Polycations capable of forming complexes with nucleic acids
    2.
    发明申请
    Polycations capable of forming complexes with nucleic acids 失效
    能够与核酸形成复合物的聚阳离子

    公开(公告)号:US20060211643A1

    公开(公告)日:2006-09-21

    申请号:US11347001

    申请日:2006-02-03

    摘要: A polycation capable of forming a complex with a nucleic acid for carriage thereof. The polycation comprising at least one cyclic compound having a cavity. A polymer backbone is threaded into the cavity of the cyclic compound. A pair of bulky moieties cap the terminals of the polymer backbone to inhibit dethreading of the cyclic compound from the polymer backbone. In use, the net positive charge of said polycation enables a complex to form with nucleic acid.

    摘要翻译: 能够与核酸形成复合体以运载的聚阳离子。 所述聚阳离子包含至少一种具有空腔的环状化合物。 聚合物骨架螺纹连接到环状化合物的空腔中。 一对蓬松的部分盖住聚合物主链的末端以抑制环状化合物从聚合物主链的脱离。 在使用中,所述聚阳离子的净正电荷使得与核酸形成复合物。

    Method and system for employing a multiple layer cache mechanism to enhance performance of a multi-user information retrieval system
    4.
    发明授权
    Method and system for employing a multiple layer cache mechanism to enhance performance of a multi-user information retrieval system 失效
    一种采用多层缓存机制提高多用户信息检索系统性能的方法和系统

    公开(公告)号:US08326828B2

    公开(公告)日:2012-12-04

    申请号:US12014221

    申请日:2008-01-15

    IPC分类号: G06F7/00

    CPC分类号: G06F17/30902

    摘要: A method and system for optimizing resource usage in an information retrieval system. Meta information in query results describes data items identified by identifiers. A chunk of the identifiers and a set of meta information are loaded into a first cache and a second cache, respectively. A portion of the set of meta information is being viewed by a user. The portion describes a data item identified by an identifier included in the chunk and in a sub-chunk of identifiers that identifies data items described by the set of meta information. If a position of the identifier in the sub-chunk satisfies a first criterion, then a second set of meta information is preloaded into the second cache. If a position of the identifier in the chunk satisfies a second criterion, then a second chunk of the identifiers is preloaded into the first cache.

    摘要翻译: 一种用于优化信息检索系统中的资源使用的方法和系统。 查询结果中的元信息描述了标识符标识的数据项。 标识符和一组元信息的块分别被加载到第一高速缓存和第二高速缓存中。 一组元信息的一部分正在由用户查看。 该部分描述由标识符识别的标识符的数据项,所述标识符包括在标识符的子块中以及标识符的子块中,该标识符标识由所述一组元信息描述的数据项。 如果子块中的标识符的位置满足第一标准,则将第二组元信息预加载到第二高速缓存中。 如果组块中的标识符的位置满足第二标准,则将第二组标识符预加载到第一高速缓存中。

    ANTIMICROBIAL HYDROGELS, METHODS OF PREPARATION THEREOF, AND ARTICLES THEREFROM
    5.
    发明申请
    ANTIMICROBIAL HYDROGELS, METHODS OF PREPARATION THEREOF, AND ARTICLES THEREFROM 有权
    抗微生物水凝胶,其制备方法及其制品

    公开(公告)号:US20120231060A1

    公开(公告)日:2012-09-13

    申请号:US13213555

    申请日:2011-08-19

    摘要: A covalently crosslinked hydrogel comprises a) three or more divalent poly(alkylene oxide) chains P′ covalently linked at respective first end units to a branched first core group C′, b) three or more divalent poly(alkylene oxide) chains P″ covalently linked at respective first end units to a branched second core group C″, the chains P″ comprising respective second end units which are covalently linked to between 0% and 100% of respective second end units of chains P′ by divalent linking groups L″, and c) at least one pendant cationic block copolymer chain A′-B′. A′-B′ comprises i) a divalent block A′ comprising a poly(alkylene oxide) backbone chain having an end unit covalently linked to a second end unit of one of the chains P′ by a divalent linking group L′, and ii) a monovalent block B′ comprising a first repeat unit, the first repeat unit comprising a backbone carbonate group and a cationic side chain group.

