公开(公告)号：US20110033904A1

公开(公告)日：2011-02-10

申请号：US12937876

申请日：2008-04-25

申请人： Jun Seong Park ,  Hye Yoon Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang ,  Byung Gee Kim ,  Chang Hyun Roh ,  Su Hyun Seo ,  Kwon Young Choi ,  June Hyung Kim ,  Min-Ho Cha ,  Prasad Pandey Bishnu

发明人： Jun Seong Park ,  Hye Yoon Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang ,  Byung Gee Kim ,  Chang Hyun Roh ,  Su Hyun Seo ,  Kwon Young Choi ,  June Hyung Kim ,  Min-Ho Cha ,  Prasad Pandey Bishnu

IPC分类号： C12P17/06

CPC分类号： C12P17/06 ,  C12N1/20

摘要： Disclosed herein is a method for preparing ortho-dihydroxyisoflavones using a biotransformation system. More specifically, disclosed is a method for preparing ortho-dihydroxyisoflavones, which comprises biotransforming daidzein or genistein by actinomycete microorganisms, particularly Streptomyces avermitilis, Nocardia farcinica or Streptomyces lincolnesis, in order to efficiently prepare ortho-dihydroxyisoflavones having an excellent antioxidant function and a whitening effect.

摘要翻译： 本文公开了使用生物转化体系制备邻二羟基异黄酮的方法。 更具体地，公开了一种制备邻二羟基异黄酮的方法，其包括通过放线菌微生物，特别是阿维链霉素（Streptomyces avermitilis），诺卡氏菌（Nocardia farcinica）或林链霉菌（Streptomyces lincolnesis））生物转化黄豆苷原或染料木黄酮，以有效制备具有优异抗氧化功能和增白效果的邻二羟基异黄酮 。

公开(公告)号：US20100113372A1

公开(公告)日：2010-05-06

申请号：US12445362

申请日：2007-04-25

申请人： Jun Seong Park ,  Hye Yoon Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang

发明人： Jun Seong Park ,  Hye Yoon Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang

IPC分类号： A61K31/70 ,  C12P19/60

CPC分类号： C12P19/60

摘要： Disclosed is a method for the preparation of kaempferol-3-O-rutinoside and a composition of a skin external application comprising kaempferol-3-O-rutinoside as an active ingredient. The method for isolating kaempferol-3-O-rutinoside through hydrolysis uses an enzyme or microbe that removes the sugar selectively from kaempferol-3-O-rutinoside glycosides in a plant extract. Disclosed also is a composition of a skin external application comprising kaempferol-3-O-rutinoside that prevents skin wrinkle.

摘要翻译： 本发明公开了山奈酚-3-O-芸香糖苷的制备方法以及含有山奈酚-3-O-芸香糖苷作为活性成分的外用皮肤组合物。 通过水解分离山奈酚-3-O-芸香糖苷的方法使用从植物提取物中的山奈酚-3-O-芸香糖苷糖苷中选择性除去糖的酶或微生物。 还公开了一种皮肤外用剂的组合物，其包含防止皮肤皱纹的山奈酚-3-O-芸香糖苷。

公开(公告)号：US08394775B2

公开(公告)日：2013-03-12

申请号：US12095654

申请日：2006-10-30

申请人： Jun Seong Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang

发明人： Jun Seong Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang

IPC分类号： A61K8/60 ,  A61Q19/08

CPC分类号： A61K8/498 ,  A61K8/602 ,  A61K2800/522 ,  A61Q19/02 ,  A61Q19/08

摘要： The present invention relates to a cosmetic composition containing hydrolysates of icariin, and more particularly, a cosmetic composition containing hydrolysates of icariin including icaritin, icariside I and icariside II. The hydrolysates of icariin is prepared by a method comprising the steps of: (a) obtaining an extract from a plant containing icariin using water or an organic solvent; and (b) hydrolyzing the plant extract with an acid, a base, an enzyme or a microorganism producing the enzyme. The cosmetic composition according to the present invention is employed for anti-oxidant, anti-aging, whitening or anti-wrinkling effects.

