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公开(公告)号：US08901291B2
公开(公告)日：2014-12-02
申请号：US13698430
申请日：2011-05-19
申请人： Julien Boutet , Gyula Dekany , Ágnes Jànosi , Gergely Pipa , Ferenc Horvàth , Krisztián Kovàcs , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkò , Lars Kröger , Christoph Röhrig
发明人： Julien Boutet , Gyula Dekany , Ágnes Jànosi , Gergely Pipa , Ferenc Horvàth , Krisztián Kovàcs , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkò , Lars Kröger , Christoph Röhrig
摘要： The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.
摘要翻译： 本申请公开了一种岩藻糖结晶方法，其特征在于从包含岩藻糖和至少一种选自6-脱氧 - 托洛糖和6-脱氧 - 古洛糖的6-脱氧糖的混合物中进行结晶。 在一个实施方案中，混合物包含岩藻糖和6-脱氧 - 托洛糖。
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公开(公告)号：US20130072675A1
公开(公告)日：2013-03-21
申请号：US13698430
申请日：2011-05-19
申请人： Julien Boutet , Gyula Dekany , Ágnes Jánosi , Gergely Pipa , Ferenc Horváth , Krisztián Kovács , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkó , Lars Kröger , Christoph Röhrig
发明人： Julien Boutet , Gyula Dekany , Ágnes Jánosi , Gergely Pipa , Ferenc Horváth , Krisztián Kovács , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkó , Lars Kröger , Christoph Röhrig
IPC分类号： C07H1/06
摘要： The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.
摘要翻译： 本申请公开了一种岩藻糖结晶方法，其特征在于从包含岩藻糖和至少一种选自6-脱氧 - 托洛糖和6-脱氧 - 古洛糖的6-脱氧糖的混合物中进行结晶。 在一个实施方案中，混合物包含岩藻糖和6-脱氧 - 托洛糖。
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公开(公告)号：US20130035481A1
公开(公告)日：2013-02-07
申请号：US13579738
申请日：2011-02-21
申请人： Ignacio Pérez Figueroa , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
发明人： Ignacio Pérez Figueroa , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
CPC分类号： A23L1/308 , A23L33/10 , A23L33/21 , A61K31/702 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18
摘要： The present invention relates to a method for preparation of the trisaccharide 6′-0-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6′-0-sialyllactose salts in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及制备三糖6'-唾液酸乳糖（式（I））或其盐的方法，以及在药物或营养物质中合成和使用6'-O-唾液酸乳糖盐的中间体 组合物。
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4.发明申请METHOD FOR PREPARATION OF THE TETRASACCHARIDE LACTO-N-NEOTETRAOSE (LNNT) CONTAINING N-ACETYLLACTOSAMINE 有权含有N-乙酰基氨基甲酰胺的四氯化钛 - 新近硝酸酯（LNNT）的制备方法公开(公告)号：US20120309949A1
公开(公告)日：2012-12-06
申请号：US13579741
申请日：2011-02-21
申请人： István Bajza , Gyula Dekany , Károly Ágoston , Ignacio Pérez Figueroa , Julien Boutet , Markus Hederos , Ferenc Horváth , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Péter Trinka , László Kalmár , Irme Kovács , Sándor Demkó , Ágnes Ágoston , Christian Risinger
发明人： István Bajza , Gyula Dekany , Károly Ágoston , Ignacio Pérez Figueroa , Julien Boutet , Markus Hederos , Ferenc Horváth , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Péter Trinka , László Kalmár , Irme Kovács , Sándor Demkó , Ágnes Ágoston , Christian Risinger
IPC分类号： C08B37/00 , C07H15/203
CPC分类号： C07H3/06 , A23L5/00 , A23L7/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , C07H1/00 , C07H11/00 , C07H13/04 , C07H15/18 , A23V2250/28
摘要： The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及一种特别是大规模制备四糖乳-N-新四糖（LNnt，式（I））的方法，以及合成中的中间体，一种LNnt的新晶型（多晶型物）和 在药物或营养组合物中的应用。
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公开(公告)号：US09102966B2
公开(公告)日：2015-08-11
申请号：US13809794
申请日：2011-07-15
申请人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
发明人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
摘要： The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.
