-
公开(公告)号：US09237764B2
公开(公告)日：2016-01-19
申请号：US13579738
申请日：2011-02-21
申请人： Ignacio Figueroa Pérez , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
发明人： Ignacio Figueroa Pérez , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
IPC分类号： C07H1/00 , C07H3/04 , C07H5/04 , C07H5/10 , A23L1/308 , C07H3/06 , C07H15/18 , A61K31/702 , C07H13/04 , A23L1/30
CPC分类号： A23L1/308 , A23L33/10 , A23L33/21 , A61K31/702 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18
摘要： The present invention relates to a method for preparation of the trisaccharide 6′-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6′-O-sialyllactose salts in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及三糖6'-O-唾液乳糖（式（I））或其盐的制备方法以及在制备或营养中合成和使用6'-O-唾液酸乳糖盐的中间体 组合物。
-
公开(公告)号：US09102966B2
公开(公告)日：2015-08-11
申请号：US13809794
申请日：2011-07-15
申请人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
发明人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
摘要： The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.
摘要翻译： 本发明涉及一种合成通式（1A）化合物及其盐的方法，其中一个R基团为α-唾液酰基部分，另一个为H，X1为碳水化合物接头，A为D-吡喃葡萄糖基 任选被岩藻糖基取代的单元，R1是通过氢解除去的保护基，整数m为0或1，通过反式仲胺反应。
-
公开(公告)号：US20130072675A1
公开(公告)日：2013-03-21
申请号：US13698430
申请日：2011-05-19
申请人： Julien Boutet , Gyula Dekany , Ágnes Jánosi , Gergely Pipa , Ferenc Horváth , Krisztián Kovács , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkó , Lars Kröger , Christoph Röhrig
发明人： Julien Boutet , Gyula Dekany , Ágnes Jánosi , Gergely Pipa , Ferenc Horváth , Krisztián Kovács , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkó , Lars Kröger , Christoph Röhrig
IPC分类号： C07H1/06
摘要： The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.
摘要翻译： 本申请公开了一种岩藻糖结晶方法，其特征在于从包含岩藻糖和至少一种选自6-脱氧 - 托洛糖和6-脱氧 - 古洛糖的6-脱氧糖的混合物中进行结晶。 在一个实施方案中，混合物包含岩藻糖和6-脱氧 - 托洛糖。
-
4.发明授权Glycoconjugates and use thereof as vaccine against Shigella flexneri serotype 3a and X 有权糖缀合物及其用作针对志贺氏菌志贺氏菌血清型3a和X的疫苗公开(公告)号：US08815239B2
公开(公告)日：2014-08-26
申请号：US12663454
申请日：2008-05-16
申请人： Laurence Mulard , Julien Boutet , Catherine Guerreiro , Farida Nato , Philippe Sansonetti , Armelle Phalipon
发明人： Laurence Mulard , Julien Boutet , Catherine Guerreiro , Farida Nato , Philippe Sansonetti , Armelle Phalipon
IPC分类号： A61K39/395 , A61K39/112 , A61P31/04 , C12N15/13
CPC分类号： C07K16/1228 , A61K47/646 , C07H1/00 , C07H3/04 , C07H3/06 , C07H5/04
摘要： The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.
摘要翻译： 本发明涉及衍生自富含志贺氏菌志贺氏菌血清型3a和X的表位的糖的化合物及其制备疫苗组合物的用途。 更具体地，本发明的主题涉及包含下文所述的寡糖或多糖的新型糖缀合化合物，涉及将这些寡糖或多糖和糖缀合物合成的方法，这些寡糖或多糖的衍生物用于含有它们的组合物，还涉及 使用糖缀合物进行疫苗接种。 最后，本发明涉及使用一种或多种寡糖或多糖或其结合物诊断志贺氏杆菌感染的方法。
-
公开(公告)号：US20120116065A1
公开(公告)日：2012-05-10
申请号：US13263716
申请日：2010-04-07
申请人： Gyula Dékany , Istvan Bajza , Julien Boutet , Ignacio Pérez Figueroa , Markus Hederos , Piroska Kovács-Pénzes , Lars Króger , Johan Olsson , Christoph Róhrig , Andreas Schroven , Ioannis Vrasidas
发明人： Gyula Dékany , Istvan Bajza , Julien Boutet , Ignacio Pérez Figueroa , Markus Hederos , Piroska Kovács-Pénzes , Lars Króger , Johan Olsson , Christoph Róhrig , Andreas Schroven , Ioannis Vrasidas
IPC分类号： C07H3/06 , C07H15/203 , C07H15/26 , C07H1/00
CPC分类号： C07H3/06 , C07H1/00 , C07H15/04 , C07H15/203
摘要： The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.
