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公开(公告)号：US06976998B2
公开(公告)日：2005-12-20
申请号：US10346701
申请日：2003-01-17
CPC分类号： A61N1/0543 , A61F2/14 , A61F9/08 , A61N1/36 , A61N1/36046 , A61N1/3787
摘要： An ocular device that can more safely and effectively perform all functions needed of a retinal prosthesis with electronic components that are placed outside the wall of an eye, are powered wirelessly provided by an external power source, and which provide a patient with a view determined by natural motion of the eye and triggered by natural incident light converging at the retina. In one aspect, the invention is an externally powered, light-activated, sub-retinal prosthesis in which natural light entering the eye conveys visual details to the sub-retinal prosthesis, while wireless radiofrequency transmission provides the power needed to stimulate the retina, which would be insufficient if it were obtained from the intensity of incoming light alone.
摘要翻译： 可以更安全和有效地执行放置在眼睛壁外部的电子部件的视网膜假体所需的所有功能的眼睛装置由外部电源无线提供，并且由患者提供由 眼睛自然运动并由自然光线会聚在视网膜上触发。 一方面，本发明是一种外部供电的光活化的次视网膜假体，其中进入眼睛的自然光将视觉细节传达到视网膜假体，而无线射频传输提供刺激视网膜所需的功率，其中 如果从独自的入射光强度获得的话将不足够。
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公开(公告)号：US5223754A
公开(公告)日：1993-06-29
申请号：US628340
申请日：1990-12-14
申请人： Steve Decker , John L. Wyatt, Jr. , Hae-Seung Lee
发明人： Steve Decker , John L. Wyatt, Jr. , Hae-Seung Lee
IPC分类号： H01L27/088
CPC分类号： H01L27/088
摘要： A simple transistor circuit which acts as a linear resistor for small applied voltages, but becomes extremely resistive for large applied voltages is disclosed. Two-dimensional resistive grids comprising these resistive fuses can be employed to smooth and segment discretized images in machine vision. Existing and previously proposed VLSI implementations of resistive fuses have required at least thirty-three transistors. The resistive fuse circuit of the present invention uses only four transistors in its simplest embodiment, thus making it possible to design much denser vision arrays.
摘要翻译： 公开了一种简单的晶体管电路，其作为用于小施加电压的线性电阻器，但是对于大的施加电压变得极大的阻力。 可以采用包含这些电阻熔丝的二维电阻栅格来平滑和分段机器视觉中的离散化图像。 电阻式熔断器的现有和先前提出的VLSI实现至少需要三十三个晶体管。 本发明的电阻式熔丝电路在其最简单的实施例中仅使用四个晶体管，从而可以设计出更加密集的视觉阵列。
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公开(公告)号：US6120538A
公开(公告)日：2000-09-19
申请号：US74196
申请日：1998-05-07
CPC分类号： A61F2/1635 , A61F2/1613 , A61F9/08 , G02B3/14 , A61N1/36046
摘要： Dynamically functional intra-ocular prosthesis. The prosthesis includes an implantable intra-ocular lens and microelectronic components mounted on the lens. One embodiment is a variable focal length implantable intra-ocular lens system for adjusting the focal length of the implantable lens. In one embodiment, a micromotor changes the tension in a band encircling the peripheral portion of the deformable lens changing its shape to vary its focal length. Another embodiment is an artificial intra-ocular lens which serves as a holding substrate for microelectronic components that form part of a prosthesis to stimulate the neural elements of the eye to restore vision to patients who are blind from retinal disease.
