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    METHOD FOR PRODUCING STEROID COMPOUND
    1.
    发明申请
    METHOD FOR PRODUCING STEROID COMPOUND 审中-公开
    生产甾体化合物的方法

    公开(公告)号：US20100063272A1

    公开(公告)日：2010-03-11

    申请号：US12160338

    申请日：2007-01-12

    申请人： Jun Takehara ,  Naoya Fujiwara ,  Kyouko Endou ,  Junya Kawai ,  Akemi Hosokawa ,  Naoko Sumitani

    发明人： Jun Takehara ,  Naoya Fujiwara ,  Kyouko Endou ,  Junya Kawai ,  Akemi Hosokawa ,  Naoko Sumitani

    IPC分类号： C07J71/00 ,  C07J9/00 ,  C07C29/10

    CPC分类号： C07J9/005 ,  C07J17/00

    摘要： It is an object of the present invention to provide a novel method for producing a steroid compound. The present invention provides a method for producing 5β-3,7-dioxocholanic acid or an ester derivative thereof, using, as a raw material, a sterol having double bonds at position 5 and at position 24, such as cholesta-5,7,24-trien-3β-ol, ergosta-5,7,24(28)-trien-3β-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3β-ol, via the following 4 steps:(I) a step involving oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4; (II) a step involving the oxidative cleavage of a side chain to convert position 24 to a carboxyl group or an ester derivative thereof; (III) a step of introducing an oxygen functional group into position 7; and (IV) a step of constructing a 5β configuration by reductive saturation of a double bond at position 4.

    摘要翻译： 本发明的目的是提供一种制备类固醇化合物的新方法。 本发明提供了使用在5位和24位具有双键的甾醇如胆石酯-5,7制备作为原料的5αb-三 - （3,7-二氧代胆烷酸）或其酯衍生物的方法 ，24-三烯-3β-醇，麦角甾-5,7,24（28） - 三烯-3β-醇，去极化醇，岩藻甾醇或麦角甾-5,24（28） - 二烯-3β-醇， 以下4个步骤：（I）涉及氧化位置3处的羟基并将位置5的双键异构化到位置4的步骤; （II）涉及侧链的氧化断裂以将位置24转化为羧基或其酯衍生物的步骤; （III）将氧官能团引入位置7的步骤; 和（四）构建5＆bgr的步骤; 通过在位置4的双键的还原饱和构型。

    METHOD FOR PRODUCING A STEROID COMPOUND
    2.
    发明申请
    METHOD FOR PRODUCING A STEROID COMPOUND 审中-公开
    生产甾体化合物的方法

    公开(公告)号：US20110009615A1

    公开(公告)日：2011-01-13

    申请号：US12827902

    申请日：2010-06-30

    申请人： Jun Takehara ,  Naoya Fujiwara ,  Junya Kawai ,  Kyouko Endou ,  Kiyoshi Ooyama

    发明人： Jun Takehara ,  Naoya Fujiwara ,  Junya Kawai ,  Kyouko Endou ,  Kiyoshi Ooyama

    IPC分类号： C07J71/00 ,  C07J9/00 ,  C07J75/00 ,  C07J17/00 ,  C07C67/31 ,  C07J13/00

    CPC分类号： C07J17/00 ,  C07J9/005

    摘要： An object of the present invention is to provide a novel method for producing a steroid compound. The present invention provides a method for producing 3,7-dioxo-5β-cholanic acid or ester derivatives thereof, which uses, as raw materials, sterols having double bonds at positions 5 and 24, such as cholesta-5,7,24-trien-3β-ol, ergosta-5,7,24(28)-trien-3β-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3β-ol, and which comprises the following 4 steps: (I) a step of performing oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4; (II) a step of converting position 24 to a carboxyl group or an ester derivative thereof by the oxidative cleavage of a side chain; (III) a step of introducing an oxygen functional group into position 7; and (IV) a step of constructing a 5β-configuration by reduction of a double bond at position 4.

    摘要翻译： 本发明的目的在于提供一种新型的类固醇化合物的制造方法。 本发明提供了制备3,7-二氧代-5'-胆烷酸或其酯衍生物的方法，该方法以5号和24号位置上具有双键的甾醇如胆甾烯-5,7,24 - 三烯-3和bgr-醇，麦角甾-5,7,24（28） - 三烯-3β-醇，去极化醇，岩藻甾醇或麦角甾-5,24（28） - 二烯-3β-醇，其包含 以下4个步骤：（I）在位置3处氧化羟基并将位置5的双键异构化到位置4的步骤; （II）通过侧链的氧化裂解将位置24转化为羧基或其酯衍生物的步骤; （III）将氧官能团引入位置7的步骤; 和（IV）通过在位置4还原双键来构建5＆bgr-构型的步骤。

    Production method of steroid compound
    3.
    发明申请
    Production method of steroid compound 审中-公开
    类固醇化合物的制备方法

