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公开(公告)号：US20050118662A1
公开(公告)日：2005-06-02
申请号：US10994851
申请日：2004-11-22
申请人： Juergen Spinke , Alfons Nichtl , Volker Klemt , Klaus Hallermayer , Michael Grol , Anneliese Borgya , Andreas Gallusser
发明人： Juergen Spinke , Alfons Nichtl , Volker Klemt , Klaus Hallermayer , Michael Grol , Anneliese Borgya , Andreas Gallusser
IPC分类号： G01N33/53 , G01N33/543 , G01N33/577 , G01N33/68 , G01N33/74 , G01N33/537
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/34 , G01N33/5302 , G01N33/543 , G01N33/558 , G01N2333/58 , Y10S436/811 , Y10S530/80
摘要： The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. One of these antibodies is directed at least against parts of the epitope of NT-proBNP comprising the amino acids 38 to 50. In addition, one of these antibodies is directed at least against parts of the epitope of NT-proBNP comprising the amino acids 1 to 37 or 43 to 76. The epitope recognized by the antibodies can slightly overlap.
摘要翻译： 本发明涉及用于测定包含至少两种NT-proBNP抗体的NT-proBNP的免疫学测试，其中至少一种NT-proBNP的抗体是单克隆抗体。 这些抗体中的一种至少针对包含氨基酸38至50的NT-proBNP表位的部分。此外，这些抗体之一至少针对包含氨基酸1的NT-proBNP的表位的至少部分 至37或43至76.由抗体识别的表位可以稍微重叠。
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公开(公告)号：US20090123947A1
公开(公告)日：2009-05-14
申请号：US12354410
申请日：2009-01-15
申请人： Juergen Spinke , Alfons Nichtl , Volker Klemt , Klaus Hallermayer , Michael Grol , Anneliese Borgya , Andreas Gallusser
发明人： Juergen Spinke , Alfons Nichtl , Volker Klemt , Klaus Hallermayer , Michael Grol , Anneliese Borgya , Andreas Gallusser
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/34 , G01N33/5302 , G01N33/543 , G01N33/558 , G01N2333/58 , Y10S436/811 , Y10S530/80
摘要： The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. The epitopes recognized by the antibodies can slightly overlap.
摘要翻译： 本发明涉及用于测定包含至少两种NT-proBNP抗体的NT-proBNP的免疫学测试，其中至少一种NT-proBNP的抗体是单克隆抗体。 由抗体识别的表位可以稍微重叠。
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公开(公告)号：US07507550B2
公开(公告)日：2009-03-24
申请号：US10994851
申请日：2004-11-22
申请人： Juergen Spinke , Alfons Nichtl , Volker Klemt , Klaus Hallermayer , Michael Grol , Anneliese Borgya , Andreas Gallusser
发明人： Juergen Spinke , Alfons Nichtl , Volker Klemt , Klaus Hallermayer , Michael Grol , Anneliese Borgya , Andreas Gallusser
IPC分类号： G01N33/53 , G01N33/543 , G01N33/544 , G01N33/545 , G01N33/558 , G01N33/577 , G01N33/551 , C07K16/26
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/34 , G01N33/5302 , G01N33/543 , G01N33/558 , G01N2333/58 , Y10S436/811 , Y10S530/80
摘要： The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. One of these antibodies is directed at least against parts of the epitope of NT-proBNP comprising the amino acids 38 to 50. In addition, one of these antibodies is directed at least against parts of the epitope of NT-proBNP comprising the amino acids 1 to 37 or 43 to 76. The epitope recognized by the antibodies can slightly overlap.