    摘要翻译: 共价交联的水凝胶包含a)在相应的第一端单元共价连接到支化的第一核心基团C'上的三个或更多个二价聚(环氧烷)链P',b)共价地三个或更多个二价聚(环氧烷)链P' 在相应的第一末端单元连接到支化的第二核心基团C“,链P”包括各自的第二末端单元,其通过二价连接基团L“共价连接到链P'的相应的第二末端单元的0%和100%之间 ,和c)至少一个阳离子嵌段共聚物链A'-B'。 A'-B'包括:i)包含聚(环氧烷)主链的二价嵌段A',其具有通过二价连接基团L'与链P'之一共价连接的末端单元,ii )包含第一重复单元的单价嵌段B',所述​​第一重复单元包含骨架碳酸酯基团和阳离子侧链基团。

    METHOD AND SYSTEM FOR EMPLOYING A MULTIPLE LAYER CACHE MECHANISM TO ENHANCE PERFORMANCE OF A MULTI-USER INFORMATION RETRIEVAL SYSTEM
    6.
    发明申请
    METHOD AND SYSTEM FOR EMPLOYING A MULTIPLE LAYER CACHE MECHANISM TO ENHANCE PERFORMANCE OF A MULTI-USER INFORMATION RETRIEVAL SYSTEM 失效
    使用多层缓存机制提高多用户信息检索系统性能的方法和系统

    公开(公告)号:US20090182946A1

    公开(公告)日:2009-07-16

    申请号:US12014221

    申请日:2008-01-15

    IPC分类号: G06F12/00

    CPC分类号: G06F17/30902

    摘要: A method and system for optimizing resource usage in an information retrieval system. Meta information in query results describes data items identified by identifiers. A chunk of the identifiers and a set of meta information are loaded into a first cache and a second cache, respectively. A portion of the set of meta information is being viewed by a user. The portion describes a data item identified by an identifier included in the chunk and in a sub-chunk of identifiers that identifies data items described by the set of meta information. If a position of the identifier in the sub-chunk satisfies a first criterion, then a second set of meta information is preloaded into the second cache. If a position of the identifier in the chunk satisfies a second criterion, then a second chunk of the identifiers is preloaded into the first cache.

    摘要翻译: 一种用于优化信息检索系统中的资源使用的方法和系统。 查询结果中的元信息描述了标识符标识的数据项。 标识符和一组元信息的块分别被加载到第一高速缓存和第二高速缓存中。 一组元信息的一部分正在由用户查看。 该部分描述由标识符识别的标识符的数据项,所述标识符包括在标识符的子块中以及标识符的子块中,该标识符标识由所述一组元信息描述的数据项。 如果子块中的标识符的位置满足第一标准,则将第二组元信息预加载到第二高速缓存中。 如果组块中的标识符的位置满足第二标准,则将第二组标识符预加载到第一高速缓存中。

    BRANCHED POLYAMINES FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS
    8.
    发明申请
    BRANCHED POLYAMINES FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS 失效
    用于交付生物活性材料的分支聚氨酯

    公开(公告)号:US20140080215A1

    公开(公告)日:2014-03-20

    申请号:US13613338

    申请日:2012-09-13

    IPC分类号: C08G73/02 C12N15/85

    CPC分类号: C12N15/85 C08G73/028

    摘要: A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n′ greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): wherein (n′+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L′ is a divalent radical comprising 3 to 30 carbons, and q/(n′+q)×100% equals about 9% to about 47%.

