送装置相对运动。 不完全的分离是通过将磁场定位成与反应容器接触的第一缩短的时间间隔来进行的，在此间隔期间颗粒部分聚集，之后从反应容器中移除。 将磁体重新定位成与反应容器接触第三时间间隔以实现颗粒与液体的完全分离。