    公开(公告)号：US20060252948A1

    公开(公告)日：2006-11-09

    申请号：US11264035

    申请日：2005-11-02

    申请人： Jun Takehara ,  Naoya Fujiwara ,  Junya Kawai ,  Kyouko Endou ,  Kiyoshi Ooyama

    发明人： Jun Takehara ,  Naoya Fujiwara ,  Junya Kawai ,  Kyouko Endou ,  Kiyoshi Ooyama

    IPC分类号： C07J9/00

    CPC分类号： C07J17/00 ,  C07J9/005

    摘要： An object of the present invention is to provide a novel method for producing a steroid compound. The present invention provides a method for producing 3,7-dioxo-5β-cholanic acid or ester derivatives thereof, which uses, as raw materials, sterols having double bonds at positions 5 and 24, such as cholesta-5,7,24-trien-3β-ol, ergosta-5,7,24(28)-trien-3β-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3β-ol, and which comprises the following 4 steps: (I) a step of performing oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4; (II) a step of converting position 24 to a carboxyl group or an ester derivative thereof by the oxidative cleavage of a side chain; (III) a step of introducing an oxygen functional group into position 7; and (IV) a step of constructing a 5β-configuration by reduction of a double bond at position 4.

    摘要翻译： 本发明的目的在于提供一种新型的类固醇化合物的制造方法。 本发明提供一种制备3,7-二氧代-5β-胆酸或其酯衍生物的方法，其以5号和24号位置具有双键的甾醇如胆甾醇-5,7,24- 三烯-3β-醇，麦角甾-5,7,24（28）三烯-3β-醇，去极化醇，岩藻甾醇或麦角甾-5,24（28） - 二烯-3β-醇，并且其包括以下4个步骤 ：（I）在位置3进行羟基氧化和在5位双键异构化到4位的步骤; （II）通过侧链的氧化裂解将位置24转化为羧基或其酯衍生物的步骤; （III）将氧官能团引入位置7的步骤; 和（IV）通过在位置4处还原双键来构建5beta构型的步骤。

    Substation instrument control system
    4.
    发明授权
    Substation instrument control system 有权
    变电站仪表控制系统

    公开(公告)号：US08682603B2

    公开(公告)日：2014-03-25

    申请号：US13158162

    申请日：2011-06-10

    申请人： Hiroyuki Maehara ,  Tomonori Nishida ,  Shigeki Katayama ,  Yukihiko Maede ,  Minoru Saito ,  Wataru Yamamori ,  Jun Takehara ,  Takaya Shono

    发明人： Hiroyuki Maehara ,  Tomonori Nishida ,  Shigeki Katayama ,  Yukihiko Maede ,  Minoru Saito ,  Wataru Yamamori ,  Jun Takehara ,  Takaya Shono

    IPC分类号： G06F19/00

    CPC分类号： H04Q9/00 ,  H04Q2209/845

    摘要： A substation instrument control system is disclosed. The substation instrument control system includes a plurality of transformers that generate a plurality of waveform signals representing electric properties of a substation instrument main body. A merging unit is communicatively coupled to the plurality of transformers and includes a signal processing unit and a control unit. The signal processing unit receives the plurality of waveform signals from the plurality of transformers and converts the plurality of waveform signals to a digital signal. The control unit controls operation of the signal processing unit using a setting data. An intelligent electronic device is communicatively coupled to the merging unit and receives the digital signal from the merging unit.

    摘要翻译： 公开了变电站仪表控制系统。 变电站仪表控制系统包括产生表示变电站仪器主体的电气特性的多个波形信号的多个变压器。 合并单元通信地耦合到多个变压器，并且包括信号处理单元和控制单元。 信号处理单元从多个变压器接收多个波形信号，并将多个波形信号转换为数字信号。 控制单元使用设定数据来控制信号处理单元的动作。 智能电子设备通信地耦合到合并单元并从合并单元接收数字信号。

    REDUNDANT SUPERVISORY CONTROL SYSTEM, AND REDUNDANCY SWITCHING METHOD OF THE SAME
    6.
    发明申请
    REDUNDANT SUPERVISORY CONTROL SYSTEM, AND REDUNDANCY SWITCHING METHOD OF THE SAME 有权
    冗余监控系统及其冗余切换方法

    公开(公告)号：US20070147232A1

    公开(公告)日：2007-06-28

    申请号：US11566310

    申请日：2006-12-04

    申请人： Jun Takehara ,  Akira Sawada ,  Makoto Toko ,  Hiroyuki Kusakabe ,  Shinya Kono ,  Yuuji Umeda

    发明人： Jun Takehara ,  Akira Sawada ,  Makoto Toko ,  Hiroyuki Kusakabe ,  Shinya Kono ,  Yuuji Umeda

    IPC分类号： H04L12/26 ,  H04J3/14

    CPC分类号： G05B9/02

    摘要： An object is to provide a redundant supervisory control system and a redundancy switching method thereof. In the redundant supervisory control system, remote I/O apparatuses are less likely to be inaccessible, even in a case where failures occur in plural locations. Thus, the reliability of the system is enhanced. The redundant supervisory control system including a plurality of first loop interface units in each of a pair of controllers, second loop interface units, and communication cables each connecting the plurality of first and second loop interface units with one another in a circular loop. The redundant supervisory control system is configured by connecting the controllers and the remote I/O units to one another in a plurality of loop networks. In a case where abnormality in the loop networks is detected by use of received data in the networks, the first and second loop interface units that can perform normal reception are automatically selected.