摘要翻译： 本发明涉及含有淫羊藿苷的水解物的化妆品组合物，更具体地说，涉及包含淫羊藿苷，吡螨苷I和鸢尾苷II的淫羊藿苷的水解物的化妆品组合物。 淫羊The苷的水解物是通过包括以下步骤的方法制备的：（a）使用水或有机溶剂从含有淫羊藿苷的植物中获得提取物; 和（b）用产生该酶的酸，碱，酶或微生物水解植物提取物。 根据本发明的化妆品组合物用于抗氧化，抗衰老，增白或起皱作用。

公开(公告)号：US20090170787A1

公开(公告)日：2009-07-02

申请号：US12095654

申请日：2006-10-30

申请人： Jun Seong Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang

发明人： Jun Seong Park ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang

IPC分类号： A61K8/60 ,  A61Q19/08

CPC分类号： A61K8/498 ,  A61K8/602 ,  A61K2800/522 ,  A61Q19/02 ,  A61Q19/08

摘要： The present invention relates to a cosmetic composition containing hydrolysates of icariin, and more particularly, a cosmetic composition containing hydrolysates of icariin including icaritin, icariside I and icariside II. The hydrolysates of icariin is prepared by a method comprising the steps of: (a) obtaining an extract from a plant containing icariin using water or an organic solvent; and (b) hydrolyzing the plant extract with an acid, a base, an enzyme or a microorganism producing the enzyme. The cosmetic composition according to the present invention is employed for anti-oxidant, anti-aging, whitening or anti-wrinkling effects.

摘要翻译： 本发明涉及含有淫羊藿苷的水解物的化妆品组合物，更具体地说，涉及包含淫羊藿苷，吡螨苷I和鸢尾苷II的淫羊藿苷的水解物的化妆品组合物。 淫羊The苷的水解物是通过包括以下步骤的方法制备的：（a）使用水或有机溶剂从含有淫羊藿苷的植物中获得提取物; 和（b）用产生该酶的酸，碱，酶或微生物水解植物提取物。 根据本发明的化妆品组合物用于抗氧化，抗衰老，增白或起皱作用。

公开(公告)号：US07943599B2

公开(公告)日：2011-05-17

申请号：US11921180

申请日：2006-05-29

申请人： Jae Won You ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang ,  Ok Sub Lee

发明人： Jae Won You ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang ,  Ok Sub Lee

IPC分类号： A61K31/66 ,  C07F9/12

CPC分类号： A61K8/55 ,  A61K2800/522 ,  A61Q19/08 ,  C07F9/65517

摘要： The present invention relates to a sesamol derivative or its salt, and a skin external composition containing the same. More particularly, the invention relates to a sesamol derivative or its salt, which consists of sesamol and 3-aminopropane phosphoric acid, linked with each other by a phosphoric acid diester bond, and can be degraded into sesamol and 3-aminopropane phosphoric acid by enzymes present on the skin so as to simultaneously show the physiological activities of sesamol and 3-aminopropane phosphoric acid, as well as a preparation method thereof and a skin external composition containing the same.

摘要翻译： 本发明涉及一种芝麻酚衍生物或其盐，以及包含其的皮肤外用组合物。 更具体地，本发明涉及由芝麻酚和3-氨基丙烷磷酸组成的芝麻酚衍生物或其盐，其通过磷酸二酯键彼此连接，并且可以通过酶降解成芝麻酚和3-氨基丙烷磷酸 存在于皮肤上，以同时显示西沙莫酚和3-氨基丙烷磷酸的生理活性，以及​​其制备方法和含有它们的皮肤外用组合物。

公开(公告)号：US20080280989A1

公开(公告)日：2008-11-13

申请号：US11990223

申请日：2006-03-20

申请人： Sung Joong Kim ,  Heung Soo Baek ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang ,  Ok Sub Lee ,  Hong Ju Shin ,  Woo Ram Park

发明人： Sung Joong Kim ,  Heung Soo Baek ,  Ho Sik Rho ,  Duck Hee Kim ,  Ih Seop Chang ,  Ok Sub Lee ,  Hong Ju Shin ,  Woo Ram Park