摘要翻译： 本发明涉及用于测定包含至少两种NT-proBNP抗体的NT-proBNP的免疫学测试，其中至少一种NT-proBNP的抗体是单克隆抗体。 这些抗体中的一种至少针对包含氨基酸38至50的NT-proBNP表位的部分。此外，这些抗体之一至少针对包含氨基酸1的NT-proBNP的表位的至少部分 至37或43至76.由抗体识别的表位可以稍微重叠。
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公开(公告)号：US09140709B2
公开(公告)日：2015-09-22
申请号：US12354410
申请日：2009-01-15
申请人： Juergen Spinke , Alfons Nichtl , Volker Klemt , Klaus Hallermayer , Michael Grol , Anneliese Borgya , Andreas Gallusser
发明人： Juergen Spinke , Alfons Nichtl , Volker Klemt , Klaus Hallermayer , Michael Grol , Anneliese Borgya , Andreas Gallusser
IPC分类号： G01N33/74 , G01N33/543 , G01N33/558 , C07K16/26 , G01N33/53
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/34 , G01N33/5302 , G01N33/543 , G01N33/558 , G01N2333/58 , Y10S436/811 , Y10S530/80
摘要： The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. The epitopes recognized by the antibodies can slightly overlap.
摘要翻译： 本发明涉及用于测定包含至少两种NT-proBNP抗体的NT-proBNP的免疫学测试，其中至少一种NT-proBNP的抗体是单克隆抗体。 由抗体识别的表位可以稍微重叠。
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公开(公告)号：US07811770B2
公开(公告)日：2010-10-12
申请号：US11644565
申请日：2006-12-22
申请人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
发明人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
IPC分类号： G01N33/53 , G01N33/577 , C07K16/26 , C12N5/20 , C12P21/08 , G01N33/543
CPC分类号： C07K16/26 , A61K39/00 , C07K14/58 , C07K2317/10 , C07K2317/34 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.
摘要翻译： 本发明涉及特异性结合天然proBNP的抗体，特异性检测天然proBNP的方法，将天然proBNP水平与心力衰竭诊断相关联的方法，用于检测天然proBNP的试剂盒和杂交瘤细胞系 产生对天然proBNP的抗体。
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公开(公告)号：US07264939B2
公开(公告)日：2007-09-04
申请号：US11271651
申请日：2005-11-10
申请人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
发明人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
IPC分类号： G01N33/53 , G01N33/577 , C07K16/26 , C12N5/20 , C12P21/08 , G01N33/543
CPC分类号： C07K16/26 , A61K39/00 , C07K14/58 , C07K2317/10 , C07K2317/34 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.
摘要翻译： 本发明涉及特异性结合天然proBNP的抗体，特异性检测天然proBNP的方法，将天然proBNP水平与心力衰竭诊断相关联的方法，用于检测天然proBNP的试剂盒和杂交瘤细胞系 产生对天然proBNP的抗体。
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公开(公告)号：US20060110776A1
公开(公告)日：2006-05-25
申请号：US11271651
申请日：2005-11-10
申请人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
发明人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
IPC分类号： G01N33/53
CPC分类号： C07K16/26 , A61K39/00 , C07K14/58 , C07K2317/10 , C07K2317/34 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.
摘要翻译： 本发明涉及特异性结合天然proBNP的抗体，特异性检测天然proBNP的方法，将天然proBNP水平与心力衰竭诊断相关联的方法，用于检测天然proBNP的试剂盒和杂交瘤细胞系 产生对天然proBNP的抗体。
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公开(公告)号：US07264938B2
公开(公告)日：2007-09-04
申请号：US11271138
申请日：2005-11-10
申请人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
发明人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
IPC分类号： G01N33/53 , G01N33/577 , C07K16/26 , C12N5/20 , C12P21/08 , G01N33/543
CPC分类号： C07K16/26 , A61K39/00 , C07K14/58 , C07K2317/10 , C07K2317/34 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.
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公开(公告)号：US20060110775A1
公开(公告)日：2006-05-25
申请号：US11271138
申请日：2005-11-10
申请人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
发明人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
IPC分类号： G01N33/53
CPC分类号： C07K16/26 , A61K39/00 , C07K14/58 , C07K2317/10 , C07K2317/34 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.
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公开(公告)号：US07807380B2
公开(公告)日：2010-10-05
申请号：US11634286
申请日：2006-12-05
申请人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
发明人： Anneliese Borgya , Andreas Gallusser , Michael Grol , Klaus Hallermayer , Volker Klemt , Christoph Seidel
IPC分类号： G01N33/53 , G01N33/577 , C07K16/26 , C12N5/20 , C12P21/08 , G01N33/543
CPC分类号： C07K16/26 , A61K39/00 , C07K14/58 , C07K2317/10 , C07K2317/34 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody to native proBNP.
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