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    Heterocyclic Amide Compound and Use Thereof as an Mmp-13 Inhibitor(Amended Ex Officio)
    1.
    发明申请
    Heterocyclic Amide Compound and Use Thereof as an Mmp-13 Inhibitor(Amended Ex Officio) 有权
    杂环酰胺化合物及其用途为Mmp-13抑制剂（经修正）

    公开(公告)号：US20080027050A1

    公开(公告)日：2008-01-31

    申请号：US11579298

    申请日：2005-04-28

    申请人： Jun Terauchi ,  Haruhiko Kuno ,  Hiroshi Nara ,  Hideyuki Oki ,  Kenjiro Sato

    发明人： Jun Terauchi ,  Haruhiko Kuno ,  Hiroshi Nara ,  Hideyuki Oki ,  Kenjiro Sato

    IPC分类号： A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P19/02 ,  C07D239/90 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04

    CPC分类号： C07D495/04 ,  C07D217/26 ,  C07D239/90 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

    摘要： The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen-containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X′ is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dimethyl-4-oxo-1,4-dihadrothieno[2,3-d]pyrimidine-2-carboxamide is excluded, or a salt thereof.

    摘要翻译： 本发明提供一种具有基质金属蛋白酶抑制活性的新型酰胺衍生物，可用作药剂，其为式（I）表示的化合物，其中环A为任选取代的含氮杂环，环B为 任选取代的单环同位素或任选取代的单环杂环，Z是N或NR 1（R 1是氢原子或任选取代的烃基），是单键 或双键，R 2是氢原子或任选取代的烃基，X是任选取代的具有1-6个原子的间隔基，环C是（1）任选取代的杂环或（2 ）除（II）表示的环以外的任选取代的杂环（X'为S，O，SO或CH 2 2），和至少一个 环B和环C具有取代基，条件是N - {（1S，2R）-1-（3,5-二氟苄基）-3 - [（3-乙基苄基）氨基] -2-羟丙基} -5 ，6-二甲基-4-氧代-1,4-二氢噻吩并[2,3-d]嘧啶-2-甲酰胺或其盐。

    Substituted 2-amidoquinazol-4-ones as matrix metalloproteinase-13 inhibitors
    2.
    发明授权
    Substituted 2-amidoquinazol-4-ones as matrix metalloproteinase-13 inhibitors 有权
    取代的2-氨基喹唑啉-4-酮作为基质金属蛋白酶-13抑制剂

    公开(公告)号：US09212149B2

    公开(公告)日：2015-12-15

    申请号：US11579298

    申请日：2005-04-28

    申请人： Jun Terauchi ,  Hiroshi Nara ,  Hideyuki Oki ,  Kenjiro Sato

    发明人： Jun Terauchi ,  Hiroshi Nara ,  Hideyuki Oki ,  Kenjiro Sato

    IPC分类号： C07D239/90 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D471/04 ,  C07D217/26 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

    CPC分类号： C07D495/04 ,  C07D217/26 ,  C07D239/90 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

    摘要： The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen-containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X′ is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-5,6-dimethyl-4-oxo-1,4-dihadrothieno[2,3-d]pyrimidine-2-carboxamide is excluded, or a salt thereof.

    摘要翻译： 本发明提供一种具有基质金属蛋白酶抑制活性的新型酰胺衍生物，可用作药剂，其为式（I）表示的化合物，其中环A为任选取代的含氮杂环，环B为 任选取代的单环同位素或任选取代的单环杂环，Z是N或NR1（R1是氢原子或任选取代的烃基），是单键或双键，R2是氢原子或任选取代的烃基 X为任选取代的具有1-6个原子的间隔基，环C为（1）任选取代的杂环，或（2）除（II）表示的环以外的任选取代的杂环（X'为S，O，SO， 或CH 2），并且环B和环C中的至少一个具有取代基，条件是N - {（1S，2R）-1-（3,5-二氟苄基）-3 - [（3-乙基苄基）氨基 ] -2-羟丙基} -5,6-二甲基-4-氧代-1,4-二氢噻吩并[2,3-d]嘧啶 -2-甲酰胺或其盐。

    Pillow
    5.
    发明申请
    Pillow 有权
    枕头

    公开(公告)号：US20100229307A1

    公开(公告)日：2010-09-16

    申请号：US12225635

    申请日：2007-02-22

    申请人： Kenjiro Sato

    发明人： Kenjiro Sato

    IPC分类号： A47G9/10

    CPC分类号： A47G9/1081

    摘要： Considering a case where a patient with whiplash syndrome can sleep safely, it is when the patient is sleeping at an appropriate orientation, whereby if a pillow enabling sleep while maintaining an appropriate orientation exists, a sick person can sleep peacefully, and furthermore, the pillow may be useful in treating the whiplash syndrome. A pillow enabling the patient with whiplash syndrome to sleep peacefully is thus developed.A pillow 1 of the present invention has a deformable pillow body 2 including an upper surface cloth 21 and a lower surface cloth 22 having an edge cloth 23 as a boundary, formed with a head depression part 4 including a bottom surface 41 at a position depressed from the upper surface cloth 21 to the lower surface cloth 22 of the pillow body 2, and a groove part 6 extending from the head depression part 4 to the edge cloth 23 of the pillow body 2 and being formed by joining the upper surface cloth 21 to the lower surface cloth 22.