摘要翻译： 本发明涉及下式的三糖的改进合成：用于合成和制备中间体的新型中间体。
-
6.发明申请MUTANTS OF GLYCOSIDE HYDROLASES AND USES THEREOF FOR SYNTHESIZING COMPLEX OLIGOSACCHARIDES AND DISACCHARIDE INTERMEDIATES 审中-公开甘油三酯水解物及其用于合成复合寡糖和不对称中间体的用途公开(公告)号：US20110144317A1
公开(公告)日：2011-06-16
申请号：US12922113
申请日：2009-03-12
申请人： Laurence Mulard , Isabelle Andre , Elise Champion , Claire Moulis , Sandrine Morel , Pierre Monsan , Magali Remaud-Simeon , Julien Boutet
发明人： Laurence Mulard , Isabelle Andre , Elise Champion , Claire Moulis , Sandrine Morel , Pierre Monsan , Magali Remaud-Simeon , Julien Boutet
IPC分类号： C12P19/12 , C12N9/10 , C12N9/24 , C07H21/00 , C12N15/63 , C12P19/26 , C07H15/04 , C07H13/02 , C07H9/04
CPC分类号： C12P19/16 , C12N9/1051 , C12N9/2402 , C12P19/18 , C12Y204/01004 , C12Y302/01048
摘要： Method for preparing the disaccharide [α-D-Gldp(1→3)]-α-L-Rhap-YR wherein Y is selected from —O— and —S— and R is selected from the group consisting of: C1-C6 alkyl, C1-C6 alkenyl, aryl, allyl, —CO-alkyl (C1-C6), —CO-alkenyl (C1-C6), —CO-aryl comprising the step of using a mutant of a wild type glycoside hydrolase.
摘要翻译： 制备二糖[α-D-Gldp（1→3）] -a-L-Rhap-YR的方法，其中Y选自-O-和-S-，R选自：C 1 -C 6 烷基，C 1 -C 6烯基，芳基，烯丙基，-CO-烷基（C 1 -C 6），-CO-烯基（C 1 -C 6），-CO-芳基，包括使用野生型糖苷水解酶突变体的步骤。
-
公开(公告)号：US08927698B2
公开(公告)日：2015-01-06
申请号：US13263716
申请日：2010-04-07
申请人： Gyula Dékany , Istvan Bajza , Julien Boutet , Ignacio Pérez Figueroa , Markus Hederos , Ferenc Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
发明人： Gyula Dékany , Istvan Bajza , Julien Boutet , Ignacio Pérez Figueroa , Markus Hederos , Ferenc Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
IPC分类号： C07H3/06 , C07H15/203 , C07H15/26 , C07H1/00 , C07H15/04
CPC分类号： C07H3/06 , C07H1/00 , C07H15/04 , C07H15/203
摘要： The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.
摘要翻译： 本发明涉及下式的三糖的改进合成：用于合成和制备中间体的新型中间体。
-
公开(公告)号：US08901291B2
公开(公告)日：2014-12-02
申请号：US13698430
申请日：2011-05-19
申请人： Julien Boutet , Gyula Dekany , Ágnes Jànosi , Gergely Pipa , Ferenc Horvàth , Krisztián Kovàcs , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkò , Lars Kröger , Christoph Röhrig
发明人： Julien Boutet , Gyula Dekany , Ágnes Jànosi , Gergely Pipa , Ferenc Horvàth , Krisztián Kovàcs , Ignacio Pérez Figueroa , Markus Hederos , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , Sándor Demkò , Lars Kröger , Christoph Röhrig
摘要： The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.
摘要翻译： 本申请公开了一种岩藻糖结晶方法，其特征在于从包含岩藻糖和至少一种选自6-脱氧 - 托洛糖和6-脱氧 - 古洛糖的6-脱氧糖的混合物中进行结晶。 在一个实施方案中，混合物包含岩藻糖和6-脱氧 - 托洛糖。
-
公开(公告)号：US08889637B2
公开(公告)日：2014-11-18
申请号：US13701085
申请日：2011-06-01
申请人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa-Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
发明人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa-Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。
-
公开(公告)号：US20130131334A1
公开(公告)日：2013-05-23
申请号：US13263708
申请日：2010-04-07
申请人： Gyula Dékany , Károly Ágoston , Istvan Bajza , Julien Boutet , Marie Bøjstrup , Mette Fanefjord , Ignacio Pérez Figueroa , Markus Hederos , Ference Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
发明人： Gyula Dékany , Károly Ágoston , Istvan Bajza , Julien Boutet , Marie Bøjstrup , Mette Fanefjord , Ignacio Pérez Figueroa , Markus Hederos , Ference Horvath , Piroska Kovács-Pénzes , Lars Kröger , Johan Olsson , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas
CPC分类号： C07H3/06 , C07H1/00 , C07H15/04 , C07H15/203
摘要： The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.
摘要翻译： 本发明涉及式（1）三糖的改进合成，用于合成和制备中间体的新型中间体。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.024 秒)