    摘要翻译： 目的在于提供一种冗余监控系统及其冗余切换方法。 在冗余监控系统中，即使在多个位置发生故障的情况下，远程I / O设备也不太可能无法访问。 因此，提高了系统的可靠性。 冗余监控系统包括在一对控制器，第二回路接口单元和通信电缆中的每一个中的多个第一回路接口单元，每个控制器，第二回路接口单元和通信电缆中的每一个以圆形回路相互连接多个第一和第二回路接口单元。 冗余监控系统通过在多个环路网络中将控制器和远程I / O单元彼此连接来配置。 在通过使用网络中的接收数据检测到环路网络中的异常的情况下，可以自动选择能够执行正常接收的第一和第二环路接口单元。

    Clock diagnosis circuit
    8.
    发明授权
    Clock diagnosis circuit 失效
    时钟诊断电路

    公开(公告)号：US08717066B2

    公开(公告)日：2014-05-06

    申请号：US13614235

    申请日：2012-09-13

    申请人： Naoya Ohnishi ,  Hiroshi Nakatani ,  Yoshito Sameda ,  Jun Takehara ,  Makoto Toko

    发明人： Naoya Ohnishi ,  Hiroshi Nakatani ,  Yoshito Sameda ,  Jun Takehara ,  Makoto Toko

    IPC分类号： H03K5/22

    CPC分类号： H03K5/19 ,  G06F1/04

    摘要： A clock diagnosis circuit includes: a delay circuit to delay the clock by a prescribed time which is not more than the clock pulse width; an integral multiplication delay circuit to delay a delayed clock outputted from the delay circuit by a prescribed number of cycles; a first exclusive OR circuit to encode the clock using the delayed clock; a second exclusive OR circuit to decode an output of the first exclusive OR circuit using an output of the integral multiplication delay circuit; and a comparison circuit to compare the clock with an output of the second exclusive OR circuit to thereby detect a malfunction of the clock.

    摘要翻译： 时钟诊断电路包括：将时钟延迟规定时间的延迟电路，该规定时间不大于时钟脉冲宽度; 整数乘法延迟电路，用于将从延迟电路输出的延迟时钟延迟预定数量的周期; 使用延迟时钟对时钟进行编码的第一异或电路; 使用积分乘法延迟电路的输出来对第一异或电路的输出进行解码的第二异或电路; 以及比较电路，用于将时钟与第二异或电路的输出进行比较，从而检测时钟的故障。

    Redundant supervisory control system, and redundancy switching method of the same
    10.
    发明授权
    Redundant supervisory control system, and redundancy switching method of the same 有权
    冗余监控系统和冗余切换方法相同

    公开(公告)号：US07613108B2

    公开(公告)日：2009-11-03

    申请号：US11566310

    申请日：2006-12-04

    申请人： Jun Takehara ,  Akira Sawada ,  Makoto Toko ,  Hiroyuki Kusakabe ,  Shinya Kono ,  Yuuji Umeda

    发明人： Jun Takehara ,  Akira Sawada ,  Makoto Toko ,  Hiroyuki Kusakabe ,  Shinya Kono ,  Yuuji Umeda

    IPC分类号： G06F11/16

    CPC分类号： G05B9/02

    摘要： An object is to provide a redundant supervisory control system and a redundancy switching method thereof. In the redundant supervisory control system, remote I/O apparatuses are less likely to be inaccessible, even in a case where failures occur in plural locations. Thus, the reliability of the system is enhanced. The redundant supervisory control system including a plurality of first loop interface units in each of a pair of controllers, second loop interface units, and communication cables each connecting the plurality of first and second loop interface units with one another in a circular loop. The redundant supervisory control system is configured by connecting the controllers and the remote I/O units to one another in a plurality of loop networks. In a case where abnormality in the loop networks is detected by use of received data in the networks, the first and second loop interface units that can perform normal reception are automatically selected.

    摘要翻译： 目的在于提供一种冗余监控系统及其冗余切换方法。 在冗余监控系统中，即使在多个位置发生故障的情况下，远程I / O设备也不太可能无法访问。 因此，提高了系统的可靠性。 冗余监控系统包括在一对控制器，第二回路接口单元和通信电缆中的每一个中的多个第一回路接口单元，每个控制器，第二回路接口单元和通信电缆中的每一个以圆形回路彼此连接多个第一和第二回路接口单元。 冗余监控系统通过在多个环路网络中将控制器和远程I / O单元彼此连接来配置。 在通过使用网络中的接收数据检测到环路网络中的异常的情况下，可以自动选择能够执行正常接收的第一和第二环路接口单元。