公开(公告)号：US20110224138A1

公开(公告)日：2011-09-15

申请号：US12878716

申请日：2010-09-09

申请人： Julie Krop ,  Marilyn Pike ,  Dean Falb ,  Bret Shirley ,  Denis Schrier ,  Mary Elizabeth Goad

发明人： Julie Krop ,  Marilyn Pike ,  Dean Falb ,  Bret Shirley ,  Denis Schrier ,  Mary Elizabeth Goad

IPC分类号： A61K38/18 ,  A61P29/00 ,  A61P19/08

CPC分类号： A61K38/1875

摘要： Described herein are methods for using bone morphogenetic proteins (BMPs), such as OP-1 (also known as BMP-7), to treat pain caused by osteoarthritis. The methods involve administering to a patient suffering from pain caused by osteoarthritis a BMP, for example, intraarticularly by injection directly into the joint afflicted with osteoarthritis. The methods of the invention provide long-term pain relief to sufferers of osteoarthritis and can improve the functionality of the joint to which the BMP is administered.

摘要翻译： 本文描述了使用骨形态发生蛋白（BMP）如OP-1（也称为BMP-7）来治疗由骨关节炎引起的疼痛的方法。 所述方法包括向患有由骨关节炎引起的疼痛的患者施用BMP，例如通过注射直接注射到患有骨关节炎的关节中。 本发明的方法为骨关节炎患者提供长期的疼痛缓解，并且可以改善施用BMP的关节的功能。

公开(公告)号：US6156500A

公开(公告)日：2000-12-05

申请号：US386844

申请日：1995-02-10

申请人： Dean Falb

发明人： Dean Falb

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  C12N9/02 ,  C12N9/08 ,  C12Q1/68

CPC分类号： C12N9/0083 ,  C07K14/47 ,  C12N9/0065 ,  C12N9/0089 ,  A61K38/00

摘要： The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease. Moreover, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of cardiovascular disease, and for monitoring the efficacy of compounds in clinical trials. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions.

摘要翻译： 本发明涉及用于治疗和诊断心血管疾病的方法和组合物，包括但不限于动脉粥样硬化，缺血/再灌注，高血压，再狭窄和动脉炎症。 具体而言，本发明鉴定和描述了相对于其在正常或非心血管疾病状态中的表达和/或响应于与心血管疾病相关的操作而在心血管疾病状态中差异表达的基因。 此外，本发明通过其基因产物与参与心血管疾病的基因产物相互作用的能力来鉴定和描述基因。 此外，本发明提供了用于鉴定和治疗使用化合物作为心血管疾病治疗的方法。 此外，本发明提供了用于诊断心血管疾病治疗临床评估的患者的诊断监测方法，以及用于监测化合物在临床试验中的功效的方法。 此外，本发明描述了各种心血管疾病的诊断评价和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。

公开(公告)号：US5834248A

公开(公告)日：1998-11-10

申请号：US480994

申请日：1995-06-07

申请人： Dean Falb

发明人： Dean Falb

IPC分类号： A01K67/027 ,  A61K31/70 ,  A61K38/00 ,  A61K38/44 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07K14/47 ,  C12N1/21 ,  C12N9/02 ,  C12N9/08 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  C12N15/00 ,  C07H21/00

CPC分类号： C12N9/0083 ,  C07K14/47 ,  C12N9/0065 ,  C12N9/0089 ,  A61K38/00

摘要： The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease. Moreover, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of cardiovascular disease, and for monitoring the efficacy of compounds in clinical trials. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions.

摘要翻译： 本发明涉及用于治疗和诊断心血管疾病的方法和组合物，包括但不限于动脉粥样硬化，缺血/再灌注，高血压，再狭窄和动脉炎症。 具体而言，本发明鉴定和描述了相对于其在正常或非心血管疾病状态中的表达和/或响应于与心血管疾病相关的操作而在心血管疾病状态中差异表达的基因。 此外，本发明通过其基因产物与参与心血管疾病的基因产物相互作用的能力来鉴定和描述基因。 此外，本发明提供了用于鉴定和治疗使用化合物作为心血管疾病治疗的方法。 此外，本发明提供了用于诊断心血管疾病治疗临床评估的患者的诊断监测方法，以及用于监测化合物在临床试验中的功效的方法。 此外，本发明描述了各种心血管疾病的诊断评价和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。