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公开(公告)号：US20130165406A1
公开(公告)日：2013-06-27
申请号：US13701085
申请日：2011-06-01
申请人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
发明人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。
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公开(公告)号：US09237764B2
公开(公告)日：2016-01-19
申请号：US13579738
申请日：2011-02-21
申请人： Ignacio Figueroa Pérez , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
发明人： Ignacio Figueroa Pérez , Ferenc Horváth , Gyula Dekany , Károly Ágoston , Ágnes Ágoston , István Bajza , Julien Boutet , Markus Hederos , Piroska Kovács-Pénzes , Lars Kröger , Christoph Röhrig , Andreas Schroven , Ioannis Vrasidas , Christian Risinger
IPC分类号： C07H1/00 , C07H3/04 , C07H5/04 , C07H5/10 , A23L1/308 , C07H3/06 , C07H15/18 , A61K31/702 , C07H13/04 , A23L1/30
CPC分类号： A23L1/308 , A23L33/10 , A23L33/21 , A61K31/702 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18
摘要： The present invention relates to a method for preparation of the trisaccharide 6′-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6′-O-sialyllactose salts in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及三糖6'-O-唾液乳糖（式（I））或其盐的制备方法以及在制备或营养中合成和使用6'-O-唾液酸乳糖盐的中间体 组合物。
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公开(公告)号：US09102966B2
公开(公告)日：2015-08-11
申请号：US13809794
申请日：2011-07-15
申请人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
发明人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
摘要： The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.
摘要翻译： 本发明涉及一种合成通式（1A）化合物及其盐的方法，其中一个R基团为α-唾液酰基部分，另一个为H，X1为碳水化合物接头，A为D-吡喃葡萄糖基 任选被岩藻糖基取代的单元，R1是通过氢解除去的保护基，整数m为0或1，通过反式仲胺反应。
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4.发明授权1,2-dideoxy-1,2-diamino oligosaccharides and polysaccharides and derivatives thereof 有权1,2-二脱氧-1,2-二氨基寡糖及其多糖及其衍生物公开(公告)号：US08802841B2
公开(公告)日：2014-08-12
申请号：US12741973
申请日：2008-11-03
申请人： Gyula Dekany , István Bajza , Marie Bøjstrup , Károly Ágoston , Lars Kröger , Ignacio Figueroa Pérez , Christoph H. Röhrig , Paulo Vital , Erzsébet Czinege
发明人： Gyula Dekany , István Bajza , Marie Bøjstrup , Károly Ágoston , Lars Kröger , Ignacio Figueroa Pérez , Christoph H. Röhrig , Paulo Vital , Erzsébet Czinege
IPC分类号： A61K31/7016 , C07H5/06 , C07H15/12 , C07H15/16 , C07H15/203 , C08B37/00
CPC分类号： C07H15/12 , C07H5/06 , C07H15/203
摘要： A 1,2-dideoxy-1,2-diamino oligosaccharide or polysaccharide in its free base, salt or metal-complex form as shown in General Formula 1 and derivative thereof is described. R1, R2 and R3 are each independently selected from the group consisting of H and a carbohydrate moiety, with the proviso that at least one of the groups R1, R2 or R3 is a carbohydrate moiety; R4 is selected from the group consisting of: H, optionally substituted C1-20-alkyl, optionally substituted heteroalkyl, optionally substituted C2-20-alkenyl, optionally substituted C2-20-alkynyl, optionally substituted C3-10-cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl.