IPC分类号： A61K31/165 ,  C07C233/07 ,  A61P17/00

CPC分类号： C07C235/56 ,  A61K8/42 ,  A61K2800/522 ,  A61Q19/08 ,  Y02P20/55

摘要： Disclosed is a hydroxybenzamide derivative represented by the following Formula. A method for preparing the same and a cosmetic composition comprising the same are also disclosed. More particularly, the hydroxybenzamide derivative is obtained by reacting a hydroxybenzoic acid having a protecting group introduced thereto with a hydroxyphenyl amine to form a benzamide derivative and by hydrolyzing the benzamide derivative in an aqueous base solution to form a hydroxybenzamide derivative. The cosmetic composition comprising the hydroxybenzamide derivative as an active ingredient has excellent anti-oxidative, anti-aging and skin wrinkle-alleviating effects. wherein R1 represents a C1˜C10 alkyl group, and n is an integer ranging from 1 to 3.

摘要翻译： 公开了由下式表示的羟基苯甲酰胺衍生物。 还公开了其制备方法和包含其的化妆品组合物。 更具体地，羟基苯甲酰胺衍生物通过使具有引入其的保护基的羟基苯甲酸与羟基苯基胺反应形成苯甲酰胺衍生物，并通过在碱性水溶液中水解苯甲酰胺衍生物以形成羟基苯甲酰胺衍生物而获得。 包含羟基苯甲酰胺衍生物作为活性成分的化妆品组合物具有优异的抗氧化，抗衰老和抗皱纹作用。 其中R1表示C1〜C10烷基，n为1〜3的整数。

公开(公告)号：US08101214B2

公开(公告)日：2012-01-24

申请号：US12745064

申请日：2008-11-13

申请人： Jun Seong Park ,  Jin Young Lee ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang

发明人： Jun Seong Park ,  Jin Young Lee ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang

IPC分类号： A61K36/00 ,  A61K8/97 ,  A61K36/736

CPC分类号： A61Q19/00 ,  A61K8/97

摘要： Disclosed is a combination for skin external use, which contains as an active ingredient an herbal extract complex consisting of Chinese herbal extracts of Granate bark, seed of Prunus armeniaca, Coix lacuma-jobi, Saururus chinensis and Perilla frutescens var. acuta. More particularly, disclosed is a composition for skin external use containing an herbal extract complex, which is prepared by mixing the Chinese herbs with each other at an optimal ratio to prepare an herbal mixture and extracting the herbal mixture to prepare an herbal extract complex, and thus shows the effects of promoting the differentiation of skin keratinocytes, restoring impaired skin barrier function and increasing skin moisturization compared to extracts obtained by extracting each of the herbs alone.

摘要翻译： 本发明公开了一种皮肤外用组合物，其含有作为活性成分的草药提取物复合物，其由中国草药提取物，花生酸树皮，李子种子，枸杞子，中华堇和紫苏等组成。 acuta。 更具体地，公开了含有草药提取物复合物的皮肤外用组合物，其通过以最佳比例混合中草药以制备草药混合物并提取草药混合物以制备草药提取物复合物而制备，以及 从而显示了与通过单独提取每种草药获得的提取物相比，促进皮肤角质化细胞分化，恢复受损的皮肤屏障功能和增加皮肤保湿的效果。

公开(公告)号：US20110014149A1

公开(公告)日：2011-01-20

申请号：US12745064

申请日：2008-11-13

申请人： Jun Seong Park ,  Jin Young Lee ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang

发明人： Jun Seong Park ,  Jin Young Lee ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang

IPC分类号： A61K8/97 ,  A61K36/736 ,  A61P17/00 ,  A61Q19/00 ,  A61Q19/10 ,  A61Q5/06 ,  A61Q5/02 ,  A61Q1/00

CPC分类号： A61Q19/00 ,  A61K8/97

摘要： Disclosed is a combination for skin external use, which contains as an active ingredient an herbal extract complex consisting of Chinese herbal extracts of Granate bark, seed of Prunus armeniaca, Coix lacuma-jobi, Saururus chinensis and Perilla frutescens var. aceta. More particularly, disclosed is a composition for skin external use containing an herbal extract complex, which is prepared by mixing the Chinese herbs with each other at an optimal ratio to prepare an herbal mixture and extracting the herbal mixture to prepare an herbal extract complex, and thus shows the effects of promoting the differentiation of skin keratinocytes, restoring impaired skin barrier function and increasing skin moisturization compared to extracts obtained by extracting each of the herbs alone.