摘要翻译： 本发明涉及一种合成通式（1A）化合物及其盐的方法，其中一个R基团为α-唾液酰基部分，另一个为H，X1为碳水化合物接头，A为D-吡喃葡萄糖基 任选被岩藻糖基取代的单元，R1是通过氢解除去的保护基，整数m为0或1，通过反式仲胺反应。
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公开(公告)号：US20130165406A1
公开(公告)日：2013-06-27
申请号：US13701085
申请日：2011-06-01
申请人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
发明人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。
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公开(公告)号：US08889637B2
公开(公告)日：2014-11-18
申请号：US13701085
申请日：2011-06-01
申请人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa-Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
发明人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa-Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。
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公开(公告)号：US20130245250A1
公开(公告)日：2013-09-19
申请号：US13878739
申请日：2011-10-13
申请人： Andreas Schroven , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Lars Kröger , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa
发明人： Andreas Schroven , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Lars Kröger , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa
IPC分类号： C07H3/02
摘要： Method for producing L-fucose includes in a first aspect, a method for the preparation of L-fucose, wherein L-fucose precursors are produced from pectin and L-fucose is produced from the L-fucose precursors; in a second aspect, a method for the preparation of L-fucose from D-galacturonic acid or a salt thereof, wherein L-fucose precursors are produced from D-galacturonic acid of a salt thereof, and L-fucose is produced from the L-fucose precursors; and an L-fucose precursor as shown in Formula A, wherein R is a linear or branched chain saturated hydrocarbon group with 1-6 carbon atoms, such as methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, n-hexyl, etc., preferably a methyl group.
摘要翻译： 生产L-岩藻糖的方法在第一方面包括一种制备L-岩藻糖的方法，其中L-果糖前体由果胶生产，L-岩藻糖由L-岩藻糖前体制备; 在第二方面，一种从D-半乳糖醛酸或其盐制备L-岩藻糖的方法，其中L-岩藻糖前体由其半盐酸D-半乳糖醛酸产生，L-岩藻糖由L 岩藻糖前体; 和式I所示的L-岩藻糖前体，其中R是具有1-6个碳原子的直链或支链饱和烃基，例如甲基，乙基，正丙基，异丙基，正丁基，异丁基， 丁基，仲丁基，叔丁基，正己基等，优选甲基。
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公开(公告)号：US20130171696A1
公开(公告)日：2013-07-04
申请号：US13809794
申请日：2011-07-15
申请人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
发明人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
摘要： The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.
摘要翻译： 本发明涉及一种合成通式（1A）化合物及其盐的方法，其中R基团之一为α-唾液酰基部分，另一个为H，X 1为碳水化合物接头，A为D-吡喃葡萄糖基 任选被岩藻糖基取代的单元，R1是通过氢解除去的保护基，整数m为0或1，通过反式仲胺反应。
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公开(公告)号：US20130172548A1
公开(公告)日：2013-07-04
申请号：US13809829
申请日：2011-07-15
申请人： Gyula Dekany , Istvan Bajza , Károly Ágoston , Ignacio Figueroa Pérez , Markus Hedros , Andreas Schroven , Ioannis Vrasidas , Julien Boutet , Lars Kröger , Christoph Röhrig , Imre Kovacs , Péter Trinka , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , László Kalmár , Elise Champion
发明人： Gyula Dekany , Istvan Bajza , Károly Ágoston , Ignacio Figueroa Pérez , Markus Hedros , Andreas Schroven , Ioannis Vrasidas , Julien Boutet , Lars Kröger , Christoph Röhrig , Imre Kovacs , Péter Trinka , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , László Kalmár , Elise Champion
IPC分类号： C07H1/06
摘要： A method for purifying, separating and/or isolating an oligosaccharide or a salt thereof is presented. An embodiment of the invention is based upon the formation of anomeric O-benzyl/substituted O-benzyl derivatives in a selective anomeric alkylation reaction.
摘要翻译： 提出了一种纯化，分离和/或分离寡糖或其盐的方法。 本发明的一个实施方案基于在选择性端基异构烷基化反应中形成端基异构O-苄基/取代的O-苄基衍生物。
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