摘要翻译： 描述了其通式1及其衍生物所示的其游离碱，盐或金属络合物形式的1,2-二脱氧-1,2-二氨基寡糖或多糖。 R 1，R 2和R 3各自独立地选自H和碳水化合物部分，条件是基团R 1，R 2或R 3中的至少一个是碳水化合物部分; R 4选自：H，任选取代的C 1-20 - 烷基，任选取代的杂烷基，任选取代的C 2-20 - 烯基，任选取代的C 2-20 - 炔基，任选取代的C 3-10 - 环烷基，任选取代的杂环基 ，任选取代的芳基和任选取代的杂芳基。
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公开(公告)号：US08889637B2
公开(公告)日：2014-11-18
申请号：US13701085
申请日：2011-06-01
申请人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa-Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
发明人： Károly Ágoston , István Bajza , Gyula Dekany , Péter Trinka , Ágnes Ágoston , Gábor Kádár , Sándor Demkó , Ignacio Figueroa-Pérez , Markus Hederos , Ferenc Horváth , Andreas Schroven , Ioannis Vrasidas , Piroska Kovács-Pénzes , Christian Risinger , László Kalmár , Gergely Pipa , Julien Boutet , Lars Kröger , Christoph Röhrig
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及式（1）的三糖2'-O-岩藻糖基乳糖（2-FL）的新型多晶型物，制备所述多晶型物的方法及其在药物或营养组合物中的用途。
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公开(公告)号：US20130245250A1
公开(公告)日：2013-09-19
申请号：US13878739
申请日：2011-10-13
申请人： Andreas Schroven , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Lars Kröger , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa
发明人： Andreas Schroven , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Lars Kröger , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa
IPC分类号： C07H3/02
摘要： Method for producing L-fucose includes in a first aspect, a method for the preparation of L-fucose, wherein L-fucose precursors are produced from pectin and L-fucose is produced from the L-fucose precursors; in a second aspect, a method for the preparation of L-fucose from D-galacturonic acid or a salt thereof, wherein L-fucose precursors are produced from D-galacturonic acid of a salt thereof, and L-fucose is produced from the L-fucose precursors; and an L-fucose precursor as shown in Formula A, wherein R is a linear or branched chain saturated hydrocarbon group with 1-6 carbon atoms, such as methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, n-hexyl, etc., preferably a methyl group.
摘要翻译： 生产L-岩藻糖的方法在第一方面包括一种制备L-岩藻糖的方法，其中L-果糖前体由果胶生产，L-岩藻糖由L-岩藻糖前体制备; 在第二方面，一种从D-半乳糖醛酸或其盐制备L-岩藻糖的方法，其中L-岩藻糖前体由其半盐酸D-半乳糖醛酸产生，L-岩藻糖由L 岩藻糖前体; 和式I所示的L-岩藻糖前体，其中R是具有1-6个碳原子的直链或支链饱和烃基，例如甲基，乙基，正丙基，异丙基，正丁基，异丁基， 丁基，仲丁基，叔丁基，正己基等，优选甲基。
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公开(公告)号：US20130172548A1
公开(公告)日：2013-07-04
申请号：US13809829
申请日：2011-07-15
申请人： Gyula Dekany , Istvan Bajza , Károly Ágoston , Ignacio Figueroa Pérez , Markus Hedros , Andreas Schroven , Ioannis Vrasidas , Julien Boutet , Lars Kröger , Christoph Röhrig , Imre Kovacs , Péter Trinka , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , László Kalmár , Elise Champion
发明人： Gyula Dekany , Istvan Bajza , Károly Ágoston , Ignacio Figueroa Pérez , Markus Hedros , Andreas Schroven , Ioannis Vrasidas , Julien Boutet , Lars Kröger , Christoph Röhrig , Imre Kovacs , Péter Trinka , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , László Kalmár , Elise Champion
IPC分类号： C07H1/06
摘要： A method for purifying, separating and/or isolating an oligosaccharide or a salt thereof is presented. An embodiment of the invention is based upon the formation of anomeric O-benzyl/substituted O-benzyl derivatives in a selective anomeric alkylation reaction.
摘要翻译： 提出了一种纯化，分离和/或分离寡糖或其盐的方法。 本发明的一个实施方案基于在选择性端基异构烷基化反应中形成端基异构O-苄基/取代的O-苄基衍生物。
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公开(公告)号：US20130171696A1
公开(公告)日：2013-07-04
申请号：US13809794
申请日：2011-07-15
申请人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
发明人： Andreas Schroven , Elise Champion , Gyula Dekany , Christoph Röhrig , Ioannis Vrasidas , Ignacio Figueroa Pérez , Markus Hederos , Julien Boutet , Ágnes Ágoston , Piroska Kovács-Pénzes , Ferenc Horváth , Christian Risinger , Gergely Pipa , Sándor Demkó , Lars Kröger
摘要： The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.
摘要翻译： 本发明涉及一种合成通式（1A）化合物及其盐的方法，其中R基团之一为α-唾液酰基部分，另一个为H，X 1为碳水化合物接头，A为D-吡喃葡萄糖基 任选被岩藻糖基取代的单元，R1是通过氢解除去的保护基，整数m为0或1，通过反式仲胺反应。
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