    摘要翻译： 考虑到患有鞭打综合症的患者可以安全地睡觉的情况，就是当患者以适当的方向睡觉时，如果存在能够保持适当取向的睡眠枕头，那么病人可以安静地睡觉，此外，枕头 可用于治疗鞭打综合征。 因此开发了使得患有鞭打综合征的患者平静地睡觉的枕头。 本发明的枕头1具有包括上表面布21和具有边缘布23作为边界的下表面布22的可变形的枕头体2，其形成有头部凹陷部分4，头部凹陷部分4包括位于凹陷处的位置处的底面41 从枕头主体2的上表面布21到下表面布22以及从头部凹陷部4延伸到枕体2的边缘布23的槽部6，并且通过将上表面布21 到下表面布22。

    Vacuum carburizing apparatus
    6.
    发明授权
    Vacuum carburizing apparatus 失效
    真空渗碳装置

    公开(公告)号：US07722801B2

    公开(公告)日：2010-05-25

    申请号：US11892983

    申请日：2007-08-29

    申请人： Kenjiro Sato

    发明人： Kenjiro Sato

    IPC分类号： C23C8/20

    CPC分类号： C23C8/20 ,  C21D1/773

    摘要： The vacuum carburizing apparatus introduces a carburizing gas into a carburizing chamber to subject the treatment material to vacuum carburizing. The vacuum carburizing apparatus comprises a carburizing chamber that houses a treatment material therein, a vacuum pump that exhausts gas from the carburizing chamber inside to obtain vacuum, a carburizing gas supply unit that supplies carburizing gas into the carburizing chamber in pulse mode, a reflux pipe which connects an intake side of the vacuum pump and an exhaust side of the vacuum pump, an opening and closing valve which is provided on the way of the reflux pipe, and a control unit which opens the opening and closing valve when a supply of the carburizing gas into the carburizing chamber is started, wherein the control unit closes the opening and closing valve when the supply ends.

    摘要翻译： 真空渗碳装置将渗碳气体引入渗碳室，使处理材料进行真空渗碳。 真空渗碳装置包括：容纳处理材料的渗碳室，将来自渗碳室内的气体排出到真空中的真空泵，以脉冲模式向渗碳室内供给渗碳气体的渗碳气体供给单元;回流管 其连接真空泵的吸入侧和真空泵的排气侧，设置在回流管路的通路上的开闭阀，以及控制单元，其在供给所述真空泵时，打开所述开闭阀 开始渗碳气体进入渗碳室，其中当供给结束时，控制单元关闭打开和关闭阀。

    Vacuum carburizing apparatus
    7.
    发明申请
    Vacuum carburizing apparatus 失效
    真空渗碳装置

    公开(公告)号：US20080006346A1

    公开(公告)日：2008-01-10

    申请号：US11892983

    申请日：2007-08-29

    申请人： Kenjiro Sato

    发明人： Kenjiro Sato

    IPC分类号： C21D1/773 ,  C23C8/20

    CPC分类号： C23C8/20 ,  C21D1/773

    摘要： The vacuum carburizing apparatus introduces a carburizing gas into a carburizing chamber to subject the treatment material to vacuum carburizing. The vacuum carburizing apparatus comprises a carburizing chamber that houses a treatment material therein, a vacuum pump that exhausts gas from the carburizing chamber inside to obtain vacuum, a carburizing gas supply unit that supplies carburizing gas into the carburizing chamber in pulse mode, a reflux pipe which connects an intake side of the vacuum pump and an exhaust side of the vacuum pump, an opening and closing valve which is provided on the way of the reflux pipe, and a control unit which opens the opening and closing valve when a supply of the carburizing gas into the carburizing chamber is started, whrein the control unit closes the opening and closing valve when the supply ends.

    摘要翻译： 真空渗碳装置将渗碳气体引入渗碳室，使处理材料进行真空渗碳。 真空渗碳装置包括：容纳处理材料的渗碳室，将来自渗碳室内的气体排出到真空中的真空泵，以脉冲模式向渗碳室内供给渗碳气体的渗碳气体供给单元;回流管 其连接真空泵的吸入侧和真空泵的排气侧，设置在回流管路的通路上的开闭阀，以及控制单元，其在供给所述真空泵时，打开所述开闭阀 开始将渗碳气体渗入渗碳室，当供给结束时，控制单元关闭开闭阀。

    Pillow
    8.
    发明授权
    Pillow 有权
    枕头

    公开(公告)号：US08020229B2

    公开(公告)日：2011-09-20

    申请号：US12225635

    申请日：2007-02-22

    申请人： Kenjiro Sato

    发明人： Kenjiro Sato

    IPC分类号： A47C9/10

    CPC分类号： A47G9/1081

    摘要： A pillow for enabling a patient with whiplash syndrome to sleep peacefully including a deformable pillow body having an upper surface cloth and a lower surface cloth with an edge cloth as a boundary, a depression part including a bottom surface at a position depressed from the upper surface cloth to the lower surface cloth of the pillow body and a grooved part extending from the depression part to the edge cloth of the pillow body and being formed by joining the upper surface cloth to the lower surface cloth.

    摘要翻译： 一种用于使患有鞭状综合征的患者平静地睡觉的枕头，包括具有上表面布和具有边缘布作为边界的下表面布的可变形枕头主体，凹陷部分包括在从上表面压下的位置处的底表面 布到枕头的下表面布上，以及从枕头部分的凹陷部分延伸到边缘布的沟槽部分，并且通过将上表面布连接到下表面布上而形成。