摘要翻译： 本发明公开了一种皮肤外用组合物，其含有作为活性成分的草药提取物复合物，其由中国草药提取物，花生酸树皮，李子种子，枸杞子，中华堇和紫苏等组成。 乙酸 更具体地，公开了含有草药提取物复合物的皮肤外用组合物，其通过以最佳比例混合中草药以制备草药混合物并提取草药混合物以制备草药提取物复合物而制备，以及 从而显示了与通过单独提取每种草药获得的提取物相比，促进皮肤角质化细胞分化，恢复受损的皮肤屏障功能和增加皮肤保湿的效果。

公开(公告)号：US08916210B2

公开(公告)日：2014-12-23

申请号：US12744600

申请日：2008-02-18

申请人： Jin Young Lee ,  Jun Seong Park ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang ,  Sun Young Kim ,  Hyun Soo Jo

发明人： Jin Young Lee ,  Jun Seong Park ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang ,  Sun Young Kim ,  Hyun Soo Jo

IPC分类号： A61K36/00 ,  A21B1/02 ,  B01J19/00 ,  A47J31/32

CPC分类号： A47J31/32

摘要： Disclosed are an extractor having a “pottery with dark brown glaze” called “Onggi” in Korean, and a method of extracting using the same. The extractor includes a body, a body cover, a heating part, a pottery and a gas valve. The pottery is located within the body. The extractor extracts by injecting nitrogen gas, etc. into the body through a gas valve, thereby rendering the inside of the body to be high pressure state during extraction. Thus, the inside of the body is maintained under high pressure during extraction. Accordingly, an extract is located only within the pottery, and thus changes that can be caused while an extract contacts with the body can be prevented.

摘要翻译： 公开了一种提取器，其具有韩文中称为“Onggi”的“具有深棕色釉的陶器”，以及使用其提取的方法。 提取器包括主体，主体盖，加热部，陶器和气阀。 陶器位于身体内。 萃取器通过气阀将氮气等注入到体内，从而使提取过程中的身体内部成为高压状态。 因此，在提取期间，身体内部保持高压。 因此，提取物仅位于陶器内，因此可以防止在提取物与身体接触时可能引起的变化。

公开(公告)号：US20100291243A1

公开(公告)日：2010-11-18

申请号：US12744600

申请日：2008-02-18

申请人： Jin Young Lee ,  Jun Seong Park ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang ,  Sun Young Kim ,  Hyun Soo Jo

发明人： Jin Young Lee ,  Jun Seong Park ,  Eun Joo Kim ,  Hye Yoon Park ,  Sung Il Park ,  Youn Joon Kim ,  Duck Hee Kim ,  Ih Seop Chang ,  Sun Young Kim ,  Hyun Soo Jo

IPC分类号： A61K36/00 ,  B01J19/00

CPC分类号： A47J31/32

摘要： Disclosed are an extractor having a “pottery with dark brown glaze” called “Onggi” in Korean, and a method of extracting using the same. The extractor includes a body, a body cover, a heating part, a pottery and a gas valve. The pottery is located within the body. The extractor extracts by injecting nitrogen gas, etc. into the body through a gas valve, thereby rendering the inside of the body to be high pressure state during extraction. Thus, the inside of the body is maintained under high pressure during extraction. Accordingly, an extract is located only within the pottery, and thus changes that can be caused while an extract contacts with the body can be prevented.

摘要翻译： 公开了一种提取器，其具有韩文中称为“Onggi”的“具有深棕色釉的陶器”，以及使用其提取的方法。 提取器包括主体，主体盖，加热部，陶器和气阀。 陶器位于身体内。 萃取器通过气阀将氮气等注入到体内，从而使提取过程中的身体内部成为高压状态。 因此，在提取期间，身体内部保持高压。 因此，提取物仅位于陶器内，因此可以防止在提取物与身体接触时可能引起的变化。