摘要翻译： 动态功能性眼内假体。 假体包括可植入的眼内透镜和安装在透镜上的微电子部件。 一个实施例是用于调节可植入透镜的焦距的可变焦距可植入眼内透镜系统。 在一个实施例中，微型电动机改变围绕可变形透镜的周边部分的带的张力，改变其形状以改变其焦距。 另一个实施方案是人造眼内透镜，其用作形成假体的一部分的微电子部件的保持基底，以刺激眼睛的神经元件以恢复对视网膜疾病失明的患者的视力。
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公开(公告)号：US5575813A
公开(公告)日：1996-11-19
申请号：US394719
申请日：1995-04-28
CPC分类号： A61N1/0543
摘要： A low-pressure neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated. The contact structure comprises a first portion for attachment to a first bodily location, such as the inner surface of the retina, and a second portion interconnected with the first portion via an interconnection and being held in contact with the neural tissue. The interconnection exhibits a weak restoring force which in conjunction with the geometry of said second portion provides a preselected desired pressure of contact against the neural tissue. As adapted for the retina, the interconnection exhibits a weak restoring force developed in response to curvature of the interconnection along the inner radius of the retina.
摘要翻译： 用于与神经组织接触的低压神经接触结构，例如视网膜的神经组织，其中是电刺激的神经节细胞。 接触结构包括用于附接到第一身体位置的第一部分，例如视网膜的内表面，以及通过互连与第一部分互连并与神经组织保持接触的第二部分。 互连表现出弱的恢复力，其结合所述第二部分的几何形状提供预定的期望的与神经组织的接触压力。 适应于视网膜时，互连呈现出响应沿着视网膜的内半径的互连的曲率而产生的弱恢复力。
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公开(公告)号：US5476494A
公开(公告)日：1995-12-19
申请号：US234725
申请日：1994-04-28
CPC分类号： A61N1/0543
摘要： A low-pressure neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated. The contact structure comprises a first portion for attachment to a first bodily location, such as the inner surface of the retina, and a second portion interconnected with the first portion via an interconnection and being held in contact with the neural tissue. The interconnection exhibits a weak restoring force which in conjunction with the geometry of said second portion provides a preselected desired pressure of contact against the neural tissue. As adapted for the retina, the interconnection exhibits a weak restoring force developed in response to curvature of the interconnection along the inner radius of the retina.
摘要翻译： 用于与神经组织接触的低压神经接触结构，例如视网膜的神经组织，其中是电刺激的神经节细胞。 接触结构包括用于附接到第一身体位置的第一部分，例如视网膜的内表面，以及通过互连与第一部分互连并与神经组织保持接触的第二部分。 互连表现出弱的恢复力，其结合所述第二部分的几何形状提供预定的期望的与神经组织的接触压力。 适应于视网膜时，互连呈现出响应沿着视网膜的内半径的互连的曲率而产生的弱恢复力。
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公开(公告)号：US5411540A
公开(公告)日：1995-05-02
申请号：US72320
申请日：1993-06-03
CPC分类号： A61N1/0543 , A61N1/0551
摘要： The invention provides a method for preferentially stimulating neural somas over neural axons located around the somas but not integral with the somas. In the invention, a positive electrical pulse is applied to a region of neural tissue consisting of one or more neural somas to be stimulated and neural axons, and due to the physiology of the somas, they are preferentially stimulated by the electrical pulse over the neural axons not integral with the somas to be stimulated. The preferential soma stimulation provided by the invention achieves the advantage of locally focusing external stimulation such that it may be directed to particular soma locations for indicating location-dependent sensory information. Thus the pulse scheme of the invention may be employed in prosthetic applications directed to, for example, the retinal ganglia neural tissue.
摘要翻译： 本发明提供了一种用于优先地刺激位于躯体周围但与体细胞不整合的神经轴突的神经细胞的方法。 在本发明中，正电脉冲被施加到由待刺激的一个或多个神经细胞组成的神经组织区域和神经轴突，并且由于躯体的生理学，它们优先地被神经元上的电脉冲刺激 轴突不与要刺激的躯体成分。 本发明提供的优选的瘤细胞刺激实现了局部聚焦外部刺激的优点，使得其可以被引导到特定的肿瘤位置以指示位置相关的感觉信息。 因此，本发明的脉冲方案可用于针对例如视网膜神经节神经组织的假体应用。
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