    摘要翻译: 支链多胺包括约45至约70个主要叔胺基团,约90至约140个骨架仲胺基团,正数n'大于0的主链终止伯胺基团,正数q大于0的骨架终止 式(2)的氨基甲酸酯基团:其中(n'+ q)是等于约45至约70的数,式(2)的星形键与支链多胺的主链氮连接,L'是二价 包含3至30个碳的基团,q /(n'+ q)×100%等于约9%至约47%。

    Compact Spectrometer Including a Diffractive Optical Element with Dual Dispersion and Focusing Functionality
    9.
    发明申请
    Compact Spectrometer Including a Diffractive Optical Element with Dual Dispersion and Focusing Functionality 有权
    包含具有双色散和聚焦功能的衍射光学元件的紧凑型光谱仪

    公开(公告)号:US20120038918A1

    公开(公告)日:2012-02-16

    申请号:US13208922

    申请日:2011-08-12

    IPC分类号: G01J3/18 B29D11/00 G02B5/18

    摘要: Embodiments of the invention provide a device called a “G-Fresnel” device that performs the functions of both a linear grating and a Fresnel lens. We have fabricated the G-Fresnel device by using PDMS based soft lithography. Three-dimensional surface profilometry has been performed to examine the device quality. We have also conducted optical characterizations to confirm its dual focusing and dispersing properties. The G-Fresnel device can be useful for the development of miniature optical spectrometers as well as emerging optofluidic applications. Embodiments of compact spectrometers using diffractive optical elements are also provided. Theoretical simulation shows that a spectral resolution of approximately 1 nm can be potentially achieved with a millimeter-sized G-Fresnel. A proof-of-concept G-Fresnel-based spectrometer with subnanometer spectral resolution is experimentally demonstrated.

    摘要翻译: 本发明的实施例提供了一种称为“G-Fresnel”器件的器件,其执行线性光栅和菲涅耳透镜的功能。 我们通过使用基于PDMS的软光刻制造了G-Fresnel器件。 已经进行三维表面轮廓测量以检查设备质量。 我们还进行了光学表征,以确认其双重聚焦和分散性能。 G-Fresnel器件可用于开发微型光谱仪以及新兴的光流体应用。 还提供了使用衍射光学元件的紧凑型光谱仪的实施例。 理论模拟显示,使用毫米级的G-Fresnel可以潜在地实现约1nm的光谱分辨率。 实验证明了具有亚纳米光谱分辨率的概念验证型G-菲涅耳光谱仪。

    BIODEGRADABLE BLOCK POLYMERS FOR DRUG DELIVERY, AND METHODS RELATED THERETO
    10.
    发明申请
    BIODEGRADABLE BLOCK POLYMERS FOR DRUG DELIVERY, AND METHODS RELATED THERETO 有权
    用于药物递送的生物可降解块聚合物及其相关方法

    公开(公告)号:US20110152167A1

    公开(公告)日:2011-06-23

    申请号:US12646024

    申请日:2009-12-23

    摘要: A biodegradable block copolymer is disclosed, comprising a hydrophilic block derived from a polyether alcohol; and a hydrophobic block comprising a first repeat unit derived by ring opening polymerization of a first cyclic carbonyl monomer initiated by the polyether alcohol, the first repeat unit comprising a side chain moiety comprising a functional group selected from the group consisting of urea groups, a carboxylic acid groups, and mixtures thereof. No side chain of the hydrophobic block comprises a covalently bound biologically active material. The block copolymer self-assembles in water forming micelles suitable for sequestering a biologically active material by a non-covalent interaction, and the block copolymer is 60% biodegraded within 180 days in accordance with ASTM D6400.

    摘要翻译: 公开了一种可生物降解的嵌段共聚物,其包含衍生自聚醚醇的亲水性嵌段; 和疏水嵌段,其包含通过由所述聚醚醇引发的第一环状羰基单体的开环聚合衍生的第一重复单元,所述第一重复单元包含侧链部分,所述侧链部分包含选自脲基,羧酸 酸基团,及其混合物。 疏水嵌段的侧链不包括共价结合的生物活性材料。 嵌段共聚物在水形成胶束中自组装,适合于通过非共价相互作用螯合生物活性材料,并且嵌段共聚物根据ASTM D6400在180天内生物降解60%。